DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mbs and PPP1R12C

DIOPT Version :9

Sequence 1:NP_001246786.1 Gene:Mbs / 49070 FlyBaseID:FBgn0005536 Length:1273 Species:Drosophila melanogaster
Sequence 2:NP_060077.1 Gene:PPP1R12C / 54776 HGNCID:14947 Length:782 Species:Homo sapiens


Alignment Length:1336 Identity:314/1336 - (23%)
Similarity:442/1336 - (33%) Gaps:642/1336 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 SAMMKRAEQLKRWEESDTNRAAPTPRHEHGRRIKFSSGCVFLAACLSGDKDE---VVQLLDQG-- 69
            :|..:|.|||::|  .....|.|.|.....|.::|.....|||||..||.||   :::..|.|  
Human    17 AARERRREQLRQW--GARAGAEPGPGERRARTVRFERAAEFLAACAGGDLDEARLMLRAADPGPG 79

  Fly    70 ------------ADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASC 122
                        |.:::.|.||::||||||||:||::|.||||:||.:|:.|||||||||..|||
Human    80 AELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASC 144

  Fly   123 GFVSIARYLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAML 187
            |::.|||||:.:||::|||||||||.||||   :..||...::..:....::|:.|::|||..:|
Human   145 GYLDIARYLLSHGANIAAVNSDGDLPLDLA---ESDAMEGLLKAEIARRGVDVEAAKRAEEELLL 206

  Fly   188 NDAKKWLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHW 252
            :|.:.||...|....| ||:|||:||||||||||.:|:.|||....:.:.:|.|||||||||:||
Human   207 HDTRCWLNGGAMPEAR-HPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHW 270

  Fly   253 GQRETAEMLVESLADMDIRNYAGQSCIDVADRKIVKFLEEL---------------------RAN 296
            |..:...:|.|....||...:|||...|:||.:::..||||                     :|.
Human   271 GVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAP 335

  Fly   297 KRNKRRPSSQIRISDAM-----------------------ENHVEKTPTKLVRVEVRT-DATKDA 337
            ..:|.|.||..|:|...                       |:..|:.||:....|.|| :.....
Human   336 SSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSP 400

  Fly   338 ENVKPNQQIHAVEHPVE-EEAPWRRKLPRTPSDSPTNNQVPDRELGTNSSETANDVILRRTQSFE 401
            .:..|       :.||: ||||:.|:.....:.|......|:|    .::|.|....|:|:.|..
Human   401 PHPSP-------KSPVQLEEAPFSRRFGLLKTGSSGALGPPER----RTAEGAPGAGLQRSASSS 454

  Fly   402 NDQKFYQKYNELR-ARIKANSCPILPANANANAAAANKSNNNNNLSSNNYHNNNNNNNKSDLLLG 465
            ..:....:..||| |||.....|.||                                       
Human   455 WLEGTSTQAKELRLARITPTPSPKLP--------------------------------------- 480

  Fly   466 YAAGTTTTTSTPTTTTTTTSSTFNNTHSNTNNTSTTQQQPAAAAAASAANQLYSVQRSASLKDNS 530
                      .|:..:..|                                              
Human   481 ----------EPSVLSEVT---------------------------------------------- 489

  Fly   531 MYYRKPTVTIATSTAATAINSPSTTVQTPPIRSQVTAKIAEKSNNGSSSTASVSDAESSKPPPKQ 595
                ||...:..|:..:.|..|.:..               |.|..::|||..:|:...:     
Human   490 ----KPPPCLENSSPPSRIPEPESPA---------------KPNVPTASTAPPADSRDRR----- 530

  Fly   596 SASNMIKNFFKSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEELVKKKNMGMANN 660
                      :|:..||||||||:||||.::.:|::|||||||||.::|.||:...|        
Human   531 ----------RSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGK-------- 577

  Fly   661 NNNNNISTTTTNTISNSGNETSSASSTSAPTPSILGSNEQQDELQPPPPPTTPPPAVIPTTTTAT 725
                                                                             
Human   578 ----------------------------------------------------------------- 577

  Fly   726 DETEIEEVVSSPPAGQSQNDTTASFTLSAPVRRSLSTEGEADANS-DPEGDQDQTVVSASYTIMP 789
                                        ||       |.|..|.| ||.                
Human   578 ----------------------------AP-------ESEKPAQSLDPS---------------- 591

  Fly   790 RRERLPESSENVESIRSPQKTEPVAKSSSEDKSEEPPHARPTDLPLIPAPAAPSTEAIKSSSAAT 854
            ||.|:|    .||:..||                                               
Human   592 RRPRVP----GVENSDSP----------------------------------------------- 605

  Fly   855 TPAALESPVRLRDKRGLSGSQESETKSDTASPVSSHPDFNARDSLLSLYARRTTDSSAGGGGVGG 919
                               :|.:|.           ||                         |.
Human   606 -------------------AQRAEA-----------PD-------------------------GQ 615

  Fly   920 GAGVGAGGASGAATSSSTSAAERRPSWRLKFDAGSKFKLEDITSGGTYPPNNSTIIPSAPAVMAA 984
            |.|..|             |.|.|                                         
Human   616 GPGPQA-------------AREHR----------------------------------------- 626

  Fly   985 ANLSTTTGVQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYVTPSARKFETNATSTGATT 1049
                                        .||:....|:||..    ..|:.|..|::....|   
Human   627 ----------------------------KVGKEWRGPAEGEE----AEPADRSQESSTLEGG--- 656

  Fly  1050 AATTTSNSTSNSVSATSANHTTATAPNATSNHDDKDNDKENDNRTQTVIQRRRKPKRRSTGVVHI 1114
                                     |:|                      ||::.:|        
Human   657 -------------------------PSA----------------------RRQRWQR-------- 666

  Fly  1115 DMDELDPERQNESSNNDNEEKEKESGSERTSRSRLGSTASTATTSESKSSSSNDKTENGDGIDYK 1179
               :|:||.:.||                                           |..|| .::
Human   667 ---DLNPEPEPES-------------------------------------------EEPDG-GFR 684

  Fly  1180 ALWEAEKLENDKLRQMLKQKDDEAVQTRATL-------ERFANATTKNSLSELEKRERRAMERKL 1237
            .|:...:.||::||:.|.:......|.:..|       ||||.   :.:|.|||:.||||:|||.
Human   685 TLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAE---RPALLELERFERRALERKA 746

  Fly  1238 SELEEELKQLDAYKSDNHRLKEENAALIRVISKLSK 1273
            :|||||||.|...::||.|||:||||||||||||||
Human   747 AELEEELKALSDLRADNQRLKDENAALIRVISKLSK 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MbsNP_001246786.1 ANK 50..164 CDD:238125 68/130 (52%)
Ank_2 53..142 CDD:289560 52/105 (50%)
ANK repeat 78..109 CDD:293786 20/30 (67%)
ANK 106..290 CDD:238125 89/183 (49%)
ANK repeat 111..142 CDD:293786 20/30 (67%)
ANK repeat 209..239 CDD:293786 16/29 (55%)
Ank_2 213..300 CDD:289560 41/107 (38%)
ANK repeat 241..272 CDD:293786 16/30 (53%)
PRKG1_interact 1177..1272 CDD:292521 47/101 (47%)
PPP1R12CNP_060077.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43 9/27 (33%)
ANK 95..279 CDD:238125 99/187 (53%)
ANK repeat 100..131 CDD:293786 20/30 (67%)
ANK 1. /evidence=ECO:0000255 100..129 19/28 (68%)
Ank_2 105..257 CDD:289560 82/155 (53%)
ANK repeat 133..164 CDD:293786 20/30 (67%)
ANK 2. /evidence=ECO:0000255 133..162 18/28 (64%)
ANK repeat 226..257 CDD:293786 17/30 (57%)
ANK 3. /evidence=ECO:0000255 226..255 17/28 (61%)
Ank_5 246..300 CDD:290568 23/53 (43%)
ANK 4. /evidence=ECO:0000255 259..288 15/28 (54%)
ANK repeat 259..283 CDD:293786 14/23 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..686 128/930 (14%)
FAM196 <424..>624 CDD:291917 82/575 (14%)
PRKG1_interact 683..781 CDD:292521 47/100 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 98 1.000 Domainoid score I7171
eggNOG 1 0.900 - - E2759_KOG0505
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D225308at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24179
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
76.880

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