DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mbs and ppp1r12a

DIOPT Version :9

Sequence 1:	NP_001246786.1	Gene:	Mbs / 49070	FlyBaseID:	FBgn0005536	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	XP_031754809.1	Gene:	ppp1r12a / 100493563	XenbaseID:	XB-GENE-5896537	Length:	1064	Species:	Xenopus tropicalis

Alignment Length:	1440	Identity:	388/1440 - (26%)
Similarity:	567/1440 - (39%)	Gaps:	558/1440 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AMMKRAEQLKRWEESDTNRAAPTPRHEHGRRIKFSSGCVFLAACLSGDKDEVVQLLDQGADINTA 75
            |..||.||||||..|:|: ..|........::||..|.||||||.|||.|||::|||:|||||.|
Frog     6 AKQKRNEQLKRWIGSETD-LEPHVIKRKKTKVKFDDGAVFLAACSSGDTDEVLKLLDRGADINYA 69

  Fly    76 NVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSIARYLVENGADVAA 140
            ||||||||||||||||:|||:||||.||.||:.|||||.||||.:|||::.||.||:..||.|..
Frog    70 NVDGLTALHQACIDDNIDMVKFLVEHGAGINQPDNEGWIPLHAASSCGYLDIAEYLISKGASVGV 134

  Fly   141 VNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKKWLRSDAAEVDRPH 205
            |||:||..||:|   :..||.|.::..|....|:|:.|||.||..||.||::||.|.... |..|
Frog   135 VNSEGDTPLDIA---EEEAMEDLLQNEVNRQGIDVEAARKEEERIMLRDARQWLNSGQIN-DIRH 195

  Fly   206 PKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRETAEMLVESLADMDI 270
            .|:|.||||||||||||:||.|||....:|:.:|.|||||||||:|||:.|..::|||:..:::.
Frog   196 SKSGGTALHVAAAKGYTEVLKLLLQAGYDVNVKDFDGWTPLHAAAHWGKEEACKILVENFCNVEA 260

  Fly   271 RNYAGQSCIDVADRKIVKFLEELRANKRN-----KRRPSSQIRISDAMENH-------------- 316
            .|..||:.:||||..|:.:||||: .|:|     |:...|.:..|...||:
Frog   261 VNKVGQTALDVADEDILSYLEELQ-KKQNLLLSEKQEKKSPLIESSTTENNQSLKTLKNKETLII 324

  Fly   317 -VEKTPTKLVRV------------------------------EVRTDATKDAENVK-------PN 343
             .|||.:.:..:                              |..||.||...:|.       |.
Frog   325 EQEKTVSAIDSLEEEKADEEDEGKKDESSCSSEEEEEEDSESEAETDKTKSLSSVNSINSNSIPQ 389

  Fly   344 QQIHAVEHPV--------------EEEAP------------WRRKLPRT-----PS-------DS 370
            ..:.||...|              |..||            ||:.|.:|     ||       .:
Frog   390 ASVTAVSSTVHSGQVTPTSPVKKYEFIAPFMPVVETMHPTSWRQGLRKTGIVLVPSKGDKSLFPT 454

  Fly   371 PTNNQVPDRELGTNSSETANDVILRRTQSF------------ENDQKF----------------- 406
            |.....|..|...:.|..:..:.||:|.|:            :.::.|
Frog   455 PPGKTSPKEEDRKDESPASWRLGLRKTGSYGALSEITASKEAQKERDFTGVMRSASSPRLSSTLD 519

  Fly   407 -YQKYNELRARIKANSCPILPANANANAAAANKSNNNNNL----SSNNY------HNNNNNNNKS 460
             .:|..:.|....|...|.:|....:.:....|.|.:::|    .|::|      .:...|.:.:
Frog   520 NKEKEKDGRGARLAYVAPTIPRRLASTSDIEEKENRDSSLGFLRGSSSYTRRKWDEDFKKNTSVN 584

  Fly   461 DLL---------LGYAAGTTTTTSTPTTTTTTTSSTFNNTHSNTNNTSTTQQQPAAAAAASAANQ 516
            :||         .|.......::..|.:|.|.|||....::|:|.|:..:....::...:|.:|:
Frog   585 ELLNTSYQRSSSFGRRQDDLVSSIPPGSTATVTSSGLARSYSSTINSGRSTVSSSSGLPSSTSNR 649

  Fly   517 LYSVQRSASLKDNSMYYRKPTVTIATS--TAATAIN--SPSTTVQTPPIRSQVTAKIAEKSNNGS 577
            .::        |:|....|.||:.|.:  .|.|.:|  |.|||:.|
Frog   650 FWA--------DDSSEKDKDTVSTAVTIPVAPTILNTTSTSTTMTT------------------- 687

  Fly   578 SSTASV-SDAESSKPPPKQSASNMIKNFFKSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLD 641
            :||.:| |.||             ::...:|::.||||||||:||||.:::.|::|||||||||.
Frog   688 TSTGTVPSSAE-------------VRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLT 739

  Fly   642 EIKSAEELVKKKNMGMANNNNNNNISTTTTNTISNSGNETSSASSTSAPTPSILGSNEQQDELQP 706
            :::.||:.:                                             |.|.
Frog   740 DLQEAEKTI---------------------------------------------GRNR------- 752

  Fly   707 PPPPTTPPPAVIPTTTTATDETEIEEVVSSPPAGQSQNDTTASFTLSAPVRRSLSTEGEADANSD 771
                        |||
Frog   753 ------------PTT-------------------------------------------------- 755

  Fly   772 PEGDQDQTVVSASYTIMPRRERLPESSENVESIRSPQKTEPVAKSSSEDKSEEPPHARPTDLPLI 836
                               ||:..|..|..:            |...|||
Frog   756 -------------------REQENEEKEKQD------------KEKQEDK--------------- 774

  Fly   837 PAPAAPSTEAIKSSSAATTPAALESPVRLRDKRGLSGSQESETKSDTASPVSSHPDFNARDSLLS 901
                                                  :|.|.::|         ||..|
Frog   775 --------------------------------------KEFENRND---------DFRQR----- 787

  Fly   902 LYARRTTDSSAGGGGVGGGAGVGAGGASGAATSSSTSAAERRPSWRLKFDAGSKFKLEDITSGGT 966
             |||.|.::
Frog   788 -YARSTEET-------------------------------------------------------- 795

  Fly   967 YPPNNSTIIPSAPAVMAAANLSTTTGVQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYV 1031
                                      :||.                   ||           ::.
Frog   796 --------------------------IQRY-------------------RP-----------SFT 804

  Fly  1032 TPSARKFETNATSTGATTAATTTSNSTSNSVSATSANHTTATAPNATS------NHDDKDNDKEN 1090
            |||     |.:.|:.:::..|::..:..||::..|::::..:..::..      :.:.|:.|||:
Frog   805 TPS-----TISLSSSSSSIYTSSQLNRPNSLTGISSSYSNLSRLSSKDPLKDKLDGEKKEEDKES 864

  Fly  1091 DNRTQ-TVIQRRRKP--KRRSTGVVHIDMDELDPERQNESSNNDNEEKEKESGSERTSRSRLGST 1152
            ::::| ..|:.||:|  |||||||.:...|. |...|:..|:.|....:||:.::..||...|.:
Frog   865 EDKSQPKSIRERRRPREKRRSTGVSYWTQDS-DENEQDHQSDTDEGTNKKENQTDSFSRYTTGLS 928

  Fly  1153 ASTAT------------TSESKSSSSNDKTENGDGIDYKALWEAEKLENDKLRQMLKQKDDEAVQ 1205
            ::.:|            :|..:|.....:.:..|..|||.|:|....||:||:..|...:.|..:
Frog   929 SAISTDRYDPVIGQSGISSYLESRRLLSRLDREDSTDYKKLYEQIIAENEKLKAQLHDTNLELTE 993

  Fly  1206 TRATL-------ERFANATTKNSLSELEKRERRAMERKLSELEEELKQLDAYKSDNHRLKEENAA 1263
            .:..|       ||||:    .||.|:|||||||:||::||:|||||.|...|:||.|||:||.|
Frog   994 LKLQLEKATQRQERFAD----RSLLEIEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGA 1054

  Fly  1264 LIRVISKLSK 1273
            ||||||||||
Frog  1055 LIRVISKLSK 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANK	50..164	CDD:238125	77/113 (68%)
		Ank_2	53..142	CDD:289560	63/88 (72%)
		ANK repeat	78..109	CDD:293786	25/30 (83%)
		ANK	106..290	CDD:238125	93/183 (51%)
		ANK repeat	111..142	CDD:293786	17/30 (57%)
		ANK repeat	209..239	CDD:293786	19/29 (66%)
		Ank_2	213..300	CDD:289560	47/91 (52%)
		ANK repeat	241..272	CDD:293786	16/30 (53%)
		PRKG1_interact	1177..1272	CDD:292521	52/101 (51%)
ppp1r12a	XP_031754809.1	PHA03095	43..>272	CDD:222980	136/232 (59%)
		ANK repeat	72..103	CDD:293786	25/30 (83%)
		ANK repeat	105..136	CDD:293786	17/30 (57%)
		ANK repeat	198..229	CDD:293786	19/30 (63%)
		ANK repeat	231..262	CDD:293786	16/30 (53%)
		IPD_PPP1R12	695..751	CDD:424067	29/113 (26%)
		PRKG1_interact	965..1063	CDD:406350	52/101 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5458
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	444	1.000	Inparanoid score	I1598
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D225308at33208
OrthoFinder	1	1.000	-	-		FOG0002673
OrthoInspector	1	1.000	-	-		otm48318
Panther	1	1.100	-	-	LDO	PTHR24179
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4930
SonicParanoid	1	1.000	-	-		X2914
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100