DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mbs and ppp1r12c

DIOPT Version :9

Sequence 1:	NP_001246786.1	Gene:	Mbs / 49070	FlyBaseID:	FBgn0005536	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	XP_017950971.1	Gene:	ppp1r12c / 734022	XenbaseID:	XB-GENE-991366	Length:	864	Species:	Xenopus tropicalis

Alignment Length:	1333	Identity:	328/1333 - (24%)
Similarity:	482/1333 - (36%)	Gaps:	549/1333 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AMMKRAEQLKRWEESDTNRAAPTPRHEH---------------------------GRRIKFSSGC 48
            |..:|.|||::|..|.||:....||.:.                           ||.::|....
Frog    11 AKERRKEQLRQWARSCTNQEPAEPRWQRRRRRRRRVGDGDEEEDEGDRGSQGEGDGRAVRFERSA 75

  Fly    49 VFLAACLSGDKDEVVQLL--DQGAD-INTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDN 110
            .|||||.:||..|...:|  |.|.: |::.|.||::||||||||:||::|||||..||::|:.||
Frog    76 EFLAACAAGDLLEAEDMLTRDSGKEVIDSTNTDGISALHQACIDENLEVVEFLVNHGANVNQADN 140

  Fly   111 EGWTPLHATASCGFVSIARYLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQ-EL--- 171
            |||||||..||||::.||.||:::.|::||||||||:.||:|.|       |.||.::: |:
Frog   141 EGWTPLHVAASCGYMEIAEYLLKHSANIAAVNSDGDVPLDIAED-------DCMENLLRAEIAKG 198

  Fly   172 NINVDEARKAEELAMLNDAKKWLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVD 236
            .::::.|::.||..||.|:::||.:...| |..|.||||:||||||||||.:|:.|||....:.:
Frog   199 GVDIEAAKREEEEVMLRDSRQWLNAGKIE-DIRHSKTGASALHVAAAKGYIEVMRLLLQANFDPN 262

  Fly   237 RQDNDGWTPLHAASHWGQRETAEMLVESLADMDIRNYAGQSCIDVADRKIVKFLEELRANK---R 298
            .:|.|||||||||:|||..|...:|||...||:..|..||...||||..::..|||||..:   |
Frog   263 ARDKDGWTPLHAAAHWGVEEACRLLVEHFCDMNALNSVGQRPCDVADEDVLSLLEELRKKQEDLR 327

  Fly   299 NKRRPSSQIRISDAMENHVEKTPTKLVRVEVRTDATKDAENVKPNQQIHAVEHPVEEEAPWRRKL 363
            |::..:.:..|...||.|...| .|..|..|...::|:..:|:...:              .||.
Frog   328 NEKEANKRAVIDTNMEQHPSYT-NKHRRSSVCRMSSKEKISVQDQSK--------------ERKT 377

  Fly   364 PRTPSDSPTNNQVPDRELGTNSSETANDVILRRTQSFENDQKFYQKYNELRARIKANSCPILPAN 428
            ..|.|       |.:.|..::|.|...|
Frog   378 LGTIS-------VGEEETISSSEEETED------------------------------------- 398

  Fly   429 ANANAAAANKSNNNNNLSSNNYHNNNNNNNKSDLLLGYAAGTTTTTSTPTTTTTTTSSTFNNTHS 493
                   |::..||..::.|....:.:|:..|.:     :.....|..|::.:..:....::..:
Frog   399 -------ASEPGNNTQVNENGLLPDTHNSAVSSV-----SSEQKFTGAPSSVSEKSELPLSSLRA 451

  Fly   494 NTNNTSTTQQQPAAAAAASAANQLYSVQRSASLK--DNSMYYRKPTVTIATSTAATAI-NSPSTT 555
            ....|.:......|..|.|:...| .::||||..  |.....::|.:.....|....| :||.:.
Frog   452 GLRKTGSYGVLQDAKLAGSSVKDL-GIKRSASSPRLDTQERNKEPLMARVQPTPGRRIFSSPESA 515

  Fly   556 ------------------VQTPPIRSQVTAKIAEKSNNGSSSTASVSDAESSKPPPKQSASNMIK 602
                              |.|..:.:..::.:...|:..||.|.|.:|::..:
Frog   516 QDGKKEDTEGGLQMKLDMVPTTQLHTNTSSSMVATSSTSSSGTGSSTDSQDKR------------ 568

  Fly   603 NFFKSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEELVKKKNMGMANNNNNNNIS 667
               :|:..||||||||:||||.::.:|::|||||||||.::|.||:
Frog   569 ---RSYQTPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEK------------------- 611

  Fly   668 TTTTNTISNSGNETSSASSTSAPTPSILGSNEQQDELQPPPPPTTPPPAVIPTTTTATDETEIEE 732

Frog   612 ----------------------------------------------------------------- 611

  Fly   733 VVSSPPAGQSQNDTTASFTLSAPVRRSLSTEGEADANSDPEGDQDQTVVSASYTIMPRRERLPES 797
                              ||..|          ||
Frog   612 ------------------TLGKP----------AD------------------------------ 618

  Fly   798 SENVESIRSPQKTEPVAKSSSEDKSEEPPHARPTDLPLIPAPAAPSTEAIKSSSAATTPAALESP 862
                    ||..|||  |:::||:.|:                |.|.|::
Frog   619 --------SPSSTEP--KTAAEDRGEK----------------AQSLESV--------------- 642

  Fly   863 VRLRDKRGLSGSQESETKSDTASPVSSHPDFNARDSLLSLYARRTTDSSAGGGGVGGGAGVGAGG 927

Frog   643 ----------------------------------------------------------------- 642

  Fly   928 ASGAATSSSTSAAERRPSWRLKFDAGSKFKLEDITSGGTYPPNNSTIIPSAPAVMAAANLSTTTG 992
                                            |||
Frog   643 --------------------------------DIT------------------------------ 645

  Fly   993 VQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYVTPSARKFETNATSTGATTAATTTSNS 1057
              ||:.......|.|...:|:|..|.:...|.|:          |.||
Frog   646 --RRLGLPSTEQNMSASPINTVNSPSNKEIESTS----------KEET----------------- 681

  Fly  1058 TSNSVSATSANHTTATAPNATSNHDDKDNDKENDNRTQTVIQRRRKPKRRSTGVVHIDMDELDPE 1122
                 .|.|.||.||                 .|.|      :.||.:|.:.|.
Frog   682 -----EAESQNHLTA-----------------RDRR------KWRKDQRLALGT----------- 707

  Fly  1123 RQNESSNNDNEEKEKESGSERTSRSRLGS--------TASTATTSESKSSSSNDKTENGDGIDYK 1179
              |..:..:|||.|..:.:|........|        |.|......|.:.||.:::|.    |||
Frog   708 --NSYAGMENEETESLNHNETAGHGVTQSWSSFLPHRTGSHTFQRHSSNFSSKEESEK----DYK 766

  Fly  1180 ALWEAEKLENDKLRQMLKQKDDEAVQTRATLERFA----NATTKNSLSELEKRERRAMERKLSEL 1240
            .|:|....:|:.||..|::.:.:..|.|..|||..    .:..:.:|.|||:.|||::|||::||
Frog   767 KLYENLLADNETLRDQLQETELKLTQIRLELERVTQRQERSAERPALLELERFERRSLERKVAEL 831

  Fly  1241 EEELKQLDAYKSDNHRLKEENAALIRVISKLSK 1273
            |||||.|...|:||.|||:||||||||||||||
Frog   832 EEELKVLSDLKADNQRLKDENAALIRVISKLSK 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANK	50..164	CDD:238125	64/116 (55%)
		Ank_2	53..142	CDD:289560	50/91 (55%)
		ANK repeat	78..109	CDD:293786	20/30 (67%)
		ANK	106..290	CDD:238125	90/187 (48%)
		ANK repeat	111..142	CDD:293786	18/30 (60%)
		ANK repeat	209..239	CDD:293786	16/29 (55%)
		Ank_2	213..300	CDD:289560	45/89 (51%)
		ANK repeat	241..272	CDD:293786	18/30 (60%)
		PRKG1_interact	1177..1272	CDD:292521	49/98 (50%)
ppp1r12c	XP_017950971.1	ANK repeat	108..139	CDD:293786	20/30 (67%)
		Ank_2	118..>276	CDD:393464	84/165 (51%)
		ANK repeat	141..265	CDD:293786	61/131 (47%)
		ANK repeat	235..259	CDD:293786	16/23 (70%)
		ANK repeat	267..298	CDD:293786	18/30 (60%)
		Ank	267..298	CDD:365815	18/30 (60%)
		PRKG1_interact	764..863	CDD:374206	49/98 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7331
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D225308at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010