DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mbs and Ppp1r12b

DIOPT Version :9

Sequence 1:	NP_001246786.1	Gene:	Mbs / 49070	FlyBaseID:	FBgn0005536	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	XP_006529770.1	Gene:	Ppp1r12b / 329251	MGIID:	1916417	Length:	1053	Species:	Mus musculus

Alignment Length:	1318	Identity:	382/1318 - (28%)
Similarity:	563/1318 - (42%)	Gaps:	336/1318 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RNNSAMMKRAEQLKRWEESDTNRAAPTPRHEHGR---------RIKFSSGCVFLAACLSGDKDEV 62
            |..||..:|||||:||..|.|.: .|..|...||         |::|..|.||||||.|||.|||
Mouse    11 RAESARARRAEQLRRWRGSLTEQ-EPAERQGAGRQLQTRRGSPRVRFEDGAVFLAACSSGDTDEV 74

  Fly    63 VQLLDQGADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSI 127
            .:||.:||||||.||||||||||||||:|||||:||||..|::|:|||||||||||.||||:::|
Mouse    75 KKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNI 139

  Fly   128 ARYLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKK 192
            |.|.:.:||.|..|||:|::..|||   :..||.|.:.:.|::..::::::||.||..||.||::
Mouse   140 AEYFISHGASVGIVNSEGEVPSDLA---EEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQ 201

  Fly   193 WLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRET 257
            ||.|...| |....::|||||||||||||::||.||:.....::.||:|||||||||:|||.:|.
Mouse   202 WLNSGRIE-DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDHDGWTPLHAAAHWGVKEA 265

  Fly   258 AEMLVESLADMDIRNYAGQSCIDVADRKIVKFLEELRANKRNKRRPSSQIRISDAMENHVEKTPT 322
            ..:|.|:|.||||||..||:..||||..:|:.||.|:..:             |.:.:..| |..
Mouse   266 CSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEMLQKKQ-------------DVLRSEKE-TRN 316

  Fly   323 KLVRVEVRTDATKDAENVKPNQQIHAVEHPVEEEAPWRRKLPRTPSDSPTNNQVPDRELGTNSS- 386
            ||:..::             |.:..:.....:|:..:..::|::......|     :|..::||
Mouse   317 KLIESDL-------------NSKFQSGLFKNKEKMLYEEEIPKSQDTEEEN-----KESSSSSSE 363

  Fly   387 -ETANDVILRRTQSFENDQKFYQKYNELRARIKANSCPILPANANANAAAANKSNNNNNLSSNNY 450
             |...|.:.......|.|:|.....|...:.||:.....:||.|            .|..|:
Mouse   364 EEEGEDEVSESETEKEADKKPEATVNHSNSEIKSRIMEQIPAPA------------QNTFSA--- 413

  Fly   451 HNNNNNNNKSDLLLGYAAGTTTTTSTPTTTTTTTSSTFNNTHSNTNNTSTTQQQPAAAAAASAAN 515
                                        ::....||.||......:.:.::.:  .......:.|
Mouse   414 ----------------------------SSARRLSSLFNKAEEPKDESPSSWR--LGLRKTGSHN 448

  Fly   516 QLYSVQRS-ASLKD-NSMYYRKPTVTIATSTAATAINSPSTTVQTPPIRSQVTAKIAEKSNNGSS 578
            .|..|..| .:|:| .|..||..:                    :|.|.:.:..|..|:.|
Mouse   449 MLSEVANSREALRDRGSSIYRSSS--------------------SPRISALLDDKDKEREN---- 489

  Fly   579 STASVSDAESSKPPPKQSASNMIKNFFKSFVP----PVRDEESETQRKAHAKRVRETRRSTQGVT 639
                                   |::|...||    ...|.|.:..|::....||....:.| :.
Mouse   490 -----------------------KSYFSMLVPRRLSSTSDIEEKENRESAVNLVRSGSHTRQ-LW 530

  Fly   640 LDEIKSAEELVKKKNMGMANNNNNNNISTTTTNTISNSGNETSSASSTSAPTPSILGSNEQQDEL 704
            .||.|.:|                 ...|...:|.:::..:::|...:|.||...:.:|....
Mouse   531 RDEAKGSE-----------------TPQTIAPSTYTSTYLKSASFGKSSDPTSPYISANRNSS-- 576

  Fly   705 QPPPPPTTPPPAVIPTTTTATDETEIEEVVSSPPAGQSQNDTTASFTLSAPVRRSLSTEGEADAN 769
                |.|:|     .|..::|......:..||.||..|.|       ..||
Mouse   577 ----PATSP-----ITIGSSTSRGSQWQPASSCPAPVSTN-------TPAP-------------- 611

  Fly   770 SDPEGDQDQTVVSASYTIMPRRERLPESSENVESIRSPQKTEPVAKSSSEDKSEEPPHARPTDLP 834
                                           |:.:|:|.|::  |.|::|..::....:.|  |.
Mouse   612 -------------------------------VQHVRTPYKSQ--ADSTAEKTADSVSSSTP--LC 641

  Fly   835 LIPAPAAPST-----EAIKSSSAATTPAALESPVRLRDKRGLSGSQESETKSDTASPVSSHPDFN 894
            :|....||||     .|...|||.|.|:     |..|:||   .|..:..:.:.|..:.......
Mouse   642 VITNRPAPSTANGVPAATVFSSAGTDPS-----VEAREKR---RSYLTPVRDEEAESLRKARSRQ 698

  Fly   895 ARDSLLSLYARRTTDSSAGGGGVGGGAGVGAGGASGAATSSSTSAAER----RPSWRLKFDAGSK 955
            ||.:      ||:|.            ||.......|..:.|.|.|||    :|..:|:...|
Mouse   699 ARQT------RRSTQ------------GVTLTDLQEAEKTFSRSRAERQAQEQPGEKLEDPGG-- 743

  Fly   956 FKLEDITSGGTYPPNNSTIIPSAPAVMAAANLSTTTGVQRRISSGPIALNASNQSLNSVGRPVSA 1020
              ||    |.|....     |||.....|       |..|.:...||.            ..:..
Mouse   744 --LE----GSTKKQE-----PSAAPTKGA-------GEGRSLEEEPIY------------HRLRY 778

  Fly  1021 PSEGTNNSAYVTPSARKFETNATSTGATTAATTTSNSTSNSVSATSANHTTATAPNATSNHDDKD 1085
            |::....:..|:|||.:   .:..||:....|:.::...:..|.|| .|.||.....||...:.|
Mouse   779 PTQPDKPTTPVSPSASR---PSLYTGSHLLRTSRASGPDSENSETS-THATAAKEMDTSEKGEAD 839

  Fly  1086 NDKENDNRTQTVIQRRRKPKRRSTGVVHIDMDELDPERQNESSNNDNEEKEKESGSERTSRSRLG 1150
            .|.::.||.....:||.|.:||.||:.....||         ...|..|:.||:..||.||...|
Mouse   840 LDDQSSNRLSVRERRRAKDRRRGTGINFWTNDE---------DETDVSEEVKEALHERLSRLESG 895

  Fly  1151 STASTATTS--------------ESKSSSSNDKTENGDGIDYKALWEAEKLENDKLRQMLKQKDD 1201
            .|..|::.|              |::.:|...:.|.....|||.|:|:...||.||:..|::...
Mouse   896 GTNPTSSDSYSDRASARARREAREARLASLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQL 960

  Fly  1202 EAVQTRATLERFA-----NATTKNSLSELEKRERRAMERKLSELEEE------LKQLDAYKSDNH 1255
            |....:|.||:.|     ..:.::|:.|:|||||||:|||:||:|||      |||:...|..|.
Mouse   961 ELADIKAKLEKMAQQKQEKTSDRSSVLEVEKRERRALERKMSEMEEEMKNLHQLKQIQTLKQMNE 1025

  Fly  1256 RLKEENAALIRVISKLSK 1273
            :|:.||.||.||:::|||
Mouse  1026 QLQAENRALTRVVARLSK 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANK	50..164	CDD:238125	75/113 (66%)
		Ank_2	53..142	CDD:289560	62/88 (70%)
		ANK repeat	78..109	CDD:293786	23/30 (77%)
		ANK	106..290	CDD:238125	94/183 (51%)
		ANK repeat	111..142	CDD:293786	18/30 (60%)
		ANK repeat	209..239	CDD:293786	17/29 (59%)
		Ank_2	213..300	CDD:289560	47/86 (55%)
		ANK repeat	241..272	CDD:293786	20/30 (67%)
		PRKG1_interact	1177..1272	CDD:292521	44/105 (42%)
Ppp1r12b	XP_006529770.1	PHA03095	61..>290	CDD:222980	134/232 (58%)
		Ank_2	65..154	CDD:372319	62/88 (70%)
		ANK repeat	90..121	CDD:293786	23/30 (77%)
		ANK repeat	123..154	CDD:293786	18/30 (60%)
		ANK repeat	156..247	CDD:293786	38/94 (40%)
		ANK repeat	249..280	CDD:293786	20/30 (67%)
		Hamartin	<530..849	CDD:367919	98/464 (21%)
		DUF5585	535..>672	CDD:375359	43/225 (19%)
		PRKG1_interact	936..1042	CDD:374206	44/105 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833368
Domainoid	1	1.000	99	1.000	Domainoid score	I7062
eggNOG	1	0.900	-	-		E2759_KOG0505
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2194
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D225308at33208
OrthoFinder	1	1.000	-	-		FOG0002673
OrthoInspector	1	1.000	-	-		otm43183
orthoMCL	1	0.900	-	-		OOG6_105882
Panther	1	1.100	-	-	O	PTHR24179
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4930
SonicParanoid	1	1.000	-	-		X2914
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790