DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mbs and mel-11

DIOPT Version :9

Sequence 1:	NP_001246786.1	Gene:	Mbs / 49070	FlyBaseID:	FBgn0005536	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_001021928.1	Gene:	mel-11 / 174484	WormBaseID:	WBGene00003196	Length:	1124	Species:	Caenorhabditis elegans

Alignment Length:	1391	Identity:	342/1391 - (24%)
Similarity:	555/1391 - (39%)	Gaps:	424/1391 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KRAEQLKRWEESDTNRAAPTPRHEHGRRIKFSSGCVFLAACLSGDKDEVVQLLDQGADINTANVD 78
            ||.:||:||:.|:.|  |...|.....:::|....:||:||:|||::||.:||::||:|||..||
Worm    25 KRKDQLRRWQSSEMN--AEAARRTKRPKVQFQDSDIFLSACMSGDEEEVEELLNKGANINTCTVD 87

  Fly    79 GLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSIARYLVENGADVAAVNS 143
            |||||||:.||...:||.||.|:|||:|.|||||||||||.|.||.|:|.|||.::|||::.|||
Worm    88 GLTALHQSVIDSKPEMVRFLCEKGADVNAQDNEGWTPLHAAACCGNVAIVRYLCQHGADLSIVNS 152

  Fly   144 DGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKKWLRSDAAEVDRPHPKT 208
            |.:||||||:|.|   ..||::...:...|::|..|..|...||.|...|: |.....|.||.:|
Worm   153 DKELALDLAVDEQ---CRDYLDDDYKRQMIDLDACRDQELQTMLKDVNMWM-SQGEYRDIPHHRT 213

  Fly   209 GATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRETAEMLVESLADMDIRNY 273
            |.||:||||.:|||::|.||:...|||..||.:||||||||:||.:|:..::|:|:.|::....:
Worm   214 GGTAMHVAAGRGYTQLLELLIKAGGNVRAQDVEGWTPLHAAAHWAERDACKILLENGAELSDLTF 278

  Fly   274 AGQSCIDVADRKIVKFLEELRANKRNKRRPSSQIRISDAMENHVEKTPTKLVRVEVRTDATKDAE 338
            .|...:.|||::.:.:|.||                                           |:
Worm   279 TGADVLGVADKECIDYLVEL-------------------------------------------AD 300

  Fly   339 NVKPNQQIHAVEHPVEEEAPWRRKLPRTPSDSPT------NNQVPDRELGTNSSETANDVILRRT 397
            .||...               :||.|.:.|..||      |:::|..|....:||...| :..:.
Worm   301 TVKVQN---------------KRKSPGSGSQPPTSILQEKNHRMPSHEEHVLTSERKRD-LQHKD 349

  Fly   398 QSFENDQKFYQKYNELRARIKANSCPILPANANANAAAANKSNNNNNLSSNNYHNNNNNNNKSDL 462
            |..||:  |...:               |:.|
Worm   350 QHSENE--FLHSH---------------PSTA--------------------------------- 364

  Fly   463 LLGYAAGTTTTTSTPTTTTTTTSSTFNNTHSNTNNTSTTQQQPAAAAAASAANQLYSVQRSASLK 527
                :.|:||:::|.|||||..        ...|:.|..|:....::..||.
Worm   365 ----SVGSTTSSNTNTTTTTIV--------IGENDISAAQKDSRESSKESAV------------- 404

  Fly   528 DNSMYYRKPTVTIATSTAATAINSPSTTVQTPPIRSQVTAKIAEKSNNGSSSTASVSDAESSKPP 592
            |:..|                                    :||.....:.......|.|..:
Worm   405 DDEEY------------------------------------VAEDEMEEAEEDEEEEDVEEEE-- 431

  Fly   593 PKQSASNMIKNFFKSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEELVKKKNMGM 657
             ::.:...:||  ...:.|:|.|.:       :.|.....||..|.| |...|..|...:.:..
Worm   432 -EEKSEAELKN--GKEISPLRSETT-------SSRSISITRSLDGYT-DRSSSGRETSAEMSEA- 484

  Fly   658 ANNNNNNNISTTTTNTISNSGNETSSASSTSAPTP-------SILGSNEQQDELQPPPPPTTPPP 715
            |::.:....|:::..|.|...::.|:|.|....||       |.:||.:|......|..|.:.||
Worm   485 ASSASTGTTSSSSRFTSSTPSSQRSAAGSVHTETPRSSMENSSSVGSGDQNVSATIPIVPLSAPP 549

  Fly   716 AVI-------------------PTTTTATDETEIEEVVSSPPAGQSQ-------NDTTASFTL-- 752
            ..:                   .::.|.:..|.:.|::|.|.:..||       |.||.:.|:
Worm   550 KAVHQSPSSWINRGVPLSSRSSTSSVTRSSSTPVSEIISPPSSIHSQLSFPSVSNTTTTTATVAP 614

  Fly   753 ------SAPVRRSLSTEGEADANSDPEGDQDQTVVSASYTIMPRRERLPESSENVESIRSPQKTE 811
                  |.||...::....:.|.:.|......|.::|::                        ::
Worm   615 TSSTVPSTPVSNVMAATISSTAKNTPSPAGSVTTINATF------------------------SK 655

  Fly   812 PVAKSSSEDKSEEPPHARPTDLP---LIPAPAAPSTEAIKS----------SSAATTP--AALES 861
            |.::..||:....|  ::||::|   |.......||..|:|          ||.::.|  :|..|
Worm   656 PSSRHPSEEVYRSP--SQPTNVPWASLWHNVNNASTGQIRSHIEQLRNASFSSLSSYPRVSAFRS 718

  Fly   862 PVRLRDKRGLSGSQESETKSDTASPVSSHPDFNARDSLLSLYARRTTDSSAGGGGVGGGAGVGAG 926
            |::.        :..|.:.:..:||:...|  :....:::.|.|...........:
Worm   719 PIKT--------TASSTSVNSASSPLLLQP--HPHPPVIAEYPRGFVPQQINPNKM--------- 764

  Fly   927 GASGAATSSSTSAAERRPSWRL--------------KFDAGSKFKLEDITSGGTYPPNNSTIIPS 977
             :...:.:.:.|.||||.:.|:              :.:..|||..:::..      .||.::.:
Worm   765 -SRWQSKTVTESEAERRNNSRMQRQHRRSTQGVTKEQLEEASKFATDEVAR------RNSQVLST 822

  Fly   978 APAVMAA------ANLSTTTGVQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYVTPSAR 1036
            .|..:.|      .:||:|:.   .:..|.::..|:...:||       |:   :|||.|...::
Worm   823 YPNSLHARLASEEKDLSSTSD---DLKDGDVSTTATVSLINS-------PN---SNSANVRRKSQ 874

  Fly  1037 KFETNATSTGAT--------TAATTTSNSTSNSVSATSANHTTATAPNATSNHDDKDNDKENDNR 1093
            ....:.::..||        ..|.:...:|:...|..|......|.|..||...:|
Worm   875 GLSISRSNRRATGPVNPEDLAPAMSLRLATAQPYSPASVRSNAGTLPTMTSRFSEK--------- 930

  Fly  1094 TQTVIQRRRKPKRRSTGVVHIDMDELDPERQNESSNNDNEEKE------KESGSERTSRSRLGST 1152
                                  ...|.|.....||......:.      ..:.|.||: :.|.||
Worm   931 ----------------------AQSLPPASNGMSSTQPLSTRSAIVAGLSSAPSMRTT-APLSST 972

  Fly  1153 ASTATTSESKSSSSNDKTENGD--------------GIDYKALWEAEKLENDKLRQMLKQKDDEA 1203
            |:::....|.|.|||..:.|..              .::||||:|.|:.|.::||     ::.|.
Worm   973 ATSSRFMPSSSLSSNGSSANQQPSSIYGLQSRPTETNLNYKALFEKERSECERLR-----REMEE 1032

  Fly  1204 VQTRATLERFANATTK----------------------NSLSELEKRERRAMERKLSELEEELKQ 1246
            ::...|.:.:..|:|:                      .||:..::.|||:||||:|:||.:||.
Worm  1033 MRRSQTADSYRGASTQLAWRARNASPSAQPHNLSVAKSTSLASFDENERRSMERKISDLELQLKT 1097

  Fly  1247 LDAYKSDNHRLKEENAALIRVISKLS 1272
            ....:.:|.||||||.||:|||||::
Worm  1098 ATNLRMENQRLKEENGALVRVISKMT 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANK	50..164	CDD:238125	71/113 (63%)
		Ank_2	53..142	CDD:289560	56/88 (64%)
		ANK repeat	78..109	CDD:293786	19/30 (63%)
		ANK	106..290	CDD:238125	86/183 (47%)
		ANK repeat	111..142	CDD:293786	19/30 (63%)
		ANK repeat	209..239	CDD:293786	16/29 (55%)
		Ank_2	213..300	CDD:289560	36/86 (42%)
		ANK repeat	241..272	CDD:293786	14/30 (47%)
		PRKG1_interact	1177..1272	CDD:292521	41/116 (35%)
mel-11	NP_001021928.1	PHA03095	60..>280	CDD:222980	116/223 (52%)
		Ank_2	62..151	CDD:372319	56/88 (64%)
		ANK repeat	87..118	CDD:293786	19/30 (63%)
		ANK repeat	120..151	CDD:293786	19/30 (63%)
		ANK repeat	153..244	CDD:293786	40/94 (43%)
		ANK repeat	246..271	CDD:293786	13/24 (54%)
		ANK repeat	279..306	CDD:293786	10/69 (14%)
		PRKG1_interact	1011..1123	CDD:374206	41/116 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166951
Domainoid	1	1.000	67	1.000	Domainoid score	I6446
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	298	1.000	Inparanoid score	I1647
Isobase	1	0.950	-	0	Normalized mean entropy	S3412
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002673
OrthoInspector	1	1.000	-	-		oto18609
orthoMCL	1	0.900	-	-		OOG6_105882
Panther	1	1.100	-	-	LDO	PTHR24179
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4930
SonicParanoid	1	1.000	-	-		X2914
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.960