DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RyR and ryr1

DIOPT Version :9

Sequence 1:	NP_001246211.1	Gene:	RyR / 49090	FlyBaseID:	FBgn0011286	Length:	5134	Species:	Drosophila melanogaster
Sequence 2:	XP_004917160.1	Gene:	ryr1 / 100495378	XenbaseID:	XB-GENE-1013509	Length:	5044	Species:	Xenopus tropicalis

Alignment Length:	5360	Identity:	2379/5360 - (44%)
Similarity:	3305/5360 - (61%)	Gaps:	554/5360 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AEGGSEQDDVSFLRTEDMVTLSCTATGE----RVCLAAEGFGNRHCFLENIAD-KNVPPDLSQCV 63
            ||||..::::.||||||:|.|.|:||..    ::|:.|||||||.||||:.:: :||||||:.|.
Frog     2 AEGGEGEEEIQFLRTEDVVVLQCSATIRKEQIKMCMGAEGFGNRLCFLESTSNAQNVPPDLAICC 66

  Fly    64 FVIEQALSVRALQELVT--------AAGSETGKGTGSGHRTLLYGNAILLRHHNSDMYLACLSTS 120
            |::||:||||||||::.        |...:.....|.||||||||:||||||.:|||||.||:||
Frog    67 FILEQSLSVRALQEMLANTVEMGNEAPNLDKWSSQGGGHRTLLYGHAILLRHCHSDMYLCCLTTS 131

  Fly   121 SS-NDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTTKENEQS 184
            .| .|||:|||||||.|.|||||||:||||||||||||||||||||||||::|||||.:..:.:.
Frog   132 RSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSTASGEL 196

  Fly   185 IVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGG-DECLTIPSTWGREAGQNIVIYEG 248
            .|:|||..|.|::.|..:|....:  |||.||.|||.|||. ||||||.||...|..:.|..|||
Frog   197 QVDASFMQTLWNMNPITSGCELAE--GYVTGGHVLRLFHGHMDECLTIASTDQGEEQRRIPHYEG 259

  Fly   249 GVVMAQARSLWRLELARTKWTGGFINWYHPMRIRHITTGRYLGVNDSNELILVKKEEASIATTTF 313
            |.|.:.||||||||..|..|:|..:.|....|:||:||||||..:|...|:::..|.|:...|.|
Frog   260 GAVCSHARSLWRLEPLRISWSGSHMKWGQSFRVRHVTTGRYLARDDEKGLVVLDAERANTKATAF 324

  Fly   314 CLRQEKDDEKKVLEDKDLEVIGSPIIKYGDTTVIVQHCETSLWLSYKSYETKKKGVGKVEEKQAI 378
            |.|..| ::..|...:|:|.:|...||||::...|||..:.|||:|.:.:.|...:|.::.| ||
Frog   325 CFRASK-EKLDVAPKRDVEGMGIAEIKYGESMCFVQHVSSGLWLTYGALDAKVVRLGPLKRK-AI 387

  Fly   379 LHEEGKMDDCLDFSRSQEEESKTARVIRKCSSLFTQFITALETLQSNRRHSIFFQKVNL--NEMV 441
            ||:||.|||.|..||||.|||:.:|:|...|.||..||..|::|....:.|   :.|.|  :.::
Frog   388 LHQEGHMDDALCLSRSQREESQASRMIYSTSGLFNLFIKGLDSLSGKNKPS---KPVTLPIDMVI 449

  Fly   442 MCLEDLINYFSQPEDDMEHEEKQNRFRALRNRQDLFQEEGVLNLILEAIDKINIITSQGFLASFL 506
            :.|:|||.||..|||:::|||||.:.|:|:|||:||||||:::|:|:.||::|:.::....:.|
Frog   450 LTLQDLIGYFQHPEDELQHEEKQTKLRSLKNRQNLFQEEGIISLVLDCIDRLNVYSTAAHFSEF- 513

  Fly   507 AGDETGQSWDLISTYLYQLLAAIIKGNHTNCAQFANSNRLNWLFSRLGSQASSEGSGMLDVLHCV 571
            ||:|..:||..|...||:||||:|:||.:|||.|  |:.|:|:.|:|....:|  ||:|:||:||
Frog   514 AGEEAAESWKEIVNLLYELLAALIRGNRSNCALF--SSNLDWVVSKLDRLEAS--SGILEVLYCV 574

  Fly   572 LIDSPEALNMMRDEHIKVIISLLEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLL 636
            ||:|||.||::::.|||.|||||:||||:.|||||||||||.|||||||:||.|.:.|||.::||
Frog   575 LIESPEVLNIIKENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQNLITENLLPRRDLL 639

  Fly   637 LQTLLVDHVASIRPNIFVGRVDGSSMYQKWYFEVTMDHIEQ-TTHMMPHLRIGWANTSGYVPYPG 700
            |||.||::|.|:|||:|:|..:||:.|:|||:|:.:||:|. .|....|||:|||.|.||.||||
Frog   640 LQTRLVNYVTSMRPNVFLGTCEGSTQYKKWYYEMVVDHVEPFVTAEATHLRVGWAMTEGYSPYPG 704

  Fly   701 GGKKWGGNGVGDDLYSFGFDGAFLWTG---------GRKTLVVDALPEEPFIRKGDVIGVAIDLS 756
            .|:.||.||||||||||||||..||:|         .:..|..|           ||:...:||:
Frog   705 AGEGWGANGVGDDLYSFGFDGLHLWSGRVCRPVTSHNQHLLAAD-----------DVVSCCLDLT 758

  Fly   757 VPIITFTFNGVKVRGSFRDFNLDGMFFPVMSCSSKLSCRFLFGGDHGRLKFAPPMGFSALVQCLM 821
            ||.|:|.|||..|:|.|.:|||||:||||:|.|:.::.|||.||.||..||.||.|::.:.:.|:
Frog   759 VPSISFRFNGHPVQGMFENFNLDGLFFPVVSFSAGINIRFLLGGRHGDFKFLPPPGYAPVYEALL 823

  Fly   822 PQQILSLDPCFYFGNLAKNV--LAGPWLIEDDTAFVPKPVDTTGVTLPSSVDQIKEKLAENIHEM 884
            |:..:.::|...:.:..:|:  |.||......|:|||.||||..:.||..:::|:|||||||||:
Frog   824 PRDRMRIEPIKEYKHDFENIRNLLGPTKSLSHTSFVPCPVDTVQIVLPPHLERIREKLAENIHEL 888

  Fly   885 WALNKIEAGWSWGEHRDDYHRIHPCLTHFEKLPAAEKRYDNQLAVQTLKTIISLGYYITM--DKP 947
            |||.:||.||::|..|||..|:||||..|..||..|:.|:.|::.:||||:::||.::.|  :|.
Frog   889 WALTRIEQGWTYGTVRDDNKRLHPCLLDFHNLPEPERNYNLQMSGETLKTLLALGCHVGMADEKA 953

  Fly   948 PARIRPVRLPNEIFMQGNGYKPAPLDLSAVTLTPKLEELVDQLAENTHNLWARERIQQGWTYGLN 1012
            ...::.::|| :.::..|||||||||||.|.|||....|||:||||.||:|||:|:.|||||.:.
Frog   954 EENLKKIKLP-KTYVMSNGYKPAPLDLSHVKLTPAQNTLVDKLAENGHNVWARDRVLQGWTYSII 1017

  Fly  1013 EDSENHRSPHLVPYAKVDEAIKKANRDTASETVRTLLVYGYVLDPPTGEGTE--ALLAEAQRLKF 1075
            :|.:|.|:|.||||:.:||..||.|||:..|.||||:.|||.::||..|.|.  .:.|.|:|:
Frog  1018 QDIKNKRNPRLVPYSLLDEKTKKTNRDSLCEAVRTLIGYGYNIEPPDQESTAQGIIKARAERM-- 1080

  Fly  1076 AGFRTYRVERNYAVTSGKWYFEFEVLTSGPMRVGWARADCYPGAMLGSEDTSWAFDGHNEEKVYG 1140
               |.:|.|::|||.|||||||||.:|:|.|||||.|.:..|...||:::.::.|:|...::.:.
Frog  1081 ---RIFRAEKSYAVKSGKWYFEFEAVTTGEMRVGWVRPEVRPDVELGADELAYVFNGCRGQRWHI 1142

  Fly  1141 GVSESFGKQCGPGDIVGVFLDLADHTISFSLNGELLMDALGGETTFADVTAEGVGFVPACTLGVG 1205
            | ||.||:...|||:||..:||.:..|.|:||||:|:...|.|..|.|:.. |.||:|.|:||:.
Frog  1143 G-SEPFGRNWLPGDVVGCMIDLTEMNIMFTLNGEMLISDSGSELAFKDIEI-GDGFIPVCSLGMS 1205

  Fly  1206 QKARLIYGQDVDSLKFFTTCGLQEGYEPFCVNMRRPVTHWYTKDQPIFENTEEMPDCRIDVTRIP 1270
            |..||..||||.||::||.||||||:|||.:||:|.:|.|::|..|.|.|. ......|:|.||.
Frog  1206 QVGRLNLGQDVSSLRYFTICGLQEGFEPFAINMKRDITTWFSKSLPQFVNV-PTDHAHIEVGRID 1269

  Fly  1271 GGADTPPHLKISHNTFETMEKAN-WEFLRLSLPVTCMGEFISEQEKARRWDEIKNRQYRLMREAE 1334
            |..|.||.||::|.||.:....| .:|.|||:||    || .|..|.........|...:..:
Frog  1270 GTVDNPPCLKVTHKTFGSQNSNNDMQFFRLSMPV----EF-HETFKCTPGATPLTRTLTIPED-- 1327

  Fly  1335 IAAQMQVQTQAAHMD---HMLKGGFNMNDIKGLTRNFDEHADAEADHMMRGPNRPPRKGSLTRNI 1396
                   ..|...||   .|||        |.::|.     :|||.:.......||::     .|
Frog  1328 -------DVQEVDMDSEFEMLK--------KAVSRK-----EAEATNEKETAKEPPKE-----QI 1367

  Fly  1397 TFETDMSAALDEMQRSTSVLDMNGLGEEMDDKKKRGRSPFKFFSKKSRDQSREKMGARTLDTSLE 1461
            ..|.:...|.:::                  |.|||   |.|.::|....|
Frog  1368 KPENEKDTASEKV------------------KTKRG---FLFKARKPAFIS-------------- 1397

  Fly  1462 RRNTVAHGRNVVNQQMTTRAPTLRLNNAEIPPSPVPQGPKQLSGSNLGQQPVETSGDEMFDAECL 1526
                                          ||..||..|:.:.         :...|:..|.|.:
Frog  1398 ------------------------------PPPVVPTMPRLMK---------DVVPDDRDDPEII 1423

  Fly  1527 KLINEYFYGVRIFPGQDPTHVYVGWVTTQYHLHSREFNKNKVRRGSVYIEDDYEMAIERIDRQSC 1591
            .....|:|.||||.||:||.|::||||..|||:...|:.:|||..::.:.||.......|.|.:|
Frog  1424 MNTTTYYYSVRIFAGQEPTGVWIGWVTPDYHLYDMNFDLSKVRVATITMGDDKGNIFNSIKRSNC 1488

  Fly  1592 YVVRADELFNEVTQDASGKGASQGMFVGCFVDTATGIIRFTCEGKDTSHRWMMEPDTKLFPAIFV 1656
            |:|...| |...||.|  :...:.:.:||.:|.|||::.||..||:.:..:.:||:||||||:|.
Frog  1489 YMVWGGE-FGNNTQQA--RVRKEDLVIGCLIDLATGLMTFTANGKEVNTFFQVEPNTKLFPAVFA 1550

  Fly  1657 EATSKEILQIELGRTPTTLPLSAAVLPTSDKHINPQSPPRLKVQCLRPHQWARVPNTALQVHALK 1721
            ...|:.:.|.|||:....:|:|||:..:.:|:..||.||||:||.|.|..|:|:||..|.|.:.:
Frog  1551 SPQSQNMFQFELGKLKNIMPISAAMFRSENKNPVPQCPPRLEVQMLTPVVWSRMPNDFLNVESER 1615

  Fly  1722 LSDVRGWSMLCEDPVSMLALHIPEEDRCIDILELIEMDKLLSFHAHSLTLYAALCYQSNYRAAHA 1786
            :|:.:||.:.|.:|:.|:|||||||.||||:|||.|...:|.||.|:|.||.::|...|.|.|||
Frog  1616 ISERQGWMVECSEPLMMMALHIPEESRCIDVLELSERLNMLKFHYHTLKLYCSVCALGNNRVAHA 1680

  Fly  1787 LCQHVDQKQLLYAIRSEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYITPLGAELKE--LYS 1849
            ||.|||:.||||.|.|.::||.||.|:|||||::||||.........||:|.|:..|.|.  |:.
Frog  1681 LCSHVDESQLLYTIESNHLSGLLRSGYYDLLISIHLESEKRARLTMNNEFIVPMTEETKSITLFP 1745

  Fly  1850 DEEMQHSLRSL-VTESVRPQLRMTEITPPVIATSSMPSVSSEPIPDIDQLY--SPKFPLEVVRQF 1911
            ::..:|.|..: ::..::|.|..:...  .::||:             :||  ||..||:|::..
Frog  1746 NDNKKHGLPGVGMSTCLKPDLHFSHTC--FVSTST-------------ELYQLSPFIPLDVLKIK 1795

  Fly  1912 VMEALKDAVEINQVHNRDPIGWTNENLFLPLIKLTDRLLLVGVLTDEDVQRLLVMIDPETW---- 1972
            .:..|.:||.....|.|||:|.:.|..|:|::||...||::||..|:||:.:|.||:|..:
Frog  1796 AINMLTEAVLDGGQHTRDPVGGSVEFQFVPVLKLISTLLIMGVFEDDDVRHILKMIEPNVFTEEE 1860

  Fly  1973 -----DQAFERE-------------GKDEH----------------------------------R 1985
                 :||.|.|             |:||.                                  .
Frog  1861 EEAEQEQAEEGEEEKEEAEEEVAEKGEDEPESGEEAEGQEKAKEDEEKALEAGEEETKEEEEGLE 1925

  Fly  1986 KGLLTMKMAEGAKLQMCYLLHHLYDTQLRHRVESIIAFSHDFVGDLQTDQLRRYIEIKQS-DLPS 2049
            :|||.||:.|..|||||.||.:..|.:|:||||:|||||...:..|||:|.:||.|:.|: .:.:
Frog  1926 EGLLQMKLPESVKLQMCNLLQYFCDRELQHRVEAIIAFSERHMESLQTNQRQRYKELMQAFTMTA 1990

  Fly  2050 AVAAKKTKEFRCPPREQMNQILCFKNLEPDDQDNCTCGLELRGRLGDFHDSLMQKVSLNALQEPD 2114
            |..|::|:|||.||:||:|.:|.|:||..||   |....::|..|.:||..|:....:.
Frog  1991 AETARRTREFRSPPQEQINMLLNFRNLSEDD---CPIPEDIRDELSEFHTDLLSHCGVQ------ 2046

  Fly  2115 GVEGTAIEEVKTGPITK-IYNFINTVK------ELEEGPKEVEEPEKKTPEEVFRKVLIKTIVSW 2172
             :||...||.:...:.| :.|.:..:|      |.|..|:|.|||:..|.:|    ::..|:|.|
Frog  2047 -MEGEEEEEHEDTSLHKRLLNLVEKLKHFRKKEEPEPEPEEKEEPKPSTLQE----LISHTMVHW 2106

  Fly  2173 AEESQIENPKLVREMFSLLLRQYDTVGELVRALEKTYVINTRARDDVAEMWVGLSQIRALLPVQM 2237
            |:||.|::|:|||.|||||.||||.:|||:|||.|.|.||..:.:|...:...|.|||:||.|||
Frog  2107 AQESFIQSPELVRVMFSLLHRQYDGLGELIRALPKAYTINAVSVEDTMNLLESLGQIRSLLIVQM 2171

  Fly  2238 SQEEEELMRKRLWKLVNNATFFQHPDLIRILRVHENVMAVMMNTLGRRAQAQSDAPTQSEVAEGA 2302
            ..|||.||.:.:..::||..|:|||:|:|.|.:||.||.||:|.||                 |.
Frog  2172 GPEEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLG-----------------GG 2219

  Fly  2303 PSKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMFDHFDFLLDNANILLARPSLRGSTPLDVAYSS 2367
            .||| ....:||..||||||||||..||||:|||||..:||.|:.|.|   .:|||||||||.:|
Frog  2220 DSKE-IRFPKMVTNCCRFLCYFCRISRQNQRAMFDHLSYLLQNSGIGL---GMRGSTPLDVAAAS 2280

  Fly  2368 LMENTELALALREHYLEKIAVYLSRCGLQSNSELVEKGYPDLGWDPVEGERYLDFLRYCVWVNGE 2432
            :::|.||||||:|..|||:..||:.|||||...|:.|||||:||:||.|||||||||:.|:||||
Frog  2281 VIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLSKGYPDIGWNPVGGERYLDFLRFAVFVNGE 2345

  Fly  2433 SVEENANLVIRLLIRRPECLGPALRGE-GEGLFRAIVEANRMSERISDRCKMQDEA-EGTIAGLN 2495
            |||||||:|:|||||||||.||||||| |.||..||.||.::||         |.| :|.....:
Frog  2346 SVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAIEEAIKISE---------DPARDGPTVKKD 2401

  Fly  2496 FTHPLPEGEE--DEDYIDTGAAILNFYCTLVDLLGRCAPDASVIEQGKNESLRARAILRSLVPLE 2558
            ....|..|||  :|:.:..|.||::||..|:||||||||:..:|:.||.|:||.|||||||||:|
Frog  2402 RRRELYGGEEVHEENRVHLGNAIMSFYSALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIE 2466

  Fly  2559 DLQGVLSLKFTLSQTAPGEE----KPKSDMPSGLLPNNKQSIVLFLERVYGIEAQDLFYRLLEDA 2619
            ||.||:||  .|...|.|::    :||  |.:..:|::|..:||||:||||||.||...::||..
Frog  2467 DLVGVISL--PLQIPAFGKDGNPIEPK--MSASFVPDHKAPMVLFLDRVYGIENQDFLLQVLEVG 2527

  Fly  2620 FLPDLRTATILDKSDGSESDMALAMNRYIGNSILPLLIKHSKFYNEAENYASLLDATLHTVYRLS 2684
            ||||:|.|..||.:..|.::||||:|||:..::|||:.|.:..:...|:.|.::|:.|||:||||
Frog  2528 FLPDMRAAASLDTAAFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTIYRLS 2592

  Fly  2685 KNRMLTKGQREAVSDFLVALTSQMQPAMLLKLLRKLTVDVSKLSEYTTVALRLLTLHFDRCAKYY 2749
            :.|.|||.||:.:.:.|:||...::|:||..|||:|..||..|:||..:.|:|||.|::||.|||
Frog  2593 RGRSLTKAQRDVIEECLMALCRYLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYY 2657

  Fly  2750 GSTQGQGSYGASSDEEKRLTMLLFSNIFDSLSNMDYDPELFGKALPCLIAIGCALPPDY---SLS 2811
            ....|..:||.:|:||..||..||..||:||::..:|.||:..|:|||.||..|:||||   |.|
Frog  2658 CLPTGWANYGVTSEEELHLTRKLFWGIFESLAHKRFDAELYKIAMPCLCAIAGAIPPDYVDASYS 2722

  Fly  2812 KNTDEDYYGRQMGAPDQPQYMPNPIDTNNVHLDNDLNSLVQKFSEHYHDAWASRRLEGGWTYGDI 2876
            ..|:     ::.....:..:.|.||:|.||.:...|:..:.|::|:.||.||..:::..|:||:.
Frog  2723 SKTE-----KKASVDAEGNFDPKPIETLNVIIPEKLDGFINKYAEYTHDKWAFEKIQNNWSYGEA 2782

  Fly  2877 RSDNDRKHPRLKPYNMLSEYERERYRDPVRECLKGLLAIGWTVEHS------EVEVALNHR---G 2932
            ..:..:.||.|:||...||.::|.||.|::|.||.::|..||||.:      ::|.....|   .
Frog  2783 VDEEAKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTVEKAREGEDDKIEKKTKSRKISQ 2847

  Fly  2933 STRRQSKPQINEFQNEGSPFNYNPHPVDMSNLTLSREMQNMAERLAENSHDIWAKKKNEELNGCG 2997
            |.::...|.:..|         :|.|:|::.:|||||:|:|||:||||.|:.|.:||.:||...|
Frog  2848 SAQQTYDPTVQTF---------SPTPMDLTGITLSRELQSMAEQLAENYHNTWGRKKKQELESKG 2903

  Fly  2998 GVIHPQLVPYDLLTDKEKKKDRERSQEFLKYMQYQGYKLHKPSKGGAVEEGGATQAAVELRFSYS 3062
            |..||.|||||.||.|||.:|||::||.||::|..||.:.:..|...::     .:::|.||:|.
Frog  2904 GGTHPLLVPYDTLTAKEKARDREKAQELLKFLQINGYAVTRGLKDMELD-----TSSIEKRFAYG 2963

  Fly  3063 LLEKLIQYLDRATINMKLLKPSTTFSRRSSFKTATRDIKFFSKVVLPLMEKYFSTHRNYFIAI-A 3126
            .|:||::.:|.|...:..|: :...|.|.......|:||||:|::|||:.:||..|..||::. |
Frog  2964 FLQKLLKLMDTAQEFIAHLE-AVVSSGRVEKSPHEREIKFFAKILLPLINQYFKNHCLYFLSTPA 3027

  Fly  3127 TATNNIGAASLKEKEMVASIFCKLAALLRNRLSAFGPDVRITVRCLQVLVKGIDARTLTKNCPEF 3191
            ....:.|.||.|||||:||:|||:|||:|:|:|.||.|....|.||.:|.:.:||||:.|:.||.
Frog  3028 KVLGSGGHASNKEKEMIASLFCKMAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEI 3092

  Fly  3192 IRTSMLTFFNQTSDDLGNTILNLQDGKYSHLRGTHLK-TSTSLGYVNQVVLPVLTAMFDHLAACD 3255
            ::..:.:||...|:|:...:.||:.||.|..| |.:| .:.::.|....:|||||::|:|:|...
Frog  3093 VKAGLRSFFEGASEDIEKMVENLKLGKVSQSR-TQVKGVAQNINYTTVALLPVLTSLFEHIAQHQ 3156

  Fly  3256 YGSDLLLDEIQVASYKILAALYHLGTDGTLTHDRKYLKTEIERHRPALGSCLGAYSSCFPVAFLE 3320
            :|.|::||::||:.|:.|.::|.|||..:         ..:|:.|||||.||...::..||||||
Frog  3157 FGDDVILDDVQVSCYRTLCSIYSLGTTKS---------PYVEKQRPALGECLARLAAAMPVAFLE 3212

  Fly  3321 PHLNKHNQYSLLNRIA---------DHSLEAQDIMVKMESC--MPNLETILAEVDQFVESDKTYN 3374
            |.||::|.||:....:         .:|:|        |.|  :|:|||::.::....||...|.
Frog  3213 PSLNEYNIYSVYTTKSPRERAILGLPNSVE--------EMCPDIPDLETLMKDISMLAESGARYT 3269

  Fly  3375 DAPHIIDVILPLLCAYLPFWWSQGPDNVSPTSGNHVTMVTADHMNPLLRNVLKMIKKNIGNDNAP 3439
            :.||:|:|.||:||.|||.||.:||:|:...|....|.||::|:|.||.|:|:::..|:|.|.|.
Frog  3270 EMPHVIEVTLPMLCNYLPRWWERGPENIPDDSSPCCTSVTSEHLNTLLGNILRIVVNNLGIDEAS 3334

  Fly  3440 WMTRIAAYTQQIIINTSEELLKDPFLPLAERVKKRTENMLHKEDSMRGFIKSATDDTSQVETQLQ 3504
            ||.|:|.:.|.|:.....|||:..|:|..|::|||...::.:|:.:|...||.::|:   |:.::
Frog  3335 WMKRLAVFAQPIVSKAKPELLRSHFIPTMEKLKKRAGKVVAEEEQLRMEAKSESEDS---ESLIR 3396

  Fly  3505 EDWNLLVRDIYSFYPLLIKYVDLQRNHWLKDNIPEAEELYNHVAEIFNIWSKSQYFLKEEQNFIS 3569
            :::::|.||:|:.|||||:|||..|.|||.:...:||||:..|.|:|..||||..|.:|||||:.
Frog  3397 DEFSVLCRDLYALYPLLIRYVDNNRAHWLTEPNLDAEELFRMVGEVFIFWSKSHNFKREEQNFVV 3461

  Fly  3570 ANEIDNMALIMPTATRRSAISE-GAPAVGGKVKKKKKNRDKKRDKDK-EVQASLMVACLKRLLPV 3632
            .|||:||:.:  ||..:|.:|: |....||..:::.|   |||..|: .||.||:||.||::||:
Frog  3462 QNEINNMSFL--TADSKSKMSKSGDSQSGGSDQERTK---KKRRGDRYSVQTSLIVATLKKMLPI 3521

  Fly  3633 GLNLFAGREQELVQHCKDRYLKKMPEYDVIEFARNQLTLPDKLDPSDEMSWQHYLYSKL-GKTEE 3696
            |||:.:..:|||:...|.||..|..:.:|.||.:|.|.|..|.|.| .|.||..||:|: ||.|:
Frog  3522 GLNMCSPTDQELITLAKTRYSLKDTDEEVREFLQNNLHLQGKCDNS-SMRWQMALYNKMSGKAED 3585

  Fly  3697 PVDEQALEKANVNSNEKGKDKTQETVDRIVAMAKVLFGLHMAASS-KNRSKRWGSKISVARRQAV 3760
            .           |:.||       .|.|:..::.|||.|.:.... |::...|...:|..||:||
Frog  3586 S-----------NNPEK-------IVKRVQEVSAVLFHLELTEHPFKSKKAVWHKLLSKQRRRAV 3632

  Fly  3761 ISSLRAKHLYRMSRHRACNIFARSYYEQWLQEE-NVGQEVMVEDLTQTFEDSEKSKKEGEETDSK 3824
            ::..|...||.:.||||||:|...|.:.|:..| :..::.|::||:::   ||..::|.|:.:.|
Frog  3633 VACFRMTPLYNLPRHRACNMFLEGYKQAWIMSEAHDFEDRMIDDLSKS---SEAEEEEEEQEEKK 3694

  Fly  3825 PDPLTQLVTTFCRGAMTERSGALQEDLLYMSYAQIAAKSTGKEEEEGGDEEGGEGGEEGEGTSIH 3889
            ||||.||:..|.|.|:||:| .|.||.|||:||.|.|||...|:|   .||..|..||.|.| ..
Frog  3695 PDPLHQLILHFSRTALTEKS-KLDEDYLYMAYADIMAKSCHMEDE---SEEAAEDEEEVELT-FE 3754

  Fly  3890 EQEMEKQKLLFHQARLSNRGVAEMVLLHISASKGIPSEMVMTTLNLGIAILRGGNIDIQMGMLNH 3954
            |:||||||||:.|:||.|||.|||||..|||.||.|..||.:||.|||:||.|||.|:|..||::
Frog  3755 EKEMEKQKLLYQQSRLHNRGAAEMVLQMISACKGEPGSMVSSTLKLGISILNGGNSDVQQKMLDY 3819

  Fly  3955 LKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEEYIPSAGAGLGVGSEGAA------GEKNMH 4013
            ||||::||||.|:..||.:||||||:||||..|||        |||:.:|...      |||.|.
Frog  3820 LKEKREVGFFQSVQALMQTCSVLDLNAFERQNKAE--------GLGMVTEDGTIINREQGEKVMA 3876

  Fly  4014 DAEFTCALFRFIQLTCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKE 4078
            |.:||..|||.:||.|||||.::|||||||.|||||:|::||||||||||||||.||||:||.|:
Frog  3877 DDQFTQDLFRLLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKD 3941

  Fly  4079 IIDPAGKANFFKAIEVASQVFNTLTEVIQGPCTLNQQALAHSRLWDAVGGFLFLFSHMQDKLSK- 4142
            |||..||.||.||:.||.||||:|||.||||||.|||:||||||||||.|||.:|:||..||::
Frog  3942 IIDDQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQM 4006

  Fly  4143 ---------HSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKY 4198
                     .|||:.||||||:|||||:.|:||:||||:|||||.:||||.||||:||||:|||:
Frog  4007 PKNGGLRDGDSSQIGLLKELLDLQKDMVVMLLSLLEGNIVNGTIARQMVDMLVESSSNVEMILKF 4071

  Fly  4199 FDMFLKLADLIESPSFHEVDMKNEGWVTPKDFREKMEQSKNYTPEEMDFLLACCERNHEGKIDYR 4263
            |||||||.|::.|.:|.:......|.::.|||::.|:..|.||..|:.|||:|.|.:....|::.
Frog  4072 FDMFLKLKDIVASDAFRDYVTDPRGLISKKDFQKAMDSQKQYTTSEIQFLLSCSEADENEMINFE 4136

  Fly  4264 AFVEHFHEPSKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEILGSSKRIE 4328
            .|.:.|.||:|:|||||||||||||||:||:.||..|||.|..::|||:|:||:|||:|:.||||
Frog  4137 EFADRFQEPAKDIGFNLAVLLTNLSEHVPNDTRLQNFLELADCIINYFKPYLGKIEIMGAGKRIE 4201

  Fly  4329 RVYFEIKDSNIEQWEKPQIRESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHASGL----- 4388
            |:||||.::|..|||.||::||||.|.:.:|.|||:.||:|.|||||||.||||..||.:
Frog  4202 RIYFEISEANKTQWEMPQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQIASQISEPEE 4266

  Fly  4389 -MATDDGGGNVKRDTAYSSYMSEEEEERAARDPIRRTITAVKEGLKFGVHMLSPANIKHQIGVMQ 4452
             .|.||     :.|....|...||.|..::..............:.....|.:..|::.|...::
Frog  4267 EKAEDD-----EDDVVEGSGEGEEAENGSSPQEASSAFGEFLNNVMNFFKMFTYKNLRRQYRKVK 4326

  Fly  4453 TKSIPELIVGFFKIIFYIFYYTGYAHF--CVVRYIFGILLNLMRG-------------------P 4496
            ..|..|:|:.....::.:|  .|..||  .|.:.||.::.:.:.|                   |
Frog  4327 KMSFKEIILAIVSFLWTVF--LGILHFVYSVCKGIFLLIWHTLFGGSLVEGAQKLTVTELLASMP 4389

  Fly  4497 APEQEE----EPVV----EEETFGRALPPLPLE----EPPGTVQAFGLDINKEENGMYKVVVHES 4549
            .|.|:|    .|.|    ||...|.....:.:.    :..|| ..||:|: |:|.|.|:....::
Frog  4390 DPTQDEVHSDGPAVAVSDEEPEAGDVTDFVDISKEEVQEEGT-DIFGIDL-KKEGGHYRASAPDA 4452

  Fly  4550 PANSSMEEGGESSPEDGAAASG----------ELVEGE-----PHQEPI-----SIVDLLGGEAA 4594
            |  ..:.:.|:::|.:.....|          |...||     |.:||.     ...||..||
Frog  4453 P--GGLGDMGDTTPVEPPTPEGSPILKRKLADEETSGEEHDVVPEEEPAPEPEPEKADLENGE-- 4513

  Fly  4595 KKAAQERQEAQKAQEAAMASIEAEAKKSSSAPQETPAVHQIDFSQYTH------RAVSFLARNFY 4653
            |.|..:.:.|.:.:|....  |...||.|.|..:.|...:..|..:..      :.:::|:||||
Frog  4514 KTAEVQEETAPEPEEPEQP--EVAPKKKSPARDKKPEAEEGGFEFWNELEIQRIKFLNYLSRNFY 4576

  Fly  4654 NLKYVALVLAFSINFMLLFYKVTSFTEEADSSAEEELILGSGSGGGADITGSG----FGGSGDGG 4714
            ||:::||.|||:|||:||||||      :||...|:           |..|||    ..|..|||
Frog  4577 NLRFLALFLAFAINFILLFYKV------SDSPLGED-----------DFEGSGIEDEISGMDDGG 4624

  Fly  4715 SGDGEMEDEIPELVHVDEDFFYMEHVLRIAACLHSLVSLAMLIAYYHLKVPLAIFKREKEIARRL 4779
             ||.:.|:|.|....::|...||:..|.:.:.:|:|::...:|.|..||:||.|||||||:||:|
Frog  4625 -GDEDEEEEGPVYFVLEESTGYMQPTLYMLSVIHTLIAFLCIIGYNCLKIPLVIFKREKELARKL 4688

  Fly  4780 EFEGLFIAEQPEDDDFKSHWDKLVISAKSFPVNYWDKFVKKKVRQKYSETYDFDSISNLLGME-- 4842
            ||:||:|.|||||||.|..||:||::..|||.||||||||:||..||.:.|..:.|:.||||:
Frog  4689 EFDGLYITEQPEDDDIKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKYGDIYGRERIAELLGMDLA 4753

  Fly  4843 ----KSTFAAQESEETGIFKYIMNIDWRYQVWKAGVTFTDNAFLYSLWYFSFSVMGNFNNFFFAA 4903
                .|....::..:..:..:..:||.:||:|..||.||||:|||.:||...|::|::||||:||
Frog  4754 SLEISSQNGKKQEPDKSLLSWFTSIDIKYQIWNFGVVFTDNSFLYLVWYMVMSLLGHYNNFFYAA 4818

  Fly  4904 HLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYIQEEDE-EVDKKC 4967
            ||||:|:|.|||||||.|||||||||::||.||.::||:|||:|||||||||.:.||| |.|.||
Frog  4819 HLLDIAMGVKTLRTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKC 4883

  Fly  4968 HDMLTCFVFHLYKGVRAGGGIGDEIGDPDGDDYEVYRIIFDITFFFFVIIILLAIIQGLIIDAFG 5032
            .||:||::||:|.||||||||||||.||.||:||:||::||||||||||:|||||||||||||||
Frog  4884 DDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFG 4948

  Fly  5033 ELRDQLESVKDNMESNCFICGMGKDFFDIVPHGFDTHVQKEHNLANYMFFLMHLINKPDTEYTGQ 5097
            |||||.|.||::||:.|||||:|.|:||..||||:.|..:||||||||||||:||||.|||:|||
Frog  4949 ELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFENHTLEEHNLANYMFFLMYLINKDDTEHTGQ 5013

  Fly  5098 ETYVWNMYQQRSWDFFPVGDCFRKQYEDEL 5127
            |:|||.|||:|.|||||.||||||.|||:|
Frog  5014 ESYVWKMYQERCWDFFPAGDCFRKTYEDQL 5043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RyR	NP_001246211.1	Ins145_P3_rec	11..202	CDD:285871	121/204 (59%)
		MIR	211..392	CDD:280906	84/181 (46%)
		MIR	270..>305	CDD:197746	13/34 (38%)
		RYDR_ITPR	443..636	CDD:279676	106/192 (55%)
		SPRY1_RyR	647..799	CDD:240457	80/161 (50%)
		RyR	854..944	CDD:280244	47/89 (53%)
		RyR	967..1057	CDD:280244	54/89 (61%)
		SPRY2_RyR	1079..1213	CDD:240458	61/133 (46%)
		SPRY3_RyR	1518..1669	CDD:293937	59/150 (39%)
		RYDR_ITPR	2228..2452	CDD:279676	129/223 (58%)
		RyR	2831..2921	CDD:280244	34/89 (38%)
		RyR	2954..3038	CDD:280244	46/83 (55%)
		RIH_assoc	4017..4130	CDD:285630	84/112 (75%)
		RR_TM4-6	4525..4768	CDD:283990	83/272 (31%)
		Ion_trans	4856..>4976	CDD:278921	75/120 (63%)
ryr1	XP_004917160.1	Ins145_P3_rec	11..211	CDD:285871	120/199 (60%)
		MIR	220..274	CDD:197746	33/55 (60%)
		MIR	221..401	CDD:280906	84/181 (46%)
		MIR	281..369	CDD:197746	34/88 (39%)
		RYDR_ITPR	451..639	CDD:279676	106/192 (55%)
		SPRY1_RyR	650..801	CDD:240457	80/161 (50%)
		RyR	858..948	CDD:280244	47/89 (53%)
		RyR	972..1062	CDD:280244	54/89 (61%)
		SPRY2_RyR	1081..1213	CDD:240458	61/133 (46%)
		SPRY3_RyR	1421..1563	CDD:293937	57/144 (40%)
		RYDR_ITPR	2162..2365	CDD:279676	129/223 (58%)
		RyR	2737..2827	CDD:280244	34/89 (38%)
		RyR	2860..2944	CDD:280244	47/92 (51%)
		RIH_assoc	3880..3993	CDD:285630	84/112 (75%)
		EF-hand_8	4094..4144	CDD:290545	17/49 (35%)
		RR_TM4-6	4387..4677	CDD:283990	92/315 (29%)
		Ion_trans	4771..4955	CDD:278921	128/183 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	723	1.000	Domainoid score	I113
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37423
Inparanoid	1	1.050	4063	1.000	Inparanoid score	I7
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4054at33208
OrthoFinder	1	1.000	-	-		FOG0001801
OrthoInspector	1	1.000	-	-		otm48458
Panther	1	1.100	-	-	O	PTHR13715
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1009
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160