DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NSF and nsfa

DIOPT Version :9

Sequence 1:	NP_006169.2	Gene:	NSF / 4905	HGNCID:	8016	Length:	744	Species:	Homo sapiens
Sequence 2:	XP_021325418.1	Gene:	nsfa / 368483	ZFINID:	ZDB-GENE-030616-37	Length:	747	Species:	Danio rerio

Alignment Length:	738	Identity:	641/738 - (86%)
Similarity:	699/738 - (94%)	Gaps:	0/738 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAGRSMQAARCPTDELSLTNCAVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSIAFSLP 65
            ||.|:|||||||||||||||||||:|||.||||||.|||:|.|::.||:|.|.||:||:||||||
Zfish     1 MATRTMQAARCPTDELSLTNCAVVSEKDLQSGQHVTVRTTPTHKFVFTVKGHHSVLPGTIAFSLP 65

Human    66 QRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQAF 130
            ||||||||||||||||.|.|||::||||.||||||||||||.||:|||:|||||||||.||||:|
Zfish    66 QRKWAGLSIGQEIEVSNYNFDKSRQCIGAMTIEIDFLQKKSTDSSPYDSDKMAAEFIQHFNNQSF 130

Human   131 SVGQQLVFSFNEKLFGLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGNSQVAFEKAENSSLNL 195
            ||||||||||.:||||||:|||||||.||||||||:||:|||||||:||||||.|||:|:|||.|
Zfish   131 SVGQQLVFSFCDKLFGLLIKDIEAMDSSILKGEPASGKKQKIEVGLLVGNSQVIFEKSESSSLTL 195

Human   196 IGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYG 260
            :|||||||.||:|||||||||||||||||||||||||||||||||||:|||||||||||||||:|
Zfish   196 VGKAKTKEARQTIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPDIVEQMGCKHVKGILLFG 260

Human   261 PPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHII 325
            ||||||||:||||||||||||||:|||||||||||||||||||||||||||||:|||||||||||
Zfish   261 PPGCGKTLMARQIGKMLNAREPKIVNGPEILNKYVGESEANIRKLFADAEEEQKRLGANSGLHII 325

Human   326 IFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLE 390
            ||||:||||||||:.|.|||||||||||||||||||||||||||||||||||||||||:||||.|
Zfish   326 IFDELDAICKQRGTGASSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALMRPGRFE 390

Human   391 VKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNR 455
            |||||||||||||:|||:||||:||..:||::|||:||||.||||:|||||||||||||||||||
Zfish   391 VKMEIGLPDEKGRVQILNIHTAKMREFKLLASDVDVKELAAETKNYSGAELEGLVRAAQSTAMNR 455

Human   456 HIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDD 520
            ||||::.||||||:||.|||||.||:|||.||||||||||||||:||||||||||||||||||:|
Zfish   456 HIKATSTVEVDMERAEKLQVTRTDFMASLNNDIKPAFGTNQEDYSSYIMNGIIKWGDPVTRVLED 520

Human   521 GELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAM 585
            ||||||||||||||||||||||||||||||||||||:|:|.||||||||||||||.||.:||||:
Zfish   521 GELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKISEDSQFPFIKICSPDKMIGHSEISKCQAI 585

Human   586 KKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKD 650
            |||||||||||||||||||||||||||||||||||||||||||||||.||.||||||||||||||
Zfish   586 KKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKTPPHGRKLLIIGTTSRKD 650

Human   651 VLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIE 715
            ||||||||:||||||||.||::|:.|:|||||||:|.|.|||||||.||||:|||||||||||||
Zfish   651 VLQEMEMLDAFSTTIHVQNISSGDHLVEALELLGSFTDAERTTIAQHVKGKRVWIGIKKLLMLIE 715

Human   716 MSLQMDPEYRVRKFLALLREEGA 738
            ||||||.||||.|||:||::|||
Zfish   716 MSLQMDQEYRVSKFLSLLKDEGA 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NSF	NP_006169.2	CDC48_N	6..83	CDD:215012	63/76 (83%)
		CDC48_2	111..>159	CDD:308534	40/47 (85%)
		SpoVK	<142..490	CDD:223540	304/347 (88%)
		AAA	538..670	CDD:214640	120/131 (92%)
nsfa	XP_021325418.1	CDC48_N	6..83	CDD:215012	63/76 (83%)
		CDC48_2	111..183	CDD:215011	61/71 (86%)
		TIP49	160..>606	CDD:332389	396/445 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194331155
Domainoid	1	1.000	238	1.000	Domainoid score	I10306
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4502
Inparanoid	1	1.050	1283	1.000	Inparanoid score	I1393
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52406
OrthoDB	1	1.010	-	-		D156590at33208
OrthoFinder	1	1.000	-	-		FOG0003053
OrthoInspector	1	1.000	-	-		oto50040
orthoMCL	1	0.900	-	-		OOG6_101440
Panther	1	1.100	-	-	LDO	PTHR23078
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2410
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.270