DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RyR and ryr3

DIOPT Version :9

Sequence 1:	NP_001246211.1	Gene:	RyR / 49090	FlyBaseID:	FBgn0011286	Length:	5134	Species:	Drosophila melanogaster
Sequence 2:	XP_031747158.1	Gene:	ryr3 / 101731188	XenbaseID:	XB-GENE-949980	Length:	4884	Species:	Xenopus tropicalis

Alignment Length:	5282	Identity:	2357/5282 - (44%)
Similarity:	3259/5282 - (61%)	Gaps:	556/5282 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AEGGSEQDDVSFLRTEDMVTLSCTAT----GERVCLAAEGFGNRHCFLENIAD-KNVPPDLSQCV 63
            ||||..:|::.||||:|.|.|.|.||    ..:.||||||.|||.||||..:: |.|||||..|.
Frog     2 AEGGEVEDEIQFLRTDDEVVLQCVATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPPDLCICN 66

  Fly    64 FVIEQALSVRALQELV--TAAGSETG-------KGTGSGHRTLLYGNAILLRHHNSDMYLACLST 119
            ||:||:||||||||::  |.|....|       ...|.||||||||:||||||..|.|||.||:|
Frog    67 FVLEQSLSVRALQEMLANTMANGNEGPSDLSRWASQGGGHRTLLYGHAILLRHSFSGMYLTCLTT 131

  Fly   120 SSS-NDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKENEQ 183
            |.| .|||:||||||..|.|||||||:||||||||||||||:|||||||||::|||||.:..|..
Frog   132 SRSLTDKLAFDVGLQNTSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSISNGM 196

  Fly   184 S--IVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTWGREAGQNIVIY 246
            |  .|:|||..|.|:|.|..:|.|..:  ||:.||.|:|||||.|||||||||...||....|.|
Frog   197 SNIQVDASFMQTLWNVHPTCSGSSVEE--GYLLGGHVVRFFHGHDECLTIPSTDSGEAQHRKVNY 259

  Fly   247 EGGVVMAQARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNDSNELILVKKEEASIATT 311
            |.|...|:||||||:|..|..|:|..|.|....|:||||||:||.:.:...|:|..:.::...::
Frog   260 EAGGAGARARSLWRVEPLRISWSGSHIRWGQTFRLRHITTGQYLALTEDQGLVLQDRAKSDTKSS 324

  Fly   312 TFCLRQEK---DDEKKVLEDKDLEVIGSPIIKYGDTTVIVQHCETSLWLSYKSYETKKKGVGKVE 373
            .||.|..|   |...|    :|::.:|:..|||||:...|||..:.|||:||:.:.|...:|.:
Frog   325 AFCFRASKEKLDTGSK----RDIDGMGAAEIKYGDSICFVQHVNSGLWLTYKAQDAKTARLGPL- 384

  Fly   374 EKQAILHEEGKMDDCLDFSRSQEEESKTARVIRKCSSLFTQFITALETLQSNRRHSIFFQKVNLN 438
            :::||||:||.|||.:...:.|.|||:.||:||..::||:|||:.|:::..|.........:.:.
Frog   385 KRRAILHQEGHMDDGVTLQKCQHEESQAARIIRNTTALFSQFISDLDSVTGNNWAGSTPITLPIE 449

  Fly   439 EMVMCLEDLINYFSQPEDDMEHEEKQNRFRALRNRQDLFQEEGVLNLILEAIDKINIITSQGFLA 503
            |:|..|:|||:||..||:::|||:|||:.|:|:|||:||:|||:|.|:|..||::|:.:|....|
Frog   450 EVVQTLQDLIDYFKPPEEELEHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYSSAAHFA 514

  Fly   504 SFLAGDETGQSWDLISTYLYQLLAAIIKGNHTNCAQFANSNRLNWLFSRLGSQASSEGSGMLDVL 568
            .|| |::.|.:|..|...||:||||:|:||.:|||||  ||.|:||.|:|....||  ||:|:||
Frog   515 EFL-GEKDGPAWKEIMNLLYELLAALIRGNRSNCAQF--SNNLDWLISKLERLESS--SGILEVL 574

  Fly   569 HCVLIDSPEALNMMRDEHIKVIISLLEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGK 633
            ||:||:||||||::...||:.|||||:||||:.|||||||||||.||||||::||.|||.|||.:
Frog   575 HCILIESPEALNLIEKGHIRSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRTNQNLICDNLLPRR 639

  Fly   634 NLLLQTLLVDHVASIRPNIFVGRVDGSSMYQKWYFEVTMDHIEQTTHMMP-HLRIGWANTSGYVP 697
            :|||||.||:.|.|:|||||:|..:||:.|:|||||:.:|.::......| |||:|||:||||.|
Frog   640 DLLLQTRLVNDVTSMRPNIFLGVAEGSAQYKKWYFEMIIDQVDPFLTPEPTHLRVGWASTSGYAP 704

  Fly   698 YPGGGKKWGGNGVGDDLYSFGFDGAFLWTGGRKTLVVDALPEEPFIRKGDVIGVAIDLSVPIITF 762
            |||||:.||||||||||:|:||||..||:|.....|  |...:..:...||:...:||.||.|:|
Frog   705 YPGGGEGWGGNGVGDDLFSYGFDGLHLWSGRVPRAV--ASTNQHLLASDDVVSCCLDLGVPSISF 767

  Fly   763 TFNGVKVRGSFRDFNLDGMFFPVMSCSSKLSCRFLFGGDHGRLKFAPPMGFSALVQCLMPQQILS 827
            ..||..|:|.|.:||.:|:||||:|.|:.:..|||.||.||..||.||.|::...:.|:|::.:.
Frog   768 RINGQPVQGMFENFNTEGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPAGYAPCYEALLPKEKMR 832

  Fly   828 LDPCFYFGNLAKNV--LAGPWLIEDDTAFVPKPVDTTGVTLPSSVDQIKEKLAENIHEMWALNKI 890
            ::|...:......|  |.|........:|:|.|:||:.:.||..:::|::||||||||:|.:|||
Frog   833 VEPVKEYKRDFDGVRDLLGTTHFLSQASFIPCPIDTSQIVLPPHLEKIRDKLAENIHELWGMNKI 897

  Fly   891 EAGWSWGEHRDDYHRIHPCLTHFEKLPAAEKRYDNQLAVQTLKTIISLGYYITMDKPPA--RIRP 953
            |.||.:|:.|||..|.||||..|.|||..||.|:.|::.:||||:::||..|......|  .::.
Frog   898 ELGWIYGKVRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCLIVHSNQTAEENLKK 962

  Fly   954 VRLPNEIFMQGNGYKPAPLDLSAVTLTPKLEELVDQLAENTHNLWARERIQQGWTYGLNEDSENH 1018
            |:||.. :|..|||||||||||.|.|.|..|.|||:||||.||:||::||:||||||:.:|.:|.
Frog   963 VKLPKN-YMMSNGYKPAPLDLSDVKLLPAQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNK 1026

  Fly  1019 RSPHLVPYAKVDEAIKKANRDTASETVRTLLVYGYVLDPPTGEGTEALLAEAQRLKFAGFRTYRV 1083
            |:|.|||||.:||..||:|||:..|.|||.:.|||.::||..|.|:.:   .:|:.....|.:||
Frog  1027 RNPRLVPYALLDERTKKSNRDSLREAVRTFIGYGYNIEPPDQEITDQM---TERVGIDKIRFFRV 1088

  Fly  1084 ERNYAVTSGKWYFEFEVLTSGPMRVGWARADCYPGAMLGSEDTSWAFDGHNEEKVYGGVSESFGK 1148
            |:.|||.:|||||||||:|.|.|||||||..|.|...||:::.::.|:| :..:.:...|..||:
Frog  1089 EKTYAVETGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADEQAFVFEG-SRAQCWNMGSSFFGR 1152

  Fly  1149 QCGPGDIVGVFLDLADHTISFSLNGELLMDALGGETTFADVTAEGVGFVPACTLGVGQKARLIYG 1213
            ...|||:||..::|.|.::.|:||||||:...|.|..|||...|. ||||.|:||:.|..|:..|
Frog  1153 SWQPGDVVGCMINLEDKSMIFTLNGELLITNQGSELAFADFEIEN-GFVPVCSLGLSQIGRMNLG 1216

  Fly  1214 QDVDSLKFFTTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFENT-EEMPDCRIDVTRIPGGADTPP 1277
            :|..:.|::|.||||||::||.|||.|.:..|::|..|.|.|. ::.|  .|:||||.|..::||
Frog  1217 KDASTFKYYTMCGLQEGFQPFAVNMTRDIVMWFSKRLPTFVNVPKDHP--HIEVTRIDGTVESPP 1279

  Fly  1278 HLKISHNTFETMEKANWE--FLRLSLPVTCMGEFISEQEKARRWDEIKNRQYRLMREAEIAAQMQ 1340
            .||::|.||.| :.:|.:  :.|||:||    ||.|
Frog  1280 CLKVTHKTFGT-QNSNEDMIYCRLSMPV----EFHS----------------------------- 1310

  Fly  1341 VQTQAAHMDHMLKGGFNMNDIKGLTRNFDEHADAEADHMMRGPNRPPRKGSLTRNITFETDMSAA 1405
                          .||..:      ||                       |.||
Frog  1311 --------------AFNTEE------NF-----------------------LKRN---------- 1322

  Fly  1406 LDEMQRSTSVLDMNGLGEEMDDKKKRGRSPFKFFSKKSRDQSREKMGARTLDTSLERRNTVAHGR 1470
              ::|.::|
Frog  1323 --QLQEASS-------------------------------------------------------- 1329

  Fly  1471 NVVNQQMTTRAPTLRLNNAEIPPSPVPQGPKQLSGSNLGQQPVETSGDEMFDAECLKLINEYFYG 1535
                 ..||                                                   .|:|.
Frog  1330 -----HTTT---------------------------------------------------TYYYS 1338

  Fly  1536 VRIFPGQDPTHVYVGWVTTQYHLHSREFNKNKVRRGSVYIEDDYEMAIERIDRQSCYVVRADELF 1600
            ||||.||||:.|:|||||..||.:|.:|:..|....:|.:.|:.....|.:.|.:||:|...:|
Frog  1339 VRIFAGQDPSCVWVGWVTPDYHFYSEKFDLAKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDL- 1402

  Fly  1601 NEVTQDASGKGASQG---MFVGCFVDTATGIIRFTCEGKDTSHRWMMEPDTKLFPAIFVEATSKE 1662
                 .|..:.:|:.   :.:||.||.|:|::.||..|||....:.:||:||||||:|::.||..
Frog  1403 -----SAGSQRSSRSNVDIDIGCLVDLASGLLSFTANGKDLGTCYQVEPNTKLFPAVFLQPTSTN 1462

  Fly  1663 ILQIELGRTPTTLPLSAAVLPTSDKHINPQSPPRLKVQCLRPHQWARVPNTALQVHALKLSDVRG 1727
            ::|.||||...|:|||||:..:.:|:..||.||||.||.:.|..|:|:||..|:|...::|:..|
Frog  1463 LIQFELGRLKNTMPLSAAIFKSEEKNPVPQCPPRLDVQTITPVLWSRMPNIFLKVETERVSERHG 1527

  Fly  1728 WSMLCEDPVSMLALHIPEEDRCIDILELIEMDKLLSFHAHSLTLYAALCYQSNYRAAHALCQHVD 1792
            |.:.|.:|:.|:|||||||:||||||||.|.:.|:.||.|:|.||.|:|...|.|.:||||.|||
Frog  1528 WVVQCLEPLQMMALHIPEENRCIDILELSEQEDLMKFHYHTLKLYCAVCALGNNRVSHALCSHVD 1592

  Fly  1793 QKQLLYAIRSEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYITPLGAELKE--LYSDEEMQH 1855
            |.||||.|.::|:.|.||.|||:|||::.|||......:..||:|.|:..|.::  |:.||..:|
Frog  1593 QSQLLYTIDNQYLPGLLRSGFYNLLISMFLESAKEGKLMMNNEFIIPITDETRKIRLFPDESKRH 1657

  Fly  1856 SL----RSLVTESVRPQLRMTEITPPVIATSSMPSVSSEPIPDIDQLYSPKFPLEVVRQFVMEAL 1916
            .|    ||...:|   .|..|  .|..:.|:           :..|.:.|:.|:::::...:..|
Frog  1658 GLPGVGRSTCLKS---DLHFT--VPCFLLTA-----------EERQQHGPEIPIDILKSKALSML 1706

  Fly  1917 KDAVEINQVHNRDPIGWTNENLFLPLIKLTDRLLLVGVLTDEDVQRLLVMIDPETWDQAFEREGK 1981
            .:||:.:..:.|||:|...|..|:|::||...||::|...||||:::|::|||..:....|.|.:
Frog  1707 TEAVQSSGEYIRDPVGGKVEFQFVPVLKLIATLLIMGEFEDEDVRQILLLIDPNVFGDNKEEETE 1771

  Fly  1982 DEHR-------------------------KGLLTMKMAEGAKLQMCYLLHHLYDTQLRHRVESII 2021
            :..:                         ||||..::.|..|||||.|||:..|.:|:||||||:
Frog  1772 EYEKEEVAQVEEKAVEAGEKATRDPTAPTKGLLQTRLPESVKLQMCELLHYFCDCELKHRVESIV 1836

  Fly  2022 AFSHDFVGDLQTDQLRRYIEIKQS-DLPSAVAAKKTKEFRCPPREQMNQILCFKNLEPDDQDNCT 2085
            :||.:||..||.:|..||.|:.|: ::.:|:.||||:|||.||:||:|.:|.|:     .||:|.
Frog  1837 SFSDNFVSKLQYNQKFRYNELMQALNMSAALTAKKTREFRSPPQEQINMLLNFR-----VQDDCP 1896

  Fly  2086 CGLELRGRLGDFHDSLMQKVSLNALQEPDGVEGTAIEEVKTGPI-TKIYNFINTVKELEEGPKEV 2149
            |..|:|..|.:||:.|:....:...:|.:..|.|:    .||.: |.:|......|..|..|
Frog  1897 CPEEIRDELFEFHEDLLMHCGIPLDEEEEEEEDTS----WTGRLRTLLYKIKGRPKTEENDP--- 1954

  Fly  2150 EEPEKKTPEEVFRKVLIKTIVSWAEESQIENPKLVREMFSLLLRQYDTVGELVRALEKTYVINTR 2214
            :|.|:|:| ...::::.:|:|.||:|..|::|:|||.|||||.||||::|||:||:.|||.|:..
Frog  1955 DEEEEKSP-TTLKELISQTMVRWAQEDHIQDPELVRIMFSLLRRQYDSIGELLRAMRKTYTISAA 2018

  Fly  2215 ARDDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNATFFQHPDLIRILRVHENVMAVMM 2279
            :.:|...:...|.|||:||.|:|.:|||.||...|..::||..|:|||:|:|:|.:||.||.||:
Frog  2019 SVEDTINLLASLGQIRSLLSVRMGKEEEMLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMV 2083

  Fly  2280 NTLGRRAQAQSDAPTQSEVAEGAPSKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFDHFDFLLD 2344
            |.||.....|...|                  :||.:||||||||||..||||||||:|..:||:
Frog  2084 NVLGGDKSQQIAFP------------------KMVASCCRFLCYFCRISRQNQKAMFEHLGYLLE 2130

  Fly  2345 NANILLARPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQSNSELVEKGYPDL 2409
            |:::.||.||:|||||||||.:|:|:|.||||||:|..|||:..||:.|||||...|:.|||||:
Frog  2131 NSSVGLASPSMRGSTPLDVAAASVMDNNELALALQEPDLEKVVTYLAGCGLQSCPMLIAKGYPDI 2195

  Fly  2410 GWDPVEGERYLDFLRYCVWVNGESVEENANLVIRLLIRRPECLGPALRGE-GEGLFRAIVEANRM 2473
            ||:|:||||||.|||:.|:||||||||||::|::||||||||.||:|||| |.||..|:.||..:
Frog  2196 GWNPIEGERYLSFLRFAVFVNGESVEENASVVVKLLIRRPECFGPSLRGEGGNGLLSAMQEAINI 2260

  Fly  2474 SERISDRCKMQDEAEGTIAGLNFTHPLPEGEEDEDYIDTGAAILNFYCTLVDLLGRCAPDASVIE 2538
            ||..:    :...::|      :...:.|.:|:|:.:..|.||::||..|:||||||||:..:||
Frog  2261 SENPA----LDLPSQG------YQREVVEEDEEEEIVHMGNAIMSFYSALIDLLGRCAPETHLIE 2315

  Fly  2539 QGKNESLRARAILRSLVPLEDLQGVLSLKFTLSQTAPGEEKPKS----DMPSGLLPNNKQSIVLF 2599
            .||.|::|.|:|||||||.|||.|::|:...|    |...|..|    ||.:...|::|..:|||
Frog  2316 AGKGEAIRIRSILRSLVPTEDLVGIISIPLKL----PAFNKDGSVFEPDMAASFCPDHKAPMVLF 2376

  Fly  2600 LERVYGIEAQDLFYRLLEDAFLPDLRTATILDKSDGSESDMALAMNRYIGNSILPLLIKHSKFYN 2664
            |:|||||:.|.....|||.|||||||.:..||.:..|.::||||:||||.:::||||.:.:..::
Frog  2377 LDRVYGIKDQSFLLHLLEVAFLPDLRASASLDTASLSVTEMALALNRYICSAVLPLLTRCAPLFS 2441

  Fly  2665 EAENYASLLDATLHTVYRLSKNRMLTKGQREAVSDFLVALTSQMQPAMLLKLLRKLTVDVSKLSE 2729
            ..|:||:|:|:||||:|||||.|.|||.||:.:.:.|:::...|:|:||.:|||:|..||..|:|
Frog  2442 GTEHYAALIDSTLHTIYRLSKGRSLTKAQRDTIEECLLSICHHMRPSMLQQLLRRLVFDVPLLNE 2506

  Fly  2730 YTTVALRLLTLHFDRCAKYYGSTQGQGSYGASSDEEKRLTMLLFSNIFDSLSN------MDYDPE 2788
            |..:.|:|||.|:::|.|||....|.||||.:|:||..||..||..|||||||      ..||.|
Frog  2507 YCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLASEEELHLTEKLFWGIFDSLSNKFLSLLQKYDAE 2571

  Fly  2789 LFGKALPCLIAIGCALPPDY--SLSKNTDEDYYGRQMGAPDQPQYMPNPIDTNNVHLDNDLNSLV 2851
            ||..::|||.||..||||||  :..|.|.|    :||....:..:.|.||:|:|:.|...|..:|
Frog  2572 LFRMSMPCLSAIAGALPPDYVDTRIKATPE----KQMSVDAEGNFDPKPINTSNLTLPEKLEYIV 2632

  Fly  2852 QKFSEHYHDAWASRRLEGGWTYGDIRSDNDRKHPRLKPYNMLSEYERERYRDPVRECLKGLLAIG 2916
            .|.:||.||.||..::..||.||....:|.:.||.|:|:..|||.|:|.||.|:||.:|.:||:|
Frog  2633 NKNAEHSHDKWAYDKIHSGWKYGLSLDENMKTHPLLRPFKTLSEKEKEIYRWPLRESVKTMLAMG 2697

  Fly  2917 WTVEHS-EVEVALNHRGSTRRQSKPQINEFQNEGSPFNYNPHPVDMSNLTLSREMQNMAERLAEN 2980
            |:||.: |.|....||.:.:.:|..|    .::|:  .|||.|.|:||:.||||:|.|.|.:|||
Frog  2698 WSVERTKEGEALALHRENEKMRSISQ----SSQGN--GYNPAPQDLSNVVLSRELQGMVEVMAEN 2756

  Fly  2981 SHDIWAKKKNEELNGCGGVIHPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQGYKLHKPSKGGAV 3045
            .|:||||||..||...||..||.|||||.||.|||.:|||::||..|::|..||.:.:..|...:
Frog  2757 YHNIWAKKKKMELESKGGGSHPLLVPYDTLTAKEKARDREKAQELFKFLQVNGYAISRGLKDMEL 2821

  Fly  3046 EEGGATQAAVELRFSYSLLEKLIQYLDRATINMKLLKPSTTFSRRSSFKTATRDIKFFSKVVLPL 3110
            :     .:::|.||::..|:|::.|:|.|...:..|: :...|.:|......::||||:||:|||
Frog  2822 D-----ASSMEKRFAFKFLKKVLHYVDSAQEFIAHLE-AVVSSGKSEKSPHEQEIKFFAKVLLPL 2880

  Fly  3111 MEKYFSTHRNYFIAIATAT-NNIGAASLKEKEMVASIFCKLAALLRNRLSAFGPDVRITVRCLQV 3174
            :::||..|..||::..|.| ::.|.||.||||||||:|||||||:|:|:|.||.|....|.||.:
Frog  2881 VDQYFKNHCLYFLSSPTKTLSSSGYASNKEKEMVASLFCKLAALVRHRISLFGSDSATMVSCLHI 2945

  Fly  3175 LVKGIDARTLTKNCPEFIRTSMLTFFNQTSDDLGNTILNLQDGKYSHLRGTHLK-TSTSLGYVNQ 3238
            |.:.:|.||:.|:..|.::..:..||...::||..|:.||:.||::|.| |.:| .|.::.|...
Frog  2946 LAQTLDTRTVMKSGSELVKAGVRAFFENAAEDLEKTLENLKLGKFTHSR-TQMKGVSQNINYTTV 3009

  Fly  3239 VVLPVLTAMFDHLAACDYGSDLLLDEIQVASYKILAALYHLGTDGTLTHDRKYLKTEIERHRPAL 3303
            .:||:||::|:|:|...:|.|||||::||:.|:||.:||.|||...:         .:||.||||
Frog  3010 ALLPILTSIFEHVARHQFGVDLLLDDVQVSCYRILCSLYALGTGKNI---------YVERQRPAL 3065

  Fly  3304 GSCLGAYSSCFPVAFLEPHLNKHNQYSLLNRIADHS---LEAQDIMVKMESCMPNLETILAEVDQ 3365
            |.||.|.:...|||||||.||.:|..::.|..:...   |...|.:.:|...||:||.::.|::.
Frog  3066 GECLAALAGAIPVAFLEPSLNLNNPLTVFNTKSPRERAILGMPDTVEEMCPDMPHLEGLMKEIND 3130

  Fly  3366 FVESDKTYNDAPHIIDVILPLLCAYLPFWWSQGPDNVSPTSGNHVTMVTADHMNPLLRNVLKMIK 3430
            ..||...|.:.||:|:||||:||.||.:||.:|.:||...:....|.||::|::.:|.|:||:|.
Frog  3131 LAESGARYTEMPHVIEVILPMLCNYLSYWWERGTENVPENARPCCTQVTSEHLSVILGNILKIIN 3195

  Fly  3431 KNIGNDNAPWMTRIAAYTQQIIINTSEELLKDPFLPLAERVKKRTENMLHKEDSMRGFIKSATDD 3495
            .|:|.|.|.||.|||.|.|.||.....:|||..|:|..|::||:...::.:|:.::...|:   |
Frog  3196 NNLGIDEASWMKRIAVYAQPIISKAQPDLLKSHFIPTLEKLKKKAIKIVLEEEQLKADSKA---D 3257

  Fly  3496 TSQVETQLQEDWNLLVRDIYSFYPLLIKYVDLQRNHWLKDNIPEAEELYNHVAEIFNIWSKSQYF 3560
            |.:.|..:.:::.:|.||:|:|||:||:|||..|::|||....:::||:..|||:|.:|.||..|
Frog  3258 TQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKKPDIDSDELFRMVAEVFILWCKSHNF 3322

  Fly  3561 LKEEQNFISANEIDNMALIMPTATRRSAISEGAPAVGGKVKKKKKNRDKKRDKDKEVQASLMVAC 3625
            .:|||||:..|||:|:|.:  |...:|.:|:......|....::| |.|:|.....:|.||:||.
Frog  3323 KREEQNFVIQNEINNLAFL--TGNNKSKMSKPIQVKSGGQDLERK-RTKRRGDLYSIQTSLIVAA 3384

  Fly  3626 LKRLLPVGLNLFAGREQELVQHCKDRYLKKMPEYDVIEFARNQLTLPDKL-DPSDEMSWQHYLYS 3689
            ||::||:|||:....:|||:...|.||..|..:.:|.|..||.|.|.:|. ||:  :.||..||.
Frog  3385 LKKMLPIGLNMCTPGDQELISLAKGRYSLKDTDDEVKEHLRNNLHLQEKSEDPA--VKWQLNLYK 3447

  Fly  3690 KLGKTEEPVDEQALEKANVNSNEKGKDKTQETVDRIVAMAKVLFGLHMAASSKNRSKR--WGSKI 3752
            .:.::||..|                  :::.|:|:..::..:|.|.. .....|||:  |...:
Frog  3448 DIRRSEEQSD------------------SEKIVERVQKISAAIFHLEQ-VEQPLRSKKAVWHKLL 3493

  Fly  3753 SVARRQAVISSLRAKHLYRMSRHRACNIFARSYYEQWLQE--ENVGQEVMVEDLTQTFEDSEKSK 3815
            |..|::||::..|...||.:.||:..|.|..||...||::  ||...:.::..||:..:..|
Frog  3494 SKQRKRAVVACFRMAPLYNLPRHKINNFFLSSYQRIWLEKVHENSDYDSLILVLTKPKKTDE--- 3555

  Fly  3816 KEGEETDSKPDPLTQLVTTFCRGAMTERSGALQEDLLYMSYAQIAAKSTGKEEEEGGDEEGGEGG 3880
            :|.|||:.|||||.|::..|.|.|:|||| .|::|.||.:||.:.|||...|||   ||:
Frog  3556 EEEEETEKKPDPLHQIILHFSRNALTERS-KLEDDPLYTAYAAMMAKSCQNEEE---DED----- 3611

  Fly  3881 EEGEGTSIHEQEMEKQKLLFHQARLSNRGVAEMVLLHISASKGIPSEMVMTTLNLGIAILRGGNI 3945
            ||.|.| ..|:||||||.|:.||||..||.|||||..||||||....||:.||.||||:|.|||.
Frog  3612 EEKEKT-FEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMGPMVVETLKLGIAVLNGGNT 3675

  Fly  3946 DIQMGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEEYIPSAGAGLG-VGSEGA--- 4006
            .:|..||::||||||.|||.|::|||.|||||||:||||..|||        ||| |..||.
Frog  3676 VVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAE--------GLGMVTEEGTPVI 3732

  Fly  4007 ---AGEKNMHDAEFTCALFRFIQLTCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIM 4068
               .|||.:.:.|||..||||:||.|||||.::||:||||.|||||||::|.||||||||||||.
Frog  3733 VRERGEKVLQNDEFTRDLFRFLQLLCEGHNNDFQNFLRTQMGNTTTVNIIISTVDYLLRLQESIS 3797

  Fly  4069 DFYWHYSSKEIIDPAGKANFFKAIEVASQVFNTLTEVIQGPCTLNQQALAHSRLWDAVGGFLFLF 4133
            ||||:||.||:||.:|:.||.|::.|..|:||:|||.|||||..|||:||||||||||.|||.:|
Frog  3798 DFYWYYSGKEVIDESGQHNFSKSLAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVF 3862

  Fly  4134 SHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKY 4198
            ::||.|||:.|||::||||||:|.:||:.|:||:|||||||||||||||||||||:||||:|||:
Frog  3863 ANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKF 3927

  Fly  4199 FDMFLKLADLIESPSFHEVDMKNEGWVTPKDFREKMEQSKNYTPEEMDFLLACCERNHEGKIDYR 4263
            |||||||.||..|.:|.|.|.:.:|.::.|:|::.||..|.|...|::|||:|.|.:.....:|.
Frog  3928 FDMFLKLKDLTSSDAFKEYDPEGKGVISKKEFQKAMEGQKQYAQSEIEFLLSCAEADENDMFNYV 3992

  Fly  4264 AFVEHFHEPSKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEILGSSKRIE 4328
            .||:.||||:|:||||:|||||||:|||||:.||...||.|.|||:||.|:||||||:|.:||||
Frog  3993 EFVDRFHEPAKDIGFNVAVLLTNLNEHMPNDSRLQCLLEPASSVLSYFSPYLGRIEIMGGAKRIE 4057

  Fly  4329 RVYFEIKDSNIEQWEKPQIRESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHASGLMATDD 4393
            ||||||.:|:..||||||::||||.|.:.:|.|||::||:|.|||||||.||||..||.:..:|.
Frog  4058 RVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDA 4122

  Fly  4394 GGGNVKRDTAYSSY---MSEEEEERAARDPIRRTI---TAVKEGLKFGVHMLSPANIKHQIGVMQ 4452
            .....:.:.....:   :.||:||..:.:.....|   |::|......:.||:..||..|:..::
Frog  4123 AERPEEEEEEEPHHIIEVGEEDEETESLESSSAFIVACTSLKNNTSNFLKMLTLKNIGKQLRKVK 4187

  Fly  4453 TKSIPELIVGFFKIIFYIFYYTGYAHFCVVRYIFGILLNLMRGPAPEQEEEPVVEEETFGRALPP 4517
            ..::.||:..||...:.:|.......|.:|..||.||.:.:.|....:..:.:...:..|
Frog  4188 KMTLKELVKVFFSFFWMLFVGLFQFVFTIVWGIFQILWSTVFGGGLVEGAKNIKVTKILG----- 4247

  Fly  4518 LPLEEPPGTVQAFGL--DINKEENGMYKVVVHESPANSSM----------------------EEG 4558
                :.|...| ||:  |:.:.|    ||...|..|::.:                      :||
Frog  4248 ----DMPDPTQ-FGIHDDVLEAE----KVDAPEHAASTELTNLVKGDKGDTDIPDIFGIQAKKEG 4303

  Fly  4559 GESSPEDGAAASGELVEGEPHQEPISIVDLLGGEAAKKAAQERQEAQKAQEAAMASIE------- 4616
            .:..||.|.....|.|..|......:.|.......|.:.|:|.:|..|| |:..|.:|
Frog  4304 SKHGPEIGLGDFSEAVSAESTPSLENAVRKKKNAIAAELAKEHEEQSKA-ESEKADLEDGEKKDK 4367

  Fly  4617 ---------AEAKKSSS------APQETPAVHQIDF----SQYTHRAVSFLARNFYNLKYVALVL 4662
                     .|:|:|.|      ..:|.|.....:|    ..|..:.:::||||||||:::||.:
Frog  4368 VKAEEQSELVESKESISKKKRRGQKKEEPEAFMANFLAGLEIYQTKMLNYLARNFYNLRFLALFV 4432

  Fly  4663 AFSINFMLLFYKVTSFTEEADSSAEEELILGSGSGGGADITGSGFGGSGDGGSGDGEMEDEIPEL 4727
            ||:|||:|||||||......||..:..|                    .|....|.|..:|....
Frog  4433 AFAINFILLFYKVTEEHSSEDSDNDTNL--------------------WDTFQEDDEDANEGAVY 4477

  Fly  4728 VHVDEDFFYMEHVLRIAACLHSLVSLAMLIAYYHLKVPLAIFKREKEIARRLEFEGLFIAEQPED 4792
            ..:.|:..||...|||.|.:|:::|...:|.||.|||||.:|||||||||.:||:||:|.|||.:
Frog  4478 FVLQENTGYMAPTLRILAIIHTIISFLCVIGYYCLKVPLVVFKREKEIARNVEFDGLYITEQPSE 4542

  Fly  4793 DDFKSHWDKLVISAKSFPVNYWDKFVKKKVRQKYSETYDFDSISNLLGMEK-----STFAAQESE 4852
            ||.|..||:|||:..|||.||||||||:||..||.:.|..|.|:.|||::|     |.....:.|
Frog  4543 DDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGADRIAELLGLDKNALDFSPVKKTKPE 4607

  Fly  4853 ETGIFKYIMNIDWRYQVWKAGVTFTDNAFLYSLWYFSFSVMGNFNNFFFAAHLLDVAVGFKTLRT 4917
            |..:..::.:||.:|.:||.||.||||:|||..||.:.|::|::|||||||||||:|:|||||||
Frog  4608 EGSLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRT 4672

  Fly  4918 ILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYIQEEDE-EVDKKCHDMLTCFVFHLYKG 4981
            ||.|||||||||||||.||.::||:|||:|||||||||.:.||| :.|.||.||:||::||:|.|
Frog  4673 ILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDDPDMKCDDMMTCYLFHMYVG 4737

  Fly  4982 VRAGGGIGDEIGDPDGDDYEVYRIIFDITFFFFVIIILLAIIQGLIIDAFGELRDQLESVKDNME 5046
            |||||||||||.||.||.||:|||:||||||||||:||||||||||||||||||||.|.|:::||
Frog  4738 VRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDME 4802

  Fly  5047 SNCFICGMGKDFFDIVPHGFDTHVQKEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRSWD 5111
            :.|||||:|.|:||..||||:||..:|||||||:||||:||||.:||:||||:|||.|||:|.||
Frog  4803 TKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWD 4867

  Fly  5112 FFPVGDCFRKQYEDELS 5128
            |||.||||||||||:||
Frog  4868 FFPAGDCFRKQYEDQLS 4884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RyR	NP_001246211.1	Ins145_P3_rec	11..202	CDD:285871	125/207 (60%)
		MIR	211..392	CDD:280906	81/183 (44%)
		MIR	270..>305	CDD:197746	14/34 (41%)
		RYDR_ITPR	443..636	CDD:279676	112/192 (58%)
		SPRY1_RyR	647..799	CDD:240457	78/152 (51%)
		RyR	854..944	CDD:280244	47/89 (53%)
		RyR	967..1057	CDD:280244	55/89 (62%)
		SPRY2_RyR	1079..1213	CDD:240458	63/133 (47%)
		SPRY3_RyR	1518..1669	CDD:293937	55/153 (36%)
		RYDR_ITPR	2228..2452	CDD:279676	127/223 (57%)
		RyR	2831..2921	CDD:280244	40/89 (45%)
		RyR	2954..3038	CDD:280244	49/83 (59%)
		RIH_assoc	4017..4130	CDD:285630	79/112 (71%)
		RR_TM4-6	4525..4768	CDD:283990	81/292 (28%)
		Ion_trans	4856..>4976	CDD:278921	78/120 (65%)
ryr3	XP_031747158.1	Ins145_P3_rec	9..220	CDD:418637	126/210 (60%)
		MIR	224..402	CDD:397103	81/182 (45%)
		RYDR_ITPR	452..647	CDD:396093	118/199 (59%)
		SPRY1_RyR	653..804	CDD:240457	78/152 (51%)
		RyR	861..949	CDD:396561	46/87 (53%)
		RyR	975..1065	CDD:396561	55/89 (62%)
		SPRY2_RyR	1084..1216	CDD:240458	63/133 (47%)
		SPRY3_RyR	1331..1469	CDD:293937	57/194 (29%)
		RYDR_ITPR	2030..2243	CDD:396093	131/230 (57%)
		RyR	2612..2702	CDD:396561	40/89 (45%)
		RyR	2730..2814	CDD:396561	49/83 (59%)
		RIH_assoc	3742..3859	CDD:400656	80/116 (69%)
		EF-hand_7	3941..3998	CDD:404394	19/56 (34%)
		RR_TM4-6	4249..4518	CDD:399455	82/294 (28%)
		Ion_trans	4617..4795	CDD:395416	132/177 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	723	1.000	Domainoid score	I113
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	4063	1.000	Inparanoid score	I7
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4054at33208
OrthoFinder	1	1.000	-	-		FOG0001801
OrthoInspector	1	1.000	-	-		otm48458
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1009
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060