Protein Alignment NSF and CG12010

DIOPT Version :10

• Sequence 1: NP_006169.2
• Gene: NSF / 4905
• HGNCID: 8016
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_728878.1
• Gene: CG12010 / 38421
• FlyBaseID: FBgn0035443
• Length: 717
• Species: Drosophila melanogaster
• Alignment Length: 536
• Identity: 125/536 - (23%)
• Similarity: 218/536 - (40%)
• Gaps: 177/536 - (33%)

Human    83 YTFDKAKQCIGTM--TIEIDFLQK---KSIDSNPYDTDK--MAAEFIQQFNNQAFSV-------- 132
            ::|::..:.:..:  |.:|.|..:   .::...|.|..|  :.:||:::.:...|.:
  Fly   195 HSFERPMEQLEKLLETSKISFSHRFPTTALVVGPVDCGKSGLLSEFLRRHSCNCFYITASQVLRS 259

Human   133 --GQ---------QLVFSFNEKL-----FGLLVKDIEAMDPSILKGE------------------ 163
              |:         |...:|.|||     ..:|::|:|.:.||....:
  Fly   260 YPGETEEELRRIFQAAQTFKEKLRPLLPIVILIEDLELLCPSTAVADAKNSSNSLRISAELYKLL 324

Human   164 -----------------------------------PATGKRQKI-----EV-------------- 174
                                               |:.|:|:::     ||
  Fly   325 DALPRGIICLATSGVPDSLHEHARRRFVREVTINMPSEGQRRQLVEHLCEVHELNISQTLLEHIA 389

Human   175 ----GLVVGNSQVAFEKAENSSL--------NLIGKAKTKENRQSIINPDWNFEKMG-----IGG 222
                |.|:.:..:...:.:...|        ::..|:.::....:..:.|....||.     |||
  Fly   390 RNTQGYVIADLTLLLRRVQQQLLTKDDFDIEHIFLKSLSQTQPSASRSTDVRVSKMTAGFEVIGG 454

Human   223 LDKEFSDIFRR--------------AFASRVFPPEIVEQMGCKHVKGILLYGPPGCGKTLLARQI 273
            :     :..:|              |||          :.|....||:||||||||.||.:|:.:
  Fly   455 M-----EALKRTLQVSVLAGIRQSAAFA----------RFGLSLPKGVLLYGPPGCAKTTVAKCL 504

Human   274 GKMLNAREPKV----VNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAIC 334
                 |:|..:    .:..|:.:.|||.:|..|.::|..|.:....|        |..||||::.
  Fly   505 -----AKEADMTFIATSAAEVYSPYVGCAERFISRIFDTARKNAPCL--------IFLDEIDSLV 556

Human   335 KQRGSMAGSTG--VHDTVVNQLLSKIDGV---EQLNNILVIGMTNRPDLIDEALLRPGRLEVKME 394
            .:|...:|..|  |...:::.||::::|:   ....:|||:..|||||:||:|||||||.:..:.
  Fly   557 GRRTVSSGGGGGQVQLRILSTLLTEMNGIVGGGSQQHILVVAATNRPDMIDDALLRPGRFDKLIH 621

Human   395 IGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKA 459
            :..||||.||.:|.:|:.||..|:    :|.::|:|..|..:|||:|..|...|...|..|..||
  Fly   622 VPAPDEKSRLALLKLHSQRMPFHE----NVFLQEIAARTDRYSGADLCNLCNEAAIEAFQRDFKA 682

Human   460 STKVEV-DMEKAESLQ 474
             |::|: |.||..:.|
  Fly   683 -TEIELQDFEKVLTKQ 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSF	NP_006169.2	CDC48_N	6..83	CDD:215012	125/536 (23%)
		CDC48_2	111..183	CDD:215011	24/173 (14%)
		CDC48	159..>606	CDD:273521	104/429 (24%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	61/203 (30%)
CG12010	NP_728878.1	CDC48	<220..713	CDD:273521	121/511 (24%)