DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mbs and zmp:0000001167

DIOPT Version :9

Sequence 1:	NP_001246786.1	Gene:	Mbs / 49070	FlyBaseID:	FBgn0005536	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	XP_002666820.2	Gene:	zmp:0000001167 / 571837	ZFINID:	ZDB-GENE-140106-127	Length:	889	Species:	Danio rerio

Alignment Length:	1346	Identity:	346/1346 - (25%)
Similarity:	513/1346 - (38%)	Gaps:	530/1346 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSLD-ARNNSAMMKRAEQLKRWEESDTNRAAPTPRHE-----HGR-RIKFSSGCVFLAACLSGD 58
            |::.| :|:.:|..:|.:||:||:.|:|:|.....|..     |.| |::|:.|.||:|||.:||
Zfish     1 MAATDRSRSEAAKQRRQDQLQRWQGSETDRTGAEARSHSVAPGHRRARVRFAQGAVFMAACSAGD 65

  Fly    59 KDEVVQLLDQGADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCG 123
            ::||.:||.||||||.||:||||||||||||:|.:||:||||.|:::||.||||||||||.||||
Zfish    66 REEVAELLRQGADINHANIDGLTALHQACIDENAEMVQFLVENGSEVNRGDNEGWTPLHAAASCG 130

  Fly   124 FVSIARYLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLN 188
            |:.|.:||:|:||.|.||||:|:|.||:|.:   .||...::..|::..|:||:||:.||..||.
Zfish   131 FIQITKYLIEHGAHVGAVNSEGELPLDVATE---DAMNRLLKAEVKKQGIDVDQARREEERVMLQ 192

  Fly   189 DAKKWLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWG 253
            ||...|....:.|  |||.|.||||||||||||.:||.:||....:||.:|:||||..|||:|||
Zfish   193 DAMTVLAGSGSLV--PHPNTQATALHVAAAKGYIEVLKVLLKCGIDVDSRDSDGWTAFHAAAHWG 255

  Fly   254 QRETAEMLVESLADMDIRNYAGQSCIDVADRKIVKFLEEL-------RANKRNKRRP-------- 303
            |.|...:|.|.:.||...|..||:.:||||..|:..||||       |:.|:..:.|
Zfish   256 QEEACSLLAEHMCDMTAVNNVGQTPLDVADENIIDNLEELQKKQNAMRSEKQKIQTPVIETSPPV 320

  Fly   304 ---------------SSQIRIS-DAMENHVEKTPTKLVRVEVRTDATKDAENVKPNQQIHAVEHP 352
                           ||:.:|: ...|.|...|...|...|...::|:.|...||:....:
Zfish   321 SMAPARPRRTSISRMSSREKITLHGREKHAPPTLQTLPTEEDEDESTRTASQSKPSSSSSS---- 381

  Fly   353 VEEEAPWRRKLPRTPSDSPTNNQVPDREL--GTNSSETANDVILRRTQSFENDQKFYQKYNELRA 415
             |||:       .:.||: .:.:...||:  ..|:...|..|....|.|..|..|   |....|.
Zfish   382 -EEES-------ESESDA-ESEKAKTREMINNLNNKRNAAPVTSSVTSSGPNQVK---KTEAGRT 434

  Fly   416 RI------------KANSCPILPANANANAAAANKSNNNNNL----SSNNYHNNNNNNNKSDLLL 464
            .:            ||.|...|.:...::||:....:....|    |:::...::..:||...|
Zfish   435 PVTEAPGSWRTSLRKAGSSVTLGSTGASDAASEALKDPETKLGMTRSASSPRLSSEADNKEPRL- 498

  Fly   465 GYAAGTTTTTSTPTTTTTTTSSTFNNTHSNTNNTSTTQQQPAAAAAASAANQLYSVQRSASLKDN 529
               |....|.|....:.:..|:..:||.|..:.:|:..::....:|:.|:|        .||..:
Zfish   499 ---ARVQPTPSRRLFSISDNSTNSDNTSSLLSRSSSYTRRLNTQSASDASN--------PSLPRS 552

  Fly   530 SMYYRKPTVTIATSTAATAINSPSTTVQTPPIRSQVTAKIAEK--------SNNGSSSTASVSDA 586
            |.|.||     ...::.|::||.::.:..  :.:.|..:.|::        ||:.:::|.:..::
Zfish   553 SSYGRK-----LDESSVTSVNSATSGLSR--LNNLVAQRSAQEEAEKKDPVSNSVTTTTTTTGES 610

  Fly   587 ESSKPPPKQSASNMIKNFFKSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEELVK 651
            |:             |...||::.||||||:|.||||.::..|::|||||||||.:::.||:.:|
Zfish   611 ET-------------KQRRKSYLTPVRDEEAEAQRKARSRHARQSRRSTQGVTLTDLQEAEKTMK 662

  Fly   652 KKNMGMANNNNNNNISTTTTNTISNSGNETSSASSTSAPTPSILGSNEQQDELQPPPPPTTPPPA 716
            .:|.|                                          :::||
Zfish   663 TENKG------------------------------------------KKEDE------------- 672

  Fly   717 VIPTTTTATDETEIEEVVSSPPAGQSQNDTTASFTLSAPVRRSLSTEGEADANSDPEGDQDQTVV 781
                                                                  :.||.|
Zfish   673 ------------------------------------------------------EKEGKQ----- 678

  Fly   782 SASYTIMPRRERLPESSENVESIRSPQKTEPVAKSSSEDKSEEPPHARPTDLPLIPAPAAPSTEA 846

Zfish   679 ----------------------------------------------------------------- 678

  Fly   847 IKSSSAATTPAALESPVRLRDKRGLSGSQESETKSDTASPVSSHPDFNARDSLLSLYARRTTDSS 911
                                 |:|    :|.|.
Zfish   679 ---------------------KKG----EEGEV-------------------------------- 686

  Fly   912 AGGGGVGGGAGVGAGGASGAATSSSTSAAERRPSWRLKFDAGSKFKLEDITSGGTYPPNNSTIIP 976
                                             |||.:.   :..:..|:. |.|:|       |
Zfish   687 ---------------------------------SWRSRI---ANLQKSDLL-GLTHP-------P 707

  Fly   977 SAPAVMAAANLSTTTGVQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYVTPSARKFETN 1041
            .||                                    ||
Zfish   708 GAP------------------------------------RP------------------------ 712

  Fly  1042 ATSTGATTAATTTSNSTSNSVSATSANHTTATAPNATSNHDDKDNDKENDNRTQTVIQRRRKPKR 1106
                         ....::|:.|                    |.::....|.:|..:||.||
Zfish   713 -------------DRPDADSIVA--------------------DIEERMLERRKTRARRRGKP-- 742

  Fly  1107 RSTGVVHIDMDELDPERQNESSNNDNEEKEKESGSERTSRSRLGSTASTATTSESKSSSSND--K 1169
                              .||.:|:...:|:.||.......|        .||....|..||  .
Zfish   743 ------------------GESDDNEPSGEEESSGGREPQTDR--------HTSSRADSLLNDCIL 781

  Fly  1170 TENGDGIDYKALWEAEKLENDKLRQMLKQKDDEAVQTRATL-------ERFANATTKNSLSELEK 1227
            |...|..|:|.|:|....||.:|:..|.........||..|       |||.:.|   :|.|:||
Zfish   782 TRGADSRDFKKLFEEMSRENRRLQSQLSDTQRTISLTRVELENATKRQERFTDCT---ALLEMEK 843

  Fly  1228 RERRAMERKLSELEEELKQLDAYKSDNHRLKEENAALIRVISKLSK 1273
            :|::.:||:.:|||||||.|...::||.|||:||.|||||||||||
Zfish   844 KEKKMLERRAAELEEELKVLGDLRADNQRLKDENGALIRVISKLSK 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANK	50..164	CDD:238125	73/113 (65%)
		Ank_2	53..142	CDD:289560	61/88 (69%)
		ANK repeat	78..109	CDD:293786	22/30 (73%)
		ANK	106..290	CDD:238125	96/183 (52%)
		ANK repeat	111..142	CDD:293786	21/30 (70%)
		ANK repeat	209..239	CDD:293786	18/29 (62%)
		Ank_2	213..300	CDD:289560	46/93 (49%)
		ANK repeat	241..272	CDD:293786	16/30 (53%)
		PRKG1_interact	1177..1272	CDD:292521	45/101 (45%)
zmp:0000001167	XP_002666820.2	Ank_2	57..149	CDD:289560	63/91 (69%)
		ANK repeat	57..83	CDD:293786	16/25 (64%)
		ANK	80..263	CDD:238125	107/187 (57%)
		ANK repeat	85..116	CDD:293786	22/30 (73%)
		ANK repeat	118..149	CDD:293786	21/30 (70%)
		Ank_2	123..274	CDD:289560	79/155 (51%)
		ANK repeat	151..241	CDD:293786	43/94 (46%)
		ANK repeat	243..274	CDD:293786	16/30 (53%)
		PRKG1_interact	789..888	CDD:292521	45/101 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D225308at33208
OrthoFinder	1	1.000	-	-		FOG0002673
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920