DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RyR and Ryr1

DIOPT Version :9

Sequence 1:NP_001246211.1 Gene:RyR / 49090 FlyBaseID:FBgn0011286 Length:5134 Species:Drosophila melanogaster
Sequence 2:XP_036008707.1 Gene:Ryr1 / 20190 MGIID:99659 Length:5054 Species:Mus musculus


Alignment Length:5345 Identity:2367/5345 - (44%)
Similarity:3280/5345 - (61%) Gaps:517/5345 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 GGSEQDDVSFLRTEDMVTLSCTAT----GERVCLAAEGFGNRHCFLENIAD-KNVPPDLSQCVFV 65
            ||..:|:|.||||:|.|.|.|:||    ..::||||||||||.||||..:: :||||||:.|.|:
Mouse     5 GGEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAICCFI 69

  Fly    66 IEQALSVRALQELV---TAAGSETGKGTGSGHRTLLYGNAILLRHHNSDMYLACLSTS-SSNDKL 126
            :||:||||||||::   ..||.|:.:  |.||||||||:||||||.:|.|||:||:|| |..|||
Mouse    70 LEQSLSVRALQEMLANTVEAGVESSQ--GGGHRTLLYGHAILLRHAHSRMYLSCLTTSRSMTDKL 132

  Fly   127 SFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKENEQSIVNASFH 191
            :|||||||.:.|||||||:||||||||||||||||||||||||::|||||.:..:.:..|:|||.
Mouse   133 AFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSTASGELQVDASFM 197

  Fly   192 VTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGG-DECLTI-PSTWGREAGQNIVIYEGGVVMAQ 254
            .|.|::.|..:|...    |:|.||.|||.|||. |||||| ||  ..:..:.:|.||||.|...
Mouse   198 QTLWNMNPICSGCEE----GFVTGGHVLRLFHGHMDECLTISPS--DSDDQRRLVYYEGGPVCTH 256

  Fly   255 ARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNDSNELILVKKEEASIATTTFCLRQEK 319
            ||||||||..|..|:|..:.|..|:||||:|||||||:.:...|::|...:|....|:||.|..|
Mouse   257 ARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLGLTEDQGLVVVDASKAHTKATSFCFRISK 321

  Fly   320 DDEKKVLEDKDLEVIGSPIIKYGDTTVIVQHCETSLWLSYKSYETKKKGVGKVEEKQAILHEEGK 384
             ::..|...:|:|.:|.|.||||::...|||..:.|||:|.:.:.|...:| |.:|:|:||:||.
Mouse   322 -EKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLG-VLKKKAMLHQEGH 384

  Fly   385 MDDCLDFSRSQEEESKTARVIRKCSSLFTQFITALETLQSNRRHS--IFFQKVNLNEMVMCLEDL 447
            |||.|..:|.|:|||:.||:|...:.|:.|||..|::.....|.|  .....:.:..:::.|:||
Mouse   385 MDDALSLTRCQQEESQAARMIYSTAGLYNQFIKGLDSFSGKPRGSGPPAGSALPIEGVILSLQDL 449

  Fly   448 INYFSQPEDDMEHEEKQNRFRALRNRQDLFQEEGVLNLILEAIDKINIITSQGFLASFLAGDETG 512
            |.||..|.::::|||||.:.|:|||||.||||||:|:|:|..||::|:.|:....|.| ||:|..
Mouse   450 IGYFEPPSEELQHEEKQTKLRSLRNRQSLFQEEGMLSLVLNCIDRLNVYTTAAHFAEF-AGEEAA 513

  Fly   513 QSWDLISTYLYQLLAAIIKGNHTNCAQFANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLIDSPE 577
            :||..|...||:|||::|:||.||||.|  |..|:||.|:|....:|  ||:|:||:||||:|||
Mouse   514 ESWKEIVNLLYELLASLIRGNRTNCALF--STNLDWLVSKLDRLEAS--SGILEVLYCVLIESPE 574

  Fly   578 ALNMMRDEHIKVIISLLEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTLLV 642
            .||::::.|||.|||||:||||:.|||||||||||.|||||||:|:.|.:.||||:.|||||.|:
Mouse   575 VLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLI 639

  Fly   643 DHVASIRPNIFVGRVDGSSMYQKWYFEVTMDHIEQ-TTHMMPHLRIGWANTSGYVPYPGGGKKWG 706
            ::|.||||||||||.:||:.|.||||||.:|.:.. .|....|||:|||.:.||.||||||:.||
Mouse   640 NYVTSIRPNIFVGRAEGSTQYGKWYFEVMVDEVAPFLTAQATHLRVGWALSEGYSPYPGGGEGWG 704

  Fly   707 GNGVGDDLYSFGFDGAFLWTGGRKTLVVDALPEEPFIRKGDVIGVAIDLSVPIITFTFNGVKVRG 771
            ||||||||||:||||..||||.....|..  |.:..:...||:...:|||||.|:|..||..|:|
Mouse   705 GNGVGDDLYSYGFDGLHLWTGHVARPVTS--PGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQG 767

  Fly   772 SFRDFNLDGMFFPVMSCSSKLSCRFLFGGDHGRLKFAPPMGFSALVQCLMPQQILSLDPCFYF-- 834
            .|..|||||:||||:|.|:.:..|||.||.||..||.||.|::...:.::|::.|.|.|...:  
Mouse   768 VFESFNLDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLQPIKEYRR 832

  Fly   835 -GNLAKNVLAGPWLIEDDTAFVPKPVDTTGVTLPSSVDQIKEKLAENIHEMWALNKIEAGWSWGE 898
             |....: |.||........|||.||||..:.||..:::|:|||||||||:|||.:||.||::|.
Mouse   833 EGPRGPH-LVGPSRCLSHLDFVPCPVDTIQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGP 896

  Fly   899 HRDDYHRIHPCLTHFEKLPAAEKRYDNQLAVQTLKTIISLGYYITM--DKPPARIRPVRLPNEIF 961
            .|||..|:||||.:|..||..|:.|:.|::.:||||:::||.::.|  :|....::..:|| :.:
Mouse   897 VRDDNKRLHPCLVNFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLP-KTY 960

  Fly   962 MQGNGYKPAPLDLSAVTLTPKLEELVDQLAENTHNLWARERIQQGWTYGLNEDSENHRSPHLVPY 1026
            |..|||||||||||.|.|||....|||:||||.||:|||:|:.|||:|...:|....|:|.||||
Mouse   961 MMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPRLVPY 1025

  Fly  1027 AKVDEAIKKANRDTASETVRTLLVYGYVLDPPTGEGTEALLAEAQRLKFAGFRTYRVERNYAVTS 1091
            ..:|||.|::|||:..:.|||||.|||.::||..|.::   .::|. :....|.:|.|::|||.|
Mouse  1026 RLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQ---VDSQS-RGDRARIFRAEKSYAVQS 1086

  Fly  1092 GKWYFEFEVLTSGPMRVGWARADCYPGAMLGSEDTSWAFDGHNEEKVYGGVSESFGKQCGPGDIV 1156
            |:||||||.:|:|.|||||||.:..|...||::|.::.|:||..::.:.| ||.||:....||:|
Mouse  1087 GRWYFEFEAVTTGEMRVGWARPELRPDVELGADDLAYVFNGHRGQRWHLG-SEPFGRPWQSGDVV 1150

  Fly  1157 GVFLDLADHTISFSLNGELLMDALGGETTFADVTAEGVGFVPACTLGVGQKARLIYGQDVDSLKF 1221
            |..:||.::||.|:||||:||...|.||.|.|:.. |.||:|.|:||.||...|..||||.||:|
Mouse  1151 GCMIDLTENTIIFTLNGEVLMSDSGSETAFRDIEI-GDGFLPVCSLGPGQVGHLNLGQDVSSLRF 1214

  Fly  1222 FTTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFENTE-EMPDCRIDVTRIPGGADTPPHLKISHNT 1285
            |..||||||:|||.:||:||||.|::|..|.||... |.|  ..:|.|:.|..||||.|:::|.|
Mouse  1215 FAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEPVPLEHP--HYEVARMDGTVDTPPCLRLTHRT 1277

  Fly  1286 FETMEK-ANWEFLRLSLPVTCMGEFISEQEKARRWDEIKNRQYRLMREAEIAAQMQVQ------T 1343
            :.:... ....||||||||    :|              ::.:|....|...|...:|      .
Mouse  1278 WGSQNSLVEMLFLRLSLPV----QF--------------HQHFRCTAGATPLASPGLQPPAEDEA 1324

  Fly  1344 QAAHMDHMLKGGFNMNDIKGLTRNFDEHADAEADHMMRGPNRPPRKGSL--TRNITFETDMSAAL 1406
            :||..|         .|.:.|.|:.....:||.     |.:...::|:.  |.....|...:.|.
Mouse  1325 RAAEPD---------TDYENLRRSAGGWGEAEG-----GKDGTAKEGTPGGTAQAGVEAQPARAE 1375

  Fly  1407 DEMQRSTSVLDMNGLGEEMDDKKKRGRSPFKFFSKKSRDQSREKMGARTLDTSLERRNTVAHGRN 1471
            :|...:|            :..||||   |.|.:||                       ||    
Mouse  1376 NEKDATT------------EKNKKRG---FLFKAKK-----------------------VA---- 1398

  Fly  1472 VVNQQMTTRAPTLRLNNAEIPPS--PVPQGPKQLSGSNLGQQPVETSGDEMFDAECLKLINEYFY 1534
                 |.|:           |||  .:|:.|:.:           ...|...|.|.:.....|:|
Mouse  1399 -----MMTQ-----------PPSTPALPRLPRDV-----------VPADNRDDPEIILNTTTYYY 1436

  Fly  1535 GVRIFPGQDPTHVYVGWVTTQYHLHSREFNKNKVRRGSVYIEDDYEMAIERIDRQSCYVVRADEL 1599
            .||:|.||:|:.|:|||||..||.|...|:.:|||..:|.:.|:.......:...:||:|...:.
Mouse  1437 SVRVFAGQEPSCVWVGWVTPDYHQHDMSFDLSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGDF 1501

  Fly  1600 FNEVTQDASGKGASQGMFVGCFVDTATGIIRFTCEGKDTSHRWMMEPDTKLFPAIFVEATSKEIL 1664
               |:....|:.:...:.:||.||.|||::.||..||:::..:.:||:||||||:||..|.:.::
Mouse  1502 ---VSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVV 1563

  Fly  1665 QIELGRTPTTLPLSAAVLPTSDKHINPQSPPRLKVQCLRPHQWARVPNTALQVHALKLSDVRGWS 1729
            |.|||:....:|||||:..:..|:..||.||||:||.|.|..|:|:||..|||...:..:..||:
Mouse  1564 QFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMPNHFLQVDTRRAGERLGWA 1628

  Fly  1730 MLCEDPVSMLALHIPEEDRCIDILELIEMDKLLSFHAHSLTLYAALCYQSNYRAAHALCQHVDQK 1794
            :.|::|:.|:|||||||:||:|||||.|...|..||:|:|:||.::|...|.|.|||||.||||.
Mouse  1629 VQCQEPLMMMALHIPEENRCMDILELSERLDLQRFHSHTLSLYRSVCALGNNRVAHALCSHVDQA 1693

  Fly  1795 QLLYAIRSEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYITPLGAELKEL--------YSDE 1851
            |||:|:....:.||||.|:|||||::||||...:.....:|||.||..|.:.:        ..|.
Mouse  1694 QLLHALEDARLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPGRSAEDG 1758

  Fly  1852 EMQHSLRSL-VTESVRPQLRMTEITPPVIATSSMPSVSSEPIPDIDQLYSPKFPLEVVRQFVMEA 1915
            ..:|.|..: ||.|:||.   ...:||.... ::|:..:...|   ...||..|||.:|...:..
Mouse  1759 PRRHGLPGVGVTTSLRPP---HHFSPPCFVV-ALPAAGATEAP---ARLSPAIPLEALRDKALRM 1816

  Fly  1916 LKDAVEINQVHNRDPIGWTNENLFLPLIKLTDRLLLVGVLTDEDVQRLLVMIDPETW--DQAFER 1978
            |.:||.....|.|||:|.:.|..|:|::||...||::||.:||||:::|.||:||.:  ::..|.
Mouse  1817 LGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGVFSDEDVKQILKMIEPEVFREEEEVEE 1881

  Fly  1979 EGKDE---------------HRK---------------------GLLTMKMAEGAKLQMCYLLHH 2007
            ||::|               |.|                     |||.||:.|..|||||:||.:
Mouse  1882 EGEEEEEDEEEKEEDEEEEAHEKEDEEKEEAEDAAEEEKEELEEGLLQMKLPESVKLQMCHLLEY 1946

  Fly  2008 LYDTQLRHRVESIIAFSHDFVGDLQTDQLRRY-IEIKQSDLPSAVAAKKTKEFRCPPREQMNQIL 2071
            ..|.:|:|||||:.||:..:|..:|.:|..|| :.:|...:.:|..|::|:|||.||:||:|.:|
Mouse  1947 FCDQELQHRVESLAAFAECYVDKMQGNQRGRYGLLMKAFTMSAAETARRTREFRSPPQEQINMLL 2011

  Fly  2072 CFKNLEPDDQDNCTCGLELRGRLGDFHDSLMQKVSLNALQEPDGVEGTAIEEVKTGP-ITKIYNF 2135
            .|||  ..|::.|....|:|..|.:||..|:....:    :.:|.|....||...|. :..:...
Mouse  2012 HFKN--GADEEECPLPEEIRQELVNFHQDLLAHCGI----QLEGEEEEPEEESTLGSRLMSLLEK 2070

  Fly  2136 INTVKELEEGPKEVEEPEKKTPEEVFRKVLIKTIVSWAEESQIENPKLVREMFSLLLRQYDTVGE 2200
            :..||:.||.|:|...||:..|:.: ::::..|:|.||:|..:::|:|||.|||||.||||.:||
Mouse  2071 VKLVKKTEEKPEEEPAPEEHKPQSL-QELVSHTVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGE 2134

  Fly  2201 LVRALEKTYVINTRARDDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNATFFQHPDLI 2265
            |:|||.:.|.|:..:.:|...:...|.|||:||.|||..:||.||.:.:..::||..|:|||:|:
Mouse  2135 LLRALPRAYTISVSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLM 2199

  Fly  2266 RILRVHENVMAVMMNTLGRRAQAQSDAPTQSEVAEGAPSKEKDTSHEMVVACCRFLCYFCRTGRQ 2330
            |.|.:||.||.||:|.||                 |..||| ....:||.:||||||||||..||
Mouse  2200 RALGMHETVMEVMVNVLG-----------------GGESKE-IRFPKMVTSCCRFLCYFCRISRQ 2246

  Fly  2331 NQKAMFDHFDFLLDNANILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGL 2395
            ||::||||..:||:|:.|.|   .::||||||||.:|:::|.||||||:|..|||:..||:.|||
Mouse  2247 NQRSMFDHLSYLLENSGIGL---GMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGL 2308

  Fly  2396 QSNSELVEKGYPDLGWDPVEGERYLDFLRYCVWVNGESVEENANLVIRLLIRRPECLGPALRGE- 2459
            ||...|:.|||||:||:|..|||||||||:.|:|||||||||||:|:|||||:|||.||||||| 
Mouse  2309 QSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEG 2373

  Fly  2460 GEGLFRAIVEANRMSERISDRCKMQDEAEGTIAGLNFTHPLPEGEE--DEDYIDTGAAILNFYCT 2522
            |.||..||.||.|:||   |..:   :..|........|   .|||  :|:.:..|.||::||..
Mouse  2374 GSGLLAAIEEAIRISE---DPAR---DGPGVRRDRRREH---FGEEPPEENRVHLGHAIMSFYAA 2429

  Fly  2523 LVDLLGRCAPDASVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFTLSQTAPGEEKPKSDMPSG 2587
            |:||||||||:..:|:.||.|:||.||||||||||:||.|::||...:..........:..|.:.
Mouse  2430 LIDLLGRCAPETHLIQAGKGEALRIRAILRSLVPLDDLVGIISLPLQIPTLGKDGALVQPKMSAS 2494

  Fly  2588 LLPNNKQSIVLFLERVYGIEAQDLFYRLLEDAFLPDLRTATILDKSDGSESDMALAMNRYIGNSI 2652
            .:|::|.|:||||:||||||.||....:|:..||||:|.|..||.:..|.::||||:|||:..::
Mouse  2495 FVPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAV 2559

  Fly  2653 LPLLIKHSKFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDFLVALTSQMQPAMLLKLL 2717
            |||:.|.:..:...|:.|.::|:.||||||||:.|.|||.||:.:.|.|:||...::|:||..||
Mouse  2560 LPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLL 2624

  Fly  2718 RKLTVDVSKLSEYTTVALRLLTLHFDRCAKYYGSTQGQGSYGASSDEEKRLTMLLFSNIFDSLSN 2782
            |:|..||..|:|:..:.|:|||.|::||.|||....|..::|.:|:||..||..||..|||||::
Mouse  2625 RRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAH 2689

  Fly  2783 MDYDPELFGKALPCLIAIGCALPPDY---SLSKNTDEDYYGRQMGAPDQPQYMPNPIDTNNVHLD 2844
            ..||.||:..|:|||.||..||||||   |.|..|:     ::.....:..:.|.|::|.||.:.
Mouse  2690 KKYDQELYRIAMPCLCAIAGALPPDYVDASYSSKTE-----KKATVDAEGNFDPRPVETLNVIIP 2749

  Fly  2845 NDLNSLVQKFSEHYHDAWASRRLEGGWTYGDIRSDNDRKHPRLKPYNMLSEYERERYRDPVRECL 2909
            ..|:|.:.||:|:.|:.||..:::..|:||:...:..:.||.|:||...||.::|.||.|::|.|
Mouse  2750 EKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESL 2814

  Fly  2910 KGLLAIGWTVEHS-EVEVALNHRGSTRRQSKPQINEFQNEGSPFNYNPHPVDMSNLTLSREMQNM 2973
            |.::|..||||.: |.|.....:..||:.|:........||    |||.|.|:|.:|||||:|.|
Mouse  2815 KAMIAWEWTVEKAREGEEEKTEKKKTRKISQTAQTYDPREG----YNPQPPDLSVVTLSRELQAM 2875

  Fly  2974 AERLAENSHDIWAKKKNEELNGCGGVIHPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQGYKLHK 3038
            ||:||||.|:.|.:||.:||...||..||.|||||.||.|||.:|||::||.||::|..||.:.:
Mouse  2876 AEQLAENYHNTWGRKKKQELEAKGGGSHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTR 2940

  Fly  3039 PSKGGAVEEGGATQAAVELRFSYSLLEKLIQYLDRATINMKLLK--PSTTFSRRSSFKTATRDIK 3101
            ..|...::     .:::|.||::..|::|::::|   |:.:.:.  .:...|.|.......::||
Mouse  2941 GLKDMELD-----TSSIEKRFAFGFLQQLLRWMD---ISQEFIAHLEAVVSSGRVEKSPHEQEIK 2997

  Fly  3102 FFSKVVLPLMEKYFSTHRNYFIAI-ATATNNIGAASLKEKEMVASIFCKLAALLRNRLSAFGPDV 3165
            ||:|::|||:.:||:.|..||::. |....:.|.||.|||||:.|:|||||||:|:|:|.||.|.
Mouse  2998 FFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTDA 3062

  Fly  3166 RITVRCLQVLVKGIDARTLTKNCPEFIRTSMLTFFNQTSDDLGNTILNLQDGKYSHLRGTHLK-T 3229
            ...|.||.:|.:.:||||:.|:.||.::..:.:||...|:|:...:.||:.||.|..| |.:| .
Mouse  3063 PAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQAR-TQVKGV 3126

  Fly  3230 STSLGYVNQVVLPVLTAMFDHLAACDYGSDLLLDEIQVASYKILAALYHLGTDGTLTHDRKYLKT 3294
            ..:|.|....:|||||.:|.|:|...:|.|::||::||:.|:.|.::|.|||.         ...
Mouse  3127 GQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTT---------RNP 3182

  Fly  3295 EIERHRPALGSCLGAYSSCFPVAFLEPHLNKHNQYSLLNRIA---------DHSLEAQDIMVKME 3350
            .:|:.|||||.||...::..|||||||.||::|..|:....:         .:|:|        |
Mouse  3183 YVEKLRPALGECLARLAAAMPVAFLEPELNEYNACSVYTTKSPRERAILGLPNSVE--------E 3239

  Fly  3351 SC--MPNLETILAEVDQFVESDKTYNDAPHIIDVILPLLCAYLPFWWSQGPDNVSPT----SGNH 3409
            .|  :|.||.::||:....||...|.:.||:|::.||:||:|||.||.:||:...|.    :...
Mouse  3240 MCPDIPVLERLMAEIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALPAGAPPP 3304

  Fly  3410 VTMVTADHMNPLLRNVLKMIKKNIGNDNAPWMTRIAAYTQQIIINTSEELLKDPFLPLAERVKKR 3474
            .|.||:||:|.||.|:|::|..|:|.|.|.||.|:|.:.|.|:.....|||:..|:|...|::||
Mouse  3305 CTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLRSHFIPTIGRLRKR 3369

  Fly  3475 TENMLHKEDSMRGFIKSATDDTSQVETQLQEDWNLLVRDIYSFYPLLIKYVDLQRNHWLKDNIPE 3539
            ...::.:|:.:|   ..|..:..:.|..:::::::|.||:|:.|||||:|||..|.|||.:..|.
Mouse  3370 AGKVVAEEEQLR---LEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDNNRAHWLTEPNPN 3431

  Fly  3540 AEELYNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMALIMPTATRRSAISE-GAPAVGGKVKKK 3603
            ||||:..|.|||..||||..|.:|||||:..|||:||:.:  ||..:|.::: |....||..:::
Mouse  3432 AEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFL--TADNKSKMAKAGDVQSGGSDQER 3494

  Fly  3604 KKNRDKKRDKDK-EVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRYLKKMPEYDVIEFARN 3667
            .|   |||..|: .||.||:||.||::||:|||:.|..:|:|:...|.||..|..:.:|.||.:|
Mouse  3495 TK---KKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLIVLAKARYALKDTDEEVREFLQN 3556

  Fly  3668 QLTLPDKLDPSDEMSWQHYLYSKLGKTEEPVDEQALEKANVNSNEKGKDKTQETVDRIVAMAKVL 3732
            .|.|..|::.|..:.||..||                 ..|...|:..|..::.|.|:..::.||
Mouse  3557 NLNLQGKVEGSPSLRWQMALY-----------------RGVPGREEDADDPEKIVRRVQEVSAVL 3604

  Fly  3733 FGLHMAASS-KNRSKRWGSKISVARRQAVISSLRAKHLYRMSRHRACNIFARSYYEQW-LQEENV 3795
            :.|...... |::...|...:|..||:||::..|...||.:..|||||:|..||...| |.|::.
Mouse  3605 YHLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKASWILTEDHS 3669

  Fly  3796 GQEVMVEDLTQTFEDSEKSKKEGEETDSKPDPLTQLVTTFCRGAMTERSGALQEDLLYMSYAQIA 3860
            .::.|::||::.   .|:.::|.|..:.|||||.|||..|.|.|:||:| .|.||.|||:||.|.
Mouse  3670 FEDRMIDDLSKA---GEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKS-KLDEDYLYMAYADIM 3730

  Fly  3861 AKSTGKEEEEGGDEEGGEGGEEGE-GTSIHEQEMEKQKLLFHQARLSNRGVAEMVLLHISASKGI 3924
            |||...||   |.|.|.|||||.| ..|..|:|||||:||:.|:||.|||.|||||..|||.||.
Mouse  3731 AKSCHLEE---GGENGEEGGEEEEVEVSFEEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGE 3792

  Fly  3925 PSEMVMTTLNLGIAILRGGNIDIQMGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAE 3989
            ...||.:||.|||:||.|||.::|..||::||:||:||||.||..||.:||||||:||||..|||
Mouse  3793 TGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAE 3857

  Fly  3990 EYIPSAGAGLGVGSEGAA------GEKNMHDAEFTCALFRFIQLTCEGHNLEWQNYLRTQAGNTT 4048
                    |||:.:|...      |||.|.|.|||..||||:||.|||||.::|||||||.||||
Mouse  3858 --------GLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTT 3914

  Fly  4049 TVNVVICTVDYLLRLQESIMDFYWHYSSKEIIDPAGKANFFKAIEVASQVFNTLTEVIQGPCTLN 4113
            |:|::||||||||||||||.||||:||.|::|:..||.||.||:.||.||||:|||.||||||.|
Mouse  3915 TINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGN 3979

  Fly  4114 QQALAHSRLWDAVGGFLFLFSHMQDKL-------------------SKHSSQVDLLKELLNLQKD 4159
            ||:||||||||||.|||.:|:||..||                   |:.|||::||||||:||||
Mouse  3980 QQSLAHSRLWDAVVGFLHVFAHMMMKLAQKTPVPSTHDEHVWTRVPSEDSSQIELLKELLDLQKD 4044

  Fly  4160 MITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKLADLIESPSFHEVDMKNEGW 4224
            |:.|:||:||||||||.|.:||||.||||:||||:|||:|||||||.|::.|.:|.:......|.
Mouse  4045 MVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGL 4109

  Fly  4225 VTPKDFREKMEQSKNYTPEEMDFLLACCERNHEGKIDYRAFVEHFHEPSKEIGFNLAVLLTNLSE 4289
            ::.|||::.|:..|.:|..|:.|||:|.|.:....|:...|...|.||:::||||:|||||||||
Mouse  4110 ISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSE 4174

  Fly  4290 HMPNEPRLARFLETAGSVLNYFEPFLGRIEILGSSKRIERVYFEIKDSNIEQWEKPQIRESKRAF 4354
            |:|::|||..|||.|.|:|.||.|:||||||:|:|:||||:||||.::|..|||.||::||||.|
Mouse  4175 HVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQF 4239

  Fly  4355 FYSIVTEGGDKEKLEAFVNFCEDAIFEMTHASGLMATDDGGGNVKRDTAYSSYMSEEEEERAARD 4419
            .:.:|.|||:.||:|.||:||||.||||..|:.:...:   |..:.|   ....:||.||.||..
Mouse  4240 IFDVVNEGGESEKMEMFVSFCEDTIFEMQIAAQISEPE---GEPEED---EDEGAEEAEEGAAGS 4298

  Fly  4420 PIRRTITAVKEGLKFGVHM------------LSPANIKHQIGVMQTKSIPELIVGFFKIIFYIFY 4472
            ....:..|.      ||.:            ||..:::.::..::..:..|.......:::.:..
Mouse  4299 DGSGSAAAA------GVWVWLAATAGRTLRGLSYRSLRRRVRRLRRLTAREAATAVAALLWALVT 4357

  Fly  4473 YTG----YAHFCVVRYIFGILLNLMRGPAPEQEEEPVVEEETFGRALPPLPL------EEPPGTV 4527
            ..|    .|....:|.::|   :|..|...:..::..|.|...|.   |.|.      ::|.|. 
Mouse  4358 RAGGAGAGAAAGALRLLWG---SLFGGGLVDSAKKVTVTELLAGM---PDPTGDEVHGQQPSGA- 4415

  Fly  4528 QAFGLDINKEENGMYKVVVHESPANSSMEEGGESSPED----------------------GAAAS 4570
               |.|...|..|       |...:::...|.|.:..|                      ||...
Mouse  4416 ---GSDAEGEGEG-------EGEGDAADGAGDEEAAADQAGTGGADGAVAVADGSPFRPEGAGGL 4470

  Fly  4571 GELVEGEPHQEPIS-----IVDLLGGEAAKKAAQERQEAQKAQEAAMASIEAEAKKSSSAPQETP 4630
            |::.:..|.:.|..     :...||.:..::......|.:...|...|..|...|:....|.|.|
Mouse  4471 GDMGDTTPVEPPTPEGSPILKRKLGVDGEEEEPPPEPEPEPEPEPEKADTENGEKEVPEPPPEPP 4535

  Fly  4631 --------------------------AVHQIDFSQYTHRAVSFLARNFYNLKYVALVLAFSINFM 4669
                                      .|.::.|       :::|:||||.|:::||.|||:|||:
Mouse  4536 KKTPPPPPPKKEEAGGAGLEEFWGELEVQRVKF-------LNYLSRNFYTLRFLALFLAFAINFI 4593

  Fly  4670 LLFYKVTSFTEEADSSAEEELILGSGSGGGADITGSGFG-GSGDGGSGDGEME-DEIPELVH--V 4730
            ||||||      :||...|:.|.|||:|   |::|:|.| |||.|.....|:| ||...:|:  :
Mouse  4594 LLFYKV------SDSPPGEDDIEGSGAG---DMSGAGSGDGSGWGSRAGEEVEGDEDENMVYYFL 4649

  Fly  4731 DEDFFYMEHVLRIAACLHSLVSLAMLIAYYHLKVPLAIFKREKEIARRLEFEGLFIAEQPEDDDF 4795
            :|...|||..||..:.||:||:...:|.|..|||||.|||||||:||:|||:||:|.|||||||.
Mouse  4650 EESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDV 4714

  Fly  4796 KSHWDKLVISAKSFPVNYWDKFVKKKVRQKYSETYDFDSISNLLGMEKSTFAAQESEE------T 4854
            |..||:||::..|||.||||||||:||..|:.:.:..:.|:.||||:.::.......|      .
Mouse  4715 KGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMDLASLEITAHNERKPDPPP 4779

  Fly  4855 GIFKYIMNIDWRYQVWKAGVTFTDNAFLYSLWYFSFSVMGNFNNFFFAAHLLDVAVGFKTLRTIL 4919
            |:..:||:||.:||:||.||.||||:|||..||...|::|::|||||||||||:|:|.|||||||
Mouse  4780 GLLTWIMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTIL 4844

  Fly  4920 QSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYIQEEDE-EVDKKCHDMLTCFVFHLYKGVR 4983
            .||||||||||:||.||.::||:|||:|||||||||.:.||| |.|.||.||:||::||:|.|||
Mouse  4845 SSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVR 4909

  Fly  4984 AGGGIGDEIGDPDGDDYEVYRIIFDITFFFFVIIILLAIIQGLIIDAFGELRDQLESVKDNMESN 5048
            |||||||||.||.||:||:||::||||||||||:||||||||||||||||||||.|.||::||:.
Mouse  4910 AGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETK 4974

  Fly  5049 CFICGMGKDFFDIVPHGFDTHVQKEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRSWDFF 5113
            |||||:|.|:||..||||:||..:||||||||||||:||||.:||:||||:|||.|||:|.||||
Mouse  4975 CFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFF 5039

  Fly  5114 PVGDCFRKQYEDELS 5128
            |.||||||||||:||
Mouse  5040 PAGDCFRKQYEDQLS 5054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RyRNP_001246211.1 Ins145_P3_rec 11..202 CDD:285871 124/199 (62%)
MIR 211..392 CDD:280906 85/182 (47%)
MIR 270..>305 CDD:197746 16/34 (47%)
RYDR_ITPR 443..636 CDD:279676 109/192 (57%)
SPRY1_RyR 647..799 CDD:240457 85/152 (56%)
RyR 854..944 CDD:280244 47/89 (53%)
RyR 967..1057 CDD:280244 52/89 (58%)
SPRY2_RyR 1079..1213 CDD:240458 65/133 (49%)
SPRY3_RyR 1518..1669 CDD:293937 55/150 (37%)
RYDR_ITPR 2228..2452 CDD:279676 124/223 (56%)
RyR 2831..2921 CDD:280244 34/89 (38%)
RyR 2954..3038 CDD:280244 49/83 (59%)
RIH_assoc 4017..4130 CDD:285630 83/112 (74%)
RR_TM4-6 4525..4768 CDD:283990 84/299 (28%)
Ion_trans 4856..>4976 CDD:278921 80/120 (67%)
Ryr1XP_036008707.1 Ins145_P3_rec 12..211 CDD:418637 124/200 (62%)
MIR 213..391 CDD:397103 85/181 (47%)
RYDR_ITPR 445..638 CDD:396093 114/197 (58%)
SPRY1_RyR 644..795 CDD:240457 85/152 (56%)
RyR 852..942 CDD:396561 47/89 (53%)
RyR 966..1056 CDD:396561 52/89 (58%)
SPRY2_RyR 1074..1206 CDD:240458 65/133 (49%)
SPRY3_RyR 1420..1568 CDD:293937 55/150 (37%)
RYDR_ITPR 2160..2370 CDD:396093 129/230 (56%)
RyR 2736..2826 CDD:396561 34/89 (38%)
RyR 2856..2940 CDD:396561 49/83 (59%)
RIH_assoc 3880..3996 CDD:400656 85/115 (74%)
RR_TM4-6 4399..4687 CDD:399455 87/317 (27%)
Ion_trans 4781..4965 CDD:395416 133/183 (73%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167836725
Domainoid 1 1.000 714 1.000 Domainoid score I115
eggNOG 1 0.900 - - E1_KOG2243
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 4418 1.000 Inparanoid score I5
Isobase 1 0.950 - 0 Normalized mean entropy S6257
OMA 1 1.010 - - QHG46584
OrthoDB 1 1.010 - - D4054at33208
OrthoFinder 1 1.000 - - FOG0001801
OrthoInspector 1 1.000 - - otm43310
orthoMCL 1 0.900 - - OOG6_102727
Panther 1 1.100 - - O PTHR13715
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3036
SonicParanoid 1 1.000 - - X1009
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1716.750

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