DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mbs and Ppp1r12a

DIOPT Version :9

Sequence 1:	NP_001246786.1	Gene:	Mbs / 49070	FlyBaseID:	FBgn0005536	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	XP_006241370.1	Gene:	Ppp1r12a / 116670	RGDID:	620013	Length:	1070	Species:	Rattus norvegicus

Alignment Length:	1432	Identity:	396/1432 - (27%)
Similarity:	563/1432 - (39%)	Gaps:	536/1432 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AMMKRAEQLKRWEESDTNRAAPTPRHEHGRRIKFSSGCVFLAACLSGDKDEVVQLLDQGADINTA 75
            |..||.||||||..|:|:...|..:.:. .::||..|.||||||.|||.|||::||.:|||||.|
  Rat     6 AKQKRNEQLKRWIGSETDLEPPVVKRQK-TKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYA 69

  Fly    76 NVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSIARYLVENGADVAA 140
            ||||||||||||||||:|||:||||.||:||:.|||||.||||.||||::.||.:|:..||.|.|
  Rat    70 NVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGA 134

  Fly   141 VNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKKWLRSDAAEVDRPH 205
            |||:||..||:|   :..||.:.::..|....::::.|||.||..||.||::||.|.... |..|
  Rat   135 VNSEGDTPLDIA---EEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHIS-DVRH 195

  Fly   206 PKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRETAEMLVESLADMDI 270
            .|:|.||||||||||||:||.||:....:|:.:|.|||||||||:|||:.|...:||::|.||:.
  Rat   196 AKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMET 260

  Fly   271 RNYAGQSCIDVADRKIVKFLEELR-------ANKRNKRRPSSQIRISDAMENH------------ 316
            .|..||:..||||..|:.:||||:       :.||:|:.|  .|..:..|||:
  Rat   261 VNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSP--LIESTANMENNQPQKTFKNKETL 323

  Fly   317 ---VEKTPTKLVRV------------------------------EVRTDATKDAENV-------- 340
               .||..:::..:                              |..||.||...:|
  Rat   324 IIEPEKNASRIESLEQEKADEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPMASVTNAHTAST 388

  Fly   341 -----------------KPNQQIHAVEH-----PVE--EEAPWRRKLPRT-----PSDS-----P 371
                             .|...:...:.     |||  :.|.||:.|.:|     ||..     |
  Rat   389 QAAPAAVTTPTLSSNQGTPTSPVKKFDFIASLMPVESVDPASWRQGLRKTGIVLVPSKGEKSMFP 453

  Fly   372 TNNQ--VPDRELGTNSSETANDVILRRTQSFENDQKFYQKYNELRARIKANSCPILPANANANAA 434
            |:..  .|..|...:.|..:..:.||:|.|          |..| |.|.|:.    .|....:.|
  Rat   454 TSTTKISPKEEERKDESPASWRLGLRKTGS----------YGAL-AEITASK----EAQKEKDTA 503

  Fly   435 AANKSNNNNNLSSNNYHNNNNNNNKSDLLLGYAAGTTTTTSTPTT-----TTTTTSSTFNNTHSN 494
            ...:|.::..|||:..:.....:||         ||......||.     :|:......|...||
  Rat   504 GVIRSASSPRLSSSLDNKEKEKDNK---------GTRLAYVAPTIPRRLGSTSDIEEKENRESSN 559

  Fly   495 TNNTSTTQQQPAAAAAASAANQLYSVQRSASLKDNSMYYRK---------------------PTV 538
            ...:|:..::....          .:::::|:.:.|.|:|.                     |||
  Rat   560 LRTSSSYTRRKWED----------DLKKNSSINEGSTYHRSCSFGRRQDDLISCSVPSTTSTPTV 614

  Fly   539 TIATSTAATAINSPSTTVQTPP------IRSQVTAKI-----AEKSNNGS-------------SS 579
            |.|.....:.::|.|||.:|||      .:|..:.::     .||..:.:             |:
  Rat   615 TSAAGLQKSFLSSTSTTAKTPPGSSPAGTQSSTSNRLWAEDSTEKEKDSAPTAATIPVAPTVVSA 679

  Fly   580 TASVSDAESSKPPPKQSASNMIKNFFKSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIK 644
            .||.:.|.::......|:::.::...:|::.||||||||:||||.:::.|::|||||||||.:::
  Rat   680 AASSTTALTTTTAGTLSSTSEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQ 744

  Fly   645 SAEELVKKKNMGMANNNNNNNISTTTTNTISNSGNETSSASSTSAPTPSILGSNEQQDELQPPPP 709
            .||:                        ||..|
  Rat   745 EAEK------------------------TIGRS-------------------------------- 753

  Fly   710 PTTPPPAVIPTTTTATDETEIEEVVSSPPAGQSQNDTTASFTLSAPVRRSLSTEGEADANSDPEG 774
                       .:|.|.|.|.||
  Rat   754 -----------RSTRTREQENEE------------------------------------------ 765

  Fly   775 DQDQTVVSASYTIMPRRERLPESSENVESIRSPQKTEPVAKSSSEDKSEEPPHARPTDLPLIPAP 839
                                          :..::.|...|...|:|.|
  Rat   766 ------------------------------KDKEEKEKQDKEKQEEKKE---------------- 784

  Fly   840 AAPSTEAIKSSSAATTPAALESPVRLRDKRGLSGSQESETKSDTASPVSSHPDFNARDSLLSLYA 904
                                                         |.||...::..:.|
  Rat   785 ---------------------------------------------SEVSREDEYKQKYS------ 798

  Fly   905 RRTTDSSAGGGGVGGGAGVGAGGASGAATSSSTSAAERRPSWRLKFDAGSKFKLEDITSGGTYPP 969
             ||.|.                                                       ||
  Rat   799 -RTYDE-------------------------------------------------------TY-- 805

  Fly   970 NNSTIIPSAPAVMAAANLSTTTGVQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYVTPS 1034
                                                       :..||||..|..       |||
  Rat   806 -------------------------------------------ARYRPVSTSSSS-------TPS 820

  Fly  1035 ARKFETNATSTGATTAATTTSNSTSNSVSATSANHTTATAPNATSNHDDKDNDKENDNRTQ-TVI 1098
            :....|    .|::..|::..|..::.|..|||.....|..|.... :.|:.:||.::::| ..|
  Rat   821 SSSLST----LGSSLYASSQLNRPNSLVGITSAYSRGLTKDNEREG-EKKEEEKEGEDKSQPKSI 880

  Fly  1099 QRRRKP--KRRSTGVVH--IDMDELDPERQNE----SSNNDNE-------EKEKESGSERTSRSR 1148
            :.||:|  |||||||..  .|.||.:.|||::    ||..|.:       :....|.|:|.. |.
  Rat   881 RERRRPREKRRSTGVSFWTQDSDENEQERQSDTEDGSSKRDTQTDSVSRYDSSSTSSSDRYD-SL 944

  Fly  1149 LGSTASTATTSESKSSSSNDKTENGDGIDYKALWEAEKLENDKLRQMLKQKDDEAVQTRATL--- 1210
            ||.:||.:...|.|...|  :.|..|..|:|.|:|....||:||:..|...:.|....:..|
  Rat   945 LGRSASYSYLEERKPYGS--RLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKA 1007

  Fly  1211 ----ERFANATTKNSLSELEKRERRAMERKLSELEEELKQLDAYKSDNHRLKEENAALIRVISKL 1271
                ||||:    .||.|:|||||||:||::||:|||||.|...|:||.|||:||.|||||||||
  Rat  1008 TQRQERFAD----RSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKL 1068

  Fly  1272 SK 1273
            ||
  Rat  1069 SK 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANK	50..164	CDD:238125	76/113 (67%)
		Ank_2	53..142	CDD:289560	63/88 (72%)
		ANK repeat	78..109	CDD:293786	25/30 (83%)
		ANK	106..290	CDD:238125	92/183 (50%)
		ANK repeat	111..142	CDD:293786	18/30 (60%)
		ANK repeat	209..239	CDD:293786	18/29 (62%)
		Ank_2	213..300	CDD:289560	48/93 (52%)
		ANK repeat	241..272	CDD:293786	18/30 (60%)
		PRKG1_interact	1177..1272	CDD:292521	51/101 (50%)
Ppp1r12a	XP_006241370.1	Ank_2	47..136	CDD:289560	63/88 (72%)
		ANK	67..252	CDD:238125	107/188 (57%)
		ANK repeat	72..103	CDD:293786	25/30 (83%)
		ANK repeat	105..136	CDD:293786	18/30 (60%)
		ANK repeat	138..229	CDD:293786	41/94 (44%)
		Ank_4	199..252	CDD:290365	32/52 (62%)
		ANK	226..>301	CDD:238125	35/76 (46%)
		ANK repeat	231..262	CDD:293786	18/30 (60%)
		Ank_4	232..280	CDD:290365	25/47 (53%)
		PRKG1_interact	971..1069	CDD:292521	51/101 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7413
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2095
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D225308at33208
OrthoFinder	1	1.000	-	-		FOG0002673
OrthoInspector	1	1.000	-	-		otm45253
orthoMCL	1	0.900	-	-		OOG6_105882
Panther	1	1.100	-	-	LDO	PTHR24179
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2914
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970