Protein Alignment Mbs and LOC100487727

DIOPT Version :10

• Sequence 1: NP_001246786.1
• Gene: Mbs / 49070
• FlyBaseID: FBgn0005536
• Length: 1273
• Species: Drosophila melanogaster
• Sequence 2: XP_031756415.1
• Gene: LOC100487727 / 100487727
• XenbaseID: XB-GENE-29078875
• Length: 908
• Species: Xenopus tropicalis
• Alignment Length: 1335
• Identity: 357/1335 - (26%)
• Similarity: 511/1335 - (38%)
• Gaps: 502/1335 - (37%)

  Fly     7 RNNSAMMKRAEQLKRWEESDTNRAAPTPRHEHGRRIKFSSGCVFLAACLSGDKDEVVQLLDQGAD 71
            |:::|.:||.|||.||..|:|.|...........|::|:.|.||:|||.:||:|||.:||..||.
 Frog     8 RSDAAKVKRKEQLNRWMGSETERCGGPGVSRRAARVRFAQGAVFMAACSAGDRDEVRELLAAGAP 72

  Fly    72 INTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSIARYLVENGA 136
            ||..||||||||||||||:|::||:||||.|:::|:.||||||||||.|||||||||::|:.|||
 Frog    73 INGTNVDGLTALHQACIDENIEMVQFLVENGSNVNQPDNEGWTPLHAAASCGFVSIAQFLITNGA 137

  Fly   137 DVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKKWLRSDAAEV 201
            .||||||:|:|.||::   ...||...::..|::..::.|.||:.||..||.|.:.||....||
 Frog   138 SVAAVNSEGELPLDVS---HESAMEKLLKSEVKKQGVDADVARREEEEVMLRDVRHWLNCGKAE- 198

  Fly   202 DRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRETAEMLVESLA 266
            |..||.||||.||||:||||.:|:.|||....:||.:|.|||||||||:||||.|...:|||:|.
 Frog   199 DVRHPTTGATTLHVASAKGYNEVIRLLLQLGFDVDARDFDGWTPLHAAAHWGQEEACRLLVEALC 263

  Fly   267 DMDIRNYAGQSCIDVADRKIVKFLEELR------------------------ANKRNKRRPSS-- 305
            ||:|.|..||:.:||||..:...||:|:                        .|..||.|.||
 Frog   264 DMEIINKVGQTAMDVADDSLESVLEKLKDKQSVLRLEKKKMAPQIMNQTSLNQNAANKSRRSSIS 328

  Fly   306 --------QIRISDAMENHVEKTPTKL--VRVEVRTDATK----DAENVKPNQQIHAVEHPVEEE 356
                    .:|:.|.........|..|  :...|.:||..    :::.||..::|:.:
 Frog   329 RMSSQEKVALRVQDKERRAQPPPPVGLPSIPTAVGSDAESGSDTESQKVKAQERINNL------- 386

  Fly   357 APWRRKLPRTPSDSPTNNQVPDRELGTNSSETANDVILRRTQSFENDQKFYQKYNELRARI-KAN 420
                            |||:      .|..|.|    .::|.|.::.:|........||.: |..
 Frog   387 ----------------NNQL------RNLPEPA----AKKTSSLQDQEKSEPASGSWRASLRKTG 425

  Fly   421 SCPIL---PANANANAAAANKSNNNNNLSSN--------------NYHNNNNNNNKSDLLLGYAA 468
            |...|   .|......||..||.:::.||..              |....:|..|..|.:||
 Frog   426 STGALSTGTAPEEGRRAALPKSASSSQLSEREKAGSELRLARVPPNQKLFSNQENARDTVLG--- 487

  Fly   469 GTTTTTSTPTTTTTTTSSTFNNTHSNTNNTSTTQQQPAAAAAASAANQLYSVQRSASLKDNSMYY 533
                           ..|.........::.|:.::|.....|....|         |:....:..
 Frog   488 ---------------QRSYLRQRTDGEDSISSLRRQRGETLANKTEN---------SIPRRELLT 528

  Fly   534 RKPTVTIATSTAATAINSPSTTVQTPPIRSQVTAKIAEKSNNGSSSTASVSDAESSKPPPKQSAS 598
            .||...:...|...|  .....:.||....:.|.    .:|..:::|..|.:.|:
 Frog   529 PKPEAPVPNKTPIAA--KEENQISTPDALGRRTG----TTNAITTNTVPVVNTET---------- 577

  Fly   599 NMIKNFFKSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEELVKKKNMGMANNNNN 663
               |...:|::.||||||:|.||||.::..|::|||||||||.::|.||:::|
 Frog   578 ---KERRRSYLTPVRDEEAEAQRKARSRHARQSRRSTQGVTLTDLKEAEKVMK------------ 627

  Fly   664 NNISTTTTNTISNSGNETSSASSTSAPTPSILGSNEQQDELQPPPPPTTPPPAVIPTTTTATDET 728
                                                                             
 Frog   628 ----------------------------------------------------------------- 627

  Fly   729 EIEEVVSSPPAGQSQNDTTASFTLSAPVRRSLSTEGEADANSDPEGDQDQTVVSASYTIMPRRER 793
                       ||..|.                   ||:|..:|
 Frog   628 -----------GQQDNK-------------------EAEATPEP--------------------- 641

  Fly   794 LPESSENVESIRSPQKTEPVAKSSSEDKSEEPPHARPTDLPLIPAPAAPSTEAIKSSSAATTPAA 858
                                .|:..|:.:.
 Frog   642 --------------------VKAQEEETNR----------------------------------- 651

  Fly   859 LESPVRLRDKRGLSGSQESETKSDTASPVSSHPDFNARDSLLSLYARRTTDSSAGGGGVGGGAGV 923
             ||.|:.|..||.|   |..|:
 Frog   652 -ESQVKARTGRGAS---EEGTE------------------------------------------- 669

  Fly   924 GAGGASGAATSSSTSAAERRPSWRLKFDAGSKFKLEDITSGGTYPPNNSTIIPSAPAVMAAANLS 988
                                .|||.:..:..|..|..:|:     |:      |||
 Frog   670 --------------------VSWRARIASLQKSDLLGLTT-----PD------SAP--------- 694

  Fly   989 TTTGVQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYVTPSARKFETNATSTGATTAATT 1053
            |::|..||.:.|        |||.|                      ::.:
 Frog   695 TSSGSHRRTTGG--------QSLES----------------------KEMQ-------------- 715

  Fly  1054 TSNSTSNSVSATSANHTTATAPNATSNHDDKDNDKENDNRTQTVIQRRRKP--KRRSTGVVHIDM 1116
                                    .|..|:|::| |...:.:..::.||:|  |||||||
 Frog   716 ------------------------KSQEDEKESD-EKGGKNKAGVKDRRRPRGKRRSTGV----- 750

  Fly  1117 DELDPERQNESSNNDNEEKEKESGSERTS----RSRLGSTASTATTSESKSSSSNDKTENGDGID 1177
                |....:|...|:|::|....|.:|.    .||..|...|.||.:.:.|.:   :|..|..|
 Frog   751 ----PLTTRDSDEEDSEDEEGNGESTQTQVDGLVSRADSRFHTRTTVQGEPSLA---SEYRDTRD 808

  Fly  1178 YKALWEAEKLENDKLRQMLKQKDDEAVQTRATLERF----ANATTKNSLSELEKRERRAMERKLS 1238
            :|.|:|....:|.:||..|....:...:|:|.|||.    ..:..::.|.:.||:|:..:||:||
 Frog   809 FKKLYEELMRDNGRLRSQLLNTQNLVNETKAELERAQQRQERSVDRSFLIDTEKKEKVILERRLS 873

  Fly  1239 ELEEELKQLDAYKSDNHRLKEENAALIRVISKLSK 1273
            ||:||||.|...|:||.|||:||.|||||||||||
 Frog   874 ELQEELKVLGDLKADNQRLKDENGALIRVISKLSK 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANKYR	50..300	CDD:440430	140/273 (51%)
		ANK repeat	78..109	CDD:293786	21/30 (70%)
		ANK repeat	111..142	CDD:293786	24/30 (80%)
		ANK repeat	209..239	CDD:293786	17/29 (59%)
		ANK repeat	241..272	CDD:293786	21/30 (70%)
		IPD_PPP1R12	606..648	CDD:412018	24/41 (59%)
		PRKG1_interact	1177..1273	CDD:464927	45/99 (45%)
LOC100487727	XP_031756415.1	ANKYR	51..303	CDD:440430	139/255 (55%)
		ANK repeat	51..77	CDD:293786	15/25 (60%)
		ANK repeat	79..110	CDD:293786	21/30 (70%)
		ANK repeat	112..143	CDD:293786	24/30 (80%)
		ANK repeat	145..236	CDD:293786	40/94 (43%)
		ANK repeat	238..269	CDD:293786	21/30 (70%)
		IPD_PPP1R12	575..624	CDD:424067	26/61 (43%)
		PRKG1_interact	808..908	CDD:464927	45/99 (45%)