Protein Alignment Mbs and Ppp1r12b

DIOPT Version :10

• Sequence 1: NP_001246786.1
• Gene: Mbs / 49070
• FlyBaseID: FBgn0005536
• Length: 1273
• Species: Drosophila melanogaster
• Sequence 2: XP_006529770.1
• Gene: Ppp1r12b / 329251
• MGIID: 1916417
• Length: 1053
• Species: Mus musculus
• Alignment Length: 1318
• Identity: 382/1318 - (28%)
• Similarity: 563/1318 - (42%)
• Gaps: 336/1318 - (25%)

  Fly     7 RNNSAMMKRAEQLKRWEESDTNRAAPTPRHEHGR---------RIKFSSGCVFLAACLSGDKDEV 62
            |..||..:|||||:||..|.|.: .|..|...||         |::|..|.||||||.|||.|||
Mouse    11 RAESARARRAEQLRRWRGSLTEQ-EPAERQGAGRQLQTRRGSPRVRFEDGAVFLAACSSGDTDEV 74

  Fly    63 VQLLDQGADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSI 127
            .:||.:||||||.||||||||||||||:|||||:||||..|::|:|||||||||||.||||:::|
Mouse    75 KKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNI 139

  Fly   128 ARYLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKK 192
            |.|.:.:||.|..|||:|::..|||   :..||.|.:.:.|::..::::::||.||..||.||::
Mouse   140 AEYFISHGASVGIVNSEGEVPSDLA---EEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQ 201

  Fly   193 WLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRET 257
            ||.|...| |....::|||||||||||||::||.||:.....::.||:|||||||||:|||.:|.
Mouse   202 WLNSGRIE-DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDHDGWTPLHAAAHWGVKEA 265

  Fly   258 AEMLVESLADMDIRNYAGQSCIDVADRKIVKFLEELRANKRNKRRPSSQIRISDAMENHVEKTPT 322
            ..:|.|:|.||||||..||:..||||..:|:.||.|:..:             |.:.:..| |..
Mouse   266 CSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEMLQKKQ-------------DVLRSEKE-TRN 316

  Fly   323 KLVRVEVRTDATKDAENVKPNQQIHAVEHPVEEEAPWRRKLPRTPSDSPTNNQVPDRELGTNSS- 386
            ||:..::             |.:..:.....:|:..:..::|::......|     :|..::||
Mouse   317 KLIESDL-------------NSKFQSGLFKNKEKMLYEEEIPKSQDTEEEN-----KESSSSSSE 363

  Fly   387 -ETANDVILRRTQSFENDQKFYQKYNELRARIKANSCPILPANANANAAAANKSNNNNNLSSNNY 450
             |...|.:.......|.|:|.....|...:.||:.....:||.|            .|..|:
Mouse   364 EEEGEDEVSESETEKEADKKPEATVNHSNSEIKSRIMEQIPAPA------------QNTFSA--- 413

  Fly   451 HNNNNNNNKSDLLLGYAAGTTTTTSTPTTTTTTTSSTFNNTHSNTNNTSTTQQQPAAAAAASAAN 515
                                        ::....||.||......:.:.::.:  .......:.|
Mouse   414 ----------------------------SSARRLSSLFNKAEEPKDESPSSWR--LGLRKTGSHN 448

  Fly   516 QLYSVQRS-ASLKD-NSMYYRKPTVTIATSTAATAINSPSTTVQTPPIRSQVTAKIAEKSNNGSS 578
            .|..|..| .:|:| .|..||..:                    :|.|.:.:..|..|:.|
Mouse   449 MLSEVANSREALRDRGSSIYRSSS--------------------SPRISALLDDKDKEREN---- 489

  Fly   579 STASVSDAESSKPPPKQSASNMIKNFFKSFVP----PVRDEESETQRKAHAKRVRETRRSTQGVT 639
                                   |::|...||    ...|.|.:..|::....||....:.| :.
Mouse   490 -----------------------KSYFSMLVPRRLSSTSDIEEKENRESAVNLVRSGSHTRQ-LW 530

  Fly   640 LDEIKSAEELVKKKNMGMANNNNNNNISTTTTNTISNSGNETSSASSTSAPTPSILGSNEQQDEL 704
            .||.|.:|                 ...|...:|.:::..:::|...:|.||...:.:|....
Mouse   531 RDEAKGSE-----------------TPQTIAPSTYTSTYLKSASFGKSSDPTSPYISANRNSS-- 576

  Fly   705 QPPPPPTTPPPAVIPTTTTATDETEIEEVVSSPPAGQSQNDTTASFTLSAPVRRSLSTEGEADAN 769
                |.|:|     .|..::|......:..||.||..|.|       ..||
Mouse   577 ----PATSP-----ITIGSSTSRGSQWQPASSCPAPVSTN-------TPAP-------------- 611

  Fly   770 SDPEGDQDQTVVSASYTIMPRRERLPESSENVESIRSPQKTEPVAKSSSEDKSEEPPHARPTDLP 834
                                           |:.:|:|.|::  |.|::|..::....:.|  |.
Mouse   612 -------------------------------VQHVRTPYKSQ--ADSTAEKTADSVSSSTP--LC 641

  Fly   835 LIPAPAAPST-----EAIKSSSAATTPAALESPVRLRDKRGLSGSQESETKSDTASPVSSHPDFN 894
            :|....||||     .|...|||.|.|:     |..|:||   .|..:..:.:.|..:.......
Mouse   642 VITNRPAPSTANGVPAATVFSSAGTDPS-----VEAREKR---RSYLTPVRDEEAESLRKARSRQ 698

  Fly   895 ARDSLLSLYARRTTDSSAGGGGVGGGAGVGAGGASGAATSSSTSAAER----RPSWRLKFDAGSK 955
            ||.:      ||:|.            ||.......|..:.|.|.|||    :|..:|:...|
Mouse   699 ARQT------RRSTQ------------GVTLTDLQEAEKTFSRSRAERQAQEQPGEKLEDPGG-- 743

  Fly   956 FKLEDITSGGTYPPNNSTIIPSAPAVMAAANLSTTTGVQRRISSGPIALNASNQSLNSVGRPVSA 1020
              ||    |.|....     |||.....|       |..|.:...||.            ..:..
Mouse   744 --LE----GSTKKQE-----PSAAPTKGA-------GEGRSLEEEPIY------------HRLRY 778

  Fly  1021 PSEGTNNSAYVTPSARKFETNATSTGATTAATTTSNSTSNSVSATSANHTTATAPNATSNHDDKD 1085
            |::....:..|:|||.:   .:..||:....|:.::...:..|.|| .|.||.....||...:.|
Mouse   779 PTQPDKPTTPVSPSASR---PSLYTGSHLLRTSRASGPDSENSETS-THATAAKEMDTSEKGEAD 839

  Fly  1086 NDKENDNRTQTVIQRRRKPKRRSTGVVHIDMDELDPERQNESSNNDNEEKEKESGSERTSRSRLG 1150
            .|.::.||.....:||.|.:||.||:.....||         ...|..|:.||:..||.||...|
Mouse   840 LDDQSSNRLSVRERRRAKDRRRGTGINFWTNDE---------DETDVSEEVKEALHERLSRLESG 895

  Fly  1151 STASTATTS--------------ESKSSSSNDKTENGDGIDYKALWEAEKLENDKLRQMLKQKDD 1201
            .|..|::.|              |::.:|...:.|.....|||.|:|:...||.||:..|::...
Mouse   896 GTNPTSSDSYSDRASARARREAREARLASLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQL 960

  Fly  1202 EAVQTRATLERFA-----NATTKNSLSELEKRERRAMERKLSELEEE------LKQLDAYKSDNH 1255
            |....:|.||:.|     ..:.::|:.|:|||||||:|||:||:|||      |||:...|..|.
Mouse   961 ELADIKAKLEKMAQQKQEKTSDRSSVLEVEKRERRALERKMSEMEEEMKNLHQLKQIQTLKQMNE 1025

  Fly  1256 RLKEENAALIRVISKLSK 1273
            :|:.||.||.||:::|||
Mouse  1026 QLQAENRALTRVVARLSK 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANKYR	50..300	CDD:440430	140/249 (56%)
		ANK repeat	78..109	CDD:293786	23/30 (77%)
		ANK repeat	111..142	CDD:293786	18/30 (60%)
		ANK repeat	209..239	CDD:293786	17/29 (59%)
		ANK repeat	241..272	CDD:293786	20/30 (67%)
		IPD_PPP1R12	606..648	CDD:412018	11/45 (24%)
		PRKG1_interact	1177..1273	CDD:464927	45/106 (42%)
Ppp1r12b	XP_006529770.1	ANKYR	<62..290	CDD:440430	133/231 (58%)
		ANK repeat	90..121	CDD:293786	23/30 (77%)
		ANK repeat	123..154	CDD:293786	18/30 (60%)
		ANK repeat	156..247	CDD:293786	38/94 (40%)
		PLN03192	<169..>257	CDD:215625	42/88 (48%)
		ANK repeat	249..280	CDD:293786	20/30 (67%)
		DUF5585	542..>810	CDD:465521	82/395 (21%)
		IPD_MYPT1	669..724	CDD:412019	15/80 (19%)
		PRKG1_interact	936..1043	CDD:464927	45/106 (42%)