DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mbs and Ppp1r12b

DIOPT Version :9

Sequence 1:	NP_001246786.1	Gene:	Mbs / 49070	FlyBaseID:	FBgn0005536	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_001100648.1	Gene:	Ppp1r12b / 304813	RGDID:	1309287	Length:	993	Species:	Rattus norvegicus

Alignment Length:	1346	Identity:	371/1346 - (27%)
Similarity:	543/1346 - (40%)	Gaps:	452/1346 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RNNSAMMKRAEQLKRWEESDTNRAAPTPRHEHGR---------RIKFSSGCVFLAACLSGDKDEV 62
            |..||..:|||||:||..|.|.: .|..|...||         |::|..|.||||||.|||.|||
  Rat    11 RAESARARRAEQLRRWRGSLTEQ-EPAERQGAGRQLQTRRGSPRVRFEDGAVFLAACSSGDTDEV 74

  Fly    63 VQLLDQGADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSI 127
            .:||.:||||||.||||||||||||||:|||||:||||..|:||:|||||||||||.||||:::|
  Rat    75 KKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANINQQDNEGWTPLHAAASCGYLNI 139

  Fly   128 ARYLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKK 192
            |.|.:.:||.|..|||:|::..|||   :..||.|.:.:.|::..::::::||.||..||.||::
  Rat   140 AEYFISHGASVGIVNSEGEVPSDLA---EEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQ 201

  Fly   193 WLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRET 257
            ||.|...| |....::|||||||||||||::||.||:.....::.||:|||||||||:|||.:|.
  Rat   202 WLNSGKIE-DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDHDGWTPLHAAAHWGVKEA 265

  Fly   258 AEMLVESLADMDIRNYAGQSCIDVADRKIVKFLEELRANKRNKRRPSSQIRISDAMENHVEKTPT 322
            ..:|.|:|.||||||..||:..||||..:|:.||.|:..:             |.:.:..| |..
  Rat   266 CSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEMLQKKQ-------------DVLRSEKE-TRN 316

  Fly   323 KLVRVEVRTDATKDAENVKPNQQIHAVEHPVEEEAPWRRKLPRTPSDSPTNNQVPDRELGTNSS- 386
            ||:..::             |.:..:.....:|:..:..::|::......|     :|..::||
  Rat   317 KLIESDL-------------NSKFQSGLFKNKEKMLYEEEIPKSQETEEEN-----KESSSSSSE 363

  Fly   387 -ETANDVILRRTQSFENDQKFYQKYNELRARIKANSCPILPANANANAAAA---------NKSNN 441
             |...|.:.......|.|:|.....|...:..|:.....:|..|....:|:         ||:..
  Rat   364 EEEGEDEVSESETEKEADKKPEVTVNHSNSESKSRIVEQIPTPAQNTFSASSARRLSGLFNKAEE 428

  Fly   442 NNNLSSNNY---------HNN-NNNNNKSDLLLGYAAGTTTTTSTPTTTT---TTTSSTFNNTHS 493
            ..:.|.:::         ||. :...|..:.|....:....::|:|..:|   .......|.::.
  Rat   429 PKDESPSSWRLGLRKTGSHNMLSEVTNPREALRDRGSSIYRSSSSPRISTLLDDKDKERENRSYF 493

  Fly   494 NT------NNTSTTQQQPAAAAAASAANQLYSVQRSASL-KDNSMYYRKPTVTIATSTAATAINS 551
            :|      :.||..:::   ....||.|.:.|...:..| :|.:.....|. |:|.||..
  Rat   494 STLVPRRLSGTSDIEEK---ENRESAVNLVRSGSHTRQLWRDEAKGNETPQ-TVAPSTYT----- 549

  Fly   552 PSTTVQTPPIRSQVTAKIAEKSNNGSS-------------STASVSDAESSKPPPKQSASNMIKN 603
             ||.::..|.:||..: .||::::|||             |||:...|.:....|...||...:.
  Rat   550 -STYLKRTPYKSQADS-TAERTDSGSSSTPLCVITNRPAPSTANGVPAATVLSSPAADASVEPRE 612

  Fly   604 FFKSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEELVKKKNMGMANNNNNNNIST 668
            ..:|::.||||||:|:.|||.:::.|:||||||||||.:::.||:
  Rat   613 QRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAEK-------------------- 657

  Fly   669 TTTNTISNSGNETSSASSTSAPTPSILGSNEQQDELQPPPPPTTPPPAVIPTTTTATDETEIEEV 733
                |.|.|                   ..|:|.:.||
  Rat   658 ----TFSRS-------------------RAERQAQEQP--------------------------- 672

  Fly   734 VSSPPAGQSQNDTTASFTLSAPVRRSLSTEGEADANSDPEGDQDQTVVSASYTIMPRRERLPESS 798
                                                                     .|:|.:|.
  Rat   673 ---------------------------------------------------------GEKLEDSG 680

  Fly   799 ENVESIRSPQKTEPVAKSSSEDKSEEPPHARPTD-LPLIPAPAAPSTEAIKSSSAATTPAALESP 862
            | :|.  |.:|.||.|..:.|....:.|..|..| .|:......|           |.|..|.:|
  Rat   681 E-LEG--STKKQEPSAAPTKEAGEGQQPWGRSLDEEPIYHRLRCP-----------TQPDKLTAP 731

  Fly   863 VRLRDKRGLSGSQESETKSDTASPVSSHPDFNARDSLLSLYARRTTDSSAGGGGVGGGAGVGAGG 927
            |                     ||.:|.|         |||
  Rat   732 V---------------------SPSASRP---------SLY------------------------ 742

  Fly   928 ASGAATSSSTSAAERRPSWRLKFDAGSKFKLEDITSGGTYPPNNSTIIPSAPAVMAAANLSTTTG 992
                                                                           ||
  Rat   743 ---------------------------------------------------------------TG 744

  Fly   993 VQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYVTPSARKFETNATSTGATTAATTTSNS 1057
            .|        .|:.|..|       |..|...||
  Rat   745 SQ--------LLHTSRAS-------VPDPEATTN------------------------------- 763

  Fly  1058 TSNSVSATSANHTTATAPNATSNHDDKDNDKENDNRTQTVIQRRRKPKRRSTGVVHIDMDELDPE 1122
                        |||.....||..::.|.|.::.||.....:||.:.:||.||:.....||
  Rat   764 ------------TTAAKEMDTSEKEEADLDDQSSNRLSVRERRRLRDRRRGTGINFWTKDE---- 812

  Fly  1123 RQNESSNNDNEEKEKESGSERTSRSRLGSTASTATTS--------------ESKSSSSNDKTENG 1173
                 ...|..|:.||:..||.||...|.:..|::.|              |::.:|...:.|..
  Rat   813 -----DETDVSEEVKEAWHERLSRLESGGSNPTSSDSHSDRASARARREAREARLASLTSRVEED 872

  Fly  1174 DGIDYKALWEAEKLENDKLRQMLKQKDDEAVQTRATLERFA-----NATTKNSLSELEKRERRAM 1233
            ...|||.|:|:...||.||:..|::...|....:|.||:.|     ..:.::|:.|:|||||||:
  Rat   873 SSRDYKKLYESALTENQKLKTKLQEAQLELADIKAKLEKMAQQKQEKTSDRSSVLEVEKRERRAL 937

  Fly  1234 ERKLSELEEE------LKQLDAYKSDNHRLKEENAALIRVISKLSK 1273
            |||:||:|||      |||:...|..|.:|:.||.||.||:::||:
  Rat   938 ERKMSEMEEEMKNLHQLKQIQTLKQMNEQLQAENRALTRVVARLSR 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANK	50..164	CDD:238125	76/113 (67%)
		Ank_2	53..142	CDD:289560	63/88 (72%)
		ANK repeat	78..109	CDD:293786	24/30 (80%)
		ANK	106..290	CDD:238125	94/183 (51%)
		ANK repeat	111..142	CDD:293786	18/30 (60%)
		ANK repeat	209..239	CDD:293786	17/29 (59%)
		Ank_2	213..300	CDD:289560	47/86 (55%)
		ANK repeat	241..272	CDD:293786	20/30 (67%)
		PRKG1_interact	1177..1272	CDD:292521	44/105 (42%)
Ppp1r12b	NP_001100648.1	Ank_2	65..154	CDD:289560	63/88 (72%)
		ANK	85..269	CDD:238125	105/187 (56%)
		ANK repeat	90..121	CDD:293786	24/30 (80%)
		ANK repeat	123..154	CDD:293786	18/30 (60%)
		ANK repeat	156..247	CDD:293786	38/94 (40%)
		Ank_4	219..269	CDD:290365	30/49 (61%)
		ANK repeat	249..280	CDD:293786	20/30 (67%)
		Ank_4	250..302	CDD:290365	30/51 (59%)
		PRKG1_interact	876..982	CDD:292521	44/105 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336924
Domainoid	1	1.000	92	1.000	Domainoid score	I7413
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2095
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D225308at33208
OrthoFinder	1	1.000	-	-		FOG0002673
OrthoInspector	1	1.000	-	-		otm45253
orthoMCL	1	0.900	-	-		OOG6_105882
Panther	1	1.100	-	-	O	PTHR24179
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2914
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900