Protein Alignment NSF and CG14183

DIOPT Version :10

• Sequence 1: NP_006169.2
• Gene: NSF / 4905
• HGNCID: 8016
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_649172.3
• Gene: CG14183 / 40192
• FlyBaseID: FBgn0036931
• Length: 872
• Species: Drosophila melanogaster
• Alignment Length: 773
• Identity: 162/773 - (20%)
• Similarity: 279/773 - (36%)
• Gaps: 214/773 - (27%)

Human    38 RTSPNHRYTFTLKTHPSVVPGSIAFSLPQRKWAGLSIGQEIEVSLYTFD--KAKQCIGTMTIEID 100
            |...|:::||.        |.. |.|:|.::            ::::.|  ||.:....: |:.|
  Fly   195 RKKINYKFTFK--------PDQ-AMSIPVKR------------TIFSADFLKADESCENL-IKKD 237

Human   101 FLQKKSIDSNPYDTDKMAAEFIQQFNNQAFSVGQ-----------QLVFSFNEKLFGLLVKDIEA 154
            .:...:||      |:.|...||  ||.|..:..           ::...|.|:|:|:  |.|..
  Fly   238 DVADTAID------DEEALSAIQ--NNAACKIQSCWRGYKTRKIVKIRKRFKEELYGM--KKIRK 292

Human   155 MDPSILKGEPATGKR--QKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEK 217
            :            ||  |.....:.:..:::..:|.:...:|||...:|   |.......|..|.
  Fly   293 L------------KRPNQTANSIMEMYKNEMLKKKLDEDFINLINDERT---RLLQFRSPWMMED 342

Human   218 MG--IGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAR 280
            :.  |....|||.|      |:..|.|                |..|....|:|. .|.:.:...
  Fly   343 ISDHIRAWFKEFYD------ATGNFHP----------------YPDPVKQGTVLV-VIDETMTPM 384

Human   281 EPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTG 345
            |.:...|.:.|:|      |.::|| .|.|::::| .....|..:...|    .|:|..:. ..|
  Fly   385 EFQESLGKKPLSK------AELKKL-RDKEKKEKR-KKKEKLKQLKMKE----AKRRKKLR-DAG 436

Human   346 VHDTVVNQLLSK-IDGVEQL--------NNILVIGMTNRPDLIDEALLRPGRLEVKMEI-GLPDE 400
            |.|.......|| |:.:|:.        .|:... :....|.|.|.:......::..|: ||.||
  Fly   437 VIDIGYELTASKAIENIEETMKKYSKDWRNVDEY-LNKNHDPIKEWVTEEQLAKIHQEVRGLVDE 500

Human   401 KGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEV 465
            ..|::...:..|       |:.|.|.|..|::.|                         ..|.:.
  Fly   501 YMRVEYELLREA-------LAKDNDEKYKALKVK-------------------------YPKKKK 533

Human   466 DMEKAESLQVTRGDFLASLENDIKPAFGTNQE----DYASYIM------------NGIIKWG--- 511
            :..|.:...:|....|.||.|::|.| |..:|    |:..:|.            :|:...|
  Fly   534 EKRKKKPKDMTGDRTLESLYNELKDA-GIIEEIGHRDFDEFITDFNFVADDTRDEDGLTTLGPAK 597

Human   512 DPVTRVLDD-----GELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPD 571
            ..:..|:.:     ||..|.:.|        |:||.||.:|||..|...||.|.:..|:.: ||:
  Fly   598 GDIKMVIQESMLGMGEFDVPKPK--------SLLLIGPLNSGKRLLCEIIASELDAVFMNL-SPE 653

Human   572 KMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLL------DYVPIGPRFSNLVLQA-LLVL 629
            ....:::..| ..:..|...|...|.:.:.:::..||.      :.|.|.||.....|.: :|..
  Fly   654 NTYKYAKDLK-YFLHVILKVAKAFQPTIMYIEEAHRLFWKKVPPEAVEINPRLLGTSLASKILKP 717

Human   630 LKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTI 694
            |||    ..|::::| ||.........:..||...:.:|....|...|..|||:        |..
  Fly   718 LKK----NDKIVLVG-TSNMPWAANGGIKRAFQKVLLIPKCDYGTSFLLWLELM--------TEN 769

Human   695 AQQVKGKKVWIGIKKLLML---------IEMSLQMDPEYRVRKFLALLREEGASPLDF 743
            |.....:..:..:.::|..         ::.:|.:|.:.|       |:.|...|.:|
  Fly   770 APDDMKEYAYSALARVLQAYNSGDIDDNVKETLNIDRKMR-------LKNEALDPNEF 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSF	NP_006169.2	CDC48_N	6..83	CDD:215012	8/44 (18%)
		CDC48_2	111..183	CDD:215011	16/84 (19%)
		CDC48	159..>606	CDD:273521	101/484 (21%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	38/186 (20%)
CG14183	NP_649172.3	Adgb_C_mid-like	<201..>278	CDD:412094	20/106 (19%)
		globin helix H	201..232	CDD:412094	9/51 (18%)
		IQCD	247..278	CDD:467745	6/32 (19%)
		IQ motif	259..277	CDD:412094	0/17 (0%)
		P-loop containing Nucleoside Triphosphate Hydrolases	617..750	CDD:476819	37/147 (25%)