DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RyR and Ryr3

DIOPT Version :9

Sequence 1:	NP_001246211.1	Gene:	RyR / 49090	FlyBaseID:	FBgn0011286	Length:	5134	Species:	Drosophila melanogaster
Sequence 2:	XP_017172189.1	Gene:	Ryr3 / 20192	MGIID:	99684	Length:	4895	Species:	Mus musculus

Alignment Length:	5307	Identity:	2355/5307 - (44%)
Similarity:	3257/5307 - (61%)	Gaps:	593/5307 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEA-EGGSEQDDVSFLRTEDMVTLSCTAT----GERVCLAAEGFGNRHCFLENIAD-KNVPPDL 59
            |||| |||  :|::.||||||.|.|.|.|.    ..:.||||||.|||.||||..:: |.:||||
Mouse     1 MAEAGEGG--EDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIPPDL 63

  Fly    60 SQCVFVIEQALSVRALQELVTAAGSETGKG-------------TGSGHRTLLYGNAILLRHHNSD 111
            ..|.||:||:||||||||::.......|:|             .|.||||||||:||||||..|.
Mouse    64 CVCNFVLEQSLSVRALQEMLANTVENGGEGLSDLSEWFQRKAAQGGGHRTLLYGHAILLRHSFSG 128

  Fly   112 MYLACLSTS-SSNDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL 175
            |||.||:|| |..|||:|||||:||:.|||||||:||||||||||||||:|||||||||::||||
Mouse   129 MYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYL 193

  Fly   176 HTTKENEQSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTWGREAG 240
            |.:..|....|:|||..|.|:|.|..:|.|..:  ||:.||.|:|.|||.|||||||||...::.
Mouse   194 HLSISNGSIQVDASFMQTLWNVHPTCSGSSIEE--GYLLGGHVVRLFHGHDECLTIPSTDQNDSQ 256

  Fly   241 QNIVIYEGGVVMAQARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNDSNELILVKKEE 305
            ...|.||.|....:||||||:|..|..|:|..|.|....|:||:|||.||.:.:...|:|..:.:
Mouse   257 HRRVFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQGLLLQDRGK 321

  Fly   306 ASIATTTFCLRQEKDDEKKV--LEDKDLEVIGSPIIKYGDTTVIVQHCETSLWLSYKSYETKKKG 368
            :...:|.|..|..|:.::|:  ...:|:|.:|.|.|||||:...|||..:.||::||:.:.|...
Mouse   322 SDTKSTAFSFRASKEIKEKLDSSHKRDMEGMGVPEIKYGDSVCFVQHVASGLWVTYKAQDAKTSR 386

  Fly   369 VGKVEEKQAILHEEGKMDDCLDFSRSQEEESKTARVIRKCSSLFTQFITALETLQSNRRHSIFFQ 433
            :|.::.| .|||:||.|||.|...|.|:|||:.||:||..::||:||::.     :||..:
Mouse   387 LGPLKRK-VILHQEGHMDDGLTLQRCQQEESQAARIIRNTTALFSQFVSG-----NNRTTA---- 441

  Fly   434 KVNL--NEMVMCLEDLINYFSQPEDDMEHEEKQNRFRALRNRQDLFQEEGVLNLILEAIDKINII 496
            .|.|  .|::..|:|||.||..|||:|:||:|||:.|:|:|||:||:|||:|.|:|..||::||.
Mouse   442 PVALPTEEVLQTLQDLIAYFQPPEDEMQHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNIY 506

  Fly   497 TSQGFLASFLAGDETGQSWDLISTYLYQLLAAIIKGNHTNCAQFANSNRLNWLFSRLGSQASSEG 561
            .|....|. :..:|:|.:|..|...||:||||:|:||..|||||  ||.|:||.|:|....||
Mouse   507 NSVAHFAG-IVREESGMAWKEILNLLYKLLAALIRGNRNNCAQF--SNNLDWLISKLDRLESS-- 566

  Fly   562 SGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNIC 626
            ||:|:||||:||:||||||::.:.|||.|||||:||||:.||||||||||:.||||||::||.||
Mouse   567 SGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQNLIC 631

  Fly   627 DFLLPGKNLLLQTLLVDHVA---------------SIRPNIFVGRVDGSSMYQKWYFEVTMDHIE 676
            |.|||.:||||||.|::.|.               |||||||:|..:||..|:|||||:.:|.:|
Mouse   632 DNLLPRRNLLLQTRLINDVTSYLLSAEAACPMFNFSIRPNIFLGVAEGSPQYKKWYFELIIDQVE 696

  Fly   677 QTTHMMP-HLRIGWANTSGYVPYPGGGKKWGGNGVGDDLYSFGFDGAFLWTGGRKTLVVDALPEE 740
            ......| |||:|||::|||.||||||:.||||||||||||:||||..||:|.....|  |...:
Mouse   697 PFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRAV--ASINQ 759

  Fly   741 PFIRKGDVIGVAIDLSVPIITFTFNGVKVRGSFRDFNLDGMFFPVMSCSSKLSCRFLFGGDHGRL 805
            ..::..||:...:||.||.|:|..||..|:|.|.:||.||:||||||.|:.:..|||.||.||..
Mouse   760 HLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMSFSAGVKVRFLMGGRHGEF 824

  Fly   806 KFAPPMGFSALVQCLMPQQILSLDPCFYFGNLAKNV--LAGPWLIEDDTAFVPKPVDTTGVTLPS 868
            ||.||.|::...:.|:|::.:.|:|...:...|..|  |.|........:|:|.|:||:.|.||.
Mouse   825 KFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGVRDLLGTTQFLSQASFIPCPIDTSQVVLPL 889

  Fly   869 SVDQIKEKLAENIHEMWALNKIEAGWSWGEHRDDYHRIHPCLTHFEKLPAAEKRYDNQLAVQTLK 933
            .:::|:::|||||||:|.:||||.||::|:.|||..|.||||..|.|||..||.|:.|::.:|||
Mouse   890 HLEKIRDRLAENIHELWGMNKIELGWTYGKVRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLK 954

  Fly   934 TIISLGYYITMDKPPAR--IRPVRLPNEIFMQGNGYKPAPLDLSAVTLTPKLEELVDQLAENTHN 996
            |:::||.:|....|.|.  ::.|:||.. :|..|||||||||||.|.|.|..|.|||:||||.||
Mouse   955 TLLALGCHIAHVNPAAEEDLKKVKLPKN-YMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHN 1018

  Fly   997 LWARERIQQGWTYGLNEDSENHRSPHLVPYAKVDEAIKKANRDTASETVRTLLVYGYVLDPPTGE 1061
            :||::||:||||||:.:|.:|.|:|.|||||.:||..||:|||:..|.|||.:.|||.::|...|
Mouse  1019 VWAKDRIKQGWTYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQE 1083

  Fly  1062 GTEALLAE--AQRLKFAGFRTYRVERNYAVTSGKWYFEFEVLTSGPMRVGWARADCYPGAMLGSE 1124
                |:|:  .:::.....|.:||||:|||.||||||||||:|.|.|||||||..|.|...||::
Mouse  1084 ----LVADPTVEKVSIDKIRFFRVERSYAVKSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGAD 1144

  Fly  1125 DTSWAFDGHNEEKVYGGVSESFGKQCGPGDIVGVFLDLADHTISFSLNGELLMDALGGETTFADV 1189
            |.::.|:|...::.:.| |..||:...|||:||..::|.|.::.|:||||||:...|.|..|||.
Mouse  1145 DQAFVFEGSRGQRWHQG-SGYFGRTWQPGDVVGCMINLDDASMVFTLNGELLITNKGSELAFADY 1208

  Fly  1190 TAEGVGFVPACTLGVGQKARLIYGQDVDSLKFFTTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFE 1254
            ..|. ||||.|:||:.|..|:..|.|..:.||:|.||||||:|||.|||.|.|..|::|..|.|.
Mouse  1209 EIEN-GFVPICSLGLSQIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAVWFSKRLPTFV 1272

  Fly  1255 NT-EEMPDCRIDVTRIPGGADTPPHLKISHNTFETM-EKANWEFLRLSLPVTCMGEFISEQEKAR 1317
            |. ::.|  .|:|.||.|..|:||.||::|.||.|. ..||..:.|||:||.|...|
Mouse  1273 NVPKDHP--HIEVVRIDGTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHSSF-------- 1327

  Fly  1318 RWDEIKNRQYRLMREAEIAAQMQVQTQAAHMDHMLKGGFNMNDIKGLTRNFDEHADAEADHMMRG 1382
                                        :|...:                     |:||
Mouse  1328 ----------------------------SHSPCL---------------------DSEA------ 1337

  Fly  1383 PNRPPRKGSLTRNITFETDMSAALDEMQRSTSVLDMNGLGEEMDDKKKRGRSPFKFFSKKSRDQS 1447
                                                                    |.|  |.|.
Mouse  1338 --------------------------------------------------------FQK--RKQM 1344

  Fly  1448 REKMGARTLDTSLERRNTVAHGRNVVNQQMTTRAPTLRLNNAEIPPSPVPQGPKQLSGSNLGQQP 1512
            :|.:...|
Mouse  1345 QEILSHTT--------------------------------------------------------- 1352

  Fly  1513 VETSGDEMFDAECLKLINEYFYGVRIFPGQDPTHVYVGWVTTQYHLHSREFNKNKVRRGSVYIED 1577
                      .:|       :|.:|||.||||:.|:|||||..|||:|.:|:.||....:|.:.|
Mouse  1353 ----------TQC-------YYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGD 1400

  Fly  1578 DYEMAIERIDRQSCYVVRADELFNEVTQDASGKGASQG---MFVGCFVDTATGIIRFTCEGKDTS 1639
            :.....|.:.|.:||:|...::.      ||.:.:|:.   :.:||.:|.|.|::.|:..||:..
Mouse  1401 ERGRVHESVKRSNCYMVWGGDIV------ASSQRSSRSNVDLEIGCLLDLAMGMLSFSANGKELG 1459

  Fly  1640 HRWMMEPDTKLFPAIFVEATSKEILQIELGRTPTTLPLSAAVLPTSDKHINPQSPPRLKVQCLRP 1704
            ..:.:||:||:|||:|::.||..:.|.|||:....:|||||:..:.:|:..||.||||.||.::|
Mouse  1460 TCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPTPQCPPRLDVQTIQP 1524

  Fly  1705 HQWARVPNTALQVHALKLSDVRGWSMLCEDPVSMLALHIPEEDRCIDILELIEMDKLLSFHAHSL 1769
            ..|:|:|::.|:|...::|:..||.:.|.:|:.|:|||||||:||:|||||.|.:.|:.||.|:|
Mouse  1525 VLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMQFHYHTL 1589

  Fly  1770 TLYAALCYQSNYRAAHALCQHVDQKQLLYAIRSEYMSGPLRQGFYDLLIALHLESHATTMEVCKN 1834
            .||:|:|...|.|.|.|||.|||..||.|||.::|:.|.||.|||||||::||.:......:.||
Mouse  1590 RLYSAVCALGNSRVASALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKERKLMMKN 1654

  Fly  1835 EYITPLGAELK--ELYSDEEMQHSLRSL-VTESVRPQLRMTEITPPVIATSSMPSVSSEPIPDID 1896
            |||.|:.:..:  .||.||..:|.|..: :...::|..|.:  ||..:.||           :..
Mouse  1655 EYIIPITSATRNIRLYPDESKRHGLPGVGLRTCLKPGFRFS--TPCFVVTS-----------EDH 1706

  Fly  1897 QLYSPKFPLEVVRQFVMEALKDAVEINQVHNRDPIGWTNENLFLPLIKLTDRLLLVGVLTDEDVQ 1961
            |..||:.||::::...:..|.:||..:..|.|||:|.:.|..|:|::||...||::||..|:||:
Mouse  1707 QKQSPEIPLQILKTKALSMLTEAVHCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDDDDVR 1771

  Fly  1962 RLLVMIDPETWD----------------------QAFEREGKDEHRKGLLTMKMAEGAKLQMCYL 2004
            ::|::|||..:.                      :|.|:..|:...||||..::.|..|||||.|
Mouse  1772 QILLLIDPSVFGEHSGETEEGVEKEVTHAEEKAVEAGEKACKEAPVKGLLQTRLPESVKLQMCEL 1836

  Fly  2005 LHHLYDTQLRHRVESIIAFSHDFVGDLQTDQLRRYIEIKQS-DLPSAVAAKKTKEFRCPPREQMN 2068
            |.:|.|.:|:||||:|:||...:|..||.:|..||.|:.|: ::.:|:.|:||:|||.||:||:|
Mouse  1837 LSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTARKTREFRSPPQEQIN 1901

  Fly  2069 QILCFKNLEPDDQDNCTCGLELRGRLGDFHDSLMQKVSLNALQEPDGVEGTAIEEVKTGPI-TKI 2132
            .:|.|...|     ||.|..|:|..|.|||:.|:....:...:|.:..|.|:    .||.: ..:
Mouse  1902 MLLNFHLGE-----NCPCPEEIREELYDFHEDLLVHCGVPLEEEEEEEEDTS----WTGKLCALV 1957

  Fly  2133 YNFINTVKELEEGPKEVEEPEKKTPEEVFRKVLIKTIVSWAEESQIENPKLVREMFSLLLRQYDT 2197
            |......|..:|.|.|.|:|...|    .::::.:|::.||:|:||::.:|||.||:||.||||:
Mouse  1958 YKIKGPPKPEKEQPTEEEKPYPTT----LKELVSQTMIRWAQENQIQDAELVRMMFNLLRRQYDS 2018

  Fly  2198 VGELVRALEKTYVINTRARDDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNATFFQHP 2262
            :|||::||.|||.|:..:.:|...:...|.|||:||.|:|.:|||.||...|..::||..|:|||
Mouse  2019 IGELLQALRKTYTISQASVNDTINLLAALGQIRSLLSVRMGREEELLMINGLGDIMNNKVFYQHP 2083

  Fly  2263 DLIRILRVHENVMAVMMNTLGRRAQAQSDAPTQSEVAEGAPSKEKDTSHEMVVACCRFLCYFCRT 2327
            :|:|:|.:||.||.||:|.||..         :|::|          ..:||.:||||||||||.
Mouse  2084 NLMRVLGMHETVMEVMVNVLGTE---------KSQIA----------FPKMVASCCRFLCYFCRI 2129

  Fly  2328 GRQNQKAMFDHFDFLLDNANILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSR 2392
            .||||||||:|..:||:|:::.||.||:|||||||||.||:|:|.||||.|.|..|||:..||:.
Mouse  2130 SRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLEKVVTYLAG 2194

  Fly  2393 CGLQSNSELVEKGYPDLGWDPVEGERYLDFLRYCVWVNGESVEENANLVIRLLIRRPECLGPALR 2457
            |||||...|:.:||||:||:|:||||||.|||:.|:||.|||||||::|::||||||||.|||||
Mouse  2195 CGLQSCPMLLARGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALR 2259

  Fly  2458 GE-GEGLFRAIVEANRMSERISDRCKMQDEAEGTIAGLNFTHPLPEGEEDEDYIDTGAAILNFYC 2521
            || |.||..|:..|.::||..:.....|        |........:||| |:.:..|.||::||.
Mouse  2260 GEGGNGLLAAMQGAIKISENPALDLPSQ--------GYKTEVTQDDGEE-EEIVHMGNAIMSFYS 2315

  Fly  2522 TLVDLLGRCAPDASVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFTLSQTAPGEEKPKSDMPS 2586
            .|:||||||||:..:|:.||.|::|.|:|||||||.|||.|::|:...|..........:.||.:
Mouse  2316 ALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAA 2380

  Fly  2587 GLLPNNKQSIVLFLERVYGIEAQDLFYRLLEDAFLPDLRTATILDKSDGSESDMALAMNRYIGNS 2651
            ...|::|..:||||:|||||:.|.....|||..||||||.:..||....|.::.|||:|||:.::
Mouse  2381 NFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYLCSA 2445

  Fly  2652 ILPLLIKHSKFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDFLVALTSQMQPAMLLKL 2716
            :||||.:.:..::..|:..||:|:||.|:|||||.|.|||.||:.:.:.|:|:.:.::|:||.:|
Mouse  2446 VLPLLTRCAPLFSGTEHCTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQL 2510

  Fly  2717 LRKLTVDVSKLSEYTTVALRLLTLHFDRCAKYYGSTQGQGSYGASSDEEKRLTMLLFSNIFDSLS 2781
            ||:|..||.:||||..:.|:|||.|:::|.|||....|.||||.:.:||..||..||..||||||
Mouse  2511 LRRLVFDVPQLSEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLS 2575

  Fly  2782 NMDYDPELFGKALPCLIAIGCALPPDY-------SLSKNTDEDYYGRQMGAPDQPQYMPNPIDTN 2839
            :..||.:||..|||||.||..||||||       :|.|....|..|         .:.|.||:|.
Mouse  2576 HKKYDLDLFRMALPCLSAIAGALPPDYLDTRITATLEKQVSVDADG---------NFDPKPINTM 2631

  Fly  2840 NVHLDNDLNSLVQKFSEHYHDAWASRRLEGGWTYGDIRSDNDRKHPRLKPYNMLSEYERERYRDP 2904
            |..|...|..:|.|::||.||.||..:...||.||....:|.:.||.::|:..|:|.|:|.||.|
Mouse  2632 NFSLPEKLEYIVTKYAEHSHDKWACDKSHSGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWP 2696

  Fly  2905 VRECLKGLLAIGWTVEHSEVEVALNHRGSTRRQSKPQINEFQNEGSPFNYNPHPVDMSNLTLSRE 2969
            .||.||.:||:|||||.::...||..:   |...|.:.....|:|:  :|:|.|:|:||:.||||
Mouse  2697 ARESLKTMLAVGWTVERTKEGEALVQQ---RENEKLRCVSQTNQGN--SYSPAPLDLSNVVLSRE 2756

  Fly  2970 MQNMAERLAENSHDIWAKKKNEELNGCGGVIHPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQGY 3034
            :|.|.|.:|||.|:||||||..||...||..||.|||||.||.|||.:|||::|:..|::|..|.
Mouse  2757 LQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGI 2821

  Fly  3035 KLHKPSKGGAVEEGGATQAAVELRFSYSLLEKLIQYLDRATINMKLLKPSTTFSRRSSFKTA--- 3096
            .:.:..|...::     .:::|.||:|..|:|:::|:|.|...:..|:...     ||.||.
Mouse  2822 LVSRGMKDLELD-----ASSMEKRFAYKFLKKILKYVDAAQEFIAHLEAIV-----SSGKTEKSP 2876

  Fly  3097 -TRDIKFFSKVVLPLMEKYFSTHRNYFIAI-ATATNNIGAASLKEKEMVASIFCKLAALLRNRLS 3159
             .::||||:||:|||:::||:.||.||::. ....::.|.||.||||||||:|||||||:|:|:|
Mouse  2877 HDQEIKFFAKVLLPLVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRIS 2941

  Fly  3160 AFGPDVRITVRCLQVLVKGIDARTLTKNCPEFIRTSMLTFFNQTSDDLGNTILNLQDGKYSHLRG 3224
            .||.|....|.||.:|.:.:|.||:.|:..|.::..:..||...::||..|..||:.||::|.|
Mouse  2942 LFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSR- 3005

  Fly  3225 THLK-TSTSLGYVNQVVLPVLTAMFDHLAACDYGSDLLLDEIQVASYKILAALYHLGTDGTLTHD 3288
            |.:| .|.::.|....:||:||::|:|:|...:|.||||.::||:.|.||.:||.|||...:
Mouse  3006 TQIKGVSQNINYTTVALLPILTSIFEHIAQHQFGVDLLLSDVQVSCYHILCSLYSLGTGKNI--- 3067

  Fly  3289 RKYLKTEIERHRPALGSCLGAYSSCFPVAFLEPHLNKHNQYSLLNRIADHSLEAQDIMVKMES-C 3352
                  .:||.|||||.||.:.::..|||||||.||:||..|:.|...........:..|:|. |
Mouse  3068 ------YVERQRPALGECLASLAAAIPVAFLEPSLNRHNPLSVFNTKTPRERSILGMPDKVEDMC 3126

  Fly  3353 --MPNLETILAEVDQFVESDKTYNDAPHIIDVILPLLCAYLPFWWSQGPDNVSPTSGNHVTMVTA 3415
              :|.||.::.|::...||...|.:.||:|:||||:||.||.:||.:||:|:.|::|...|.||:
Mouse  3127 PDIPQLEGLMKEINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTS 3191

  Fly  3416 DHMNPLLRNVLKMIKKNIGNDNAPWMTRIAAYTQQIIINTSEELLKDPFLPLAERVKKRTENMLH 3480
            :|::.:|.|:||:|..|:|.|.|.||.|||.|.|.||.....:||:..|:|..|::||:....:.
Mouse  3192 EHLSLILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQ 3256

  Fly  3481 KEDSMRGFIKSATD---DTSQVETQLQEDWNLLVRDIYSFYPLLIKYVDLQRNHWLKDNIPEAEE 3542
            :|:.::      ||   ||.:.|..:.:::.:|.||:|:|||:||:|||..|::|||...|::::
Mouse  3257 EEEQLK------TDGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDPDSDQ 3315

  Fly  3543 LYNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMALIMPTATRRSAISEGAPA-VGGKVKKKKKN 3606
            |:..|||:|.:|.||..|.:|||||:..|||:|:|.:  |...:|.:|:.... .||:.:::||.
Mouse  3316 LFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFL--TGDSKSKMSKAMQVKSGGQDQERKKT 3378

  Fly  3607 RDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRYLKKMPEYDVIEFARNQLTL 3671
              |:|.....:|.||:||.||::||:|||:....:|||:...|.||..:..:.:|.|..||.|.|
Mouse  3379 --KRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSCRDTDEEVKEHLRNNLHL 3441

  Fly  3672 PDKLDPSDEMSWQHYLYSKLGKTEEPVDEQALEKANVNSNEKGKDKTQETVDRIVAMAKVLFGLH 3736
            .:|.| ...:.||..||..:.:.:||            ||      .::||:|:.:::..||.|.
Mouse  3442 QEKSD-DPAVKWQLNLYKDVLRNDEP------------SN------PEKTVERVQSISAALFHLE 3487

  Fly  3737 MAASSKNRSKR--WGSKISVARRQAVISSLRAKHLYRMSRHRACNIFARSYYEQWLQ-EENVGQE 3798
            . .....|||:  |...:|..|::||::..|...||.:.|||:.|:|...|...|:: |.:..:|
Mouse  3488 Q-VEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEAHFFEE 3551

  Fly  3799 VMVEDLTQT--FEDSEKSKKEGEETDSKPDPLTQLVTTFCRGAMTERSGALQEDLLYMSYAQIAA 3861
            .:|:||.::  .||.|:     |||:.:||||.|::..|.|.|:|||| .|::|.||.||:.:.|
Mouse  3552 KLVQDLAKSPRVEDEEE-----EETERQPDPLHQIILHFSRNALTERS-KLEDDPLYTSYSSMMA 3610

  Fly  3862 KS--TGKEEEEGGDEEGGEGGEEGEGTSIHEQEMEKQKLLFHQARLSNRGVAEMVLLHISASKGI 3924
            ||  :|::|||          ||.:..:..|:||||||.|:.||||..||.|||||..||||||.
Mouse  3611 KSCQSGEDEEE----------EEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGE 3665

  Fly  3925 PSEMVMTTLNLGIAILRGGNIDIQMGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAE 3989
            .|.||:.||.||||||.|||..:|..||::||||||.|||.|::|||.|||||||:||||..|||
Mouse  3666 MSPMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAE 3730

  Fly  3990 EYIPSAGAGLG-VGSEGA-----AGEKNMHDAEFTCALFRFIQLTCEGHNLEWQNYLRTQAGNTT 4048
                    ||| |..||.     .|||.:.:.|||..||||:||.|||||.::||:||||.||||
Mouse  3731 --------GLGMVTEEGTLIVRERGEKVLQNDEFTQDLFRFLQLLCEGHNSDFQNFLRTQMGNTT 3787

  Fly  4049 TVNVVICTVDYLLRLQESIMDFYWHYSSKEIIDPAGKANFFKAIEVASQVFNTLTEVIQGPCTLN 4113
            |||::|.||||||||||||.||||:||.|:|||.:|:.||.||:.|..|:||:|||.|||||..|
Mouse  3788 TVNIIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGN 3852

  Fly  4114 QQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIG 4178
            ||:||||||||||.|||.:|::||.|||:.|||::||||||:|.:||:.|:||:|||||||||||
Mouse  3853 QQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIG 3917

  Fly  4179 KQMVDTLVESASNVELILKYFDMFLKLADLIESPSFHEVDMKNEGWVTPKDFREKMEQSKNYTPE 4243
            ||||||||||::|||:|||:|||||||.||..|.:|.|.|...:|.::.|:|::.||..|.||..
Mouse  3918 KQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISRKEFQKAMEGLKQYTQS 3982

  Fly  4244 EMDFLLACCERNHEGKIDYRAFVEHFHEPSKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVL 4308
            |:||||:|.|.:.....:|..|||.||||:|:||||:|||||||||||||:.||...|:.|.|||
Mouse  3983 EIDFLLSCTEADENDMFNYVDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKSLLDPAESVL 4047

  Fly  4309 NYFEPFLGRIEILGSSKRIERVYFEIKDSNIEQWEKPQIRESKRAFFYSIVTEGGDKEKLEAFVN 4373
            |||||:||||||:|.:|:||||||||.:|:..||||||::||||.|.:.:|.|||::||:|.|||
Mouse  4048 NYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVN 4112

  Fly  4374 FCEDAIFEMTHASGLMATD-----DGGGNVKRDTAYSSYMSEEEEERAARDPIRRTI--TAVKEG 4431
            ||||.||||..||.:..:|     :.......|:|||.....||||::.......|:  .:||..
Mouse  4113 FCEDTIFEMQLASQISESDSTDRPEEEEEEDEDSAYSIETEGEEEEKSFESASAFTMACVSVKRN 4177

  Fly  4432 LKFGVHMLSPANIKHQIGVMQTKSIPELIVGFFKIIFYIFYYTGYAHFCVVRYIFGILLNLMRG- 4495
            :...:...:..|::.|...::..|..||:..||...:.:|.......|.:...||.||.|.:.|
Mouse  4178 VTKFLKRATLKNLRKQYRNVKKMSAKELVKVFFSFFWMLFVGLFQLLFTIFGGIFQILWNTVFGG 4242

  Fly  4496 ------------------PAPEQ--EEEPVVEEETFGRALPPLPLEEPPGTV--------QAFGL 4532
                              |.|.|  ..:.|:|.:   ||    .:.||..|.        :|...
Mouse  4243 GLVEGAKNIRVTKILGDMPDPTQFGIHDDVIETD---RA----EVTEPGVTTELVHFVKGEAGDT 4300

  Fly  4533 DINKEENGMYKVVVHESPANSSMEEGG-ESSPEDGAAASGELV-EGEPHQEPISIVDLLGGEAAK 4595
            ||..:..|::           |.:||| :..||.|.....|:: :.||.....::......:||:
Mouse  4301 DIMSDLFGIH-----------SKKEGGLKQGPEVGLGDLSEIIGKDEPPTLESTVRKKRKAQAAE 4354

  Fly  4596 -KAAQERQEAQKAQEAAMASIEAE-----------------AKKSSSAPQ--ETPAVHQIDFSQ- 4639
             ||..|.:...::::|.|...|.|                 .||:....|  |.|.....:|.:
Mouse  4355 MKAVHEAEGKAESEKADMEDREKEDKIKEEGQTDYLWADVTVKKTRRRGQKAEKPEAFMANFFKG 4419

  Fly  4640 ---YTHRAVSFLARNFYNLKYVALVLAFSINFMLLFYKVTSFTEEADSSAEEELILGSGSGGGAD 4701
               |..:.:.:||||||||:::||.:||:|||:|||||||.  |..:...|:...|.:
Mouse  4420 LEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTE--EPLEEETEDVANLWN------- 4475

  Fly  4702 ITGSGFGGSGDGGSGDGEMEDEIPELVHVDEDFFYMEHVLRIAACLHSLVSLAMLIAYYHLKVPL 4766
                         |.:.:.|:|......:.|...||...||..|.:|:::||..::.||.|||||
Mouse  4476 -------------SFNDDDEEEAMVFFVLQESTGYMAPTLRALAIVHTIISLVCVVGYYCLKVPL 4527

  Fly  4767 AIFKREKEIARRLEFEGLFIAEQPEDDDFKSHWDKLVISAKSFPVNYWDKFVKKKVRQKYSETYD 4831
            .:|||||||||:|||:||:|.|||.:||.|..||:|||:..|||.||||||||:||..||.:.|.
Mouse  4528 VVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYG 4592

  Fly  4832 FDSISNLLGMEKST--FAAQE---SEETGIFKYIMNIDWRYQVWKAGVTFTDNAFLYSLWYFSFS 4891
            .:.|:.|||::|:.  |:..|   :|...:..::.:||.:|.:||.||.||||:|||..||.:.|
Mouse  4593 AERIAELLGLDKNALDFSPVEEAKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMS 4657

  Fly  4892 VMGNFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYI 4956
            |:|::|||||||||||:|:|||||||||.|||||||||||||.||.::||:|||:|||||||||.
Mouse  4658 VLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYN 4722

  Fly  4957 Q-EEDEEVDKKCHDMLTCFVFHLYKGVRAGGGIGDEIGDPDGDDYEVYRIIFDITFFFFVIIILL 5020
            : |:|:|.|.||.||:||::||:|.||||||||||||.||.||.||:|||:||||||||||:|||
Mouse  4723 KSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILL 4787

  Fly  5021 AIIQGLIIDAFGELRDQLESVKDNMESNCFICGMGKDFFDIVPHGFDTHVQKEHNLANYMFFLMH 5085
            |||||||||||||||||.|.|:::||:.|||||:|.|:||..||||:||..:|||||||:||||:
Mouse  4788 AIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMY 4852

  Fly  5086 LINKPDTEYTGQETYVWNMYQQRSWDFFPVGDCFRKQYEDEL 5127
            ||||.:||:||||:|||.|||:|.|||||.||||||||||:|
Mouse  4853 LINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL 4894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RyR	NP_001246211.1	Ins145_P3_rec	11..202	CDD:285871	122/209 (58%)
		MIR	211..392	CDD:280906	77/182 (42%)
		MIR	270..>305	CDD:197746	13/34 (38%)
		RYDR_ITPR	443..636	CDD:279676	113/192 (59%)
		SPRY1_RyR	647..799	CDD:240457	82/152 (54%)
		RyR	854..944	CDD:280244	47/89 (53%)
		RyR	967..1057	CDD:280244	55/89 (62%)
		SPRY2_RyR	1079..1213	CDD:240458	67/133 (50%)
		SPRY3_RyR	1518..1669	CDD:293937	52/153 (34%)
		RYDR_ITPR	2228..2452	CDD:279676	125/223 (56%)
		RyR	2831..2921	CDD:280244	40/89 (45%)
		RyR	2954..3038	CDD:280244	46/83 (55%)
		RIH_assoc	4017..4130	CDD:285630	80/112 (71%)
		RR_TM4-6	4525..4768	CDD:283990	75/276 (27%)
		Ion_trans	4856..>4976	CDD:278921	79/120 (66%)
Ryr3	XP_017172189.1	Ins145_P3_rec	14..218	CDD:388622	120/203 (59%)
		MIR	227..408	CDD:367197	77/181 (43%)
		RYDR_ITPR	451..632	CDD:366595	107/185 (58%)
		SPRY1_RyR	667..818	CDD:240457	82/152 (54%)
		RyR	875..963	CDD:366883	46/87 (53%)
		RyR	989..1079	CDD:366883	55/89 (62%)
		SPRY2_RyR	1099..1231	CDD:240458	67/133 (50%)
		SPRY3_RyR	1351..1489	CDD:293937	53/217 (24%)
		RYDR_ITPR	2047..2259	CDD:366595	130/230 (57%)
		RyR	2623..2713	CDD:366883	40/89 (45%)
		RyR	2741..2825	CDD:366883	46/83 (55%)
		RIH_assoc	3756..3869	CDD:369886	80/112 (71%)
		EF-hand_8	3960..4008	CDD:372744	19/47 (40%)
		RR_TM4-6	4259..4529	CDD:368919	84/309 (27%)
		Ion_trans	<4646..4806	CDD:366146	122/159 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836729
Domainoid	1	1.000	714	1.000	Domainoid score	I115
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	4418	1.000	Inparanoid score	I5
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46584
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001801
OrthoInspector	1	1.000	-	-		otm43310
orthoMCL	1	0.900	-	-		OOG6_102727
Panther	1	1.100	-	-	O	PTHR13715
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1009
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900