DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mbs and AVO2

DIOPT Version :9

Sequence 1:NP_001246786.1 Gene:Mbs / 49070 FlyBaseID:FBgn0005536 Length:1273 Species:Drosophila melanogaster
Sequence 2:NP_013784.1 Gene:AVO2 / 855090 SGDID:S000004672 Length:426 Species:Saccharomyces cerevisiae


Alignment Length:468 Identity:96/468 - (20%)
Similarity:158/468 - (33%) Gaps:161/468 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 LHQACIDDNLDMVEFLVERGADI--NRQDNEGWTPLHATASCGFVSIARYLVENGADVAAV--NS 143
            |.:|.|:.||.:|:.|:.|..|:  |.....||:.||..:..|...|..||::.|.|...:  ..
Yeast     9 LREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHELIKTF 73

  Fly   144 DGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKKWLRSDAAEVDRPHPKT 208
            .|:..:.||:          |:...|.|::            :|....:::..        ..:.
Yeast    74 KGNTCVHLAL----------MKGHEQTLHL------------LLQQFPRFINH--------RGEN 108

  Fly   209 GATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRETAEMLV---ESLADMDI 270
            |...:|:|....|.:.|.||:....::...|.:|.||||....:|.....:||:   |...|.::
Yeast   109 GRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNV 173

  Fly   271 RNYAGQSCIDVADRKIV-----KFLEELR------------------------------------ 294
            |:......||||....|     |.|:|::                                    
Yeast   174 RDKGNWKPIDVAQTFEVGNIYSKVLKEVKKKGPPLGAGKKPSSFRTPILNAKATFEDGPSPVLSM 238

  Fly   295 -----------------------------ANKR--------NKRRP-------------SSQIRI 309
                                         .|:|        |.|:|             ||::|:
Yeast   239 NSPYSLYSNNSPLPVLPRRISTHTTSGNGGNRRSSITNPVFNPRKPTLSTDSFSSSSNSSSRLRV 303

  Fly   310 SDA-MENHVEKTPTK-LVRVEVRTDATKDAENVKPNQQIHAVEHPVEEEAPWRRKLPRTPSDSPT 372
            :.. ::..|..:|.| ||...||..||.    ..|:..|..:.         |..||...:|:..
Yeast   304 NSINVKTPVGVSPKKELVSESVRHSATP----TSPHNNIALIN---------RYLLPNKSNDNVR 355

  Fly   373 NNQ----VPDRELGTNSSETANDVILRRTQSFENDQKFYQKYN--ELRARIKANSCPILPANANA 431
            .:.    :.|...|.|..:....:.||:....||:.|:..|.|  |.|.|:...:.||       
Yeast   356 GDSQTATINDDGGGGNGGDATIGMGLRKDPDDENENKYKIKVNNGEPRRRVSLLNIPI------- 413

  Fly   432 NAAAANKSNNNNN 444
                 :|..|:||
Yeast   414 -----SKLRNSNN 421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MbsNP_001246786.1 ANK 50..164 CDD:238125 23/84 (27%)
Ank_2 53..142 CDD:289560 20/62 (32%)
ANK repeat 78..109 CDD:293786 10/27 (37%)
ANK 106..290 CDD:238125 43/193 (22%)
ANK repeat 111..142 CDD:293786 10/32 (31%)
ANK repeat 209..239 CDD:293786 7/29 (24%)
Ank_2 213..300 CDD:289560 28/167 (17%)
ANK repeat 241..272 CDD:293786 10/33 (30%)
PRKG1_interact 1177..1272 CDD:292521
AVO2NP_013784.1 Ank_4 9..60 CDD:372654 17/50 (34%)
ANK repeat 9..37 CDD:293786 10/27 (37%)
ANKYR 37..>185 CDD:223738 38/177 (21%)
ANK repeat 39..72 CDD:293786 10/32 (31%)
ANK repeat 75..106 CDD:293786 7/60 (12%)
ANK repeat 108..139 CDD:293786 7/30 (23%)
ANK repeat 141..165 CDD:293786 8/23 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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