DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RyR and RYR3

DIOPT Version :9

Sequence 1:	NP_001246211.1	Gene:	RyR / 49090	FlyBaseID:	FBgn0011286	Length:	5134	Species:	Drosophila melanogaster
Sequence 2:	NP_001027.3	Gene:	RYR3 / 6263	HGNCID:	10485	Length:	4870	Species:	Homo sapiens

Alignment Length:	5273	Identity:	2336/5273 - (44%)
Similarity:	3251/5273 - (61%)	Gaps:	550/5273 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAE-AEGGSEQDDVSFLRTEDMVTLSCTAT----GERVCLAAEGFGNRHCFLENIAD-KNVPPDL 59
            ||| .|||  :|::.||||||.|.|.|.||    ..:.||||||.|||.||||..:: |.:||||
Human     1 MAEGGEGG--EDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIPPDL 63

  Fly    60 SQCVFVIEQALSVRALQELVTAAGSETGKGT--GSGHRTLLYGNAILLRHHNSDMYLACLSTS-S 121
            ..|.||:||:||||||||::...|...|:|.  |.||||||||:|:||||..|.|||.||:|| |
Human    64 CVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYLTCLTTSRS 128

  Fly   122 SNDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKENEQSIV 186
            ..|||:|||||:||:.|||||||:||||||||||||||:|||||||||::|||||.:..|....|
Human   129 QTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSVSNGNIQV 193

  Fly   187 NASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTWGREAGQNIVIYEGGVV 251
            :|||..|.|:|.|..:|.|..:  ||:.||.|:|.|||.|||||||||...::....:.||.|..
Human   194 DASFMQTLWNVHPTCSGSSIEE--GYLLGGHVVRLFHGHDECLTIPSTDQNDSQHRRIFYEAGGA 256

  Fly   252 MAQARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNDSNELILVKKEEASIATTTFCLR 316
            ..:||||||:|..|..|:|..|.|....|:||:|||.||.:.:...|||..:.::...:|.|..|
Human   257 GTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQGLILQDRAKSDTKSTAFSFR 321

  Fly   317 QEKDDEKKV--LEDKDLEVIGSPIIKYGDTTVIVQHCETSLWLSYKSYETKKKGVGKVEEKQAIL 379
            ..|:.::|:  ...:|:|.:|.|.|||||:...|||..:.||::||:.:.|...:|.::.| .||
Human   322 ASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIASGLWVTYKAQDAKTSRLGPLKRK-VIL 385

  Fly   380 HEEGKMDDCLDFSRSQEEESKTARVIRKCSSLFTQFITALETLQSNRRHSIFFQKVNLNEMVMCL 444
            |:||.|||.|...|.|.|||:.||:||..::||:||::.     :||..:..  .:.:.|::..|
Human   386 HQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQFVSG-----NNRTAAPI--TLPIEEVLQTL 443

  Fly   445 EDLINYFSQPEDDMEHEEKQNRFRALRNRQDLFQEEGVLNLILEAIDKINIITSQGFLASFLAGD 509
            :|||.||..||::|.||:|||:.|:|:|||:||:|||:|.|:|..||::|:..|....|. :|.:
Human   444 QDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYNSVAHFAG-IARE 507

  Fly   510 ETGQSWDLISTYLYQLLAAIIKGNHTNCAQFANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLID 574
            |:|.:|..|...||:||||:|:||..|||||  ||.|:||.|:|....||  ||:|:||||:|.:
Human   508 ESGMAWKEILNLLYKLLAALIRGNRNNCAQF--SNNLDWLISKLDRLESS--SGILEVLHCILTE 568

  Fly   575 SPEALNMMRDEHIKVIISLLEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQT 639
            ||||||::.:.|||.|||||:||||:.||||:|||||:.||||||::||.|||.|||.:||||||
Human   569 SPEALNLIAEGHIKSIISLLDKHGRNHKVLDILCSLCLCNGVAVRANQNLICDNLLPRRNLLLQT 633

  Fly   640 LLVDHVASIRPNIFVGRVDGSSMYQKWYFEVTMDHIEQTTHMMP-HLRIGWANTSGYVPYPGGGK 703
            .|::.|.|||||||:|..:||:.|:|||||:.:|.::......| |||:|||::|||.||||||:
Human   634 RLINDVTSIRPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGE 698

  Fly   704 KWGGNGVGDDLYSFGFDGAFLWTGGRKTLVVDALPEEPFIRKGDVIGVAIDLSVPIITFTFNGVK 768
            .||||||||||||:||||..||:|.....|  |...:..:|..||:...:||.||.|:|..||..
Human   699 GWGGNGVGDDLYSYGFDGLHLWSGRIPRAV--ASINQHLLRSDDVVSCCLDLGVPSISFRINGQP 761

  Fly   769 VRGSFRDFNLDGMFFPVMSCSSKLSCRFLFGGDHGRLKFAPPMGFSALVQCLMPQQILSLDPCFY 833
            |:|.|.:||.||:||||||.|:.:..|||.||.||..||.||.|::...:.|:|::.:.|:|...
Human   762 VQGMFENFNTDGLFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKE 826

  Fly   834 FGNLAKNV--LAGPWLIEDDTAFVPKPVDTTGVTLPSSVDQIKEKLAENIHEMWALNKIEAGWSW 896
            :...|..:  |.|........:|:|.||||:.|.||..:::|:::|||||||:|.:||||.||::
Human   827 YKRDADGIRDLLGTTQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTF 891

  Fly   897 GEHRDDYHRIHPCLTHFEKLPAAEKRYDNQLAVQTLKTIISLGYYITMDKPPAR--IRPVRLPNE 959
            |:.|||..|.||||..|.|||..||.|:.|::.:||||:::||.:|....|.|.  ::.|:||..
Human   892 GKIRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKN 956

  Fly   960 IFMQGNGYKPAPLDLSAVTLTPKLEELVDQLAENTHNLWARERIQQGWTYGLNEDSENHRSPHLV 1024
             :|..|||||||||||.|.|.|..|.|||:||||.||:||::||:||||||:.:|.:|.|:|.||
Human   957 -YMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV 1020

  Fly  1025 PYAKVDEAIKKANRDTASETVRTLLVYGYVLDPPTGEGTEALLAEA--QRLKFAGFRTYRVERNY 1087
            |||.:||..||:|||:..|.|||.:.|||.::|...|     ||::  :::.....|.:||||:|
Human  1021 PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQE-----LADSAVEKVSIDKIRFFRVERSY 1080

  Fly  1088 AVTSGKWYFEFEVLTSGPMRVGWARADCYPGAMLGSEDTSWAFDGHNEEKVYGGVSESFGKQCGP 1152
            ||.||||||||||:|.|.|||||||..|.|...||::|.::.|:|:..::.:.| |..||:...|
Human  1081 AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWHQG-SGYFGRTWQP 1144

  Fly  1153 GDIVGVFLDLADHTISFSLNGELLMDALGGETTFADVTAEGVGFVPACTLGVGQKARLIYGQDVD 1217
            ||:||..::|.|.::.|:||||||:...|.|..|||...|. ||||.|.||:.|..|:..|.|..
Human  1145 GDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIEN-GFVPICCLGLSQIGRMNLGTDAS 1208

  Fly  1218 SLKFFTTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFENT-EEMPDCRIDVTRIPGGADTPPHLKI 1281
            :.||:|.||||||:|||.|||.|.|..|::|..|.|.|. ::.|  .|:|.||.|..|:||.||:
Human  1209 TFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHP--HIEVMRIDGTMDSPPCLKV 1271

  Fly  1282 SHNTFETM-EKANWEFLRLSLPVTCMGEFISEQEKARRWDEIKNRQYRLMREAEIAAQMQVQTQA 1345
            :|.||.|. ..|:..:.|||:||.|...|
Human  1272 THKTFGTQNSNADMIYCRLSMPVECHSSF------------------------------------ 1300

  Fly  1346 AHMDHMLKGGFNMNDIKGLTRNFDEHADAEADHMMRGPNRPPRKGSLTRNITFETDMSAALDEMQ 1410
            :|...:                     |:||
Human  1301 SHSPCL---------------------DSEA---------------------------------- 1310

  Fly  1411 RSTSVLDMNGLGEEMDDKKKRGRSPFKFFSKKSRDQSREKMGARTLDTSLERRNTVAHGRNVVNQ 1475
                                        |.|  |.|.:|.:...|
Human  1311 ----------------------------FQK--RKQMQEILSHTT-------------------- 1325

  Fly  1476 QMTTRAPTLRLNNAEIPPSPVPQGPKQLSGSNLGQQPVETSGDEMFDAECLKLINEYFYGVRIFP 1540
                                                           .:|       :|.:|||.
Human  1326 -----------------------------------------------TQC-------YYAIRIFA 1336

  Fly  1541 GQDPTHVYVGWVTTQYHLHSREFNKNKVRRGSVYIEDDYEMAIERIDRQSCYVVRADELFNEVTQ 1605
            ||||:.|:|||||..|||:|.:|:.||....:|.:.|:.....|.:.|.:||:|...::   |..
Human  1337 GQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDI---VAS 1398

  Fly  1606 DASGKGASQGMFVGCFVDTATGIIRFTCEGKDTSHRWMMEPDTKLFPAIFVEATSKEILQIELGR 1670
            ......::..:.:||.||.|.|::.|:..||:....:.:||:||:|||:|::.||..:.|.|||:
Human  1399 SQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGK 1463

  Fly  1671 TPTTLPLSAAVLPTSDKHINPQSPPRLKVQCLRPHQWARVPNTALQVHALKLSDVRGWSMLCEDP 1735
            ....:|||||:..:.:|:..||.||||.||.::|..|:|:||:.|:|...::|:..||.:.|.:|
Human  1464 LKNAMPLSAAIFRSEEKNPVPQCPPRLDVQTIQPVLWSRMPNSFLKVETERVSERHGWVVQCLEP 1528

  Fly  1736 VSMLALHIPEEDRCIDILELIEMDKLLSFHAHSLTLYAALCYQSNYRAAHALCQHVDQKQLLYAI 1800
            :.|:|||||||:||:|||||.|.:.|:.||.|:|.||:|:|...|.|.|:|||.|||..||.|||
Human  1529 LQMMALHIPEENRCVDILELCEQEDLMRFHYHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAI 1593

  Fly  1801 RSEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYITPLGAELK--ELYSDEEMQHSLRSL-VT 1862
            .::|:.|.||.|||||||::||.|......:.|||||.|:.:..:  .|:.||..:|.|..: :.
Human  1594 DNKYLPGLLRSGFYDLLISIHLASAKERKLMMKNEYIIPITSTTRNIRLFPDESKRHGLPGVGLR 1658

  Fly  1863 ESVRPQLRMTEITPPVIATSSMPSVSSEPIPDIDQLYSPKFPLEVVRQFVMEALKDAVEINQVHN 1927
            ..::|..|.:  ||..:.|.           :..|..||:.|||.:|...:..|.:||:.:..|.
Human  1659 TCLKPGFRFS--TPCFVVTG-----------EDHQKQSPEIPLESLRTKALSMLTEAVQCSGAHI 1710

  Fly  1928 RDPIGWTNENLFLPLIKLTDRLLLVGVLTDEDVQRLLVMIDPETWD------------------- 1973
            |||:|.:.|..|:|::||...||::||..|:||:::|::|||..:.
Human  1711 RDPVGGSVEFQFVPVLKLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHSAGTEEGAEKEEVTQVE 1775

  Fly  1974 ----QAFEREGKDEHRKGLLTMKMAEGAKLQMCYLLHHLYDTQLRHRVESIIAFSHDFVGDLQTD 2034
                :|.|:.||:...||||..::.|..|||||.||.:|.|.:|:||||:|:||...:|..||.:
Human  1776 EKAVEAGEKAGKEAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQAN 1840

  Fly  2035 QLRRYIEIKQS-DLPSAVAAKKTKEFRCPPREQMNQILCFKNLEPDDQDNCTCGLELRGRLGDFH 2098
            |..||.|:.|: ::.:|:.|:||||||.||:||:|.:|.|:..|     ||.|..|:|..|.|||
Human  1841 QKFRYNELMQALNMSAALTARKTKEFRSPPQEQINMLLNFQLGE-----NCPCPEEIREELYDFH 1900

  Fly  2099 DSLMQKVSLNALQEPDGVEGTAIEEVKTGPITKIYNFINTVKELEEGPKEVEEPEKKTPEE---- 2159
            :.|:....:...:|.:       ||..|....|:...:..:|    ||   .:|||:.|.|
Human  1901 EDLLLHCGVPLEEEEE-------EEEDTSWTGKLCALVYKIK----GP---PKPEKEQPTEEEER 1951

  Fly  2160 ---VFRKVLIKTIVSWAEESQIENPKLVREMFSLLLRQYDTVGELVRALEKTYVINTRARDDVAE 2221
               ..::::.:|::.||:|.||::.:|||.||:||.||||::|||::||.|||.|:..:..|...
Human  1952 CPTTLKELISQTMICWAQEDQIQDSELVRMMFNLLRRQYDSIGELLQALRKTYTISHTSVSDTIN 2016

  Fly  2222 MWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNATFFQHPDLIRILRVHENVMAVMMNTLGRRA 2286
            :...|.|||:||.|:|.:|||.||...|..::||..|:|||:|:|:|.:||.||.||:|.||..
Human  2017 LLAALGQIRSLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTE- 2080

  Fly  2287 QAQSDAPTQSEVAEGAPSKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFDHFDFLLDNANILLA 2351
                    :|::|          ..:||.:||||||||||..||||||||:|..:||:|:::.||
Human  2081 --------KSQIA----------FPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLA 2127

  Fly  2352 RPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQSNSELVEKGYPDLGWDPVEG 2416
            .||:|||||||||.||:|:|.||||:|.|..|||:..||:.|||||...|:.|||||:||:|:||
Human  2128 SPSMRGSTPLDVAASSVMDNNELALSLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEG 2192

  Fly  2417 ERYLDFLRYCVWVNGESVEENANLVIRLLIRRPECLGPALRGE-GEGLFRAIVEANRMSERISDR 2480
            ||||.|||:.|:||.|||||||::|::||||||||.||||||| |.||..|:..|.::||..:..
Human  2193 ERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALD 2257

  Fly  2481 CKMQDEAEGTIAGLNFTHPLPEGEEDEDYIDTGAAILNFYCTLVDLLGRCAPDASVIEQGKNESL 2545
            ...|........|        :.||:|:.:..|.||::||..|:||||||||:..:|:.||.|::
Human  2258 LPSQGYKREVSTG--------DDEEEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAI 2314

  Fly  2546 RARAILRSLVPLEDLQGVLSLKFTLSQTAPGEEKPKSDMPSGLLPNNKQSIVLFLERVYGIEAQD 2610
            |.|:|||||||.|||.|::|:...|..........:.||.:...|::|..:||||:|||||:.|.
Human  2315 RIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQT 2379

  Fly  2611 LFYRLLEDAFLPDLRTATILDKSDGSESDMALAMNRYIGNSILPLLIKHSKFYNEAENYASLLDA 2675
            ....|||..||||||.:..||....|.::.|||:||||.:::||||.:.:..:...|:..||:|:
Human  2380 FLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDS 2444

  Fly  2676 TLHTVYRLSKNRMLTKGQREAVSDFLVALTSQMQPAMLLKLLRKLTVDVSKLSEYTTVALRLLTL 2740
            ||.|:|||||.|.|||.||:.:.:.|:|:.:.::|:||.:|||:|..||.:|:||..:.|:|||.
Human  2445 TLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTN 2509

  Fly  2741 HFDRCAKYYGSTQGQGSYGASSDEEKRLTMLLFSNIFDSLSNMDYDPELFGKALPCLIAIGCALP 2805
            |:::|.|||....|.||||.:.:||..||..||..||||||:..|||:||..|||||.||..|||
Human  2510 HYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALP 2574

  Fly  2806 PDY-------SLSKNTDEDYYGRQMGAPDQPQYMPNPIDTNNVHLDNDLNSLVQKFSEHYHDAWA 2863
            |||       :|.|....|..|         .:.|.||:|.|..|...|..:|.|::||.||.||
Human  2575 PDYLDTRITATLEKQISVDADG---------NFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWA 2630

  Fly  2864 SRRLEGGWTYGDIRSDNDRKHPRLKPYNMLSEYERERYRDPVRECLKGLLAIGWTVEHS-EVEVA 2927
            ..:.:.||.||....:|.:.||.::|:..|:|.|:|.||.|.||.||.:||:|||||.: |.|..
Human  2631 CDKSQSGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEAL 2695

  Fly  2928 LNHRGSTRRQSKPQINEFQNEGSPFNYNPHPVDMSNLTLSREMQNMAERLAENSHDIWAKKKNEE 2992
            :..|.:.:.:|..|    .|:|:  :|:|.|:|:||:.||||:|.|.|.:|||.|:||||||..|
Human  2696 VQQRENEKLRSVSQ----ANQGN--SYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLE 2754

  Fly  2993 LNGCGGVIHPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQGYKLHKPSKGGAVEEGGATQAAVEL 3057
            |...||..||.|||||.||.|||.||||::|:..|::|..|..:.:..|...::     .:::|.
Human  2755 LESKGGGSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGIIVSRGMKDMELD-----ASSMEK 2814

  Fly  3058 RFSYSLLEKLIQYLDRATINMKLLKPSTTFSRRSSFKTATRDIKFFSKVVLPLMEKYFSTHRNYF 3122
            ||:|..|:|:::|:|.|...:..|: :...|.::......::||||:||:|||:::||::|..||
Human  2815 RFAYKFLKKILKYVDSAQEFIAHLE-AIVSSGKTEKSPRDQEIKFFAKVLLPLVDQYFTSHCLYF 2878

  Fly  3123 IAI-ATATNNIGAASLKEKEMVASIFCKLAALLRNRLSAFGPDVRITVRCLQVLVKGIDARTLTK 3186
            ::. ....::.|.||.|||||||.:|||||||:|:|:|.||.|....|.||.:|.:.:|.||:.|
Human  2879 LSSPLKPLSSSGYASHKEKEMVAGLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMK 2943

  Fly  3187 NCPEFIRTSMLTFFNQTSDDLGNTILNLQDGKYSHLRGTHLK-TSTSLGYVNQVVLPVLTAMFDH 3250
            :..|.::..:..||...::||..|..||:.||::|.| |.:| .|.::.|....:||:||::|:|
Human  2944 SGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSR-TQIKGVSQNINYTTVALLPILTSIFEH 3007

  Fly  3251 LAACDYGSDLLLDEIQVASYKILAALYHLGTDGTLTHDRKYLKTEIERHRPALGSCLGAYSSCFP 3315
            :....:|.||||.::|::.|.||.:||.|||...:         .:||.|||||.||.:.::..|
Human  3008 VTQHQFGMDLLLGDVQISCYHILCSLYSLGTGKNI---------YVERQRPALGECLASLAAAIP 3063

  Fly  3316 VAFLEPHLNKHNQYSLLNRIADHS---LEAQDIMVKMESCMPNLETILAEVDQFVESDKTYNDAP 3377
            ||||||.||::|..|:.|......   |...|.:..|...:|.||.::.|::...||...|.:.|
Human  3064 VAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAESGARYTEMP 3128

  Fly  3378 HIIDVILPLLCAYLPFWWSQGPDNVSPTSGNHVTMVTADHMNPLLRNVLKMIKKNIGNDNAPWMT 3442
            |:|:||||:||.||.:||.:||:|:.|::|...|.||::|::.:|.|:||:|..|:|.|.|.||.
Human  3129 HVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILKIINNNLGIDEASWMK 3193

  Fly  3443 RIAAYTQQIIINTSEELLKDPFLPLAERVKKRTENMLHKEDSMRGFIKSATDDTSQVETQLQEDW 3507
            |||.|.|.||.....:||:..|:|..|::||:....:.:|:.::.   ....||.:.|..:.:::
Human  3194 RIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKA---DGKGDTQEAELLILDEF 3255

  Fly  3508 NLLVRDIYSFYPLLIKYVDLQRNHWLKDNIPEAEELYNHVAEIFNIWSKSQYFLKEEQNFISANE 3572
            .:|.||:|:|||:||:|||..|::|||....::::|:..|||:|.:|.||..|.:|||||:..||
Human  3256 AVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNE 3320

  Fly  3573 IDNMALIMPTATRRSAISEGAPA-VGGKVKKKKKNRDKKRDKDKEVQASLMVACLKRLLPVGLNL 3636
            |:|:|.:  |...:|.:|:.... .||:.:::||.  |:|.....:|.||:||.||::||:|||:
Human  3321 INNLAFL--TGDSKSKMSKAMQVKSGGQDQERKKT--KRRGDLYSIQTSLIVAALKKMLPIGLNM 3381

  Fly  3637 FAGREQELVQHCKDRYLKKMPEYDVIEFARNQLTLPDKLDPSDEMSWQHYLYSKLGKTEEPVDEQ 3701
            ....:|||:...|.||..:..:.:|.|..||.|.|.:|.| ...:.||..||..:.|:|||.:
Human  3382 CTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKSD-DPAVKWQLNLYKDVLKSEEPFN-- 3443

  Fly  3702 ALEKANVNSNEKGKDKTQETVDRIVAMAKVLFGLHMAASSKNRSKR--WGSKISVARRQAVISSL 3764
                            .::||:|:..::..:|.|.. .....|||:  |...:|..|::||::..
Human  3444 ----------------PEKTVERVQRISAAVFHLEQ-VEQPLRSKKAVWHKLLSKQRKRAVVACF 3491

  Fly  3765 RAKHLYRMSRHRACNIFARSYYEQWLQ-EENVGQEVMVEDLTQTFEDSEKSKKEGEETDSKPDPL 3828
            |...||.:.|||:.|:|...|...|:: ||...:|.:|:||.::   .:..::|.|||:.:||||
Human  3492 RMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKS---PKVEEEEEEETEKQPDPL 3553

  Fly  3829 TQLVTTFCRGAMTERSGALQEDLLYMSYAQIAAKS--TGKEEEEGGDEEGGEGGEEGEGTSIHEQ 3891
            .|::..|.|.|:|||| .|::|.||.||:.:.|||  :|::|||..|:|          .:..|:
Human  3554 HQIILYFSRNALTERS-KLEDDPLYTSYSSMMAKSCQSGEDEEEDEDKE----------KTFEEK 3607

  Fly  3892 EMEKQKLLFHQARLSNRGVAEMVLLHISASKGIPSEMVMTTLNLGIAILRGGNIDIQMGMLNHLK 3956
            ||||||.|:.||||..||.|||||..||||||..|.||:.||.||||||.|||..:|..||::||
Human  3608 EMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLK 3672

  Fly  3957 EKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEEYIPSAGAGLG-VGSEGA-----AGEKNMHDA 4015
            ||||.|||.|::|||.|||||||:||||..|||        ||| |..||.     .|||.:.:.
Human  3673 EKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAE--------GLGMVTEEGTLIVRERGEKVLQND 3729

  Fly  4016 EFTCALFRFIQLTCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKEII 4080
            |||..||||:||.|||||.::||:||||.||||||||:|.||||||||||||.||||:||.|:||
Human  3730 EFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDII 3794

  Fly  4081 DPAGKANFFKAIEVASQVFNTLTEVIQGPCTLNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSS 4145
            |.:|:.||.||:.|..|:||:|||.|||||..|||:||||||||||.|||.:|::||.|||:.||
Human  3795 DESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSS 3859

  Fly  4146 QVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKLADLIE 4210
            |::||||||:|.:||:.|:||:|||||||||||||||||||||::|||:|||:|||||||.||..
Human  3860 QIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTS 3924

  Fly  4211 SPSFHEVDMKNEGWVTPKDFREKMEQSKNYTPEEMDFLLACCERNHEGKIDYRAFVEHFHEPSKE 4275
            |.:|.|.|...:|.::.|:|::.||..|.||..|:||||:|.|.:.....:|..||:.||||:|:
Human  3925 SDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYVDFVDRFHEPAKD 3989

  Fly  4276 IGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEILGSSKRIERVYFEIKDSNIE 4340
            ||||:|||||||||||||:.||...|:.|.||||||||:||||||:|.:|:||||||||.:|:..
Human  3990 IGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRT 4054

  Fly  4341 QWEKPQIRESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHASGLMATDDGG----GNVKRD 4401
            ||||||::||||.|.:.:|.|||::||:|.|||||||.||||..||.:..:|...    .....|
Human  4055 QWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDED 4119

  Fly  4402 TAYSSYMSEEEEERAARDP----------IRRTITAVKEGLKFGVHMLSPANIKH------QIGV 4450
            ::|...::.||||..:.:|          ::|.:|          ..|..|.:|:      .:..
Human  4120 SSYVLEIAGEEEEDGSLEPASAFAMACASVKRNVT----------DFLKRATLKNLRKQYRNVKK 4174

  Fly  4451 MQTKSIPELIVGFFKIIFY-IFYYTGYAHFCVVRYIFGILLNLMRGPAPEQEEEPVVEEETFGRA 4514
            |..|.:.:::..||.::|. :|...    |.::..||.||.:.:.|....:..:.:...:..|..
Human  4175 MTAKELVKVLFSFFWMLFVGLFQLL----FTILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDM 4235

  Fly  4515 LPPLPLEEPPGTVQAFGLDINKEENGMYKVVVH-------ESPANSSM------EEGG-ESSPED 4565
            ..|........|::|...::  .|.|:...:||       ::...|.:      :||. :..||.
Human  4236 PDPTQFGIHDDTMEAERAEV--MEPGITTELVHFIKGEKGDTDIMSDLFGLHPKKEGSLKHGPEV 4298

  Fly  4566 GAAASGELV-EGEPHQEPISIVDLLGGEAAK-KAAQERQ---EAQKA--------------QEAA 4611
            |.....|:: :.||.....::......:||: |||.|.:   |::||              ::|.
Human  4299 GLGDLSEIIGKDEPPTLESTVQKKRKAQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAE 4363

  Fly  4612 MASIEAEAKKSSSAPQ--ETPAVHQIDFSQ----YTHRAVSFLARNFYNLKYVALVLAFSINFML 4670
            ....|...||.....|  |.|.....:|.:    |..:.:.:||||||||:::||.:||:|||:|
Human  4364 YLWTEVTKKKKRRCGQKVEKPEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFIL 4428

  Fly  4671 LFYKVTSFTEEADSSAEEELILGSGSGGGADITGSGFGGSGDGGSGDGEMEDEIPELVHVDEDFF 4735
            ||||||.  |..:...|:...|.:                    |.:.|.|:|......:.|...
Human  4429 LFYKVTE--EPLEEETEDVANLWN--------------------SFNDEEEEEAMVFFVLQESTG 4471

  Fly  4736 YMEHVLRIAACLHSLVSLAMLIAYYHLKVPLAIFKREKEIARRLEFEGLFIAEQPEDDDFKSHWD 4800
            ||...||..|.:|:::||..::.||.|||||.:|||||||||:|||:||:|.|||.:||.|..||
Human  4472 YMAPTLRALAIIHTIISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWD 4536

  Fly  4801 KLVISAKSFPVNYWDKFVKKKVRQKYSETYDFDSISNLLGMEKSTFAAQESEET-----GIFKYI 4860
            :|||:..|||.||||||||:||..||.:.|..:.|:.|||::|:.......|||     .:..::
Human  4537 RLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWL 4601

  Fly  4861 MNIDWRYQVWKAGVTFTDNAFLYSLWYFSFSVMGNFNNFFFAAHLLDVAVGFKTLRTILQSVTHN 4925
            .:||.:|.:||.||.||||:|||..||.:.||:|::|||||||||||:|:|||||||||.|||||
Human  4602 SSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHN 4666

  Fly  4926 GKQLVLTVMLLTIIVYIYTVIAFNFFRKFYIQ-EEDEEVDKKCHDMLTCFVFHLYKGVRAGGGIG 4989
            ||||||||.||.::||:|||:|||||||||.: |:|:|.|.||.||:||::||:|.|||||||||
Human  4667 GKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIG 4731

  Fly  4990 DEIGDPDGDDYEVYRIIFDITFFFFVIIILLAIIQGLIIDAFGELRDQLESVKDNMESNCFICGM 5054
            |||.||.||.||:|||:||||||||||:||||||||||||||||||||.|.|:::||:.|||||:
Human  4732 DEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGI 4796

  Fly  5055 GKDFFDIVPHGFDTHVQKEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRSWDFFPVGDCF 5119
            |.|:||..||||:||..:|||||||:||||:||||.:||:||||:|||.|||:|.|||||.||||
Human  4797 GNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCF 4861

  Fly  5120 RKQYEDEL 5127
            ||||||:|
Human  4862 RKQYEDQL 4869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RyR	NP_001246211.1	Ins145_P3_rec	11..202	CDD:285871	123/198 (62%)
		MIR	211..392	CDD:280906	77/182 (42%)
		MIR	270..>305	CDD:197746	14/34 (41%)
		RYDR_ITPR	443..636	CDD:279676	110/192 (57%)
		SPRY1_RyR	647..799	CDD:240457	82/152 (54%)
		RyR	854..944	CDD:280244	48/89 (54%)
		RyR	967..1057	CDD:280244	55/89 (62%)
		SPRY2_RyR	1079..1213	CDD:240458	67/133 (50%)
		SPRY3_RyR	1518..1669	CDD:293937	51/150 (34%)
		RYDR_ITPR	2228..2452	CDD:279676	126/223 (57%)
		RyR	2831..2921	CDD:280244	40/89 (45%)
		RyR	2954..3038	CDD:280244	47/83 (57%)
		RIH_assoc	4017..4130	CDD:285630	81/112 (72%)
		RR_TM4-6	4525..4768	CDD:283990	78/281 (28%)
		Ion_trans	4856..>4976	CDD:278921	79/120 (66%)
RYR3	NP_001027.3	Ins145_P3_rec	12..207	CDD:302989	121/194 (62%)
		MIR	215..268	CDD:197746	27/54 (50%)
		MIR	216..397	CDD:280906	77/181 (43%)
		MIR	275..368	CDD:197746	34/92 (37%)
		RYDR_ITPR	442..621	CDD:279676	104/183 (57%)
		SPRY1_RyR	641..792	CDD:240457	82/152 (54%)
		4 X approximate repeats	840..2820		915/2266 (40%)
		RyR	849..937	CDD:280244	47/87 (54%)
		RyR	963..1053	CDD:280244	55/89 (62%)
		SPRY2_RyR	1072..1204	CDD:240458	67/133 (50%)
		SPRY3_RyR	1324..1462	CDD:293937	52/214 (24%)
		RYDR_ITPR	2023..2228	CDD:279676	126/223 (57%)
		Interaction with FKBP1A. /evidence=ECO:0000269\|PubMed:22100703	2322..2335		8/12 (67%)
		RyR	2598..2688	CDD:280244	40/89 (45%)
		RyR	2716..2800	CDD:280244	47/83 (57%)
		Interaction with CALM. /evidence=ECO:0000250	3469..3498		10/28 (36%)
		RIH_assoc	3731..3844	CDD:285630	81/112 (72%)
		EF-hand_8	3935..3983	CDD:290545	18/47 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4102..4121		2/18 (11%)
		RR_TM4-6	4234..4504	CDD:283990	79/293 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4304..4360		12/55 (22%)
		Ion_trans	<4621..4781	CDD:278921	122/159 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146773
Domainoid	1	1.000	715	1.000	Domainoid score	I116
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	4434	1.000	Inparanoid score	I5
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46584
OrthoDB	1	1.010	-	-		D4054at33208
OrthoFinder	1	1.000	-	-		FOG0001801
OrthoInspector	1	1.000	-	-		otm41250
orthoMCL	1	0.900	-	-		OOG6_102727
Panther	1	1.100	-	-	O	PTHR13715
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1009
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.910