Protein Alignment Mbs and Mbs

DIOPT Version :10

• Sequence 1: NP_001246786.1
• Gene: Mbs / 49070
• FlyBaseID: FBgn0005536
• Length: 1273
• Species: Drosophila melanogaster
• Sequence 2: XP_061505057.1
• Gene: Mbs / 1277253
• VectorBaseID: AGAMI1_011888
• Length: 1766
• Species: Anopheles gambiae
• Alignment Length: 1840
• Identity: 641/1840 - (34%)
• Similarity: 824/1840 - (44%)
• Gaps: 657/1840 - (35%)

  Fly     3 SLDARNNSAMMKRAEQLKRWEESDTN-RAAPTPRHEHGRRIKFSSGCVFLAACLSGDKDEVVQLL 66
            |||.||.||..||||||||||||:.| :.:..|:....|||||||||:|||||::|||:||..||
Mosquito     2 SLDNRNTSAQYKRAEQLKRWEESEMNKKLSGAPKSPSSRRIKFSSGCIFLAACVAGDKEEVEWLL 66

  Fly    67 DQGADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSIARYL 131
            ..||||:||||||||||||||||||||||||||::|||:||:||||||||||||||||:||||||
Mosquito    67 KNGADIDTANVDGLTALHQACIDDNLDMVEFLVQKGADVNRKDNEGWTPLHATASCGFLSIARYL 131

  Fly   132 VENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKKWLRS 196
            :|||||:|::||||:||:|||   ...||.|.::..:.|..|:.:|||:|||..||:||.||||:
Mosquito   132 IENGADLASINSDGELAVDLA---NSDAMEDLIQHHLDEQGIDCEEARQAEERIMLSDATKWLRT 193

  Fly   197 DAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRETAEML 261
            |:.:.|:.||||||||:||||||||..||.|||.|||::||||.|||||||||::|||:|..:||
Mosquito   194 DSPDCDKAHPKTGATAIHVAAAKGYIGVLKLLLEGRGDIDRQDVDGWTPLHAAAYWGQKEATQML 258

  Fly   262 VESLADMDIRNYAGQSCIDVADRKIVKFLEELRAN-KRNKRRPSSQ-IRISDAMENHVEKTPTKL 324
            :.:.||:|::||:||..||:|...||..|::.|.| ||.||||.|. .||:|..||..| ||||:
Mosquito   259 LNASADIDVQNYSGQLAIDIAQDDIVPLLKDARKNGKRTKRRPPSHGNRITDNFENSTE-TPTKV 322

  Fly   325 VRVEVR-TDATKD-----------------AENVK------------------------------ 341
            :||||: .|:.|:                 .|||.
Mosquito   323 IRVEVKPIDSNKEKEAGGSVAVDYGDDDDGGENVAEALPESPQVAGDQEEEEAADEKDEEEDEET 387

  Fly   342 ------------------------------------------------------------PNQQI 346
                                                                        |.||:
Mosquito   388 MDDTVDEALEEEEEVEEEEVEEEEEEEEEDAEEEEEQQEHVSAQASRPGEDVTDSSIGSVPYQQV 452

  Fly   347 -------------HAVEHPVEEE------------------------------------------ 356
                         .:.|...|||
Mosquito   453 LPSPAQINQTKGAESEEEEEEEEEENGSVSSEPYSSSNPSADSSMTESETDELLPRPVPIISRPT 517

  Fly   357 --------------------------------------APWRR------KLPR--------TPSD 369
                                                  |||||      .:||        .|:|
Mosquito   518 PVPLTTQIVAPKPRVTEPPVPSNNAAPAIANNPAAPPTAPWRRARAVPTPVPRHFYEEAQQPPAD 582

  Fly   370 ----------SPTNNQVPDRELGTNSSETANDVILRRTQSFENDQKFYQKYNELRARIKANSCP- 423
                      :...|.|.::|    :..|..|||||||||||:|:||||:|.||||||:|||||
Mosquito   583 DVVDYANLVFTSKRNLVSEKE----NKPTEPDVILRRTQSFESDEKFYQRYAELRARIQANSCPH 643

  Fly   424 -ILPANANANAAAANKSNNNNNLSSNNYHNNNNNNNK---------------------------- 459
             |||:.. .|...:..||||||.|     |||||||.
Mosquito   644 TILPSTP-INTKTSTASNNNNNSS-----NNNNNNNSTTTTTTATTPASNISSYLVQRSASLKDH 702

  Fly   460 -------SDLLLGY-----------AAGTTTT--------------------------------T 474
                   |:|:||.           |:|.||.                                :
Mosquito   703 RTLRKTTSNLVLGSTTTSPSSATGPASGATTNLVPPAATGTGAANNTTGSTTGSSGAVSPPTSPS 767

  Fly   475 STPTTTTT-------------------TTSSTFNNTHSNTNNTSTT----------QQQPAAAAA 510
            .|||||.|                   ||.|  |||.::::.|:||          :.||.....
Mosquito   768 GTPTTTPTAGQIRSSIPTPITLNSHKNTTMS--NNTDNSSSTTTTTPFGDRYRKRYEDQPETVRK 830

  Fly   511 ASAANQLYSVQRSASLKDNSMYYRKPTVTIATSTAATAINSPSTTVQTPP--------------- 560
            .||.|...:...::|           |.|.|...|....:..:.|..|.|
Mosquito   831 PSATNSTVANDHTSS-----------TTTSAPEAADHTAHETTLTPATGPETNKNHSLFELNRKY 884

  Fly   561 IRSQVTAKIAEKSNNGSSS-------------------------------------------TAS 582
            |......||..:.|...||                                           .||
Mosquito   885 IEQAQKTKINNERNKFLSSLNEKRQQQLQEQQQQQEQQQQRRQQPAEQPRGGGRYDGRPGKPEAS 949

  Fly   583 VSDAESSKP-----------------------PP-------------KQSASNMIKNFFKSFVPP 611
            ..:|...:|                       ||             |.|..|:.||||||||||
Mosquito   950 QEEASFEEPAAVKLIMPSYTAAPAPTAVLEQQPPAGTTPVTTSPSSNKLSPGNIFKNFFKSFVPP 1014

  Fly   612 VRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEELVKKKN-MGMANNNNNNNIST-TTTNTI 674
            .|||||||||||||||||||||||||||||||||||:|||||| .|..|.|:....:| |.|.|.
Mosquito  1015 TRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEQLVKKKNATGTGNENDTMAPATATATTTT 1079

  Fly   675 SNSGNETSSASSTSAPT------PSILGSNEQQDELQPPPPPTTPPPAVIPTTT--TATDETEIE 731
            :.:.:..||.|||::|:      |:: ||...|.:.|......|...|....|:  .....|::|
Mosquito  1080 TTTPSSPSSLSSTASPSFTNDRVPAV-GSTGDQQQQQQGSNHVTEASAAHDATSGGVGGGSTKVE 1143

  Fly   732 EVVSSPPAGQSQNDTTASFTLSAPVRRSLSTEGEAD----------------ANSDPEGDQDQTV 780
            |:.           ..|||||:|| ..||...|:..                |..|.| ::|.:.
Mosquito  1144 EIA-----------VAASFTLAAP-GSSLDDGGDGGGGGGGGGGHRRHRRSVAGMDEE-EEDDSK 1195

  Fly   781 VSASYTI-MPRRERLPESSENVESIRSPQK-TEPVAKSSSEDKSEEPPHARPTDLPLIPA----P 839
            |:.|||| .|.|:..|          ||:. ...||.|:|::.::........|:|.:.|    |
Mosquito  1196 VTVSYTISAPVRQSSP----------SPRAVASAVAVSNSKESADPLDGTGAGDVPAVTATFHVP 1250

  Fly   840 AAPSTEAIKSSSAATTPAALESPVRLRDKRGLSGSQESETKSDTASPVSSHPDFNA-----RDSL 899
            ||.|...:.:|:...|.:.....|       :|.|..:.|.:.|.:..|::.:.:|     .::.
Mosquito  1251 AAASEPMVATSATIRTSSGAAGGV-------VSNSDSNTTTTTTTTNTSNNNNTSASSNTNHNTA 1308

  Fly   900 LSLYARR------------------------------------------------TTDSSAGGGG 916
            .:.|.:|                                                ||:|..||||
Mosquito  1309 ATTYTKRSLFDIDNANSLTLAEKLRHEANKYAIAAVADGDLDSHLVARVPASNSGTTNSGGGGGG 1373

  Fly   917 VGGGAGVGA-----GGASGAA--------------TSSSTSAAERRPSWRLKFDAGSKFKLED-- 960
            ........|     ..::|||              |:::...||||||||||.|.||||||||
Mosquito  1374 ESNSTSTNAPADNSAASAGAAVPPSPTLRKAEPATTTTTGVTAERRPSWRLKVDGGSKFKLEDAS 1438

  Fly   961 ----------ITSGGTYPPNNSTIIPSAPAVMAAANLSTTTGV-------QRRI-----SSGPIA 1003
                      :.|||      |...||.||..|..:..|||.:       |||.     .|...|
Mosquito  1439 TPNAATQSSSVASGG------SVYEPSGPANQAPEHGLTTTKLTSSSALAQRRAHQQNGDSSSTA 1497

  Fly  1004 LNASNQSLNSVGRPVSAPSEG-TNNSAY--VTPSARKFETNATSTG--ATTAATTTSNSTSNSVS 1063
            ...:..|..:..||:|||:.| .....|  |..||      ||:.|  .|.||.|..||..:.:
Mosquito  1498 TTGTTSSSVASSRPLSAPASGLAAGEQYNRVPGSA------ATAAGEQQTGAAATDPNSPLHHL- 1555

  Fly  1064 ATSANHTTATAPNATSNHDDKDNDKENDNR-----TQTVIQRRRKPKRRSTGVVHIDMDELDPER 1123
                     ..|..::..::|:||||||:|     ||.||||||:.||||||||.:.|::|||:|
Mosquito  1556 ---------RRPPKSAGEENKENDKENDSRSTAQATQAVIQRRRRQKRRSTGVVSVGMEDLDPDR 1611

  Fly  1124 QNESSNNDNEEKEKESGSERTSRSRLGSTASTATTSESKSSSSNDKTENGDGIDYKALWEAEKLE 1188
            |:...:.|    |||:|||| .|||:|||||...|:.....|:.:  ..||.||||||:|.||::
Mosquito  1612 QDSPVDGD----EKETGSER-GRSRVGSTASELDTANQPQDSTRE--NGGDCIDYKALYEQEKVD 1669

  Fly  1189 NDKLRQMLKQKDDEAVQTRATLERFANATTK-NSLSELEKRERRAMERKLSELEEELKQLDAYKS 1252
            ||||:..|::||:|.|..:|.|:||..|||| |||||||||||||||||:||:|||||.|..||:
Mosquito  1670 NDKLKMALRKKDEEVVTLKAALDRFTTATTKNNSLSELEKRERRAMERKMSEMEEELKLLQKYKT 1734

  Fly  1253 DNHRLKEENAALIRVISKLS 1272
            :|.||:.||.||.||:|||:
Mosquito  1735 ENERLRAENRALTRVVSKLT 1754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANKYR	50..300	CDD:440430	165/250 (66%)
		ANK repeat	78..109	CDD:293786	27/30 (90%)
		ANK repeat	111..142	CDD:293786	26/30 (87%)
		ANK repeat	209..239	CDD:293786	22/29 (76%)
		ANK repeat	241..272	CDD:293786	18/30 (60%)
		IPD_PPP1R12	606..648	CDD:412018	40/41 (98%)
		PRKG1_interact	1177..1273	CDD:464927	64/97 (66%)
Mbs	XP_061505057.1	None