DRSC/TRiP Functional Genomics Resources

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Protein Alignment NSF and spas

DIOPT Version :10

Sequence 1:NP_006169.2 Gene:NSF / 4905 HGNCID:8016 Length:744 Species:Homo sapiens
Sequence 2:NP_651206.3 Gene:spas / 42846 FlyBaseID:FBgn0039141 Length:758 Species:Drosophila melanogaster


Alignment Length:331 Identity:91/331 - (27%)
Similarity:150/331 - (45%) Gaps:74/331 - (22%)


- Green bases have known domain annotations that are detailed below.


Human   221 GGLDKEFSDI-----FRRAFASRVFPPEIVEQM--GCK-HVKGILLYGPPGCGKTLLARQI---- 273
            ||...|::||     .::|....|..|.:..::  |.: ..||:||:||||.|||||||.:    
  Fly   476 GGAKVEWTDIAGQDVAKQALQEMVILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATEC 540

Human   274 -GKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQR 337
             ...||      ::...:.:||||:.|..:|.|||.|...|.        .||..||:|::..:|
  Fly   541 SATFLN------ISAASLTSKYVGDGEKLVRALFAVARHMQP--------SIIFIDEVDSLLSER 591

Human   338 GSMAGSTGVHDT---VVNQLLSKIDGV---EQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIG 396
                 |:..|:.   :..:.|.:.||:   ...:.|:|:..||||..:|||.||  |...::.:.
  Fly   592 -----SSSEHEASRRLKTEFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVS 649

Human   397 LPDEKGRLQILHIHTARMRGHQLLSADVD-IKELAVETKNFSGAELEGLVRAAQSTAMNRHIKAS 460
            ||||:.|..:|:    |:...|....|.: ::.||..|..:||::|..|.:.|....:.      
  Fly   650 LPDEQTRELLLN----RLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIR------ 704

Human   461 TKVEVDMEKAESLQ------VTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLD 519
               |:::|:.:.|.      :|..||.:||:.        .:...|...:|...||..      |
  Fly   705 ---ELNVEQVKCLDISAMRAITEQDFHSSLKR--------IRRSVAPQSLNSYEKWSQ------D 752

Human   520 DGELLV 525
            .|::.:
  Fly   753 YGDITI 758

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSFNP_006169.2 CDC48_N 6..83 CDD:215012
CDC48_2 111..183 CDD:215011
CDC48 159..>606 CDD:273521 91/331 (27%)
RecA-like_NSF-SEC18_r1-like 219..395 CDD:410912 60/192 (31%)
spasNP_651206.3 MIT_spastin 230..308 CDD:239142
RecA-like_spastin 484..648 CDD:410932 57/184 (31%)
AAA_lid_3 676..727 CDD:465537 12/59 (20%)
Vps4_C <722..754 CDD:462762 10/45 (22%)
Blue background indicates that the domain is not in the aligned region.

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