DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RyR and ryr3

DIOPT Version :9

Sequence 1:	NP_001246211.1	Gene:	RyR / 49090	FlyBaseID:	FBgn0011286	Length:	5134	Species:	Drosophila melanogaster
Sequence 2:	XP_009293048.1	Gene:	ryr3 / 561350	ZFINID:	ZDB-GENE-041001-165	Length:	4863	Species:	Danio rerio

Alignment Length:	5292	Identity:	2336/5292 - (44%)
Similarity:	3240/5292 - (61%)	Gaps:	595/5292 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEAEGGSEQDDVSFLRTEDMVTLSCTAT----GERVCLAAEGFGNRHCFLENIAD-KNVPPDLS 60
            |||.||   :|:|.||||||.|.|.|.|.    ..:.||:|||.|||.|:||..:: |.|||||.
Zfish     1 MAEGEG---EDEVQFLRTEDEVVLQCVAAIQKENRKFCLSAEGLGNRLCYLEPTSEAKYVPPDLC 62

  Fly    61 QCVFVIEQALSVRALQELVTAAGSETGKGT---------GSGHRTLLYGNAILLRHHNSDMYLAC 116
            .|.||:||:||||||||::  || ::|:|.         |.||||||||:||||||..|.|||.|
Zfish    63 ICNFVLEQSLSVRALQEML--AG-QSGEGNPDHEQWAAQGGGHRTLLYGHAILLRHSFSGMYLTC 124

  Fly   117 LSTSSS-NDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKE 180
            |.||.| .|||||||||||.|.|||||||:||||||||||||||:|||||||||::|||||.:..
Zfish   125 LKTSRSLTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSIS 189

  Fly   181 NEQSIVNASFHVTHWSVQPYGTGISRMKY-VGYVFGGDVLRFFHGGDECLTIPSTWGREAGQNIV 244
            |....|:|||..|.|:|||   ..||... |||:.||.|:|.|||.||.||||.....:..|.:|
Zfish   190 NGSIQVDASFMQTLWNVQP---TCSRSSVAVGYLLGGQVMRLFHGHDESLTIPGYEQSQEQQRVV 251

  Fly   245 IYEGGVVMAQARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNDSNELILVKKEEASIA 309
            .||.|...::||||||||..|..|:|..:.|..|.|:||::||.|||..:...|||:.:|::..|
Zfish   252 NYEAGKGGSKARSLWRLEPLRISWSGSHMRWGQPFRLRHLSTGHYLGQTEDQGLILLDREKSDTA 316

  Fly   310 TTTFCLRQEKDDEKKVLED---KDLEVIGSPIIKYGDTTVIVQHCETSLWLSYKSYETKKKGVGK 371
            .|.||.|..|:.    :|.   :|::.:|...|||||:...:.|..|.|||||::.:.|...:|.
Zfish   317 ATAFCFRPSKEK----IESGPKRDIDGMGIAEIKYGDSVCFIMHVSTGLWLSYQAPDAKSSRLGP 377

  Fly   372 VEEKQAILHEEGKMDDCLDFSRSQEEESKTARVIRKCSSLFTQFITALETLQSNRRHSIFFQKVN 436
            : :::|.|..||.|||.|.....|.|||:.||:||..:.||||||..|::|...:...:   .:.
Zfish   378 L-KRRAFLSPEGHMDDGLILQLCQHEESRAARIIRNTTHLFTQFIRGLDSLSGEKASEV---TLP 438

  Fly   437 LNEMVMCLEDLINYFSQPEDDMEHEEKQNRFRALRNRQDLFQEEGVLNLILEAIDKINIITSQGF 501
            ::|::..|.|||.||.||:.::||||||.:.|:|..|||||:|||:|.|:...||::|:..|
Zfish   439 VSEVLETLNDLIVYFQQPDSELEHEEKQRQLRSLIKRQDLFKEEGMLTLLSHCIDRLNVYNS--- 500

  Fly   502 LASF--LAGDETGQSWDLISTYLYQLLAAIIKGNHTNCAQFANSNRLNWLFSRLGSQASSEGSGM 564
            .|.|  |||:|.|::|..|...||:||||:||||.|||.||  |.:|:||.|:|....||  ||:
Zfish   501 AAEFEELAGEEAGEAWKDILNLLYELLAALIKGNRTNCTQF--SRKLDWLVSKLERLESS--SGI 561

  Fly   565 LDVLHCVLIDSPEALNMMRDEHIKVIISLLEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFL 629
            |:||||:|.:|||:||:::..|||.|||||.||||:.|:|||||||||.||||||::||.|||.|
Zfish   562 LEVLHCILNESPESLNIIQKAHIKSIISLLYKHGRNYKILDVLCSLCVCNGVAVRANQNFICDHL 626

  Fly   630 LPGKNLLLQTLLVDHVASIRPNIFVGRVDGSSMYQKWYFEVTMDHIEQTTHMMP-HLRIGWANTS 693
            ||.::|||||.||:.|.|:|||||:|..:||:.|:|||||:.:|.::......| |||:|||.|.
Zfish   627 LPRRDLLLQTRLVNDVQSMRPNIFLGMSEGSAQYRKWYFELIIDQVDHFVTSEPTHLRVGWATTK 691

  Fly   694 GYVPYPGGGKKWGGNGVGDDLYSFGFDGAFLWTGGRKTLVVDALPEEPFIRKGDVIGVAIDLSVP 758
            ||.||||||:.||||||||||||:||||..||.|.....|  |...:..:...||:...:||..|
Zfish   692 GYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWAGRIPRAV--ASINQHLLNSDDVVSCCLDLGAP 754

  Fly   759 IITFTFNGVKVRGSFRDFNLDGMFFPVMSCSSKLSCRFLFGGDHGRLKFAPPMGFSALVQCLMPQ 823
            .::|..||..|:|.|.|||:||.||||:|.|:.:..|||.||.||..||.||.|::...:.|:|:
Zfish   755 SMSFRINGQPVQGMFEDFNVDGFFFPVVSFSAGVKVRFLLGGRHGDFKFLPPAGYAPCYEALLPK 819

  Fly   824 QILSLDPCFYFGNLAKNV--LAGPWLIEDDTAFVPKPVDTTGVTLPSSVDQIKEKLAENIHEMWA 886
            :.:.::|...:....:.|  |.|........:|:|.||||:.:.||..::.:::||||||||:|.
Zfish   820 EKMRVEPVKEYKRDLEGVRDLLGTTEFLSQASFIPVPVDTSQIVLPPHLENVRDKLAENIHELWG 884

  Fly   887 LNKIEAGWSWGEHRDDYHRIHPCLTHFEKLPAAEKRYDNQLAVQTLKTIISLGYYITMDKPPAR- 950
            :||||.||.:|:.|||..|.||||..|.|||..||.|:.|::.:||||:::||.::......|.
Zfish   885 MNKIELGWMYGKVRDDNKRQHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCHVAQVNINAED 949

  Fly   951 -IRPVRLPNEIFMQGNGYKPAPLDLSAVTLTPKLEELVDQLAENTHNLWARERIQQGWTYGLNED 1014
             ::.::||.. :|..|||||.|||||.:.|.|..|.|||:||||.||:||::||:||||||:.:|
Zfish   950 DLKKMKLPKN-YMMANGYKPTPLDLSEIKLNPGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQD 1013

  Fly  1015 SENHRSPHLVPYAKVDEAIKKANRDTASETVRTLLVYGYVLDPPTGEGTEALLAEAQRLKFAGFR 1079
            .:|.|:|.|||||.:||..||:|||:..|.:|||:.|||.:|||..|...    :.::......|
Zfish  1014 LKNRRNPRLVPYALLDERTKKSNRDSLREAIRTLVGYGYFIDPPDQETAH----QVEKEGIESIR 1074

  Fly  1080 TYRVERNYAVTSGKWYFEFEVLTSGPMRVGWARADCYPGAMLGSEDTSWAFDGHNEEKVYGGVSE 1144
            .:|||:.|||.:||||||||.:|.|.|||||||..|.|...||.:|.|:.||||...:|:.| |.
Zfish  1075 LFRVEKTYAVKTGKWYFEFEAITGGDMRVGWARPGCRPDIELGMDDQSFVFDGHRGRRVHMG-SH 1138

  Fly  1145 SFGKQCGPGDIVGVFLDLADHTISFSLNGELLMDALGGETTFADVTAEGVGFVPACTLGVGQKAR 1209
            .|.:....||:||..:::.|.::.|:||||:|:...|.|..|||...|. ||:|.|:||:.|..|
Zfish  1139 FFARSWNKGDVVGCLINMEDKSMIFTLNGEILITNKGSELCFADFETED-GFIPVCSLGLSQIGR 1202

  Fly  1210 LIYGQDVDSLKFFTTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFENT-EEMPDCRIDVTRIPGGA 1273
            :..|:|..:.|::|.||||||:|||.|||.|.||.|::|..|.|.|. |:.|  .|:||||.|..
Zfish  1203 MNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPEDHP--HIEVTRIDGTV 1265

  Fly  1274 DTPPHLKISHNTFETMEKANWEFL--RLSLPVTCMGEFISEQEKARRWDEIKNRQYRLMREAEIA 1336
            ||||.||::|.||.| :.:|.:.:  |||:||    ||
Zfish  1266 DTPPCLKVTHKTFGT-QTSNDDMICCRLSMPV----EF--------------------------- 1298

  Fly  1337 AQMQVQTQAAHMDHMLKGGFNMNDIKGLTRNFDEHADAEADHMMRGPNRPPRKGSLTRNITFETD 1401
                                              ||.             |||         .||
Zfish  1299 ----------------------------------HAG-------------PRK---------ITD 1307

  Fly  1402 MSAALDEMQRSTSVLDMNGLGEEMDDKKKRGRSPFKFFSKKSRDQSREKMGARTLDTSLERRNTV 1466
            ::..:.|.||:           :.||
Zfish  1308 INEVIAEDQRA-----------KKDD--------------------------------------- 1322

  Fly  1467 AHGRNVVNQQMTTRAPTLRLNNAEIPPSPVPQGPKQLSGSNLGQQPVETSGDEMFDAECLKLINE 1531
                                            |.|...||                      |.:
Zfish  1323 --------------------------------GGKVDYGS----------------------ITK 1333

  Fly  1532 YFYGVRIFPGQDPTHVYVGWVTTQYHLHSREFNKNKVRRGSVYIEDDYEMAIERIDRQSCYVVRA 1596
            |||.|::|.||||:.|::||||..||.:|:.|:.:.||..:|.:.|:.....|.:.|.:||:|.|
Zfish  1334 YFYSVKVFAGQDPSSVWLGWVTPDYHYYSKHFSLDTVRTVTVTLGDERGRVHESVRRSNCYMVCA 1398

  Fly  1597 DELFNEVTQDASGKGASQGMFVGCFVDTATGIIRFTCEGKDTSHRWMMEPDTKLFPAIFVEATSK 1661
            .::     ..:|...::..:.:||.:|.|:|::.||..|::....:.:||:||||||:||:.||.
Zfish  1399 GDV-----ASSSTSRSNVDLEIGCSIDLASGLVSFTANGRELPTAYQVEPNTKLFPAVFVQPTSP 1458

  Fly  1662 EILQIELGRTPTTLPLSAAVLPTSDKHINPQSPPRLKVQCLRPHQWARVPNTALQVHALKLSDVR 1726
            .:.|||..:.|..:|||:|:..:..|:..||.||||.||.:....|:|:|||.|.|...::|:..
Zfish  1459 NLFQIEFPKIPDAMPLSSAIFKSLLKNPEPQCPPRLDVQTIVSVLWSRMPNTFLTVETARVSERH 1523

  Fly  1727 GWSMLCEDPVSMLALHIPEEDRCIDILELIEMDKLLSFHAHSLTLYAALCYQSNYRAAHALCQHV 1791
            ||.:.|.:|:.|:|:|||||:|||||:||.|.:.|..||.|:|.|:.:||...|.|.||:||.|:
Zfish  1524 GWVVQCLEPLQMMAVHIPEENRCIDIMELSENEDLRKFHYHTLKLFCSLCALGNTRVAHSLCSHL 1588

  Fly  1792 DQKQLLYAIRSEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYITPLGAELK--ELYSDEEMQ 1854
            .|.|.||.|.::|::|.||:|||::||::|||:......:..||:|.|:..|.:  .|:.|:..:
Zfish  1589 GQSQFLYIIDNQYLTGQLREGFYNVLISIHLETAKEARLMMNNEFIIPVTDETRSIRLFPDDSKR 1653

  Fly  1855 HSLRSL-VTESVRPQLRMTEITPPVIATSSMPSVSSEPIPDIDQLYSPKFPLEVVRQFVMEALKD 1918
            |||..: ::.|:.|:|   ..|||...|:...:          .||||:.||.::::..:..|.:
Zfish  1654 HSLPGVGLSTSLTPRL---NFTPPCFITTKRET----------PLYSPQIPLAIMKEKAISMLTE 1705

  Fly  1919 AVEINQVHNRDPIGWTNENLFLPLIKLTDRLLLVGVLTDEDVQRLLVMIDP-------------- 1969
            ||:....|.|||:|.:.|..|:|::||...||::|.:|.|:|:.:|::|:|
Zfish  1706 AVQGGGAHIRDPVGGSVEYQFVPILKLIGTLLIMGAMTSEEVKTILLLIEPIVFGDSKEEEEQTA 1770

  Fly  1970 ---------------ETWDQAFEREGKDEHR--KGLLTMKMAEGAKLQMCYLLHHLYDTQLRHRV 2017
                           |...:|.|.|||:..:  ||||...:.|..|.|||.|||:..|.:|:.|:
Zfish  1771 VVEQGAEKEEATSNEEKAVEAGEEEGKESKQPPKGLLETSLPESVKRQMCELLHYFCDCELKQRI 1835

  Fly  2018 ESIIAFSHDFVGDLQTDQLRRYIEIKQS-DLPSAVAAKKTKEFRCPPREQMNQILCFKNLEPDDQ 2081
            |:|:|||.|||..||.:|..||.|:..: ::.:||.||||:|||.||:||:|.:|.|     ...
Zfish  1836 EAIVAFSDDFVSKLQFNQKFRYNELMLALNMSAAVTAKKTREFRSPPQEQINMLLNF-----SAG 1895

  Fly  2082 DNCTCGLELRGRLGDFHDSLMQKVSLNALQEPDGVEGTAIEEVKTGPITKIYNFINTVKELEEGP 2146
            |:|||..||:..|..||:.|.....: .::|.:..:.|::   |...:..||......::.||.|
Zfish  1896 DDCTCPEELQEELQTFHNDLRLHCGI-PMEEEEEEQDTSL---KGRLMAIIYKIKGRPQKTEEEP 1956

  Fly  2147 KEVEEPEKKTPEEVFRKVLIKTIVSWAEESQIENPKLVREMFSLLLRQYDTVGELVRALEKTYVI 2211
               .:.|:.||..: ::::.:|:||||:|.:|::|:|||.|||||.||||.:|||:|||.|:|.|
Zfish  1957 ---TKQEQATPTNL-KELISQTMVSWAQEYKIQDPELVRSMFSLLRRQYDGIGELLRALRKSYTI 2017

  Fly  2212 NTRARDDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNATFFQHPDLIRILRVHENVMA 2276
            :.::..|...:...|.|||:||.|:|.:||.:||...|..::||..|:|||:|:|:|.:||.||.
Zfish  2018 SDKSVGDAINLLASLGQIRSLLSVRMGEEEGQLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVME 2082

  Fly  2277 VMMNTLGRRAQAQSDAPTQSEVAEGAPSKEKDTSHEMVVA-CCRFLCYFCRTGRQNQKAMFDHFD 2340
            ||:|.||                   ..|.|:.:...||| ||||||||||..|||||:||||..
Zfish  2083 VMVNVLG-------------------GDKNKEIAFPKVVASCCRFLCYFCRISRQNQKSMFDHLS 2128

  Fly  2341 FLLDNANILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQSNSELVEKG 2405
            :||:|:::.||.|.:|||||||||.||:|:|..|||||.|..|||:..||:.||||:...|:.:|
Zfish  2129 YLLENSSVGLACPEMRGSTPLDVAASSVMDNNSLALALEEPDLEKVVTYLAACGLQNCPMLIARG 2193

  Fly  2406 YPDLGWDPVEGERYLDFLRYCVWVNGESVEENANLVIRLLIRRPECLGPALRGE-GEGLFRAIVE 2469
            |||:||:|:||||||.|||:.|:|||||||||||:|::||||||||.||||||| |:||..|:.|
Zfish  2194 YPDIGWNPIEGERYLSFLRFAVFVNGESVEENANVVVKLLIRRPECFGPALRGEGGQGLLAAMKE 2258

  Fly  2470 ANRMSERISDRCKMQDEAEGTIAGLNFTHPLPEG------EEDEDYIDTGAAILNFYCTLVDLLG 2528
            |.::||         |.|      |:.. .||||      |::|:....|.:|::||..|:||||
Zfish  2259 AIKISE---------DPA------LDLP-SLPEGVAPTVVEDEEEVAHMGNSIMSFYSALIDLLG 2307

  Fly  2529 RCAPDASVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFTLSQTAPGEEKPKSDMPSGLLPNNK 2593
            ||||:..:|.:||.|:||.|||||||||::||.|::|:...:..........:.||.:...|.:|
Zfish  2308 RCAPEMHLINKGKGEALRIRAILRSLVPIKDLVGIISIPLKMPVVNKDGTVTEPDMNASFCPEHK 2372

  Fly  2594 QSIVLFLERVYGIEAQDLFYRLLEDAFLPDLRTATILDKSDGSESDMALAMNRYIGNSILPLLIK 2658
            ..:||||:||||::.|.....|||..||||||.:..||......::.|||||||||:::||||.:
Zfish  2373 APMVLFLDRVYGVDDQSFLLHLLEVGFLPDLRASASLDSEVLRSTETALAMNRYIGSAVLPLLTR 2437

  Fly  2659 HSKFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDFLVALTSQMQPAMLLKLLRKLTVD 2723
            .:..:...|:||:|:|:||||:|||||.|.|||.||:|:.:.|:|:...::|:||.:|||:|..|
Zfish  2438 CAHLFAHTEHYATLVDSTLHTIYRLSKGRSLTKAQRDAIDECLLAICMHLRPSMLQQLLRRLVFD 2502

  Fly  2724 VSKLSEYTTVALRLLTLHFDRCAKYYGSTQGQGSYGASSDEEKRLTMLLFSNIFDSLSNMDYDPE 2788
            |.:|:||..:.::|||.|:::..|||....|.||||.:|:||..||..||..:||:||...||.|
Zfish  2503 VPQLTEYCKMPIKLLTNHYEQNWKYYCLPTGLGSYGMASEEELHLTKKLFWGLFDALSQKKYDSE 2567

  Fly  2789 LFGKALPCLIAIGCALPPDY-------SLSKNTDEDYYGRQMGAPDQPQYMPNPIDTNNVHLDND 2846
            ||..|:|||.||..|:||||       :|.|....|..|         .:.|.||:|.|:.|...
Zfish  2568 LFKMAMPCLSAIAGAIPPDYVDSSPGSALVKQASVDAQG---------NFDPQPINTANISLPEK 2623

  Fly  2847 LNSLVQKFSEHYHDAWASRRLEGGWTYGDIRSDNDRKHPRLKPYNMLSEYERERYRDPVRECLKG 2911
            |:.:..||:||.|:.|:|.::..|||.||...|..:.||.||||..|||.|||.||.||:|.||.
Zfish  2624 LDYIASKFAEHSHEKWSSEKIALGWTVGDKVDDKAKTHPLLKPYKALSEKERETYRYPVKETLKS 2688

  Fly  2912 LLAIGWTVEHSEVEVALNHRGSTRRQSKPQINEFQNEGSPFNYNPHPVDMSNLTLSREMQNMAER 2976
            :||:||.:|.::...|:..:..|.:|.|      .:|.:..::.|.|.|:.|:.||||:|.|.|.
Zfish  2689 MLAMGWNIERTKEGEAMFQQRETEKQRK------ISESTQGDFIPAPQDLENVVLSRELQAMVET 2747

  Fly  2977 LAENSHDIWAKKKNEELNGCGGVIHPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQGYKLHKPSK 3041
            :|||.|:||||||.:||:..||..||.|||||.||.|||.:||:::||..|::|..||.:   |:
Zfish  2748 VAENYHNIWAKKKKKELDSKGGGSHPLLVPYDTLTAKEKYRDRDKAQELFKFLQVNGYAI---SR 2809

  Fly  3042 GGAVEEGGATQAAVELRFSYSLLEKLIQYLDRATINMKLLKPSTTFSRRSSFKTATRDIKFFSKV 3106
            |  :::.....:::|.||:|..|::|:.|:|.|...:..|:...| |.::......::||||:|:
Zfish  2810 G--LKDMEQDSSSMEKRFAYKFLKRLLSYVDSAQEFIAHLEAMAT-SGKTDKSPHDQEIKFFAKI 2871

  Fly  3107 VLPLMEKYFSTHRNYFIAIATAT-NNIGAASLKEKEMVASIFCKLAALLRNRLSAFGPDVRITVR 3170
            :|||:::||..|..||::..... ::.|.||.|||||:.|:|||||||:|:|:|.||.|....|.
Zfish  2872 LLPLIDQYFKNHCLYFLSSPNINLSSSGYASNKEKEMITSLFCKLAALVRHRISLFGSDSATMVS 2936

  Fly  3171 CLQVLVKGIDARTLTKNCPEFIRTSMLTFFNQTSDDLGNTILNLQDGKYSHLRGTHLKTSTS-LG 3234
            ||.:|.:.:|.||:.|:..|.::..:.|||...::||..|:.||:.||....| |.:|..|. :.
Zfish  2937 CLHILSRTLDFRTVMKSGSELVKAGVRTFFENAAEDLEKTLENLKLGKLGQSR-TQMKGVTQIIS 3000

  Fly  3235 YVNQVVLPVLTAMFDHLAACDYGSDLLLDEIQVASYKILAALYHLGTDGTLTHDRKYLKTEIERH 3299
            |.:..:||:||.:|.|:....:|::||||:||::.|:||.:||.|||...:         .:|:.
Zfish  3001 YTSVALLPMLTVLFQHVTQHQFGAELLLDDIQLSCYRILTSLYSLGTGKNI---------YVEKQ 3056

  Fly  3300 RPALGSCLGAYSSCFPVAFLEPHLNKHNQYSLLNRIADHS---LEAQDIMVKMESCMPNLETILA 3361
            .|.||.||.:.....||||||.:||.||..|:.|......   |...|.:.:|...||:|:.::.
Zfish  3057 LPVLGECLSSLVGAMPVAFLEANLNMHNPQSVFNTKTPRERAILSMPDTVDEMCPEMPHLDGLMK 3121

  Fly  3362 EVDQFVESDKTYNDAPHIIDVILPLLCAYLPFWWSQGPDNVSPTSGNHVTMVTADHMNPLLRNVL 3426
            |:....||...|.:.|.||:|:||:||.||.:||::||:| ||...|..|.||::|::.:|.|:|
Zfish  3122 EIGDISESGARYTEMPQIIEVVLPMLCNYLSYWWAKGPEN-SPDGANCCTSVTSEHLSLILGNIL 3185

  Fly  3427 KMIKKNIGNDNAPWMTRIAAYTQQIIINTSEELLKDPFLPLAERVKKRTENMLHKEDSMRGFIKS 3491
            |::..|:|.:|||||.|:|.|||.||...|.:||:..|||..|::||:|..::.:|:.:|.   .
Zfish  3186 KILNNNLGIENAPWMKRLAVYTQPIISRASADLLRAHFLPTLEKLKKKTVKVVSEEEMLRA---E 3247

  Fly  3492 ATDDTSQVETQLQEDWNLLVRDIYSFYPLLIKYVDLQRNHWLKDNIPEAEELYNHVAEIFNIWSK 3556
            :..||.:.|.|:.:::.:|.||:|:|||:||:|||..|:.|||:...::.||:..|:|||.:|.|
Zfish  3248 SRADTQEAELQILDEFAVLCRDLYAFYPMLIRYVDNNRSTWLKEPDSDSTELFKMVSEIFILWCK 3312

  Fly  3557 SQYFLKEEQNFISANEIDNMALIMPTATRRSAISEGAPAVGGKVKKKKKNRDKKRDKDKEVQASL 3621
            |..|.:|||||:..|||:|:|.:  ....:|.:|:.    ||:.::::..  |:|.:...||.||
Zfish  3313 SHNFKREEQNFVVQNEINNLAFL--AGDSKSKMSKS----GGQDQERRGK--KRRGELYSVQTSL 3369

  Fly  3622 MVACLKRLLPVGLNLFAGREQELVQHCKDRYLKKMPEYDVIEFARNQLTLPDKL-DPSDEMSWQH 3685
            :||..|::||:|||:....:|||:...|.||..|..:.:|.::.|..|.|.:|. ||:  :.||.
Zfish  3370 IVAAHKKMLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKDYLRKNLHLQEKSEDPA--VQWQI 3432

  Fly  3686 YLYSKLG-KTEEPVDEQALEKANVNSNEKGKDKTQETVDRIVAMAKVLFGL-HMAASSKNRSKRW 3748
            .||..:. |:|.|.|                  .::.|:||.|::..::.| .:....:|:...:
Zfish  3433 NLYKDIVLKSEGPPD------------------PEQNVERIQAISSAVYHLDQVELPLRNKKILF 3479

  Fly  3749 GSKISVARRQAVISSLRAKHLYRMSRHRACNIFARSYYEQWLQ-EENVGQEVMVEDLTQT----F 3808
            ...:|..|::||::..|...||.:.|||:.|:|...|...|:: ||...:|.:|:||.:|    .
Zfish  3480 QKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLSGYQRLWIETEEYSFEEKLVQDLAKTPMTVV 3544

  Fly  3809 EDSEKSKKEGEETDSKPDPLTQLVTTFCRGAMTERSGALQEDLLYMSYAQIAAKSTGKEEEEGGD 3873
            |:.|:     ||.:.:||||.||:..|...|:|||| .|:||.||::||.:.|||..:.|||  :
Zfish  3545 EEEEE-----EEAEVQPDPLHQLILHFSHNALTERS-FLEEDPLYIAYADMMAKSCAENEEE--E 3601

  Fly  3874 EEGGEGGEEGEGTSIHEQEMEKQKLLFHQARLSNRGVAEMVLLHISASKGIPSEMVMTTLNLGIA 3938
            ||     |||:..:..|:||||||:|:.||||..||.|||||..||||||....||..||.|||:
Zfish  3602 EE-----EEGKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTGTLKLGIS 3661

  Fly  3939 ILRGGNIDIQMGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEEYIPSAGAGLG-VG 4002
            :|.|||:.:|..||::||||:|.|||.|::.||.|||:|||:||||..|||        .|| |.
Zfish  3662 VLNGGNVLVQQKMLDYLKEKRDAGFFKSLSALMMSCSILDLNAFERQNKAE--------SLGMVT 3718

  Fly  4003 SEGA-----AGEKNMHDAEFTCALFRFIQLTCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLR 4062
            .||:     .|.|.:.:.:||..||||:||.|||||.::||:||||.|||||||::|.|||||||
Zfish  3719 EEGSISVKGRGSKVLQNDDFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTTVNIIISTVDYLLR 3783

  Fly  4063 LQESIMDFYWHYSSKEIIDPAGKANFFKAIEVASQVFNTLTEVIQGPCTLNQQALAHSRLWDAVG 4127
            |||||.||||:||.|:::|.||:.||.||:.||.|:||:|||.|||||..|||:||||||||||.
Zfish  3784 LQESISDFYWYYSGKDVMDEAGQHNFSKALSVAKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVV 3848

  Fly  4128 GFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNV 4192
            |||.:|::||.|||:.|||:.|||||::|||||:.||||:|||||||||||||||||||||:|||
Zfish  3849 GFLHVFANMQMKLSQDSSQITLLKELMDLQKDMVVMMLSLLEGNVVNGTIGKQMVDTLVESSSNV 3913

  Fly  4193 ELILKYFDMFLKLADLIESPSFHEVDMKNEGWVTPKDFREKMEQSKNYTPEEMDFLLACCERNHE 4257
            |:|||:|||||||.||..|.:|.|.|...:|.::.:||::.||..|.||..|::|||:|.|.:..
Zfish  3914 EMILKFFDMFLKLKDLTSSDNFKEYDPDCKGMISKRDFQKSMESQKQYTQSEIEFLLSCVEADEN 3978

  Fly  4258 GKIDYRAFVEHFHEPSKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEILG 4322
            ...:|..|||.||||:|:||||:||||||||||||::.||:.||:.|.|||:||||:||||||:|
Zfish  3979 DMFNYSDFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLSTFLDLAESVLSYFEPYLGRIEIMG 4043

  Fly  4323 SSKRIERVYFEIKDSNIEQWEKPQIRESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHASG 4387
            .:||||||||||.:|:..||||||::||||.|.:.:|.|||:.||:|.|||||||.||||..||.
Zfish  4044 GAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGESEKMEMFVNFCEDTIFEMQLASQ 4108

  Fly  4388 LMATD--DGGGNVKRDTAYSSYMSEEEEERAARD---PIRRTITAVKEGLKFGVHMLSPANIKHQ 4447
            :...|  :.....:.:..:|......|||.|:.:   .......:||:.:.....||:..::|.|
Zfish  4109 ISEPDPTERPEEEEEEELHSLLEGLSEEEDASLESASAFTAACASVKKSMSNFRQMLTFKSMKKQ 4173

  Fly  4448 IGVMQTKSIPELIVGFFKIIFYIFYYTGYAHFCVVRYIFGILLNLMRGPAPEQEEEPVVEEETFG 4512
            :...:..:|.|:|.|||.  |:...:||:     .:.||||:.....          ::....||
Zfish  4174 MKKFRKLTIREMITGFFS--FFWMLFTGF-----FKGIFGIIFGFFH----------IIWSSMFG 4221

  Fly  4513 RALPPLP--------LEEPPGTVQAFGL--DINKEENGMYKVVVHESPANSSMEE-----GGESS 4562
            ..|....        |...|...| ||:  |:.:.|    |..:.|...::.|.:     |||..
Zfish  4222 GGLVEGAKNMKVTDILGNMPDPTQ-FGIHGDVLEAE----KAEISEMVVSADMVQMTGAGGGEKL 4281

  Fly  4563 PED----------------GAAAS-GELVE-------------------GEPHQEPISIVDLLGG 4591
            ..|                ||... |::.|                   .:|..||
Zfish  4282 ETDVIMDLLNPAVKKEGKHGAEPGLGDVCEILTETSAPVEKKKSQKVAAEKPESEP--------- 4337

  Fly  4592 EAAKKAAQERQEAQK--AQEAAMASIEAEAKKSSSAPQETPAVHQIDFS---QYTHRAVSFLARN 4651
            |.|....||:::..|  |.|...|...|...|..|:..|:||.....|:   .|..:.:::||||
Zfish  4338 EKADTENQEKEDKTKEEAPEEPAAEKPAPKVKRGSSKDESPAFMASFFAGLEVYKTKMLNYLARN 4402

  Fly  4652 FYNLKYVALVLAFSINFMLLFYKVTSFTEEADSSAEEELILGSGSGGGADITGSGFGGSGDGGSG 4716
            ||||:::||.:||:|||:|||||||.   :.|...|||     ||.||.:         .:....
Zfish  4403 FYNLRFLALFVAFAINFILLFYKVTG---DFDDEEEEE-----GSWGGEE---------EEADED 4450

  Fly  4717 DGEMEDEIPELVHVDEDFFYMEHVLRIAACLHSLVSLAMLIAYYHLKVPLAIFKREKEIARRLEF 4781
            :|.||..|     :.|...||...|...|.||:::||..:..||.|||||.:|||||||||:|||
Zfish  4451 EGGMEYFI-----LQESTGYMAPTLTFLAVLHTVISLLCVFGYYCLKVPLVVFKREKEIARKLEF 4510

  Fly  4782 EGLFIAEQPEDDDFKSHWDKLVISAKSFPVNYWDKFVKKKVRQKYSETYDFDSISNLLGMEKSTF 4846
            :||:|.|||.|||.|..||:|||:..|||.||||||||:||..||.:.|..:.|:.|||::||..
Zfish  4511 DGLYITEQPSDDDIKGQWDRLVIATPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKSAL 4575

  Fly  4847 AAQESE-----ETGIFKYIMNIDWRYQVWKAGVTFTDNAFLYSLWYFSFSVMGNFNNFFFAAHLL 4906
            ....:|     |..:..::.:||.:|.|||.||..|||:|||.:||.:.|::|::||||||||||
Zfish  4576 DFDPTEEAVVKEASLLSWLSSIDTKYHVWKMGVVMTDNSFLYLIWYTTMSILGHYNNFFFAAHLL 4640

  Fly  4907 DVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYIQEEDEEV-DKKCHDM 4970
            |:|:|||||||||.|||||||||||||.||.::||:|||:|||||||||.:.|||:. |.||.||
Zfish  4641 DIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDAPDMKCDDM 4705

  Fly  4971 LTCFVFHLYKGVRAGGGIGDEIGDPDGDDYEVYRIIFDITFFFFVIIILLAIIQGLIIDAFGELR 5035
            :||::||:|.||||||||||||.||.||.||:|||:||||||||||:||||||||||||||||||
Zfish  4706 MTCYLFHMYVGVRAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELR 4770

  Fly  5036 DQLESVKDNMESNCFICGMGKDFFDIVPHGFDTHVQKEHNLANYMFFLMHLINKPDTEYTGQETY 5100
            ||.|.||::||:.|||||:|.|:||..||||:||..:|||||||:||||:||||.:||:||||:|
Zfish  4771 DQQEQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESY 4835

  Fly  5101 VWNMYQQRSWDFFPVGDCFRKQYEDEL 5127
            ||.|||:|.|||||.||||||||||:|
Zfish  4836 VWKMYQERCWDFFPAGDCFRKQYEDQL 4862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RyR	NP_001246211.1	Ins145_P3_rec	11..202	CDD:285871	127/205 (62%)
		MIR	211..392	CDD:280906	76/183 (42%)
		MIR	270..>305	CDD:197746	14/34 (41%)
		RYDR_ITPR	443..636	CDD:279676	111/194 (57%)
		SPRY1_RyR	647..799	CDD:240457	78/152 (51%)
		RyR	854..944	CDD:280244	46/89 (52%)
		RyR	967..1057	CDD:280244	53/89 (60%)
		SPRY2_RyR	1079..1213	CDD:240458	63/133 (47%)
		SPRY3_RyR	1518..1669	CDD:293937	53/150 (35%)
		RYDR_ITPR	2228..2452	CDD:279676	125/224 (56%)
		RyR	2831..2921	CDD:280244	43/89 (48%)
		RyR	2954..3038	CDD:280244	45/83 (54%)
		RIH_assoc	4017..4130	CDD:285630	80/112 (71%)
		RR_TM4-6	4525..4768	CDD:283990	85/290 (29%)
		Ion_trans	4856..>4976	CDD:278921	78/120 (65%)
ryr3	XP_009293048.1	Ins145_P3_rec	8..209	CDD:302989	127/206 (62%)
		MIR	218..396	CDD:280906	76/182 (42%)
		MIR	218..270	CDD:197746	27/51 (53%)
		MIR	277..>304	CDD:197746	11/26 (42%)
		RYDR_ITPR	445..633	CDD:279676	111/194 (57%)
		SPRY1_RyR	644..795	CDD:240457	78/152 (51%)
		RyR	852..940	CDD:280244	46/87 (53%)
		RyR	966..1056	CDD:280244	53/89 (60%)
		SPRY2_RyR	1074..1206	CDD:240458	63/133 (47%)
		SPRY3_RyR	1320..1465	CDD:293937	58/242 (24%)
		RYDR_ITPR	2034..2240	CDD:279676	125/224 (56%)
		RyR	2608..2698	CDD:280244	43/89 (48%)
		RyR	2725..2809	CDD:280244	45/86 (52%)
		RIH_assoc	3738..3851	CDD:285630	80/112 (71%)
		RR_TM4-6	4239..4497	CDD:283990	86/293 (29%)
		Ion_trans	<4614..4774	CDD:278921	121/159 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580215
Domainoid	1	1.000	713	1.000	Domainoid score	I112
eggNOG	1	0.900	-	-		E1_KOG2243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	4145	1.000	Inparanoid score	I4
OMA	1	1.010	-	-		QHG46584
OrthoDB	1	1.010	-	-		D4054at33208
OrthoFinder	1	1.000	-	-		FOG0001801
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102727
Panther	1	1.100	-	-	O	PTHR13715
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1009
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770