DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mbs and ppp1r16b

DIOPT Version :9

Sequence 1:	NP_001246786.1	Gene:	Mbs / 49070	FlyBaseID:	FBgn0005536	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	XP_001340092.6	Gene:	ppp1r16b / 799771	ZFINID:	ZDB-GENE-131127-294	Length:	532	Species:	Danio rerio

Alignment Length:	429	Identity:	148/429 - (34%)
Similarity:	217/429 - (50%)	Gaps:	75/429 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RNNSAMMKRAEQLKRW---EESDTN-------RAAPTPRHEHGRRIKFSSGCVFLAACLSGDKDE 61
            |..:|..:|.:|||||   |:...|       |..|....|:.||:.|::....|.|....|.||
Zfish    22 RLRAAQKRRTQQLKRWAVYEKEMQNKKRKADKRRGPGSLVENRRRVSFAASVALLEASARNDPDE 86

  Fly    62 VVQLLDQGADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVS 126
            |..||......:.:|.||||||||.|||:..:||:.|:..||.:|.||||.||||||.|:||...
Zfish    87 VRYLLKNNLSPDLSNEDGLTALHQCCIDNYEEMVQILLTHGATVNAQDNELWTPLHAAATCGHTG 151

  Fly   127 IARYLVENGADVAAVNSDGDLALDL-----AIDVQHMAMIDYMEKMVQELNINVDEARKAEELAM 186
            :.:.|:::|||:.||||||::..||     .:|:...||.:  ..:.||:   ::|.|.|.|.:|
Zfish   152 LVKILIQHGADLLAVNSDGNMPYDLCEDDPTLDIIETAMAN--RGITQEM---INETRAAVERSM 211

  Fly   187 LNDAKKWLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASH 251
            |.|.:|.|: :.|:|:. |...|||.||:|:|.|||:...|||......|.:|:|||||||||:.
Zfish   212 LGDIQKILQ-EGADVNH-HDSQGATLLHIASANGYTQAAELLLDAGARSDMRDSDGWTPLHAAAC 274

  Fly   252 WGQRETAEMLVESLADMDIRNYAGQSCIDVA-DRKIVKFLEEL--------RANKRNK----RRP 303
            |||.:.||:||...|.::.:.|..::.||:. |.:....|.||        ::..::|    ||.
Zfish   275 WGQVQVAELLVSHGASLNAKTYMEETPIDLCEDEEFRNHLLELKHKHDIIMKSQLKHKTSLCRRT 339

  Fly   304 SSQ------IRISDAMENHVEKTPTKLVRVEVRTDA--------TKDAENVKPNQQIHAVEHPVE 354
            ||.      :|.:...:.|      .|.|.|.:|:|        .::.|.....:..|.:: |.|
Zfish   340 SSAGSRGKVVRRASLSDRH------NLCRKEYQTEAIVWRGGREKEERERESDQENSHTMQ-PTE 397

  Fly   355 EEAPWRRKLPRTP---SDSPTNNQVPDRELGTNSSETAN 390
            .        |::|   .||..|        |..||.:.|
Zfish   398 G--------PQSPGILKDSGQN--------GCISSPSPN 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANK	50..164	CDD:238125	54/118 (46%)
		Ank_2	53..142	CDD:289560	43/88 (49%)
		ANK repeat	78..109	CDD:293786	17/30 (57%)
		ANK	106..290	CDD:238125	79/189 (42%)
		ANK repeat	111..142	CDD:293786	15/30 (50%)
		ANK repeat	209..239	CDD:293786	14/29 (48%)
		Ank_2	213..300	CDD:289560	36/95 (38%)
		ANK repeat	241..272	CDD:293786	17/30 (57%)
		PRKG1_interact	1177..1272	CDD:292521
ppp1r16b	XP_001340092.6	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910