Protein Alignment Mbs and ppp1r12c

DIOPT Version :10

• Sequence 1: NP_001246786.1
• Gene: Mbs / 49070
• FlyBaseID: FBgn0005536
• Length: 1273
• Species: Drosophila melanogaster
• Sequence 2: XP_017950971.1
• Gene: ppp1r12c / 734022
• XenbaseID: XB-GENE-991366
• Length: 864
• Species: Xenopus tropicalis
• Alignment Length: 1333
• Identity: 328/1333 - (24%)
• Similarity: 482/1333 - (36%)
• Gaps: 549/1333 - (41%)

  Fly    11 AMMKRAEQLKRWEESDTNRAAPTPRHEH---------------------------GRRIKFSSGC 48
            |..:|.|||::|..|.||:....||.:.                           ||.::|....
 Frog    11 AKERRKEQLRQWARSCTNQEPAEPRWQRRRRRRRRVGDGDEEEDEGDRGSQGEGDGRAVRFERSA 75

  Fly    49 VFLAACLSGDKDEVVQLL--DQGAD-INTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDN 110
            .|||||.:||..|...:|  |.|.: |::.|.||::||||||||:||::|||||..||::|:.||
 Frog    76 EFLAACAAGDLLEAEDMLTRDSGKEVIDSTNTDGISALHQACIDENLEVVEFLVNHGANVNQADN 140

  Fly   111 EGWTPLHATASCGFVSIARYLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQ-EL--- 171
            |||||||..||||::.||.||:::.|::||||||||:.||:|.|       |.||.::: |:
 Frog   141 EGWTPLHVAASCGYMEIAEYLLKHSANIAAVNSDGDVPLDIAED-------DCMENLLRAEIAKG 198

  Fly   172 NINVDEARKAEELAMLNDAKKWLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVD 236
            .::::.|::.||..||.|:::||.:...| |..|.||||:||||||||||.:|:.|||....:.:
 Frog   199 GVDIEAAKREEEEVMLRDSRQWLNAGKIE-DIRHSKTGASALHVAAAKGYIEVMRLLLQANFDPN 262

  Fly   237 RQDNDGWTPLHAASHWGQRETAEMLVESLADMDIRNYAGQSCIDVADRKIVKFLEELRANK---R 298
            .:|.|||||||||:|||..|...:|||...||:..|..||...||||..::..|||||..:   |
 Frog   263 ARDKDGWTPLHAAAHWGVEEACRLLVEHFCDMNALNSVGQRPCDVADEDVLSLLEELRKKQEDLR 327

  Fly   299 NKRRPSSQIRISDAMENHVEKTPTKLVRVEVRTDATKDAENVKPNQQIHAVEHPVEEEAPWRRKL 363
            |::..:.:..|...||.|...| .|..|..|...::|:..:|:...:              .||.
 Frog   328 NEKEANKRAVIDTNMEQHPSYT-NKHRRSSVCRMSSKEKISVQDQSK--------------ERKT 377

  Fly   364 PRTPSDSPTNNQVPDRELGTNSSETANDVILRRTQSFENDQKFYQKYNELRARIKANSCPILPAN 428
            ..|.|       |.:.|..::|.|...|
 Frog   378 LGTIS-------VGEEETISSSEEETED------------------------------------- 398

  Fly   429 ANANAAAANKSNNNNNLSSNNYHNNNNNNNKSDLLLGYAAGTTTTTSTPTTTTTTTSSTFNNTHS 493
                   |::..||..::.|....:.:|:..|.:     :.....|..|::.:..:....::..:
 Frog   399 -------ASEPGNNTQVNENGLLPDTHNSAVSSV-----SSEQKFTGAPSSVSEKSELPLSSLRA 451

  Fly   494 NTNNTSTTQQQPAAAAAASAANQLYSVQRSASLK--DNSMYYRKPTVTIATSTAATAI-NSPSTT 555
            ....|.:......|..|.|:...| .::||||..  |.....::|.:.....|....| :||.:.
 Frog   452 GLRKTGSYGVLQDAKLAGSSVKDL-GIKRSASSPRLDTQERNKEPLMARVQPTPGRRIFSSPESA 515

  Fly   556 ------------------VQTPPIRSQVTAKIAEKSNNGSSSTASVSDAESSKPPPKQSASNMIK 602
                              |.|..:.:..::.:...|:..||.|.|.:|::..:
 Frog   516 QDGKKEDTEGGLQMKLDMVPTTQLHTNTSSSMVATSSTSSSGTGSSTDSQDKR------------ 568

  Fly   603 NFFKSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEELVKKKNMGMANNNNNNNIS 667
               :|:..||||||||:||||.::.:|::|||||||||.::|.||:
 Frog   569 ---RSYQTPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEK------------------- 611

  Fly   668 TTTTNTISNSGNETSSASSTSAPTPSILGSNEQQDELQPPPPPTTPPPAVIPTTTTATDETEIEE 732
                                                                             
 Frog   612 ----------------------------------------------------------------- 611

  Fly   733 VVSSPPAGQSQNDTTASFTLSAPVRRSLSTEGEADANSDPEGDQDQTVVSASYTIMPRRERLPES 797
                              ||..|          ||
 Frog   612 ------------------TLGKP----------AD------------------------------ 618

  Fly   798 SENVESIRSPQKTEPVAKSSSEDKSEEPPHARPTDLPLIPAPAAPSTEAIKSSSAATTPAALESP 862
                    ||..|||  |:::||:.|:                |.|.|::
 Frog   619 --------SPSSTEP--KTAAEDRGEK----------------AQSLESV--------------- 642

  Fly   863 VRLRDKRGLSGSQESETKSDTASPVSSHPDFNARDSLLSLYARRTTDSSAGGGGVGGGAGVGAGG 927
                                                                             
 Frog   643 ----------------------------------------------------------------- 642

  Fly   928 ASGAATSSSTSAAERRPSWRLKFDAGSKFKLEDITSGGTYPPNNSTIIPSAPAVMAAANLSTTTG 992
                                            |||
 Frog   643 --------------------------------DIT------------------------------ 645

  Fly   993 VQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYVTPSARKFETNATSTGATTAATTTSNS 1057
              ||:.......|.|...:|:|..|.:...|.|:          |.||
 Frog   646 --RRLGLPSTEQNMSASPINTVNSPSNKEIESTS----------KEET----------------- 681

  Fly  1058 TSNSVSATSANHTTATAPNATSNHDDKDNDKENDNRTQTVIQRRRKPKRRSTGVVHIDMDELDPE 1122
                 .|.|.||.||                 .|.|      :.||.:|.:.|.
 Frog   682 -----EAESQNHLTA-----------------RDRR------KWRKDQRLALGT----------- 707

  Fly  1123 RQNESSNNDNEEKEKESGSERTSRSRLGS--------TASTATTSESKSSSSNDKTENGDGIDYK 1179
              |..:..:|||.|..:.:|........|        |.|......|.:.||.:::|.    |||
 Frog   708 --NSYAGMENEETESLNHNETAGHGVTQSWSSFLPHRTGSHTFQRHSSNFSSKEESEK----DYK 766

  Fly  1180 ALWEAEKLENDKLRQMLKQKDDEAVQTRATLERFA----NATTKNSLSELEKRERRAMERKLSEL 1240
            .|:|....:|:.||..|::.:.:..|.|..|||..    .:..:.:|.|||:.|||::|||::||
 Frog   767 KLYENLLADNETLRDQLQETELKLTQIRLELERVTQRQERSAERPALLELERFERRSLERKVAEL 831

  Fly  1241 EEELKQLDAYKSDNHRLKEENAALIRVISKLSK 1273
            |||||.|...|:||.|||:||||||||||||||
 Frog   832 EEELKVLSDLKADNQRLKDENAALIRVISKLSK 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANKYR	50..300	CDD:440430	128/259 (49%)
		ANK repeat	78..109	CDD:293786	20/30 (67%)
		ANK repeat	111..142	CDD:293786	18/30 (60%)
		ANK repeat	209..239	CDD:293786	16/29 (55%)
		ANK repeat	241..272	CDD:293786	18/30 (60%)
		IPD_PPP1R12	606..648	CDD:412018	25/41 (61%)
		PRKG1_interact	1177..1273	CDD:464927	50/99 (51%)
ppp1r12c	XP_017950971.1	ANKYR	<82..336	CDD:440430	124/261 (48%)
		ANK repeat	108..139	CDD:293786	20/30 (67%)
		ANK repeat	141..265	CDD:293786	61/131 (47%)
		ANK repeat	235..259	CDD:293786	16/23 (70%)
		ANK repeat	267..298	CDD:293786	18/30 (60%)
		IPD_PPP1R12C	565..615	CDD:412020	28/166 (17%)
		PRKG1_interact	764..864	CDD:464927	50/99 (51%)