Protein Alignment NSF and pch2

DIOPT Version :10

• Sequence 1: NP_006169.2
• Gene: NSF / 4905
• HGNCID: 8016
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_524282.4
• Gene: pch2 / 41013
• FlyBaseID: FBgn0051453
• Length: 421
• Species: Drosophila melanogaster
• Alignment Length: 285
• Identity: 74/285 - (25%)
• Similarity: 130/285 - (45%)
• Gaps: 55/285 - (19%)

Human   230 IFRRAFASRVFPPEIVEQ--MGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREP--------KV 284
            :.:.|.::.:|....|:.  :.|..:  |||:||||.|||.|.:.:.:.|:.|..        ..
  Fly   143 LLKFALSALMFSEHRVDTNVIACNRL--ILLHGPPGTGKTSLCKALAQKLSIRTQGSYAYTHLVE 205

Human   285 VNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDT 349
            :|...:.:|:..||...:.:||....|   .:...:.|..::.||::::...|.:|: |....|.
  Fly   206 INSHSLFSKWFSESGKLVAQLFNKIAE---LVSDPNNLVCVLIDEVESLAYARSAMS-SNEPRDA 266

Human   350 --VVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTA 412
              |||.:|:::|.::...|:|::..:|....||.|.:  .|.::::.||.|   |...|..|:..
  Fly   267 MRVVNAVLTQLDSLKTCPNVLILATSNLAQSIDLAFV--DRADIRLFIGYP---GISAIREIYKG 326

Human   413 RMRGHQLLSADV---------DIKE-----LAVETKNFSGAELE--GLVRAAQSTAMNRHIKAST 461
            .:.  :|:||.|         |.:|     ||..:...||..|.  .|:..||.|       :||
  Fly   327 MLA--ELMSAGVLQREVLESEDAEEGLLTQLAERSVGLSGRTLRKLPLLAHAQYT-------SST 382

Human   462 KVEVDMEKAESLQVTRGDFL-ASLE 485
            ..|:|.      :::..||| |.||
  Fly   383 LFELDQ------KISLSDFLDAMLE 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSF	NP_006169.2	CDC48_N	6..83	CDD:215012
		CDC48_2	111..183	CDD:215011
		CDC48	159..>606	CDD:273521	74/285 (26%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	43/176 (24%)
pch2	NP_524282.4	RecA-like_Pch2-like	115..312	CDD:410916	43/176 (24%)