Protein Alignment RyR and unc-68

DIOPT Version :9

• Sequence 1: NP_001246211.1
• Gene: RyR / 49090
• FlyBaseID: FBgn0011286
• Length: 5134
• Species: Drosophila melanogaster
• Sequence 2: NP_001343808.1
• Gene: unc-68 / 179080
• WormBaseID: WBGene00006801
• Length: 5202
• Species: Caenorhabditis elegans
• Alignment Length: 5434
• Identity: 2452/5434 - (45%)
• Similarity: 3424/5434 - (63%)
• Gaps: 548/5434 - (10%)

  Fly     3 EAEGGSEQDDVSFLRTEDMVTLSCTAT--------GERVCLAAEGFGNRHCFLENIADKNVPPDL 59
            |.:||.||||||||||.|:|.|||.|:        .|||||..||||||.|.|||::||::|||:
 Worm     5 EEQGGGEQDDVSFLRTGDIVCLSCVASHNRDGVLGSERVCLCTEGFGNRMCTLENVSDKDIPPDI 69

  Fly    60 SQCVFVIEQALSVRALQELVTAAGSETGKGTGSGHRTLLYGNAILLRHHNSDMYLACLSTSSSND 124
            :.|:..|:.|||:|||||:::|...........||:|||||:|:.|:|..|:|||||||:.||||
 Worm    70 AMCMLYIDNALSMRALQEMMSADSDHKSASGAGGHKTLLYGHAVQLKHVQSEMYLACLSSCSSND 134

  Fly   125 KLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKENEQSIVNAS 189
            ||:||||:||.::|||||||:||||||||||||||||||:||||||||||||........:: ||
 Worm   135 KLAFDVGVQETNEGEACWWTIHPASKQRSEGEKVRVGDDVILVSVATERYLHMAYSKGYMVI-AS 198

  Fly   190 FHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTWGREAGQNIVIYEGGVVMAQ 254
            ||.|.|::|...:|..|.:.:|::||.||||.|||.|||||||..|......|:||||||..:.|
 Worm   199 FHQTLWNIQSVSSGSMRTRNMGFLFGNDVLRLFHGNDECLTIPENWSEHPQHNMVIYEGGAAVTQ 263

  Fly   255 ARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNDSNELILVKKEEASIATTTFCLRQEK 319
            ||||||:||.|.||.|..:.|....||:|||:||||||.| |.:.|..||:|....|.|.:.|.|
 Worm   264 ARSLWRVELIRMKWHGALVGWEQVFRIKHITSGRYLGVLD-NSVQLYHKEKADFDLTAFVMCQNK 327

  Fly   320 DDEKKVLEDKDLEVIGSPIIKYGDTTVIVQHCETSLWLSYKSYETKKKGVGKVEEKQAILHEEGK 384
            |.:|::|::|:.|.:|:..|:||:|...:||.:|.|||||::.|..|||:||||||:|:..::|.
 Worm   328 DPKKQMLDEKEEEGMGNATIRYGETNAFIQHVKTQLWLSYQTTEVTKKGLGKVEEKKAVALKDGH 392

  Fly   385 MDDCLDFSRSQEEESKTARVIRKCSSLFTQFITALETLQSNRRHSIFFQKVNLNEMVMCLEDLIN 449
            ||||..|..:.|||||:|||||||||:..:|:..::.||.....|..:.:|:|||::..:||||.
 Worm   393 MDDCYTFFMALEEESKSARVIRKCSSVLNKFLKGIDALQLEGNQSTDWTRVDLNEVLKLMEDLIE 457

  Fly   450 YFSQPEDDMEHEEKQNRFRALRNRQDLFQEEGVLNLILEAIDKINIITSQGFLASF--LAGDETG 512
            ||:||.|:.:.|||||..||||:||||||||||||:||:.|||.:.:.:   |..|  |.|:||.
 Worm   458 YFAQPNDEQDFEEKQNHLRALRSRQDLFQEEGVLNMILDTIDKFSQMEA---LPDFAGLIGEETH 519

  Fly   513 QSWDLISTYLYQLLAAIIKGNHTNCAQFANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLIDSPE 577
            ..|:.||||||.|:||:|||||.||||||::.||:|||.||.:..|:|  |:||||:|||.:|||
 Worm   520 VKWEQISTYLYLLVAAMIKGNHYNCAQFASAQRLDWLFGRLSNPQSAE--GILDVLYCVLTESPE 582

  Fly   578 ALNMMRDEHIKVIISLLEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTLLV 642
            ||||:.:.||:.:||||||.||||||||||.|||.|||:|||||||.|..:|||||:|||||.:.
 Worm   583 ALNMINEGHIRSVISLLEKVGRDPKVLDVLSSLCEGNGMAVRSSQNLITQYLLPGKDLLLQTSMR 647

  Fly   643 DHVASIRPNIFVGRVDGSSMYQKWYFEVTMDHIEQTTHMMPHLRIGWANTSGYVPYPGGGKKWGG 707
            |||:|:.||:.:|.|:||::::|||||..::|||..|...|:|||||||:.|:.|:||.|.|.|.
 Worm   648 DHVSSMMPNVMLGVVEGSALFRKWYFEAEVEHIETMTKQTPYLRIGWANSVGFKPFPGSGDKMGC 712

  Fly   708 NGVGDDLYSFGFDGAFLWTGGRKTLVVDALPEEPFIRKGDVIGVAIDLSVPIITFTFNGVKVRGS 772
            ||||||.||:||||..::.||:...|...|     :.||||||.:|||::|.|.|:.||..:.||
 Worm   713 NGVGDDFYSYGFDGKSMYFGGKSRRVGHKL-----LEKGDVIGCSIDLTIPEIKFSVNGTYMSGS 772

  Fly   773 FRDFNLDGMFFPVMSCSSKLSCRFLFGGDHGRLKFAPPMGFSALVQCLMPQQILSLDPCFYFGNL 837
            |:.||:||.||||||.|:|:||||:.||:.|||::.||.||||:|:.:..:  |.:..|..||:|
 Worm   773 FKKFNIDGYFFPVMSLSAKVSCRFILGGNQGRLRYGPPTGFSAVVEAVNGE--LQITDCLSFGDL 835

  Fly   838 AKNVLAGPWLIEDD-TAFVPKPVDTTGVTLPSSVDQIKEKLAENIHEMWALNKIEAGWSWGEHRD 901
            .||:.:||..|.:: ..|:|.|:|.:...|.....::.:|.|||:||:||:.|||.|||:||.|.
 Worm   836 GKNIFSGPQTIFNNLEPFIPTPIDVSATQLNHHATEMHQKYAENLHELWAMRKIELGWSYGETRS 900

  Fly   902 DYHRIHPCLTHFEKLPAAEKRYDNQLAVQTLKTIISLGYYITMDKPPARIRPVRL-PNEIFMQGN 965
            :..|.|||||.||.||..||:|:..||:.|:|||.:|||::..:.||.|:|.||| ||  |.|.|
 Worm   901 ETSRKHPCLTKFEYLPETEKKYNILLALTTMKTIEALGYHLITEDPPCRLRAVRLGPN--FQQQN 963

  Fly   966 GYKPAPLDLSAVTLTPKLEELVDQLAENTHNLWARERIQQGWTYGLNE--DSENHRSPHLVPYAK 1028
            ||||.|||...:.|..:|:.|.:.||.||||:||:|:|::|||:||:|  |:...||||||||.:
 Worm   964 GYKPGPLDTHEIQLPAELQPLTEALARNTHNIWAKEKIKRGWTFGLSEHVDATQKRSPHLVPYEQ 1028

  Fly  1029 VDEAIKKANRDTASETVRTLLVYGYVLDPPTGEGTEALLAEAQ-RLKFAGFRTYRVERNYAVTSG 1092
            |||.||:|||::|:|.:|.|.::|..|:||..|..|  :||.: |.:....||||.|..|||..|
 Worm  1029 VDERIKQANRESAAENIRALQLFGIFLEPPAHEHDE--VAEKELRARKDNTRTYRAEATYAVCGG 1091

  Fly  1093 KWYFEFEVLTSGPMRVGWARADCYPGAMLGSEDTSWAFDGHNEEKVYGGVSESFGKQCGPGDIVG 1157
            |||||||:||:|.|::||......|...||::|.|:||||:...|.:.| :|::||:...||:||
 Worm  1092 KWYFEFEILTAGYMKIGWMDIGSTPEIQLGADDRSYAFDGYLGRKWHQG-AETYGKEWKIGDVVG 1155

  Fly  1158 VFLDLADHTISFSLNGELLMDALGGETTFADVTAEGVGFVPACTLGVGQKARLIYGQDVDSLKFF 1222
            .||||.|.|||||||||||:|..|.|..|.:|.. |.|.|||.|||.||:.||.:||..:|||||
 Worm  1156 CFLDLNDRTISFSLNGELLLDPSGSEMAFDNVVC-GDGLVPAMTLGSGQRGRLNFGQQSNSLKFF 1219

  Fly  1223 TTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFENTEEMPDCRI-DVTRIPGGADTPPHLKISHNTF 1286
            ||||||||||||||||.|.:..|:.|..|.||:...:....| :|:|||...::||.|||.....
 Worm  1220 TTCGLQEGYEPFCVNMYRTMPMWFAKQLPRFEDISTLKSGSILEVSRIPATGNSPPCLKILQKVT 1284

  Fly  1287 ET----MEKANWEFLRLSLPVTCMGEFISEQEK---ARRWDEIKNRQYRL---MREAEIAAQMQV 1341
            .:    .|||..|:::|||||.|...|:..::|   .|:..|.|.|...:   :|...|..:..
 Worm  1285 ISEGGPSEKAKMEYIKLSLPVKCNDTFVKNKDKETIRRQLQEYKPRSQSVVSQIRAPGIPKEFD- 1348

  Fly  1342 QTQAAHMDHMLKGGFNMNDIKGLTRNFDEHADAEADHMMRGPNRPP-----RKGSLTRNITFETD 1401
                   |:..|.||    ::.:..:.|.| :::.|...|..::.|     ...::.|::
 Worm  1349 -------DNKEKKGF----LRSMLGSKDSH-ESDDDRRSRTNSKQPSVDGDEPPAVRRSL----- 1396

  Fly  1402 MSAALDEMQRSTSVLDMNGLGEEMDDKKKRG------------RSPFKFFSKKSRDQSRE----K 1450
            :....||.|.:..  .|..|.:...:|.|:|            |..|:...::..:::.:    |
 Worm  1397 LELPHDERQIAED--SMRDLNDRHSEKPKKGGLLSRLRDSSNTRKNFRDSDRRKEEKAAQLRQMK 1459

  Fly  1451 MGARTLDTSLERRNTVAHGRNVV-----------NQQMTTRAPTLRLN----NAEIPPSPVPQGP 1500
            ..:|:.|......:|:..|:..|           .:|:|.:..:::.|    .|||   .:.:..
 Worm  1460 ANSRSFDAGSLDTSTLPTGQKDVLASSEMPLSGPGRQLTIKRSSIKKNKKGKKAEI---ALEKME 1521

  Fly  1501 KQLSGSNLGQQPVETSGDEMFDAECLKL------INEYFYGVRIFPGQDPTHVYVGWVTTQYHLH 1559
            ::..||.:   |::...|.:.:.:...|      ::||:||:||||||||:.|:|||||||||.:
 Worm  1522 REKKGSII---PMDAQLDVLQEGDAHALVHHKDKVDEYYYGIRIFPGQDPSQVWVGWVTTQYHYY 1583

  Fly  1560 SREFNKNK-VRRGSVYIEDDYEMAIERIDRQSCYVVRADELFNEVTQDASGKGASQGMFVGCFVD 1623
            :..|:.:: ||:......|.:...::.:..|:||:|...||. ..|.|.:....| |..:||.:|
 Worm  1584 NVNFDGSQGVRKCRFSEADHHGTTVDSVQSQNCYMVNVSELL-ATTPDVANTKVS-GTLIGCIID 1646

  Fly  1624 TATGIIRFTCEGKDTSHRWMMEPDTKLFPAIFVEATSKEILQIELGRTPTTLPLSAAVLPTSDKH 1688
            |:.|.:.|.....||..::.:||...||||.||..|:.||||.||||...|.|||||:..:.:|.
 Worm  1647 TSIGELSFQVGSTDTGIKFKLEPGAMLFPAAFVTPTATEILQFELGRIKYTFPLSAAMFKSCEKS 1711

  Fly  1689 INPQSPPRLKVQCLRPHQWARVPNTALQVHALKLSDVRGWSMLCEDPVSMLALHIPEEDRCIDIL 1753
            :.|..||||.|:.:....||||||..|:..|||||:|||||:||.|||.:::::|||:|:.:|||
 Worm  1712 LVPFCPPRLTVEQIESVYWARVPNETLRTTALKLSEVRGWSVLCNDPVRIMSVYIPEKDQSLDIL 1776

  Fly  1754 ELIEMDKLLSFHAHSLTLYAALCYQSNYRAAHALCQHVDQKQLLYAIRSEYMSGPLRQGFYDLLI 1818
            |:|||..:|.||..:|.||..|....|::.||.||||:|:.|::|||:|.|:|||:||||:||||
 Worm  1777 EMIEMPDMLEFHRQTLNLYCKLASHGNHKVAHTLCQHIDEDQIMYAIKSHYLSGPMRQGFHDLLI 1841

  Fly  1819 ALHLESHATTMEVCKNEYITPLGAELKELYSDEEMQHSLRSLV---TESVRPQLRMTEITPPVIA 1880
            .|||.||.........||:.||..:|:           :::::   :||..||:....:
 Worm  1842 GLHLMSHTAARNSMAKEYVIPLVPQLQ-----------IKNVLDPDSESRYPQITGESV------ 1889

  Fly  1881 TSSMPSVSSEPI------PDIDQLYSPKFPLEVVRQFVMEALKDAVEINQVHNRDPIGWTNENLF 1939
             |.:..::|||:      .|..:|..|....|.:::.|||:|:.|.....::.||.||..|.|.|
 Worm  1890 -SMLSQMASEPVKKHVSREDEMKLLPPSVDFEALKKHVMESLQSATHHAVMNCRDLIGGDNTNHF 1953

  Fly  1940 LPLIKLTDRLLLVGVLTDEDVQRLLVMIDPETWDQAFEREGKDEHRKGLLTMKMAEGAKLQMCYL 2004
            .||.||.|:||::|::.||:::.||.:|.|:.:|:.:|   ....:|||..:::||..|:|:..:
 Worm  1954 EPLFKLFDQLLVIGLINDEELECLLRLIHPQAFDENYE---TGTTQKGLTQLELAEPVKIQLVSI 2015

  Fly  2005 LHHLYDTQLRHRVESIIAFSHDFVGDLQTDQLRRYIEIKQSDLPSAVAAKKTKEFRCPPREQMNQ 2069
            |.||.|.|||:|:||::||:..|||:||:||.:||:||||:|:|.|.||||||||||||:|||.:
 Worm  2016 LDHLCDIQLRYRIESLVAFTEGFVGELQSDQCKRYMEIKQTDMPPAEAAKKTKEFRCPPKEQMFR 2080

  Fly  2070 ILCFK--------NLEPD-DQDNCTCGLELRGRLGDFHDSLMQKVSLNALQEPDGVEGTAIEEVK 2125
            :|..|        .:|.| |.|.|.....|:.:|.||.:.|:.|:  ..::|.|..:..|:.|.:
 Worm  2081 LLMCKVKEERDPELMEEDADVDQCPMAEGLQQQLRDFCELLVGKI--GNVKEGDSDDQLALIESE 2143

  Fly  2126 TGPITKIYNFINTVKE-----LEEGPKEVEEPEKKTPEEVFRKVLIKTIVSWAEESQIENPKLVR 2185
            .|  :.:.:|...|.:     ||||    .|.:||..:. ||::::..:..||:...||:..|:|
 Worm  2144 EG--SWVDSFARIVVKVPPPVLEEG----MEMQKKGTQN-FREIIVTMLREWAQADFIESKSLIR 2201

  Fly  2186 EMFSLLLRQYDTVGELVRALEKTYVINTRARDDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLW 2250
            .||.||||||..:.|:..|:.:|||.:.|...||.:..|.|.|||.||.||....||.::::.||
 Worm  2202 NMFRLLLRQYSGIREIRDAMSQTYVFHERNEKDVTDFLVYLIQIRELLTVQFEHTEEAILKRGLW 2266

  Fly  2251 KLVNNATFFQHPDLIRILRVHENVMAVMMNTLGRRAQAQSDAPTQSEVAEGAPSKEKDTSHEMVV 2315
            ||:||..|||||||:|:|.||||||::|||.|  .||..:......|:.|.||.|:   :.||||
 Worm  2267 KLMNNRIFFQHPDLMRLLSVHENVMSIMMNIL--TAQQGTVEHEGDELKEKAPIKD---ASEMVV 2326

  Fly  2316 ACCRFLCYFCRTGRQNQKAMFDHFDFLLDNANILLARPSLRGSTPLDVAYSSLMENTELALALRE 2380
            ||.|||||||||.||||||||:|..||||||.:||||||||||.||||||||.|:|.||||||:|
 Worm  2327 ACSRFLCYFCRTSRQNQKAMFEHLSFLLDNATMLLARPSLRGSVPLDVAYSSFMDNNELALALKE 2391

  Fly  2381 HYLEKIAVYLSRCGLQSNSELVEKGYPDLGWDPVEGERYLDFLRYCVWVNGESVEENANLVIRLL 2445
            ..|:|:||||||||||.||||:.|||||:||||||||||:||||:|||:|||:||||||||||||
 Worm  2392 EELDKVAVYLSRCGLQPNSELITKGYPDIGWDPVEGERYIDFLRFCVWINGENVEENANLVIRLL 2456

  Fly  2446 IRRPECLGPALRGEGEGLFRAIVEANRMSE--RISDRCKMQDEAEGTIAGLNFTHPLPEGEEDED 2508
            ||||||||.||:|||:|||.|..||..:||  |:.:...........:.|.|.|:|..:. |.||
 Worm  2457 IRRPECLGVALKGEGQGLFSAFKEAIALSEDIRLLENDSHPSLLSSGLLGENPTYPSKDA-EGED 2520

  Fly  2509 YIDTGAAILNFYCTLVDLLGRCAPDASVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFTL--- 2570
            |||.|||.|:||.:|||||.:||||...|:.||.:|||||||||||:.|:||..:|:|:||:
 Worm  2521 YIDLGAATLDFYSSLVDLLAKCAPDPMAIQAGKGDSLRARAILRSLISLDDLGQILALRFTIPNL 2585

  Fly  2571 -------------------------------------------SQT------------------- 2573
                                                       |||
 Worm  2586 AAPSIEAVRRANAVQASHTQKAVMAHTFAMVASLASEVSNTRRSQTFTSGTNLAKRGLPCVEEVD 2650

  Fly  2574 -----------------------APGEEKPKSD----------------------------MPSG 2587
                                   ||..||.|.|                            :| |
 Worm  2651 TDDSKSSDYASVHTSFSSGNELFAPKAEKEKVDVLKLNENKYPIIQRRRSSRFNPIDNTGPLP-G 2714

  Fly  2588 LLPNNKQSIVLFLERVYGIEAQDLFYRLLEDAFLPDLRTATILDKSDGSESDMALAMNRYIGNSI 2652
            ||||:|.|::|||:|||||:.||:.:.:||.:||||||.||::|.....|||.|||:|||:.||:
 Worm  2715 LLPNHKGSVLLFLDRVYGIDQQDMLFHVLEQSFLPDLRAATMMDSPRALESDTALALNRYLCNSV 2779

  Fly  2653 LPLLIKHSKFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDFLVALTSQMQPAMLLKLL 2717
            ||||..||.|:.:||::::|||||||||||:::.:.|||.||:||||||||:|.::.|||::|||
 Worm  2780 LPLLTNHSHFFADAEHHSALLDATLHTVYRMNRLKSLTKNQRDAVSDFLVAITRELPPAMMIKLL 2844

  Fly  2718 RKLTVDVSKLSEYTT-VALRLLTLHFDRCAKYYGSTQGQGSYGASSDEEKRLTMLLFSNIFDSLS 2781
            :|:..|:..:::... |.|||:|||::||.|||||   ...||.:|::||||:||||..|||:|.
 Worm  2845 KKVITDILTMNDMNVLVPLRLITLHYERCGKYYGS---GNHYGVASEQEKRLSMLLFDAIFDTLG 2906

  Fly  2782 NMDYDPELFGKALPCLIAIGCALPPDYSLSKNTDEDYYGRQMGAPDQPQYMPNPIDTNNVHLDND 2846
            :..||||||||||||:.|||.|:.|||:|:...::   .|.....::..::|..:|.:...::.|
 Worm  2907 SRPYDPELFGKALPCMTAIGSAISPDYTLTSGLED---VRNKRREEEGAWIPRTVDVSRCEINRD 2968

  Fly  2847 LNSLVQKFSEHYHDAWASRRLEGGWTYGDIRSDNDRKHPRLKPYNMLSEYERERYRDPVRECLKG 2911
            |..:.:.|:||:||:||||:||.||.:||:.|..:..||||||:.:|.::|:..|::...||||.
 Worm  2969 LEKMTELFAEHFHDSWASRKLEKGWVHGDLYSRANFTHPRLKPFALLKDFEKSFYKERCSECLKA 3033

  Fly  2912 LLAIGWTVEHSEVEVALNHRGSTRRQ-SKPQINEFQNEGSPFNYNPHPVDMSNLTLSREMQNMAE 2975
            |:|  |......::...|.|.|..|. |...|:         |:.|.|:|:|::||.::|.|.||
 Worm  3034 LMA--WNYSFEMMDRDANDRASAARTLSGTSIS---------NFAPKPIDLSSMTLEKDMVNAAE 3087

  Fly  2976 RLAENSHDIWAKKKNEELNGCGGVIHPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQGYKLHKP- 3039
            ::||:||.|||||...:||..||.:...|||:|||||.|::|||.|:.|.||::||.||.::.|
 Worm  3088 KMAEHSHLIWAKKVMNDLNTKGGFMPIPLVPWDLLTDFERRKDRFRASEILKFLQYHGYHVNCPK 3152

  Fly  3040 ---SKGGAVEEGGATQAAVELRFSYSLLEKLIQYLDRATINMKLLKPSTTFSRRSSFKTATRDIK 3101
               |:...::..| .:.:||.||:|:||||||.||::|::.||.:|||...:||:|||...:|:|
 Worm  3153 DEQSQNDRLKSEG-ERTSVEKRFAYNLLEKLITYLEQASLKMKSVKPSQELTRRNSFKKEGQDVK 3216

  Fly  3102 FFSKVVLPLMEKYFSTHRNYFIAIATATNNIGAASLKEKEMVASIFCKLAALLRNRLSAFGPDVR 3166
            ||.|||||||..||:.|:|||:. .::....|.||.|||||||::||:||||||.:..|||...:
 Worm  3217 FFEKVVLPLMHAYFNAHKNYFLE-GSSIVQTGTASNKEKEMVANLFCRLAALLRIKNRAFGSVAK 3280

  Fly  3167 ITVRCLQVLVKGIDARTLTKNCPEFIRTSMLTFFNQTSDDLGNTILNLQD-GKYSHLRGTHLKTS 3230
            |||:|||.|.:.:|.|||.|...:.:|||:|||||..:|||..::..|:| |:||.:||..||:.
 Worm  3281 ITVKCLQGLTQALDLRTLVKVNSDIVRTSLLTFFNNCADDLYASVNELKDGGQYSLIRGQALKSW 3345

  Fly  3231 TSLGYVNQVVLPVLTAMFDHLAACDYGSDLLLDEIQVASYKILAALYHL-GTDGTLTHDRKYLKT 3294
            .|..:.||:::||||.||.|||...:|:|||||:||.|.||||.:||.: |...:::| ||.:..
 Worm  3346 NSFEFANQMIVPVLTTMFAHLARNHFGTDLLLDDIQAACYKILDSLYMVTGLSSSISH-RKSISG 3409

  Fly  3295 EIERHRPALGSCLGAYSSCFPVAFLEPHLNKHNQYSLLNRIADHSLEAQDIMVKMESCMPNLETI 3359
            |.|:|||.||.||.|::||||||||||..||.|::|:|.:..|.|::.|:::..:.:.:|:||.:
 Worm  3410 ESEKHRPGLGQCLAAFASCFPVAFLEPEFNKSNKFSVLAKSQDQSVQVQEMLQNLSTHIPHLEKL 3474

  Fly  3360 LAEVDQFVESDKTYNDAPHIIDVILPLLCAYLPFWWSQGPDNV-----SPTSGNHVTMVTADHMN 3419
            |.:::....::..|:|.|::.||.|||:|:|:..|:|.|||..     ...|....|.|:.||:|
 Worm  3475 LTDLETVANNNTMYSDVPNVYDVDLPLMCSYMAHWFSVGPDGKRDKEDQRASVVQTTSVSCDHIN 3539

  Fly  3420 PLLRNVLKMIKKNIGNDNAPWMTRIAAYTQQIIINTSEELLKDPFLPLAERVKKRTENMLHKEDS 3484
            .:...:||||:.::|.:||||:.|:..:..|||.|.:.:.:::..||:|||:::.:|....:|:.
 Worm  3540 RIFNALLKMIRNHVGIENAPWLCRVNFFAVQIIQNVTSDPVREFVLPIAERLRRMSEKAYKEEEH 3604

  Fly  3485 MRGFIKSATDDTSQVETQLQEDWNLLVRDIYSFYPLLIKYVDLQRNHWLKDNIPEAEELYNHVAE 3549
            ||    :..||..  |..:.||...||||.|:|:|:|:||.||.|..|||....|.:.:|.:||.
 Worm  3605 MR----THPDDAD--EGTVAEDNARLVRDTYAFFPILMKYTDLHRAQWLKTPTWETDGVYENVAV 3663

  Fly  3550 IFNIWSKSQYFLKEEQNFISANEIDNMALIMPTATRRSAISEGAPAVGGKVKKKKKNRDKKRD-- 3612
            ||.|||:||:|.:||.|:::..|.|      ..||....:..|..|:..:.||:::.:||.::
 Worm  3664 IFRIWSQSQHFKREELNYVAQFEED------AAATGGGDMKTGKAAIAERKKKRREGQDKMKEYF 3722

  Fly  3613 ---------KDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRYLKKMPEYDVIEFARNQ 3668
                     |||.. ||:::||||||||||||:|.|||.::||..|:::::|..|..:.||.:..
 Worm  3723 DRNGRPIIKKDKHA-ASIVIACLKRLLPVGLNVFGGRELDIVQQSKEKFIQKETEEKIREFIKGL 3786

  Fly  3669 LTLPDKLDPSDEMSWQHYLYSKLGKTEEPVDEQALEKANVNSNEKGKDKTQE--TVDRIVAMAKV 3731
            |.:|.|.||:|:.:||..||.|:||                |..:|||:..:  .:::|..|.:|
 Worm  3787 LEIPVKTDPTDKNAWQLSLYRKIGK----------------SQMRGKDEMSQDAVIEKIFNMGQV 3835

  Fly  3732 LFGLHMAASSKNR-SKRWGSKISVARRQAVISSLRAKHLYRMSRHRACNIFARSYYEQWLQEENV 3795
            ...||.....:.: |:.|...:|..|::||::..|...||.:.|||..|.|..::...|::||:.
 Worm  3836 SAILHTTEHPQMQLSQAWKKVVSTQRKRAVVACFRMVPLYGIPRHRGINFFLPAFSRLWMEEEDA 3900

  Fly  3796 GQEVMVEDLTQTFEDSE---------------KSKKEGEETDSKPDPLTQLVTTFCRGAMTER-- 3843
            ||:.::.|:....|:.|               .|.::.:|.::.||||.||:..|.|.|.:|.
 Worm  3901 GQDQLIADICSGVEEEEGPRIEIIMEEGVPIVASSEDTKEKETNPDPLKQLIRCFQRAATSEETA 3965

  Fly  3844 SGALQEDLLYMSYAQIAAKSTGKEEEEGGDEEGGEGGEEGEGTSIHEQEMEKQKLLFHQARLSNR 3908
            :.|:.||.||:.:|.:.|||...|||:      ||.|||||.....::| :.|.|...||.|::|
 Worm  3966 ASAIHEDSLYIRFADVMAKSIHIEEED------GEDGEEGEIDQAAKEE-QSQALRGEQAVLASR 4023

  Fly  3909 GVAEMVLLHISASKGIPSEMVMTTLNLGIAILRGGNIDIQMGMLNHLKEKKDVGFFTSIAGLMNS 3973
            |.|.|.|:::|||.|.|:|||..||.|||.:|.|||::||..::.:|:.||||.||||:|||||.
 Worm  4024 GAAIMCLMYLSASGGEPNEMVAQTLQLGIHLLSGGNVEIQKMLIEYLQLKKDVRFFTSMAGLMNK 4088

  Fly  3974 CSVLDLDAFERNTKAEEYIPSAGAGLGVGSEGAAGE-KNMHDAEFTCALFRFIQLTCEGHNLEWQ 4037
            ||||:|:.|||..|||        |||:|:|.|:|: :|::||:|||:||||:||||||||||:|
 Worm  4089 CSVLNLEMFERQIKAE--------GLGMGAELASGDNQNLNDADFTCSLFRFLQLTCEGHNLEFQ 4145

  Fly  4038 NYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKEIIDPAGKANFFKAIEVASQVFNTL 4102
            ||||||.|:||:||::.||||||||||||:|||||||||||:||..||..|.:||:|.|||||||
 Worm  4146 NYLRTQPGHTTSVNLINCTVDYLLRLQESVMDFYWHYSSKEVIDEGGKEYFLRAIQVCSQVFNTL 4210

  Fly  4103 TEVIQGPCTLNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSM 4167
            ||.|||||..||..||:||||||:.||.|||:||.:||.|:|:|::||:|.||||||||.:||||
 Worm  4211 TESIQGPCVGNQMTLANSRLWDAINGFFFLFAHMMEKLYKNSTQLELLREFLNLQKDMIVLMLSM 4275

  Fly  4168 LEGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKLADLIESPSFHEVDMKNEGWVTPKDFRE 4232
            |||||:||:|||||||.||||..:||.|||:.||||||.||..|.:|.:.|...:||::||:|:.
 Worm  4276 LEGNVLNGSIGKQMVDALVESQPSVEKILKFSDMFLKLKDLTTSQAFQDFDTNQDGWISPKEFQR 4340

  Fly  4233 KMEQSKNYTPEEMDFLLACCERNHEGKIDYRAFVEHFHEPSKEIGFNLAVLLTNLSEHMPNEPRL 4297
            .||..|.||.|::.:|:.|.:.|::||:||..|.|.||.|:::|||||||||.||.||:.|:|||
 Worm  4341 AMESQKMYTVEDITYLMMCTDVNNDGKVDYMEFTERFHNPARDIGFNLAVLLVNLKEHITNDPRL 4405

  Fly  4298 ARFLETAGSVLNYFEPFLGRIEILGSSKRIERVYFEIKDSNIEQWEKPQIRESKRAFFYSIV-TE 4361
            .:.:|.|.::|.||:||||||||:|||||:|::||||::|.:|||.|.|||:||.:|.:::: .:
 Worm  4406 EKIIEKAQTLLEYFDPFLGRIEIMGSSKRVEKIYFEIQESWLEQWGKQQIRDSKNSFLFNVLQDD 4470

  Fly  4362 GGDKEKLEAFVNFCEDAIFEMTHASGLMATDDGGGNVKRDTAYSSYMSEEEE--ERAARDPIRRT 4424
            |||:.|||||:|||||.||||.||:.:.:.|.       ||.....:.:.:.  ::.:.|.|..|
 Worm  4471 GGDQGKLEAFINFCEDTIFEMQHAAAISSGDS-------DTKMERAIKQRDYFLQQTSADHISET 4528

  Fly  4425 ITAVKEGLKFGV---HMLSPANIKHQI-----GVMQ---TKSIPELIVGFFKIIFYIFYYTGYAH 4478
            .   |.|..:|:   ..|||.||...:     .|.|   |:.:..:|:.|.:....|    |:|.
 Worm  4529 F---KSGYNYGISAASALSPQNISTTMRNVSSSVRQMSWTQLLYAVIILFIRAGLAI----GWAG 4586

  Fly  4479 FCVVRYI--FGILLNLMRGPAPEQEEEPVVEEETFGRALPPLPLEEPP----------GTVQAFG 4531
            :.::..|  ||..|.     ...:|||...:|:...:.....|...||          | |.|||
 Worm  4587 YLLLMTIFRFGYFLT-----TSSEEEEAARQEKEQAKMNNEHPSFNPPIIQEFHHSHVG-VTAFG 4645

  Fly  4532 LDINKEE---NGMYKVVVHESP--ANSSMEE----GGESSPEDGAAASGELVEGEPHQEPISIVD 4587
            :.:|.:.   |.:...|..|.|  ..:.:||    ..|:||.....:        |..:..||.:
 Worm  4646 VGMNADHLNVNSLPDFVPPERPETPETVLEEEKPLNQETSPPTSPTS--------PASKAPSIYE 4702

  Fly  4588 LLGGEAAKKAAQERQEAQKAQEAAMASIEAEAKKSSSAPQETPAVHQIDFSQYTHRAVSFLARNF 4652
            .:|   |.:..|.:.||...|                 .|..|.:.:.:.::.....::.|||||
 Worm  4703 SIG---APQMVQLQSEADFQQ-----------------GQYEPKIAESNSTKSRGSILNMLARNF 4747

  Fly  4653 YNLKYVALVLAFSINFMLLFYKV-TSFTEEADSSAEEELILGSGSGGGADITGSGFGGSGDGGSG 4716
            ..::.:.|.|||.||.:|||::| .|..|.|::::|                            |
 Worm  4748 KTIEKITLYLAFFINVILLFHRVDISHAENAEAASE----------------------------G 4784

  Fly  4717 DGEMEDEIPELVHVDEDFFYMEH---------VLRIAACLHSLVSLAMLIAYYHLKVPLAIFKRE 4772
            |.: ||.:..:......|.|:|:         :|...:.||...|.|:|:::|.||:||..||||
 Worm  4785 DDD-EDALESIFITGMQFPYVEYEITGWMLAQILYWISVLHLSTSFALLVSFYQLKIPLITFKRE 4848

  Fly  4773 KEIARRLEFEGLFIAEQPED-----DDFKSHWDKLVISAKSFPVNYWDKFVKKKVRQKYSETYDF 4832
            |||||:|.|:|.:|.|:..:     |.|..:.|::|:||||||:.||||||::|.|.|:.:..|.
 Worm  4849 KEIARKLMFDGCWITEEDSEELGIVDTFMWYLDRIVVSAKSFPMMYWDKFVRRKTRSKFKDQVDE 4913

  Fly  4833 DSISNLLGMEKSTFAAQESEETGIFKYIMNIDWRYQVWK-AGVTFTDNAFLYSLWYFSFSVMGNF 4896
            ::::::||.||.:..:             :.|:||..|. .||..|:..|||.:.|...|..|.|
 Worm  4914 ETLTSILGEEKMSTDS-------------SYDYRYSCWLWIGVILTNGQFLYRVGYLLCSACGVF 4965

  Fly  4897 -NNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYIQ--E 4958
             :.||:|.||:||.:.|..|:.||||||||.:||:||:|:..::||:|||||||||||||:|  |
 Worm  4966 LSPFFYAFHLIDVVLSFPMLKAILQSVTHNLQQLILTIMMTLVVVYLYTVIAFNFFRKFYVQEGE 5030

  Fly  4959 EDEEVDKKCHDMLTCFVFHLYKGVRAGGGIGDEIGDPDGDDYEVYRIIFDITFFFFVIIILLAII 5023
            |.||.|:|||:|||||::|.|.|||||||||||:..|.|||.|..|:.:||:||||||||||||:
 Worm  5031 EGEEPDRKCHNMLTCFIYHFYAGVRAGGGIGDELESPYGDDLEYPRMFYDISFFFFVIIILLAIM 5095

  Fly  5024 QGLIIDAFGELRDQLESVKDNMESNCFICGMGKDFFDIVPHGFDTHVQKEHNLANYMFFLMHLIN 5088
            ||||||||||||||.||..:.:||:||||.:||:.||.:|.||:.|..||||.|||:|||.||:|
 Worm  5096 QGLIIDAFGELRDQQESATEKLESSCFICDIGKETFDRMPRGFEIHTTKEHNFANYLFFLQHLVN 5160

  Fly  5089 KPDTEYTGQETYVWNMYQQRSWDFFPVGDCFRKQYEDEL 5127
            |.:||||||||||...|..|.|||||||:||.|||||:|
 Worm  5161 KDETEYTGQETYVREKYDNRDWDFFPVGECFVKQYEDQL 5199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RyR	NP_001246211.1	Ins145_P3_rec	11..202	CDD:285871	119/198 (60%)
		MIR	211..392	CDD:280906	94/180 (52%)
		MIR	270..>305	CDD:197746	17/34 (50%)
		RYDR_ITPR	443..636	CDD:279676	123/194 (63%)
		SPRY1_RyR	647..799	CDD:240457	80/151 (53%)
		RyR	854..944	CDD:280244	44/89 (49%)
		RyR	967..1057	CDD:280244	48/91 (53%)
		SPRY2_RyR	1079..1213	CDD:240458	73/133 (55%)
		SPRY3_RyR	1518..1669	CDD:293937	60/157 (38%)
		RYDR_ITPR	2228..2452	CDD:279676	156/223 (70%)
		RyR	2831..2921	CDD:280244	36/89 (40%)
		RyR	2954..3038	CDD:280244	43/83 (52%)
		RIH_assoc	4017..4130	CDD:285630	85/112 (76%)
		RR_TM4-6	4525..4768	CDD:283990	63/261 (24%)
		Ion_trans	4856..>4976	CDD:278921	65/123 (53%)
unc-68	NP_001343808.1	Ins145_P3_rec	13..209	CDD:327620	119/196 (61%)
		MIR	220..399	CDD:308455	94/179 (53%)
		RYDR_ITPR	449..646	CDD:307497	128/201 (64%)
		SPRY1_RyR	652..799	CDD:240457	80/151 (53%)
		RyR	853..941	CDD:307927	44/87 (51%)
		RyR	965..1057	CDD:307927	48/91 (53%)
		SPRY2_RyR	1078..1210	CDD:240458	73/133 (55%)
		SPRY3_RyR	1542..1692	CDD:293937	59/151 (39%)
		RYDR_ITPR	2242..2467	CDD:307497	160/229 (70%)
		RyR	2953..3043	CDD:307927	36/91 (40%)
		RyR	3066..3148	CDD:307927	43/81 (53%)
		RIH_assoc	4125..4238	CDD:312080	85/112 (76%)
		EFh	4321..4375	CDD:238008	21/53 (40%)
		RR_TM4-6	<4662..4842	CDD:310808	54/236 (23%)
		Ion_trans	<4969..5111	CDD:306908	98/141 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167424
Domainoid	1	1.000	765	1.000	Domainoid score	I32
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37423
Inparanoid	1	1.050	4238	1.000	Inparanoid score	I3
Isobase	1	0.950	-	0	Normalized mean entropy	S6257
OMA	1	1.010	-	-		QHG46584
OrthoDB	1	1.010	-	-		D4054at33208
OrthoFinder	1	1.000	-	-		FOG0001801
OrthoInspector	1	1.000	-	-		oto19365
orthoMCL	1	0.900	-	-		OOG6_102727
Panther	1	1.100	-	-	LDO	PTHR13715
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1009
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.860