Protein Alignment NSF and SEC18

DIOPT Version :10

• Sequence 1: NP_006169.2
• Gene: NSF / 4905
• HGNCID: 8016
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_009636.3
• Gene: SEC18 / 852372
• SGDID: S000000284
• Length: 758
• Species: Saccharomyces cerevisiae
• Alignment Length: 723
• Identity: 338/723 - (46%)
• Similarity: 482/723 - (66%)
• Gaps: 22/723 - (3%)

Human     4 RSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSIAFSLPQRK 68
            |.::.:.||.:..:|.|.|.|:..||.:..::|:    ::.:.||.:....:.||:|.|:..||.
Yeast    27 RHLKVSNCPNNSYALANVAAVSPNDFPNNIYIII----DNLFVFTTRHSNDIPPGTIGFNGNQRT 87

Human    69 WAGLSIGQEIEV---SLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQAF 130
            |.|.|:.|:::.   .|:.:...:..:|::.|:|.|..:....|..:|.|::|.:|::.:.:|.|
Yeast    88 WGGWSLNQDVQAKAFDLFKYSGKQSYLGSIDIDISFRARGKAVSTVFDQDELAKQFVRCYESQIF 152

Human   131 SVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEV-GLVVGNSQVAFEKAENSSLN 194
            |..|.|:..|....|.|.:::::|:|...:  ||.:.....||. |::...:|:.|.|..:..:|
Yeast   153 SPTQYLIMEFQGHFFDLKIRNVQAIDLGDI--EPTSAVATGIETKGILTKQTQINFFKGRDGLVN 215

Human   195 LIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLY 259
            |......:....::|.||:.||.:|:|||||||:.|||||||||:|||.::|::|..||||:|||
Yeast   216 LKSSNSLRPRSNAVIRPDFKFEDLGVGGLDKEFTKIFRRAFASRIFPPSVIEKLGISHVKGLLLY 280

Human   260 GPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHI 324
            ||||.||||:||:||.||||:|||:|||||||:||||.||.|||.||.|||.|.|..|..|.|||
Yeast   281 GPPGTGKTLIARKIGTMLNAKEPKIVNGPEILSKYVGSSEENIRNLFKDAEAEYRAKGEESSLHI 345

Human   325 IIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRL 389
            |||||:|::.|||||....|||.|.||||||:|:|||:|||||||||||||.||||.|||||||.
Yeast   346 IIFDELDSVFKQRGSRGDGTGVGDNVVNQLLAKMDGVDQLNNILVIGMTNRKDLIDSALLRPGRF 410

Human   390 EVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMN 454
            ||::||.||||||||||..|.|.:||.:.::|.||::.|||..||||||||:||||::|.|.|:|
Yeast   411 EVQVEIHLPDEKGRLQIFDIQTKKMRENNMMSDDVNLAELAALTKNFSGAEIEGLVKSASSFAIN 475

Human   455 RHI---KASTKVEV-DMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVT 515
            :.:   |.:||:.. |:.|   |:|||.|||.:| ||:.||||.::||..:.:..|::.:.:.|.
Yeast   476 KTVNIGKGATKLNTKDIAK---LKVTREDFLNAL-NDVTPAFGISEEDLKTCVEGGMMLYSERVN 536

Human   516 RVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETA 580
            .:|.:|...|:|.:.||::.|||:|:.||..||||||||:||.:|.||||::.||:::.|.||:|
Yeast   537 SILKNGARYVRQVRESDKSRLVSLLIHGPAGSGKTALAAEIALKSGFPFIRLISPNELSGMSESA 601

Human   581 KCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGT 645
            |...:...|.|||||.|:.:|:|.:|.|:|:|||||||||.:||.|.|.||:.|||.|:|||:.|
Yeast   602 KIAYIDNTFRDAYKSPLNILVIDSLETLVDWVPIGPRFSNNILQMLKVALKRKPPQDRRLLIMTT 666

Human   646 TSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNF-KDKERTTIAQQVKGK--KVWIGI 707
            ||...|||:|::|:.|...|.|||:...::|...: :..|| .|..|..:..::...  ...:||
Yeast   667 TSAYSVLQQMDILSCFDNEIAVPNMTNLDELNNVM-IESNFLDDAGRVKVINELSRSCPNFNVGI 730

Human   708 KKLLMLIE 715
            ||.|..||
Yeast   731 KKTLTNIE 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSF	NP_006169.2	CDC48_N	6..83	CDD:215012	21/79 (27%)
		CDC48_2	111..183	CDD:215011	19/72 (26%)
		CDC48	159..>606	CDD:273521	246/451 (55%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	127/175 (73%)
SEC18	NP_009636.3	CDC48_N	29..98	CDD:215012	21/72 (29%)
		CDC48_2	134..204	CDD:215011	19/71 (27%)
		CDC48	<232..>629	CDD:273521	236/400 (59%)
		RecA-like_NSF-SEC18_r1-like	240..416	CDD:410912	127/175 (73%)