DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RyR and ryr2b

DIOPT Version :9

Sequence 1:	NP_001246211.1	Gene:	RyR / 49090	FlyBaseID:	FBgn0011286	Length:	5134	Species:	Drosophila melanogaster
Sequence 2:	XP_021323063.1	Gene:	ryr2b / 568463	ZFINID:	ZDB-GENE-061226-3	Length:	4917	Species:	Danio rerio

Alignment Length:	5297	Identity:	2240/5297 - (42%)
Similarity:	3135/5297 - (59%)	Gaps:	558/5297 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GSEQDDVSFLRTEDMVTLSCTATG---ERVCLAAEGFGNRHCFLENIAD-KNVPPDLSQCVFVIE 67
            |..:|::.||||.|.:.|.|.::|   :::||||||||.|.||||:.:: ||||.||..||||::
Zfish     4 GEAEDEIQFLRTRDELVLRCCSSGPHQQKLCLAAEGFGERLCFLESTSNSKNVPADLCVCVFVLD 68

  Fly    68 QALSVRALQELVTAAGSE---TGKGTGSGHRTLLYGNAILLRHHNSDMYLACLSTSS-SNDKLSF 128
            ..||||||||::  |..|   |.....:|.||||||.|:|.||..|||||.|||||. |:|||:|
Zfish    69 HCLSVRALQEML--ANREDLCTASHEAAGRRTLLYGQAVLFRHAYSDMYLCCLSTSGLSSDKLAF 131

  Fly   129 DVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTT----KENEQSI--VN 187
            ||||||.::||.|||||||||||||||||||||||||||||::|||||.:    :.|:..:  |:
Zfish   132 DVGLQEDTKGEVCWWTVHPASKQRSEGEKVRVGDDLILVSVSSERYLHVSWTNGEGNDSGVGRVD 196

  Fly   188 ASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHG-GDECLTIPSTWGREAGQNIVIYEGGVV 251
            |:|..|.|||.|..:|....:  |:|.|||.:|..|| .||||||.:...:......|.:|||:|
Zfish   197 AAFQQTLWSVAPVSSGTVNTQ--GHVRGGDTVRLLHGHTDECLTIRAAKHKADQHRSVHFEGGLV 259

  Fly   252 MAQARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNDSNELILVKKEEASIATTTFCLR 316
            ..|||||||||.....|:|..|:|..|.|:||:|||.:||:.....|.||:::.|.:..|.|..|
Zfish   260 SLQARSLWRLETLHVVWSGSHIHWGQPFRLRHLTTGSFLGLIHDQGLQLVERDRADVKCTAFAFR 324

  Fly   317 QEKDDEKKVLE-DKDLEVIGSPIIKYGDTTVIVQHCETSLWLSYKSYETKKKGVGKVEEKQAILH 380
            ..|::..:.|: .|..:.:|:|.|||||:...:||.:|.|||:|::.::|:: ...|.::||:|.
Zfish   325 ASKEEIAESLDYVKRRDGMGAPEIKYGDSLCFIQHVDTGLWLTYQTTDSKRQ-KESVSQRQAVLQ 388

  Fly   381 EEGKMDDCLDFSRSQEEESKTARVIRKCSSLFTQFITALETLQSNRRHSIFFQKVNLNEMVMC-- 443
            .||.|||.:..||||.||||.|.:||....||:|||:.|:.:......:.|    ||...::|
Zfish   389 AEGHMDDGITLSRSQREESKAACLIRSSVLLFSQFISGLDDVTQKENITNF----NLPIEIICVT 449

  Fly   444 LEDLINYFSQPEDDMEHEEKQNRFRALRNRQDLFQEEGVLNLILEAIDKINIITSQGFLASFLAG 508
            |:||:.||..||...:|:.:|....||:|||:|||:||::.|:|:.||.:::..|....|. ..|
Zfish   450 LQDLLGYFHCPEMGQDHKIRQGDIGALKNRQNLFQDEGIILLVLDCIDHLHVYNSAAHFAE-AVG 513

  Fly   509 DETGQSWDLISTYLYQLLAAIIKGNHTNCAQFANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLI 573
            .|.|:.|:.:....|:||||:|:||..|||||:.|  |:||.|||....:|  ||:|:||||||:
Zfish   514 KEAGECWEGVLNAFYKLLAALIRGNRNNCAQFSGS--LDWLVSRLERLEAS--SGILEVLHCVLV 574

  Fly   574 DSPEALNMMRDEHIKVIISLLEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQ 638
            :||||||::::.|||.|||||:||||:.|:|||||||||.:|:||||:|:.|||.|||.::||||
Zfish   575 ESPEALNVIKESHIKTIISLLDKHGRNHKILDVLCSLCVCHGMAVRSNQHLICDTLLPERDLLLQ 639

  Fly   639 TLLVDHVASIRPNIFVGRVDGSSMYQKWYFEVTMDHIEQTTHMMP-HLRIGWANTSGYVPYPGGG 702
            |.|::.|:|:|||||:...|.|:.|:|||:||.::..|......| |||:|||:|.||.|.|.||
Zfish   640 TRLINQVSSVRPNIFLCTRDDSAQYKKWYYEVVVEKAEPFVTAEPTHLRVGWASTEGYRPSPTGG 704

  Fly   703 KKWGGNGVGDDLYSFGFDGAFLWTGGRKTLVVDALPEEPFIRKGDVIGVAIDLSVPIITFTFNGV 767
            ..||.|||||||.|:||||..|||||....|  :.|.:..:|:.|||...:|||...|:|..||.
Zfish   705 HDWGSNGVGDDLCSYGFDGLQLWTGGVGRRV--SSPNQHLLREDDVISCCLDLSATCISFRVNGQ 767

  Fly   768 KVRGSFRDFNLDGMFFPVMSCSSKLSCRFLFGGDHGRLKFAPPMGFSALVQCLMPQQILSLDPCF 832
            .|:|...:|.:||:.|||:|.|:.:..|.||||..|..:|.||.|||...:.|:|:....|:.|.
Zfish   768 PVQGMLENFCVDGLLFPVVSFSAGVQVRMLFGGRQGEFRFLPPAGFSPCAEALLPKTRCKLELCH 832

  Fly   833 YFGNLAKN------VLAGPWLIEDDTAFVPKPVDTTGVTLPSSVDQIKEKLAENIHEMWALNKIE 891
               .|.:|      .|.||.:......|.|.|||::.|..|..::||:|:||||:||:|.::|||
Zfish   833 ---ELTRNHTETQRDLLGPVVPISPVTFTPVPVDSSQVEYPPQLEQIRERLAENLHELWLIDKIE 894

  Fly   892 AGWSWGEHRDDYHRIHPCLTHFEKLPAAEKRYDNQLAVQTLKTIISLGYYITMDKPPA--RIRPV 954
            .||::|..:|:..::|.||..|.|||..|:.:..|.:...|:|:::.|.:|.:....|  .::.|
Zfish   895 QGWTYGPVKDEGKKVHLCLVEFSKLPDQERIHTLQSSEDILRTLLAFGVHIGLSDEHAEENVKYV 959

  Fly   955 RLPNEIFMQGNGYKPAPLDLSAVTLTPKLEELVDQLAENTHNLWARERIQQGWTYGLNEDSENHR 1019
            ||.|: :...|||||||:|.|.|.||...||||:.||||.||:||||||:|||:||..:|.:..|
Zfish   960 RLSNK-YELWNGYKPAPVDQSRVVLTDAQEELVEYLAENEHNIWARERIRQGWSYGPQQDVKFKR 1023

  Fly  1020 SPHLVPYAKVDEAIKKANRDTASETVRTLLVYGYVLDPPTGEGTEALLAEAQRLKFAG---FRTY 1081
            |..|||:..:||..|:|.||...:.:.|||.:||.::|     .|...|.:..:|..|   ||.:
Zfish  1024 STQLVPFYLLDERYKQAGRDAMRDALGTLLGFGYTVEP-----LEKEHASSSSVKSVGAERFRIF 1083

  Fly  1082 RVERNYAVTSGKWYFEFEVLTSGPMRVGWARADCYPGAMLGSEDTSWAFDGHNEEKVYGGVSESF 1146
            |:|:.:||.|||||||||.:|.|.|||||||..|.|...|||:|.::.|||...:..:|| :|..
Zfish  1084 RLEQLFAVHSGKWYFEFEAVTDGEMRVGWARPGCKPDVDLGSDDQAFVFDGSKGQWWHGG-AERL 1147

  Fly  1147 GKQCGPGDIVGVFLDLADHTISFSLNGELLMDALGGETTFADVTAEGVGFVPACTLGVGQKARLI 1211
            |.....||::|..|||...|:..:||||.|:::.|.|....|: .:..||:|.|::|:.|..||.
Zfish  1148 GGCWKRGDVIGCLLDLTTDTMMITLNGEQLLNSHGSEFAVKDL-IKSDGFLPVCSIGINQVGRLN 1211

  Fly  1212 YGQDVDSLKFFTTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFENTEE-MPDCRIDVTRIPGGADT 1275
            .|..::|||:|..|||||||:||.:||.:.:..|.:..:|:|...:: .|:  |.|.||.|..:.
Zfish  1212 LGCQIESLKYFNVCGLQEGYQPFGLNMSKDLPLWMSWREPLFIPIQDNHPN--IQVVRIEGTVNN 1274

  Fly  1276 PPHLKISHNTFETMEKANWE--FLRLSLPVTCMGEFISEQEKARRWDEIKNRQYRLMREAEIAAQ 1338
            .|.||::...|...|:.:..  |.|||:|:.|...|....:.:
Zfish  1275 TPCLKVTKRVFGHEERGSGSVGFYRLSMPIECAQVFCGPGDAS---------------------- 1317

  Fly  1339 MQVQTQAAHMDHMLKGGFNMNDIKGLTRNFDEHADAEADHMMRGPNRPPRKGSLTRNITFETDMS 1403
              |...:|.:.|:                                 |.|..|.:      ::|..
Zfish  1318 --VPPSSAALCHL---------------------------------RDPEDGEV------DSDFE 1341

  Fly  1404 AALDEMQRSTSVLDMNGLGEEMDDKKKRGRSPFKFFSKKSRDQSREKMGARTLDTSLERRNTVAH 1468
            ..:...:.:.|..::|...:...:|..|.:.  :|..||.::.:.....||.|:      ..:|.
Zfish  1342 LLMKAHRYAGSRDELNNHKDHSQEKPSRLKQ--RFMLKKKQELNTSHSSARLLE------EVLAI 1398

  Fly  1469 GRNVVNQQMTTRAPTLRLNNAEIPPSPVPQGPKQLSGSNLGQQPVETSGDEMFDAECLKLINEYF 1533
            .:|..|:  ..|..|                                                |:
Zfish  1399 EKNEENR--LVRCTT------------------------------------------------YY 1413

  Fly  1534 YGVRIFPGQDPTHVYVGWVTTQYHLHSREFNKNKVRRGSVYIEDDYEMAIERIDRQSCYVVRADE 1598
            |.|||...|:|:.|:|||||:::..|...|:.:::...:|.:.|::....|.:.|.|||:|.|.|
Zfish  1414 YSVRIPFSQEPSCVWVGWVTSKFSHHDVSFDLDRICTVTVTLGDEWGKVHESVKRSSCYMVCAAE 1478

  Fly  1599 LFNEVTQDASGKGASQGMFVGCFVDTATGIIRFTCEGKDTSHRWMMEPDTKLFPAIFVEATSKEI 1663
                 ....|...:|.|:.:||.||||||::.||..||:.:..:.:||.||||||:|.:|||..:
Zfish  1479 -----GSSLSHSRSSNGLEIGCLVDTATGLLTFTANGKEITTYYQVEPGTKLFPAVFAKATSSNV 1538

  Fly  1664 LQIELGRTPTTLPLSAAVLPTSDKHINPQSPPRLKVQCLRPHQWARVPNTALQVHALKLSDVRGW 1728
            .|.|||.....:||||.|..:..::.|||.||||.||.|...:|.|||:....|...:|.:..||
Zfish  1539 FQFELGCIKNVMPLSAGVFRSERRNANPQCPPRLCVQHLTHTRWTRVPDHTQSVEMSRLEERYGW 1603

  Fly  1729 SMLCEDPVSMLALHIPEEDRCIDILELIEMDKLLSFHAHSLTLYAALCYQSNYRAAHALCQHVDQ 1793
            ...|.....::.|:||||.||:|||||.|...||.||.|:|.||:||....|...:||||.||||
Zfish  1604 RAQCSHIQQIMTLYIPEESRCVDILELSESHDLLKFHNHTLLLYSALSAHGNTHVSHALCSHVDQ 1668

  Fly  1794 KQLLYAIRSEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYITPL-GAELKELYSDEEMQHSL 1857
            .|||:|::...|.|.||..:|:|||.:||::||:..:...:|||.|: ..:...||...|.
Zfish  1669 SQLLFALQCSRMPGHLRTSYYNLLINIHLDAHASARQTMNHEYIVPMTNTQSITLYKSNEK---- 1729

  Fly  1858 RSLVTESVRPQLRMTEITPPVIATSSMPSVSSEPIPDID-----------QLYSPKFPLEVVRQF 1911
                .|......|.|.:.|.:..||.....|:..|..:|           :..||:.||:|::..
Zfish  1730 ----VERFPGSDRSTSLWPKMHFTSPCFIRSNNKIDLVDGDEGRVLWSSLRQDSPEIPLDVLKAV 1790

  Fly  1912 VMEALKDAVEINQVHNRDPIGWTNENLFLPLIKLTDRLLLVGVLTDEDVQRLLVMIDPETWDQAF 1976
            |:..||:||.:.....|||.|.:.|.|.:||:.|...|||:||....|::.:..:|.|..:.:|.
Zfish  1791 VIAMLKEAVMVVGQGVRDPTGGSVELLLVPLLNLIHTLLLMGVYQGADLEAVFSLILPGEYMRAT 1855

  Fly  1977 ERE-----------GKDEHRKG------LLTMKMAEGAKLQMCYLLHHLYDTQLRHRVESIIAFS 2024
            :|.           |.:|..||      ||.||:.|..|||:|.||.:|.|.|:|||||::|:||
Zfish  1856 QRTEETDELGESDGGAEEKEKGDWKYDVLLQMKLPEAVKLQVCQLLKYLCDCQVRHRVEAVISFS 1920

  Fly  2025 HDFVGDLQTDQLRRYIEIKQS-DLPSAVAAKKTKEFRCPPREQMNQILCFKNLEPDDQDNCTCGL 2088
            .||||.||.||..||.|:..: ::.:|:.|:||||||.||:||:|.:|.|:    :|...|.|..
Zfish  1921 GDFVGHLQEDQRFRYNEVVDALNMSAALTARKTKEFRSPPQEQINMMLSFR----EDSQECPCPE 1981

  Fly  2089 ELRGRLGDFHDSLMQK--VSLNALQEPDGVEGTAIEEVKTGPITKIYNFINTVKELEEGPKEVEE 2151
            :::..:.:||..||..  :.:.:..|.:..:..:|.....|.:.||.:....:..|
Zfish  1982 DIQDLMWEFHQDLMSHCGIEIESGSENENEDDLSIRNHLHGLVDKIMHLKRRMSGL--------- 2037

  Fly  2152 PEKKTPEEV------FRKVLIKTIVSWAEESQIENPKLVREMFSLLLRQYDTV-GELVRALEKTY 2209
                 |||:      .::::.:|::.||:|..||:|.|||.:||||.:||..: |::...|:|.|
Zfish  2038 -----PEEIASKPVSLQQLISETMLHWAQEETIEDPDLVRAVFSLLHQQYAGLHGQMSAPLQKAY 2097

  Fly  2210 VINTRARDDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNATFFQHPDLIRILRVHENV 2274
            .|:..:.:|...:...|:.||:||..:|.:||||.|.:.|..::||..|:|||:|:|.|.:||.|
Zfish  2098 CISQTSVEDTLHLQWALACIRSLLKARMGKEEEECMIRGLGDIMNNKVFYQHPNLMRALGMHETV 2162

  Fly  2275 MAVMMNTLGRRAQAQSDAPTQSEVAEGAPSKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFDHF 2339
            |.||:|.||.|...:...|                  :||..||||||||||..||||||||||.
Zfish  2163 MEVMVNVLGARESKEIIFP------------------KMVAHCCRFLCYFCRISRQNQKAMFDHL 2209

  Fly  2340 DFLLDNANILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQSNSELVEK 2404
            .:||||.|:.||.||:|||||||||.:|:|:|.||||:|.|..|||:..||..|||:|.:.||.|
Zfish  2210 SYLLDNGNVGLASPSMRGSTPLDVAAASVMDNNELALSLTEADLEKVVQYLGGCGLRSCALLVSK 2274

  Fly  2405 GYPDLGWDPVEGERYLDFLRYCVWVNGESVEENANLVIRLLIRRPECLGPALRGEG-EGLFRAIV 2468
            ||||:||:||||||||||||:.|:.|||||||||.:|:|||||||||.|||||||| .||...:.
Zfish  2275 GYPDIGWNPVEGERYLDFLRFAVFCNGESVEENAYVVVRLLIRRPECFGPALRGEGANGLLATME 2339

  Fly  2469 EANRMSERISDRCKMQDEAEGTIAGLNFTHPLPEGEEDEDYIDTGAAILNFYCTLVDLLGRCAPD 2533
            ||.|:|          ::.:||.|..:........|:|.|.|..|.||:.||..|:||||||||:
Zfish  2340 EAIRIS----------NQQDGTTAHSSSRTLDTLDEDDHDVIHMGHAIMTFYSALIDLLGRCAPE 2394

  Fly  2534 ASVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFTLSQTAPGEEKPKSDMPSGLLPNNKQSIVL 2598
            ..:||.||.|::|.|||||||||.|||:|::::.|:|......:...:.||.....|::|.::||
Zfish  2395 THLIEAGKGEAIRIRAILRSLVPREDLEGIINIPFSLPVVNSDDLVVEPDMSRMFCPDHKAAMVL 2459

  Fly  2599 FLERVYGIEAQDLFYRLLEDAFLPDLRTATILDKSDGSESDMALAMNRYIGNSILPLLIKHSKFY 2663
            ||:||||::.|....|||:..||.||:.|..:|.:....:|||||:|||:..::||||.|:|...
Zfish  2460 FLDRVYGVQDQQFVLRLLKFGFLTDLKAAVNMDTTGLGGTDMALAINRYLCVAVLPLLSKYSSLL 2524

  Fly  2664 NEAENYAS-LLDATLHTVYRLSKNRMLTKGQREAVSDFLVALTSQMQPAMLLKLLRKLTVDVSKL 2727
            .|:.:..| .:|..|..||.|||...|||.||||:.|.|:|:..:::|:|:..|||.|..||.:|
Zfish  2525 CESSSSRSGPVDELLQGVYSLSKASGLTKAQREAIQDCLLAVCGKLKPSMVQPLLRNLVFDVPQL 2589

  Fly  2728 SEYTTVALRLLTLHFDRCAKYYGSTQGQGSYGASSDEEKRLTMLLFSNIFDSLSNMDYDPELFGK 2792
            .|.:.:.|:|||.|:::..|||..:.|.|.:|::|:||..||..||..||.:|:...||.:||..
Zfish  2590 PENSKMPLKLLTNHYEQSRKYYCRSYGFGDFGSASEEELCLTRRLFWGIFSALAKKSYDADLFKL 2654

  Fly  2793 ALPCLIAIGCALPPDY-SLSKNTDEDYYGRQMGAPDQPQYMPNPIDTNNVHLDNDLNSLVQKFSE 2856
            ||.||.|:..|:|||: .||.....:   |......:..:.|.|:||.||.:...|..:|.|::|
Zfish  2655 ALGCLSAVAAAIPPDHLDLSCTGGRE---RHSVMDSERGFCPQPLDTLNVTIPESLEFVVNKYAE 2716

  Fly  2857 HYHDAWASRRLEGGWTYGDIRSDNDRKHPRLKPYNMLSEYERERYRDPVRECLKGLLAIGWTVEH 2921
            |.|:.|:..:...||.:|:..|::.:.||.||||..|||.::|.||..::|.:|.:|.:|||::.
Zfish  2717 HTHEKWSMEKFGNGWVHGEQLSESSKVHPLLKPYRALSEKDKECYRGVIKETVKCMLVLGWTIKR 2781

  Fly  2922 SEVEVALNHRGSTRRQSKPQINEFQNEGSPFNYNPHPVDMSNLTLSREMQNMAERLAENSHDIWA 2986
            :....:.......||.|  |..:...||:. .::|.|||.|::||:.:...||||||||.|.|||
Zfish  2782 TNEGESHGIHNPARRIS--QSGKLSFEGAS-TFSPKPVDTSSVTLTWDQYAMAERLAENYHHIWA 2843

  Fly  2987 KKKNEELNGCGGVIHPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQGYKLHKPSKGGAVEEGGAT 3051
            .:|.:||...||..||.|||||.|:.|:|.:.|:::|:.||:....||.:.:..     |...|.
Zfish  2844 ARKLQELESKGGGSHPLLVPYDALSVKDKSRVRDKAQDVLKFFHVNGYSVKRNR-----EVADAD 2903

  Fly  3052 QAAVELRFSYSLLEKLIQYLDRATINMKLLKPSTTFSRRSSFKTATR-----DIKFFSKVVLPLM 3111
            ..|:..||:|.|:::.::..:||..::..|:.:   ..|.....|.|     .|.||.||:|||:
Zfish  2904 SPAIASRFAYGLIQQALRLTERAQESVIELEVA---QARGQINKAERVPHEQQIHFFIKVLLPLL 2965

  Fly  3112 EKYFSTHRNYFIAIATATNNIGAASL-KEKEMVASIFCKLAALLRNRLSAFGPDVRITVRCLQVL 3175
            ::||..|..||::...::...|..|. ||||||.|:||||.:|.|.|:|.||.|....|.|||:|
Zfish  2966 DQYFKNHHLYFMSTTMSSLRDGCQSTSKEKEMVTSLFCKLGSLARRRISIFGNDALALVNCLQIL 3030

  Fly  3176 VKGIDARTLTKNCPEFIRTSMLTFFNQTSDDLGNTILNLQ-DG-KYSHLRGTHLKTSTSLGYVNQ 3238
            .:.:|.|.|.|...|.:|.|:.:||...::||...:.|:. || ..:..||    ....:.|...
Zfish  3031 AQSLDGRMLMKTTSESVRGSIGSFFEAAAEDLELMVENVTLDGLNRAQKRG----DPELITYTTT 3091

  Fly  3239 VVLPVLTAMFDHLAACDYGSDLLLDEIQVASYKILAALYHLGT-DGTLTHDRKYLKTEIERHRPA 3302
            .::|||:|:|.|.:....|:.|:|||:|...|:||::||.||| .|:.          |||.|..
Zfish  3092 ALIPVLSAIFQHDSQRQSGAGLILDEVQSCCYRILSSLYILGTCSGSF----------IERQRSV 3146

  Fly  3303 LGSCLGAYSSCFPVAFLEPHLNKHNQYSLLNRIADH--SLEAQDIMVKMESCMPNLETILAEVDQ 3365
            ||.||.|.|:.|||.|||           |:.:..|  :|..:.|..|....:|||.....||::
Zfish  3147 LGECLAALSAAFPVCFLE-----------LSDLHSHFDTLSNEGIEEKACKLLPNLHEAFLEVEE 3200

  Fly  3366 FVESDKTYNDA--PHIIDVILPLLCAYLPFWWSQGPDNVSPTSGNHVTMVTADHMNPLLRNVLKM 3428
            ...:..:...|  ..:.:|.|||||:|:..|..  .||.:...| |.:.||..|.|.||..:|.:
Zfish  3201 LAGAGSSARHALLLRVTEVTLPLLCSYVSRWGE--VDNQASQEG-HCSSVTPQHANALLGYILSI 3262

  Fly  3429 IKKNIGNDNAPWMTRIAAYTQQIIINTSEELLKDPFLPLAERVKKRTENMLHKEDSMRGFIKSAT 3493
            |..::|..::.||.|:|.:.|.||......|||..||||.|:::||.|::|.:|:.::   ....
Zfish  3263 IHAHLGTSDSAWMKRLAVFGQPIINKAEPHLLKSHFLPLMEKLRKRAESVLLEEEHLK---MEGR 3324

  Fly  3494 DDTSQVETQLQEDWNLLVRDIYSFYPLLIKYVDLQRNHWLKDNIPEAEELYNHVAEIFNIWSKSQ 3558
            .|.|:.|..:||.:.:||:|||:||||||.::||.|..||::...:||:|::.|||:|..|:||.
Zfish  3325 GDVSEQELDIQERFTVLVQDIYAFYPLLIPFIDLHRMSWLREVNADAEKLFSLVAEVFIFWAKSH 3389

  Fly  3559 YFLKEEQNFISANEIDNMALIMPTATRRSAISEGAPAVGGKVKKKKKNRDKKRDKDKEVQASLMV 3623
            .|..|||||:..|||:|||.::.::  :|.:::     ||...::::...:|.|: .....||:|
Zfish  3390 NFKWEEQNFVVQNEINNMAFLVNSS--KSRMNK-----GGVFCQERRKVKRKADR-YSTHTSLIV 3446

  Fly  3624 ACLKRLLPVGLNLFAGREQELVQHCKDRYLKKMPEYDVIEFARNQLTLPDKLDPSDEMSWQHYLY 3688
            |..|:||.|.:|.....:|.||.|.|.|:.::                    |..||:  :.|::
Zfish  3447 AAPKKLLSVAMNGCCHGDQGLVSHAKSRFAQR--------------------DTEDEV--RAYIH 3489

  Fly  3689 SKLGKTEEPVDEQALEKANVNSNEK-----------------------GKDKTQETVDRIVAMAK 3730
            |.|    :.|.:||..:::.|.. |                       |.......|:||:::|:
Zfish  3490 SIL----QQVSQQAACESDNNVLXKCYLCLLGFIFPFFFFFFFYQDLCGNSVDPLRVERILSIAR 3550

  Fly  3731 VLFGLHMAASSKNRSKR--WGSKISVARRQAVISSLRAKHLYRMSRHRACNIFARSYYEQWLQEE 3793
            |||.|.. .....:.||  |...:|..|::||::.||...||.:.||||.|:|.:.|...||:.|
Zfish  3551 VLFHLDQ-VEHPQKMKRPVWYKMLSKQRKRAVVACLRMAPLYNLPRHRAVNLFLQGYERVWLKAE 3614

  Fly  3794 NVG-QEVMVEDLTQTFEDSEKSKKEGEETDSKPDPLTQLVTTFCRGAMTERSGALQEDLLYMSYA 3857
            |.. ::.::|||.:...  .:..|||.|..:..|||.||:..|.:.|:|:|| .|:||.|||.||
Zfish  3615 NDSPEDRLIEDLAKAAH--VEILKEGAEQRNSIDPLHQLINLFSQCALTQRS-KLEEDGLYMCYA 3676

  Fly  3858 QIAAKSTGKEEEEGGDEEGGEGGEEGEGTSIHEQEMEKQKLLFHQARLSNRGVAEMVLLHISASK 3922
            :|.|||...|||:  ||:|.:        |..|:|||||:||:.||||.:||.|||:|..:|||:
Zfish  3677 EIMAKSCQSEEEQ--DEDGLK--------SFEEKEMEKQRLLYQQARLHDRGAAEMILQKLSASR 3731

  Fly  3923 GIPSEMVMTTLNLGIAILRGGNIDIQMGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTK 3987
            |....||..||.||||||.|||..:|..||.:|:.|||||||.|:||||.|||||||:||||..|
Zfish  3732 GDMGPMVAATLKLGIAILNGGNTSVQQKMLGYLRRKKDVGFFHSLAGLMQSCSVLDLNAFERQIK 3796

  Fly  3988 AEEYIPSAGAGLGVGSEGAAGEKNMHDAEFTCALFRFIQLTCEGHNLEWQNYLRTQAGNTTTVNV 4052
            ||        .||||:|..:|||.|.|.:.||.||||:||.|||||.::|||||||.||.||||:
Zfish  3797 AE--------SLGVGAEDNSGEKVMADEQLTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNI 3853

  Fly  4053 VICTVDYLLRLQESIMDFYWHYSSKEIIDPAGKANFFKAIEVASQVFNTLTEVIQGPCTLNQQAL 4117
            :|.|||||||:||||.||||:||.|::||..|:.||.|||.||.||||||||.||||||.|||:|
Zfish  3854 IISTVDYLLRVQESISDFYWYYSGKDVIDERGQHNFSKAITVAKQVFNTLTEYIQGPCTGNQQSL 3918

  Fly  4118 AHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMV 4182
            |||||||||.|||.:|:|||.|||:.|||::|||.|::|||||:.|:||||||||||||||||||
Zfish  3919 AHSRLWDAVVGFLHVFAHMQMKLSRDSSQIELLKALMDLQKDMVVMLLSMLEGNVVNGTIGKQMV 3983

  Fly  4183 DTLVESASNVELILKYFDMFLKLADLIESPSFHEVDMKNEGWVTPKDFREKMEQSKNYTPEEMDF 4247
            |.||||:||||:|||:|||||||.||..|.:|||.|..::|.::.|||:..||..|.|:..|::|
Zfish  3984 DMLVESSSNVEMILKFFDMFLKLKDLTSSEAFHEYDPDSKGLISKKDFQRAMEVFKRYSQSEIEF 4048

  Fly  4248 LLACCERNHEGKIDYRAFVEHFHEPSKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFE 4312
            ||:|.|......:||..||..||||:||||||:|||||||||||||:.||..|||.|.|||.||.
Zfish  4049 LLSCAEMAESELLDYPDFVTRFHEPAKEIGFNMAVLLTNLSEHMPNDARLQNFLELADSVLKYFH 4113

  Fly  4313 PFLGRIEILGSSKRIERVYFEIKDSNIEQWEKPQIRESKRAFFYSIVTEGGDKEKLEAFVNFCED 4377
            |.|||||||||.||||||||||.:|:..||||||::||||.|.:.:|.:||:|||:|.|||||||
Zfish  4114 PHLGRIEILGSGKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNKGGEKEKMELFVNFCED 4178

  Fly  4378 AIFEMTHASGLMATDDG------GGNVKRDTAYSSYMSEEEEERAARDPIRRTITAVKEGLKFGV 4436
            .||||..|:.:..|:.|      .|..:::...:..:  .|::|..||                :
Zfish  4179 TIFEMQLAAQISGTESGEELKAKKGKEEKEVEKTETL--PEDKRMTRD----------------L 4225

  Fly  4437 HMLSPANIKHQIGVMQTKSIPELIVG-FFKIIFYIFY-YTGYAHFC--VVRYIF--GILLNL--- 4492
            :..|..||:..|..:..|||..:|.. |:.::.:|.: :.|...||  ::.:||  |.::::
Zfish  4226 NCFSVRNIRKHIRRISMKSIISVIFSLFYNVLLFITHAFLGLLWFCLYLLYHIFLSGWIIDVAKE 4290

  Fly  4493 ---------MRGPAPEQE---EEPVVEEETFGRA------LPPLPLE------EPPGTVQAFGLD 4533
                     :|.|...:.   ::...|.:...|.      |..:.|:      :|......|||.
Zfish  4291 MKLTDLFGDLRDPTMVEAIGVQDAFRENDNQARVFSSRGNLRGMSLDLSAVSRDPQLLTDIFGLC 4355

  Fly  4534 INKEENGMYKVVVHESPANSSMEEGGESSPEDGAAASGELVEGEPHQEPISIVDLLGGEAAKKAA 4598
            : |.:.|.|.:                 |..|.:|:..|.:....:|..|...|.       .|.
Zfish  4356 L-KRQGGKYTL-----------------SSGDHSASLDEFLNTSKYQVEIREEDF-------HAV 4395

  Fly  4599 QERQEAQKAQEAAMA-----SIEAEAKK-----SSSAPQETP----AVHQIDFSQYTHRAVSFLA 4649
            |:.:|..:.::|..:     :.|.:||:     |||.|.||.    ||.::..||.| :.::..|
Zfish  4396 QDEEEDTETKKAFCSDEDKHNKEKKAKRRIRKLSSSNPDETEIQEWAVWKMISSQKT-KLLNCFA 4459

  Fly  4650 RNFYNLKYVALVLAFSINFMLLFYKVTSFTEEADSSAEEELILGSGSGGGADITGSGFGGSGDGG 4714
            |||||::.:||.|||:|||:||||||:|.|::.:.:..:|....|
Zfish  4460 RNFYNMRLLALFLAFAINFILLFYKVSSTTDDVEIAFHDESTKSS-------------------- 4504

  Fly  4715 SGDGEMEDEIPELVHVDEDFFYMEHVLRIAACLHSLVSLAMLIAYYHLKVPLAIFKREKEIARRL 4779
                   .|:  ...::|:..||:.:|...|.||:::||..:|.||.|||||.|||||||:||:|
Zfish  4505 -------QEV--YFELEENSGYMKMILHCLAVLHTIISLCCIIGYYCLKVPLVIFKREKELARKL 4560

  Fly  4780 EFEGLFIAEQPEDDDFKSHWDKLVISAKSFPVNYWDKFVKKKVRQKYSETYDFDSISNLLGMEKS 4844
            ||:||:|.|||.:||.|..||::||:..|:|.||||||||:||..||.|.|....:|.|||::|:
Zfish  4561 EFDGLYITEQPSEDDIKGQWDRMVINTPSYPSNYWDKFVKRKVMAKYGELYGSARVSELLGLDKA 4625

  Fly  4845 TF----AAQESE---ETGIFKYIMNIDWRYQVWKAGVTFTDNAFLYSLWYFSFSVMGNFNNFFFA 4902
            ..    .|||.:   :.||...:...|.:|.:||.||.||||:|||..||...||:|::||||||
Zfish  4626 ALDFSSGAQERKRPMQKGILFRLNTTDVKYHMWKLGVVFTDNSFLYLAWYMFVSVLGHYNNFFFA 4690

  Fly  4903 AHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYIQEED-EEVDKK 4966
            |||||:|:|||||||||.|||||||||||||.||.::||:|||:|||||||||.:.|| |.:|.|
Zfish  4691 AHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGEPMDMK 4755

  Fly  4967 CHDMLTCFVFHLYKGVRAGGGIGDEIGDPDGDDYEVYRIIFDITFFFFVIIILLAIIQGLIIDAF 5031
            |.|||||::||:|.||||||||||||.||.||::|.||||||||||||||:||||||||||||||
Zfish  4756 CDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEFEFYRIIFDITFFFFVIVILLAIIQGLIIDAF 4820

  Fly  5032 GELRDQLESVKDNMESNCFICGMGKDFFDIVPHGFDTHVQKEHNLANYMFFLMHLINKPDTEYTG 5096
            ||||||.|.||::||:.|||||:|.::||.|||||::|..:|||||||:||||:||||..||:||
Zfish  4821 GELRDQQEQVKEDMETKCFICGIGNEYFDTVPHGFESHTLQEHNLANYLFFLMYLINKDVTEHTG 4885

  Fly  5097 QETYVWNMYQQRSWDFFPVGDCFRKQYEDELS 5128
            ||:|||.|:|:|.|:||||||||||||||:||
Zfish  4886 QESYVWKMFQERCWEFFPVGDCFRKQYEDQLS 4917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RyR	NP_001246211.1	Ins145_P3_rec	11..202	CDD:285871	120/204 (59%)
		MIR	211..392	CDD:280906	75/182 (41%)
		MIR	270..>305	CDD:197746	15/34 (44%)
		RYDR_ITPR	443..636	CDD:279676	100/194 (52%)
		SPRY1_RyR	647..799	CDD:240457	73/152 (48%)
		RyR	854..944	CDD:280244	37/89 (42%)
		RyR	967..1057	CDD:280244	48/89 (54%)
		SPRY2_RyR	1079..1213	CDD:240458	59/133 (44%)
		SPRY3_RyR	1518..1669	CDD:293937	54/150 (36%)
		RYDR_ITPR	2228..2452	CDD:279676	129/223 (58%)
		RyR	2831..2921	CDD:280244	35/89 (39%)
		RyR	2954..3038	CDD:280244	40/83 (48%)
		RIH_assoc	4017..4130	CDD:285630	83/112 (74%)
		RR_TM4-6	4525..4768	CDD:283990	73/256 (29%)
		Ion_trans	4856..>4976	CDD:278921	80/120 (67%)
ryr2b	XP_021323063.1	Ins145_P3_rec	8..209	CDD:327620	119/202 (59%)
		MIR	218..400	CDD:308455	75/182 (41%)
		RYDR_ITPR	449..642	CDD:307497	104/197 (53%)
		SPRY1_RyR	648..799	CDD:240457	73/152 (48%)
		RyR	857..945	CDD:307927	36/87 (41%)
		RyR	971..1061	CDD:307927	48/89 (54%)
		SPRY	1081..1213	CDD:322017	59/133 (44%)
		SPRY3_RyR	1410..1544	CDD:293937	55/186 (30%)
		RYDR_ITPR	2114..2327	CDD:307497	134/230 (58%)
		RyR	2691..2781	CDD:307927	35/89 (39%)
		RyR	2811..2895	CDD:307927	40/83 (48%)
		RIH_assoc	3818..3931	CDD:312080	83/112 (74%)
		EF-hand_7	4013..4070	CDD:316058	22/56 (39%)
		RR_TM4-6	4299..4549	CDD:310808	80/304 (26%)
		Ion_trans	<4668..4828	CDD:306908	123/159 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580211
Domainoid	1	1.000	713	1.000	Domainoid score	I112
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	4145	1.000	Inparanoid score	I4
OMA	1	1.010	-	-		QHG46584
OrthoDB	1	1.010	-	-		D4054at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24923
orthoMCL	1	0.900	-	-		OOG6_102727
Panther	1	1.100	-	-	O	PTHR13715
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1009
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910