DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RyR and RYR1

DIOPT Version :9

Sequence 1:	NP_001246211.1	Gene:	RyR / 49090	FlyBaseID:	FBgn0011286	Length:	5134	Species:	Drosophila melanogaster
Sequence 2:	NP_000531.2	Gene:	RYR1 / 6261	HGNCID:	10483	Length:	5038	Species:	Homo sapiens

Alignment Length:	5323	Identity:	2357/5323 - (44%)
Similarity:	3267/5323 - (61%)	Gaps:	480/5323 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEAEGGSEQDDVSFLRTEDMVTLSCTAT----GERVCLAAEGFGNRHCFLENIAD-KNVPPDLS 60
            |.:|||   :|:|.||||:|.|.|.|:||    ..::||||||||||.||||..:: :||||||:
Human     1 MGDAEG---EDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLA 62

  Fly    61 QCVFVIEQALSVRALQELV---TAAGSETGKGTGSGHRTLLYGNAILLRHHNSDMYLACLSTS-S 121
            .|.||:||:||||||||::   ..||.|:.:  |.||||||||:||||||.:|.|||:||:|| |
Human    63 ICCFVLEQSLSVRALQEMLANTVEAGVESSQ--GGGHRTLLYGHAILLRHAHSRMYLSCLTTSRS 125

  Fly   122 SNDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKENEQSIV 186
            ..|||:|||||||.:.|||||||:||||||||||||||||||:|||||::|||||.:..:.:..|
Human   126 MTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLHLSTASGELQV 190

  Fly   187 NASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGG-DECLTIPSTWGREAGQNIVIYEGGV 250
            :|||..|.|::.|.   .||.: .|:|.||.|||.|||. |||||| |....:..:.:|.||||.
Human   191 DASFMQTLWNMNPI---CSRCE-EGFVTGGHVLRLFHGHMDECLTI-SPADSDDQRRLVYYEGGA 250

  Fly   251 VMAQARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNDSNELILVKKEEASIATTTFCL 315
            |...||||||||..|..|:|..:.|..|:|:||:|||:||.:.:...|::|...:|....|:||.
Human   251 VCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVVVDASKAHTKATSFCF 315

  Fly   316 RQEKDDEKKVLEDKDLEVIGSPIIKYGDTTVIVQHCETSLWLSYKSYETKKKGVGKVEEKQAILH 380
            |..| ::..|...:|:|.:|.|.||||::...|||..:.|||:|.:.:.|...:| |.:|:|:||
Human   316 RISK-EKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLG-VLKKKAMLH 378

  Fly   381 EEGKMDDCLDFSRSQEEESKTARVIRKCSSLFTQFITALETLQSNRRHS--IFFQKVNLNEMVMC 443
            :||.|||.|..:|.|:|||:.||:|...:.|:.|||.:|::.....|.|  .....:.:..:::.
Human   379 QEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSFSGKPRGSGPPAGTALPIEGVILS 443

  Fly   444 LEDLINYFSQPEDDMEHEEKQNRFRALRNRQDLFQEEGVLNLILEAIDKINIITSQGFLASFLAG 508
            |:|||.||..|.:|::|||||::.|:|||||.||||||:|:::|..||::|:.|:....|.| ||
Human   444 LQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEF-AG 507

  Fly   509 DETGQSWDLISTYLYQLLAAIIKGNHTNCAQFANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLI 573
            :|..:||..|...||:|||::|:||.:|||.|  |..|:||.|:|....:|  ||:|:||:||||
Human   508 EEAAESWKEIVNLLYELLASLIRGNRSNCALF--STNLDWLVSKLDRLEAS--SGILEVLYCVLI 568

  Fly   574 DSPEALNMMRDEHIKVIISLLEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQ 638
            :|||.||::::.|||.|||||:||||:.|||||||||||.|||||||:|:.|.:.||||:.||||
Human   569 ESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQ 633

  Fly   639 TLLVDHVASIRPNIFVGRVDGSSMYQKWYFEVTMDHIEQ-TTHMMPHLRIGWANTSGYVPYPGGG 702
            |.|:::|.||||||||||.:|::.|.||||||.:|.:.. .|....|||:|||.|.||.||||.|
Human   634 TNLINYVTSIRPNIFVGRAEGTTQYSKWYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAG 698

  Fly   703 KKWGGNGVGDDLYSFGFDGAFLWTGGRKTLVVDALPEEPFIRKGDVIGVAIDLSVPIITFTFNGV 767
            :.||||||||||||:||||..||||.....|..  |.:..:...|||...:|||||.|:|..||.
Human   699 EGWGGNGVGDDLYSYGFDGLHLWTGHVARPVTS--PGQHLLAPEDVISCCLDLSVPSISFRINGC 761

  Fly   768 KVRGSFRDFNLDGMFFPVMSCSSKLSCRFLFGGDHGRLKFAPPMGFSALVQCLMPQQILSLDPCF 832
            .|:|.|..|||||:||||:|.|:.:..|||.||.||..||.||.|::...:.::|::.|.|:|..
Human   762 PVQGVFESFNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIK 826

  Fly   833 YF---GNLAKNVLAGPWLIEDDTAFVPKPVDTTGVTLPSSVDQIKEKLAENIHEMWALNKIEAGW 894
            .:   |....: |.||......|.|||.||||..:.||..:::|:|||||||||:|||.:||.||
Human   827 EYRREGPRGPH-LVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGW 890

  Fly   895 SWGEHRDDYHRIHPCLTHFEKLPAAEKRYDNQLAVQTLKTIISLGYYITM--DKPPARIRPVRLP 957
            ::|..|||..|:||||..|..||..|:.|:.|::.:||||:::||.::.|  :|....::..:||
Human   891 TYGPVRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLP 955

  Fly   958 NEIFMQGNGYKPAPLDLSAVTLTPKLEELVDQLAENTHNLWARERIQQGWTYGLNEDSENHRSPH 1022
             :.:|..|||||||||||.|.|||....|||:||||.||:|||:|:.|||:|...:|....|:|.
Human   956 -KTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPR 1019

  Fly  1023 LVPYAKVDEAIKKANRDTASETVRTLLVYGYVLDPPTGEGTEALLAEAQRLKFAGFRTYRVERNY 1087
            ||||..:|||.|::|||:..:.|||||.|||.::||..|.::.    ..:.:....|.:|.|::|
Human  1020 LVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQV----ENQSRCDRVRIFRAEKSY 1080

  Fly  1088 AVTSGKWYFEFEVLTSGPMRVGWARADCYPGAMLGSEDTSWAFDGHNEEKVYGGVSESFGKQCGP 1152
            .|.||:||||||.:|:|.|||||||.:..|...||:::.::.|:||..::.:.| ||.||:...|
Human  1081 TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLG-SEPFGRPWQP 1144

  Fly  1153 GDIVGVFLDLADHTISFSLNGELLMDALGGETTFADVTAEGVGFVPACTLGVGQKARLIYGQDVD 1217
            ||:||..:||.::||.|:||||:||...|.||.|.::.. |.||:|.|:||.||...|..||||.
Human  1145 GDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEI-GDGFLPVCSLGPGQVGHLNLGQDVS 1208

  Fly  1218 SLKFFTTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFENTE-EMPDCRIDVTRIPGGADTPPHLKI 1281
            ||:||..||||||:|||.:||:||||.|::|..|.||... |.|  ..:|:|:.|..||||.|::
Human  1209 SLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHP--HYEVSRVDGTVDTPPCLRL 1271

  Fly  1282 SHNTFETMEK-ANWEFLRLSLPVTCMGEFISEQEKARRWDEIKNRQYRLMREAEIAAQMQVQ--- 1342
            :|.|:.:... ....||||||||    :|              ::.:|....|...|...:|
Human  1272 THRTWGSQNSLVEMLFLRLSLPV----QF--------------HQHFRCTAGATPLAPPGLQPPA 1318

  Fly  1343 ---TQAAHMDHMLKGGFNMNDIKGLTRNFDEHADA----EADHMMRGPNRPPRKGSLTRNITFET 1400
               .:||..|         .|.:.|.|:....::|    |.......|...|:.|.       |.
Human  1319 EDEARAAEPD---------PDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGG-------EA 1367

  Fly  1401 DMSAALDEMQRSTSVLDMNGLGEEMDDKKKRGRSPFKFFSKKSRDQSREKMGARTLDTSLERRNT 1465
            ..:.|.:|...:|            :..||||   |.|.:||
Human  1368 QPARAENEKDATT------------EKNKKRG---FLFKAKK----------------------- 1394

  Fly  1466 VAHGRNVVNQQMTTRAPTLRLNNAEIPPSPVPQGPKQLSGSNLGQQPVETSGDEMFDAECLKLIN 1530
                  |.........|||    ..:|...||                   .|...|.|.:....
Human  1395 ------VAMMTQPPATPTL----PRLPHDVVP-------------------ADNRDDPEIILNTT 1430

  Fly  1531 EYFYGVRIFPGQDPTHVYVGWVTTQYHLHSREFNKNKVRRGSVYIEDDYEMAIERIDRQSCYVVR 1595
            .|:|.||:|.||:|:.|:.||||..||.|...|:.:|||..:|.:.|:.......:...:||:|.
Human  1431 TYYYSVRVFAGQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVW 1495

  Fly  1596 ADELFNEVTQDASGKGASQGMFVGCFVDTATGIIRFTCEGKDTSHRWMMEPDTKLFPAIFVEATS 1660
            ..:.   |:....|:.:...:.:||.||.|||::.||..||:::..:.:||:||||||:||..|.
Human  1496 GGDF---VSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTH 1557

  Fly  1661 KEILQIELGRTPTTLPLSAAVLPTSDKHINPQSPPRLKVQCLRPHQWARVPNTALQVHALKLSDV 1725
            :.::|.|||:....:|||||:..:..|:..||.||||::|.|.|..|:|:||..|||...:..:.
Human  1558 QNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAGER 1622

  Fly  1726 RGWSMLCEDPVSMLALHIPEEDRCIDILELIEMDKLLSFHAHSLTLYAALCYQSNYRAAHALCQH 1790
            .||::.|::|::|:|||||||:||:|||||.|...|..||:|:|.||.|:|...|.|.|||||.|
Human  1623 LGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRVAHALCSH 1687

  Fly  1791 VDQKQLLYAIRSEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYITPLGAELKEL-------- 1847
            |||.|||:|:...::.||||.|:|||||::||||...:.....:|||.||..|.:.:
Human  1688 VDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPGRS 1752

  Fly  1848 YSDEEMQHSLRSL-VTESVRPQLRMTEITPPVIATSSMPSVSSEPIPDIDQLYSPKFPLEVVRQF 1911
            ..:...:|.|..: ||.|:||.   ...:||.. .:::|:..:...|   ...||..|||.:|..
Human  1753 TENGHPRHGLPGVGVTTSLRPP---HHFSPPCF-VAALPAAGAAEAP---ARLSPAIPLEALRDK 1810

  Fly  1912 VMEALKDAVEINQVHNRDPIGWTNENLFLPLIKLTDRLLLVGVLTDEDVQRLLVMIDPETW---- 1972
            .:..|.:||.....|.|||:|.:.|..|:|::||...||::|:..||||:::|.||:||.:
Human  1811 ALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEE 1875

  Fly  1973 ---DQAFEREGKDEHRK--------------------------------GLLTMKMAEGAKLQMC 2002
               |:..|.|.:||..|                                |||.||:.|..|||||
Human  1876 EEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMC 1940

  Fly  2003 YLLHHLYDTQLRHRVESIIAFSHDFVGDLQTDQLRRY-IEIKQSDLPSAVAAKKTKEFRCPPREQ 2066
            :||.:..|.:|:|||||:.||:..:|..||.:|..|| :.||...:.:|..|::|:|||.||:||
Human  1941 HLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQ 2005

  Fly  2067 MNQILCFKNLEPDDQDNCTCGLELRGRLGDFHDSLMQKVSLNALQEPDGVEGTAIEEVKTGP-IT 2130
            :|.:|.||  :..|:::|....|:|..|.|||..|:....:    :.||.|....||...|. :.
Human  2006 INMLLQFK--DGTDEEDCPLPEEIRQDLLDFHQDLLAHCGI----QLDGEEEEPEEETTLGSRLM 2064

  Fly  2131 KIYNFINTVKELEEGPKEVEEPEKKTPEEVFRKVLIKTIVSWAEESQIENPKLVREMFSLLLRQY 2195
            .:...:..||:.||.|:|....|:..|..: ::::...:|.||:|..:::|:|||.|||||.|||
Human  2065 SLLEKVRLVKKKEEKPEEERSAEESKPRSL-QELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQY 2128

  Fly  2196 DTVGELVRALEKTYVINTRARDDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNATFFQ 2260
            |.:|||:|||.:.|.|:..:.:|...:...|.|||:||.|||..:||.||.:.:..::||..|:|
Human  2129 DGLGELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQ 2193

  Fly  2261 HPDLIRILRVHENVMAVMMNTLGRRAQAQSDAPTQSEVAEGAPSKEKDTSHEMVVACCRFLCYFC 2325
            ||:|:|.|.:||.||.||:|.||                 |..||| ....:||.:|||||||||
Human  2194 HPNLMRALGMHETVMEVMVNVLG-----------------GGESKE-IRFPKMVTSCCRFLCYFC 2240

  Fly  2326 RTGRQNQKAMFDHFDFLLDNANILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYL 2390
            |..||||::||||..:||:|:.|.|   .::||||||||.:|:::|.||||||:|..|||:..||
Human  2241 RISRQNQRSMFDHLSYLLENSGIGL---GMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYL 2302

  Fly  2391 SRCGLQSNSELVEKGYPDLGWDPVEGERYLDFLRYCVWVNGESVEENANLVIRLLIRRPECLGPA 2455
            :.|||||...||.|||||:||:|..|||||||||:.|:|||||||||||:|:|||||:|||.|||
Human  2303 AGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPA 2367

  Fly  2456 LRGE-GEGLFRAIVEANRMSERISDRCKMQDEAEGTIAGLNFTHPLPEGEE--DEDYIDTGAAIL 2517
            |||| |.||..||.||.|:||   |..:   :..|........|   .|||  :|:.:..|.||:
Human  2368 LRGEGGSGLLAAIEEAIRISE---DPAR---DGPGIRRDRRREH---FGEEPPEENRVHLGHAIM 2423

  Fly  2518 NFYCTLVDLLGRCAPDASVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFTLSQTAPGEEKPKS 2582
            :||..|:||||||||:..:|:.||.|:||.|||||||||||||.|::||...:..........:.
Human  2424 SFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQIPTLGKDGALVQP 2488

  Fly  2583 DMPSGLLPNNKQSIVLFLERVYGIEAQDLFYRLLEDAFLPDLRTATILDKSDGSESDMALAMNRY 2647
            .|.:..:|::|.|:||||:||||||.||....:|:..||||:|.|..||.:..|.::||||:|||
Human  2489 KMSASFVPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRY 2553

  Fly  2648 IGNSILPLLIKHSKFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDFLVALTSQMQPAM 2712
            :..::|||:.|.:..:...|:.|.::|:.||||||||:.|.|||.||:.:.|.|::|...::|:|
Human  2554 LCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSM 2618

  Fly  2713 LLKLLRKLTVDVSKLSEYTTVALRLLTLHFDRCAKYYGSTQGQGSYGASSDEEKRLTMLLFSNIF 2777
            |..|||:|..||..|:|:..:.|:|||.|::||.|||....|..::|.:|:||..||..||..||
Human  2619 LQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIF 2683

  Fly  2778 DSLSNMDYDPELFGKALPCLIAIGCALPPDYSLSKNTDEDYYG---RQMGAPDQPQYMPNPIDTN 2839
            |||::..|||||:..|:|||.||..||||||     .|..|..   ::.....:..:.|.|::|.
Human  2684 DSLAHKKYDPELYRMAMPCLCAIAGALPPDY-----VDASYSSKAEKKATVDAEGNFDPRPVETL 2743

  Fly  2840 NVHLDNDLNSLVQKFSEHYHDAWASRRLEGGWTYGDIRSDNDRKHPRLKPYNMLSEYERERYRDP 2904
            ||.:...|:|.:.||:|:.|:.||..:::..|:||:...:..:.||.|:||...||.::|.||.|
Human  2744 NVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWP 2808

  Fly  2905 VRECLKGLLAIGWTVEHS-EVEVALNHRGSTRRQSKPQINEFQNEGSPFNYNPHPVDMSNLTLSR 2968
            ::|.||.::|..||:|.: |.|.....:..||:.|:........||    |||.|.|:|.:||||
Human  2809 IKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQTYDPREG----YNPQPPDLSAVTLSR 2869

  Fly  2969 EMQNMAERLAENSHDIWAKKKNEELNGCGGVIHPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQG 3033
            |:|.|||:||||.|:.|.:||.:||...||..||.|||||.||.|||.:|||::||.||::|..|
Human  2870 ELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNG 2934

  Fly  3034 YKLHKPSKGGAVEEGGATQAAVELRFSYSLLEKLIQYLDRATINMKLLK--PSTTFSRRSSFKTA 3096
            |.:.:..|...::     .:::|.||::..|::|::::|   |:.:.:.  .:...|.|......
Human  2935 YAVTRGLKDMELD-----SSSIEKRFAFGFLQQLLRWMD---ISQEFIAHLEAVVSSGRVEKSPH 2991

  Fly  3097 TRDIKFFSKVVLPLMEKYFSTHRNYFIAI-ATATNNIGAASLKEKEMVASIFCKLAALLRNRLSA 3160
            .::||||:|::|||:.:||:.|..||::. |....:.|.||.|||||:.|:|||||||:|:|:|.
Human  2992 EQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSL 3056

  Fly  3161 FGPDVRITVRCLQVLVKGIDARTLTKNCPEFIRTSMLTFFNQTSDDLGNTILNLQDGKYSHLRGT 3225
            ||.|....|.||.:|.:.:||||:.|:.||.::..:.:||...|:|:...:.||:.||.|..| |
Human  3057 FGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQAR-T 3120

  Fly  3226 HLK-TSTSLGYVNQVVLPVLTAMFDHLAACDYGSDLLLDEIQVASYKILAALYHLGTDGTLTHDR 3289
            .:| ...:|.|....:|||||.:|.|:|...:|.|::||::||:.|:.|.::|.|||.
Human  3121 QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTT------- 3178

  Fly  3290 KYLKTEIERHRPALGSCLGAYSSCFPVAFLEPHLNKHNQYSLLNRIA---------DHSLEAQDI 3345
              ..|.:|:.|||||.||...::..|||||||.||::|..|:....:         .:|:|
Human  3179 --KNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVE---- 3237

  Fly  3346 MVKMESC--MPNLETILAEVDQFVESDKTYNDAPHIIDVILPLLCAYLPFWWSQGPDNVSPTSG- 3407
                |.|  :|.||.::|::....||...|.:.||:|::.||:||:|||.||.:||:  :|.|.
Human  3238 ----EMCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPE--APPSAL 3296

  Fly  3408 -----NHVTMVTADHMNPLLRNVLKMIKKNIGNDNAPWMTRIAAYTQQIIINTSEELLKDPFLPL 3467
                 ...|.||:||:|.||.|:|::|..|:|.|.|.||.|:|.:.|.|:.....|||:..|:|.
Human  3297 PAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIPT 3361

  Fly  3468 AERVKKRTENMLHKEDSMRGFIKSATDDTSQVETQLQEDWNLLVRDIYSFYPLLIKYVDLQRNHW 3532
            ..|::||...::.:|:.:|   ..|..:..:.|..:::::::|.||:|:.|||||:|||..|..|
Human  3362 IGRLRKRAGKVVSEEEQLR---LEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNRAQW 3423

  Fly  3533 LKDNIPEAEELYNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMALIMPTATRRSAISE-GAPAV 3596
            |.:..|.||||:..|.|||..||||..|.:|||||:..|||:||:.:  ||..:|.::: |....
Human  3424 LTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFL--TADNKSKMAKAGDIQS 3486

  Fly  3597 GGKVKKKKKNRDKKRDKDK-EVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRYLKKMPEYD 3660
            ||..:::.|   |||..|: .||.||:||.||::||:|||:.|..:|:|:...|.||..|..:.:
Human  3487 GGSDQERTK---KKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRYALKDTDEE 3548

  Fly  3661 VIEFARNQLTLPDKLDPSDEMSWQHYLYSKLGKTEEPVDEQALEKANVNSNEKGKDKTQETVDRI 3725
            |.||..|.|.|..|::.|..:.||..||                 ..|...|:..|..::.|.|:
Human  3549 VREFLHNNLHLQGKVEGSPSLRWQMALY-----------------RGVPGREEDADDPEKIVRRV 3596

  Fly  3726 VAMAKVLFGLHMAASS-KNRSKRWGSKISVARRQAVISSLRAKHLYRMSRHRACNIFARSYYEQW 3789
            ..::.||:.|...... |::...|...:|..||:||::..|...||.:..|||||:|..||...|
Human  3597 QEVSAVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAAW 3661

  Fly  3790 -LQEENVGQEVMVEDLTQTFEDSEKSKKEGEETDSKPDPLTQLVTTFCRGAMTERSGALQEDLLY 3853
             |.|::..::.|::||::.   .|:.::|.|..:.|||||.|||..|.|.|:||:| .|.||.||
Human  3662 ILTEDHSFEDRMIDDLSKA---GEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKS-KLDEDYLY 3722

  Fly  3854 MSYAQIAAKSTGKEEEEGGDEEGGEGGEEGEGTSIHEQEMEKQKLLFHQARLSNRGVAEMVLLHI 3918
            |:||.|.|||.  ..||||  |.||..||.| .|..|::||||:||:.||||..||.|||||..|
Human  3723 MAYADIMAKSC--HLEEGG--ENGEAEEEVE-VSFEEKQMEKQRLLYQQARLHTRGAAEMVLQMI 3782

  Fly  3919 SASKGIPSEMVMTTLNLGIAILRGGNIDIQMGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFE 3983
            ||.||....||.:||.|||:||.|||.::|..||::||:||:||||.||..||.:||||||:|||
Human  3783 SACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFE 3847

  Fly  3984 RNTKAEEYIPSAGAGLGVGSEGAA------GEKNMHDAEFTCALFRFIQLTCEGHNLEWQNYLRT 4042
            |..|||        |||:.:|...      |||.|.|.|||..||||:||.|||||.::||||||
Human  3848 RQNKAE--------GLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRT 3904

  Fly  4043 QAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKEIIDPAGKANFFKAIEVASQVFNTLTEVIQ 4107
            |.|||||:|::||||||||||||||.||||:||.|::|:..||.||.||:.||.||||:|||.||
Human  3905 QTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQ 3969

  Fly  4108 GPCTLNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNV 4172
            ||||.|||:||||||||||.|||.:|:||..||::.|||::||||||:|||||:.|:||:|||||
Human  3970 GPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNV 4034

  Fly  4173 VNGTIGKQMVDTLVESASNVELILKYFDMFLKLADLIESPSFHEVDMKNEGWVTPKDFREKMEQS 4237
            |||.|.:||||.||||:||||:|||:|||||||.|::.|.:|.:......|.::.|||::.|:..
Human  4035 VNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQ 4099

  Fly  4238 KNYTPEEMDFLLACCERNHEGKIDYRAFVEHFHEPSKEIGFNLAVLLTNLSEHMPNEPRLARFLE 4302
            |.::..|:.|||:|.|.:....|:...|...|.||:::||||:||||||||||:|::|||..|||
Human  4100 KQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLE 4164

  Fly  4303 TAGSVLNYFEPFLGRIEILGSSKRIERVYFEIKDSNIEQWEKPQIRESKRAFFYSIVTEGGDKEK 4367
            .|.|:|.||.|:||||||:|:|:||||:||||.::|..|||.||::||||.|.:.:|.|||:.||
Human  4165 LAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEK 4229

  Fly  4368 LEAFVNFCEDAIFEMTHASGLMA--------TDDGGGNVKRDTAYSSYMSEEEEE---------- 4414
            :|.||:||||.||||..|:.:..        .|:|.|..:..       :|..||
Human  4230 MELFVSFCEDTIFEMQIAAQISEPEGEPETDEDEGAGAAEAG-------AEGAEEGAAGLEGTAA 4287

  Fly  4415 RAARDPIRRTITAVKEGLKFGVHMLSPANIKHQIGVMQTKSIPELIVGFFKIIFYIFYYTGYAHF 4479
            .||.....|.:.|....|:    .||..:::.::..::..:..|.......:::......|.|..
Human  4288 TAAAGATARVVAAAGRALR----GLSYRSLRRRVRRLRRLTAREAATAVAALLWAAVTRAGAAGA 4348

  Fly  4480 CVVRYIFGILL-NLMRGPAPEQEEEPVVEE-----------ETFGRALPPLPLEEPPGTVQAFGL 4532
            .......|:|. :|..|...|..::..|.|           |..|.. |..|..:..|...:.|.
Human  4349 GAAAGALGLLWGSLFGGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQ-PAGPGGDADGEGASEGA 4412

  Fly  4533 DINKEENGMYKVVVHES-PANS----SMEEGGESSPEDGAAASGELVEGEPHQEPIS-----IVD 4587
            ....|..|..:..|||: |..:    ::.:||...|| ||...|::.:..|.:.|..     :..
Human  4413 GDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPE-GAGGLGDMGDTTPAEPPTPEGSPILKR 4476

  Fly  4588 LLGGEAAKKAAQERQEAQKAQEAAMASIEAEAKKSSSAPQETP---------------------- 4630
            .||.:..::......|.:...|......:||..:....|:.||
Human  4477 KLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEF 4541

  Fly  4631 ----AVHQIDFSQYTHRAVSFLARNFYNLKYVALVLAFSINFMLLFYKVTSFTEEADSSAEEELI 4691
                .|.::.|       :::|:||||.|:::||.|||:|||:||||||      :||...|:.:
Human  4542 WGELEVQRVKF-------LNYLSRNFYTLRFLALFLAFAINFILLFYKV------SDSPPGEDDM 4593

  Fly  4692 LGSGSGGGADITGSGFGGSGDGGSGDGEM----EDEIPELVHVDEDFFYMEHVLRIAACLHSLVS 4752
            .||.:|   |::|:|.|||...|.|.||.    |||......::|...|||..||..:.||:||:
Human  4594 EGSAAG---DVSGAGSGGSSGWGLGAGEEAEGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVA 4655

  Fly  4753 LAMLIAYYHLKVPLAIFKREKEIARRLEFEGLFIAEQPEDDDFKSHWDKLVISAKSFPVNYWDKF 4817
            ...:|.|..|||||.|||||||:||:|||:||:|.|||||||.|..||:||::..|||.||||||
Human  4656 FLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKF 4720

  Fly  4818 VKKKVRQKYSETYDFDSISNLLGMEKSTFAAQESEE------TGIFKYIMNIDWRYQVWKAGVTF 4876
            ||:||..|:.:.|..:.|:.||||:.:|.......|      .|:..::|:||.:||:||.||.|
Human  4721 VKRKVLDKHGDIYGRERIAELLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIF 4785

  Fly  4877 TDNAFLYSLWYFSFSVMGNFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVY 4941
            |||:|||..||...|::|::|||||||||||:|:|.|||||||.||||||||||:||.||.::||
Human  4786 TDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVY 4850

  Fly  4942 IYTVIAFNFFRKFYIQEEDE-EVDKKCHDMLTCFVFHLYKGVRAGGGIGDEIGDPDGDDYEVYRI 5005
            :|||:|||||||||.:.||| |.|.||.||:||::||:|.||||||||||||.||.||:||:||:
Human  4851 LYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRV 4915

  Fly  5006 IFDITFFFFVIIILLAIIQGLIIDAFGELRDQLESVKDNMESNCFICGMGKDFFDIVPHGFDTHV 5070
            :||||||||||:||||||||||||||||||||.|.||::||:.|||||:|.|:||..||||:||.
Human  4916 VFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT 4980

  Fly  5071 QKEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRSWDFFPVGDCFRKQYEDELS 5128
            .:||||||||||||:||||.:||:||||:|||.|||:|.|||||.||||||||||:||
Human  4981 LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 5038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RyR	NP_001246211.1	Ins145_P3_rec	11..202	CDD:285871	124/199 (62%)
		MIR	211..392	CDD:280906	81/181 (45%)
		MIR	270..>305	CDD:197746	13/34 (38%)
		RYDR_ITPR	443..636	CDD:279676	108/192 (56%)
		SPRY1_RyR	647..799	CDD:240457	85/152 (56%)
		RyR	854..944	CDD:280244	47/89 (53%)
		RyR	967..1057	CDD:280244	52/89 (58%)
		SPRY2_RyR	1079..1213	CDD:240458	63/133 (47%)
		SPRY3_RyR	1518..1669	CDD:293937	54/150 (36%)
		RYDR_ITPR	2228..2452	CDD:279676	125/223 (56%)
		RyR	2831..2921	CDD:280244	33/89 (37%)
		RyR	2954..3038	CDD:280244	49/83 (59%)
		RIH_assoc	4017..4130	CDD:285630	83/112 (74%)
		RR_TM4-6	4525..4768	CDD:283990	84/282 (30%)
		Ion_trans	4856..>4976	CDD:278921	79/120 (66%)
RYR1	NP_000531.2	Ins145_P3_rec	8..203	CDD:302989	123/196 (63%)
		MIR	210..263	CDD:197746	30/53 (57%)
		MIR	211..389	CDD:280906	81/180 (45%)
		MIR	270..358	CDD:197746	34/88 (39%)
		RYDR_ITPR	443..631	CDD:279676	108/192 (56%)
		SPRY1_RyR	642..793	CDD:240457	85/152 (56%)
		Interaction with FKBP1A. /evidence=ECO:0000250\|UniProtKB:P11716	669..680		1/10 (10%)
		6 X approximate repeats	841..2959		932/2288 (41%)
		RyR	850..940	CDD:280244	47/89 (53%)
		RyR	964..1054	CDD:280244	52/89 (58%)
		SPRY2_RyR	1072..1204	CDD:240458	63/133 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1307..1385		17/105 (16%)
		SPRY3_RyR	1418..1566	CDD:293937	54/150 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1867..1923		8/55 (15%)
		RYDR_ITPR	2161..2364	CDD:279676	125/223 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2391..2412		5/26 (19%)
		RyR	2735..2825	CDD:280244	33/89 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2828..2858		9/33 (27%)
		RyR	2855..2939	CDD:280244	49/83 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3478..3501		7/25 (28%)
		Interaction with CALM. /evidence=ECO:0000269\|PubMed:18650434	3614..3643		9/28 (32%)
		RIH_assoc	3879..3992	CDD:285630	83/112 (74%)
		EF-hand_8	4083..4133	CDD:290545	15/49 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4251..4280		6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4382..4538		30/157 (19%)
		RR_TM4-6	4383..4671	CDD:283990	88/305 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4589..4621		14/34 (41%)
		Ion_trans	4765..4949	CDD:278921	132/183 (72%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P11716	4895..4901		5/5 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146769
Domainoid	1	1.000	715	1.000	Domainoid score	I116
eggNOG	1	0.900	-	-		E1_KOG2243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	4434	1.000	Inparanoid score	I5
Isobase	1	0.950	-	0	Normalized mean entropy	S6257
OMA	1	1.010	-	-		QHG46584
OrthoDB	1	1.010	-	-		D4054at33208
OrthoFinder	1	1.000	-	-		FOG0001801
OrthoInspector	1	1.000	-	-		otm41250
orthoMCL	1	0.900	-	-		OOG6_102727
Panther	1	1.100	-	-	O	PTHR13715
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3036
SonicParanoid	1	1.000	-	-		X1009
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750