DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mbs and ppp1r16a

DIOPT Version :9

Sequence 1:NP_001246786.1 Gene:Mbs / 49070 FlyBaseID:FBgn0005536 Length:1273 Species:Drosophila melanogaster
Sequence 2:NP_001072353.1 Gene:ppp1r16a / 779806 XenbaseID:XB-GENE-5762924 Length:549 Species:Xenopus tropicalis


Alignment Length:617 Identity:171/617 - (27%)
Similarity:269/617 - (43%) Gaps:123/617 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 RNNSAMMKRAEQLKRW---EESDTNRAAPTPRHEHG----RRIKFSSGCVFLAACLSGDKDEVVQ 64
            |...|..:||:|||:|   |:....:.|...:.:.|    ||:.|......|.|....|.:||..
 Frog    22 RLKHAQKRRAQQLKKWAQFEKDGQGKKAKGRQKKQGSKEERRVMFPQNVTLLEAAARNDIEEVRH 86

  Fly    65 LLDQGADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSIAR 129
            ||..|...|..|.||||||||.||||..::|..|:..|||:|..|:|.||||||.|:||.:.:..
 Frog    87 LLQNGFSPNLYNEDGLTALHQCCIDDYEEIVRMLIGAGADVNACDSELWTPLHAAATCGHLHLVE 151

  Fly   130 YLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNI---NVDEARKAEELAMLNDAK 191
            .|:::||::.||||||::..||..|   ...:|::|..:.|..|   .::|.|.|.|..||.|.:
 Frog   152 LLIKHGANLLAVNSDGNMPYDLCED---DVTLDHIETAMAEQGITQEKIEECRGATEQHMLEDIQ 213

  Fly   192 KWLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRE 256
            . |.....||:..:|. |.:.||:|||.||.....|||..:..|:.:|.|||.|||||:.|||..
 Frog   214 H-LVETGGEVNAHNPH-GTSLLHIAAANGYLATAELLLEHKAQVNARDQDGWEPLHAAACWGQIH 276

  Fly   257 TAEMLVESLADMDIRNYAGQSCIDV-ADRKI-VKFLE-----ELRANKRNKRRPSSQIRISDAME 314
            ..|:||...||::.::...::.:|| .|.:: .|.||     |.....::|.|.:.|.|.|.|  
 Frog   277 VVELLVAHGADLNSKSQLDETPLDVCGDEEVRAKILELKHKHEAIRKSQDKHRTALQRRTSSA-- 339

  Fly   315 NHVEKTPTKLVRVEVRTDATKDAENVKPNQQIHAVEHPVEEEAPWRRKLPRTPSDSPTNNQVPDR 379
                .:..|:||....|:.|          .::..||. :|...|:::..|       .|:|..:
 Frog   340 ----GSRGKVVRRVSVTERT----------NMYRREHQ-KEAMVWQQRGSR-------ENEVEQQ 382

  Fly   380 ELGTNSSETANDVILRRTQSFENDQKFYQKYNELRARIKANSCPI----LPANANANAAAANKSN 440
            :  .:..:|.|..:.:...|.|.:.       |..||.:.:..|.    :|.:::..:     .:
 Frog   383 D--EDEDKTTNTEMQQHQPSAEAEP-------EKAARNEGDEGPAEGSDVPVSSSLQS-----FH 433

  Fly   441 NNNNLSSNNYHNNNNNNNKSDLLLGYAAGTTTTTSTPTTTTTTTSSTFNNTHSNTNNTSTTQQQP 505
            .|.:|...:.|..:...::|             .|....|...|....:|..|:.......:|:.
 Frog   434 RNGSLVPASKHTFSKRLDRS-------------VSYQLATQGDTGPDLSNERSHHTLAELKRQRA 485

  Fly   506 AAAAAASAANQLYSVQRSA----SLKDNSMYYRKPTVTIATSTAATAINSP---STTVQTPPIRS 563
            ||           .:||.|    .|.|:.          |..::.:|...|   :|....||:  
 Frog   486 AA-----------KLQRHAPPPPPLSDSE----------AQDSSGSAPEEPVYYTTASGEPPL-- 527

  Fly   564 QVTAKIAEKSNNGSSSTASVSDAESSKPPPKQ 595
               .|:             ::.||.:.|..|:
 Frog   528 ---LKL-------------IAPAEETTPAEKR 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MbsNP_001246786.1 ANK 50..164 CDD:238125 52/113 (46%)
Ank_2 53..142 CDD:289560 42/88 (48%)
ANK repeat 78..109 CDD:293786 18/30 (60%)
ANK 106..290 CDD:238125 72/188 (38%)
ANK repeat 111..142 CDD:293786 14/30 (47%)
ANK repeat 209..239 CDD:293786 12/29 (41%)
Ank_2 213..300 CDD:289560 35/93 (38%)
ANK repeat 241..272 CDD:293786 16/30 (53%)
PRKG1_interact 1177..1272 CDD:292521
ppp1r16aNP_001072353.1 ANK repeat 72..98 CDD:293786 9/25 (36%)
ANK 95..282 CDD:238125 83/191 (43%)
ANK repeat 100..131 CDD:293786 18/30 (60%)
ANK repeat 133..164 CDD:293786 14/30 (47%)
ANK 223..332 CDD:238125 39/109 (36%)
ANK repeat 228..259 CDD:293786 12/31 (39%)
ANK repeat 261..289 CDD:293786 16/27 (59%)
GREB1 <328..>530 CDD:318077 49/278 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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