DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment epsilonTry and PRSS36

DIOPT Version :9

Sequence 1:	NP_525112.1	Gene:	epsilonTry / 49080	FlyBaseID:	FBgn0010425	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	286	Identity:	80/286 - (27%)
Similarity:	123/286 - (43%)	Gaps:	51/286 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLSVLACALAGTIPDGLL--------------PQLDGRIVGGYETSIDAHPYQVSLQRYGSHFCG 57
            |:.::...:.|...|..|              |:...|||||........|:||||...|.|.||
Human     9 LVMLVISPIPGAFQDSALSPTQEEPEDLDCGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICG 73

  Fly    58 GSIYSHDIVITAAHC---------------LQSIEAKDLKIRVGSTYWRSGGSVHSVRSFRNHEG 107
            ||:.:...|::||||               |..:.::|..:        .|....:|.:......
Human    74 GSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGVHSQDGPL--------DGAHTRAVAAIVVPAN 130

  Fly   108 YNSRTMVNDIAIIRIESDLSFRSSIREIRIADSNPR--EGATAVVSGWG-TTESGGSTIPDHLLA 169
            |:...:..|:|::|:.|..|...::..:.:..::.|  .|.....:||| ..|:....:|..|..
Human   131 YSQVELGADLALLRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQE 195

  Fly   170 VDLEIIDVSRC-----RSDEFGYGKKIKDTMLCAYAP--HKDACQGDSGGPLV--SGDR--LVGV 223
            |:|.::..:.|     :...|....:|...||||..|  .:|.||||||||||  .|.|  ..|:
Human   196 VELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGI 260

  Fly   224 VSWGYGCGDVRYPGVYADVAHFHEWI 249
            .|:|:|||....|||:..||.:..||
Human   261 TSFGFGCGRRNRPGVFTAVATYEAWI 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
epsilonTry	NP_525112.1	Tryp_SPc	30..249	CDD:214473	73/247 (30%)
epsilonTry	NP_525112.1	Tryp_SPc	31..252	CDD:238113	74/248 (30%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	73/247 (30%)
		Tryp_SPc	47..289	CDD:238113	74/248 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149393
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940