Protein Alignment NSF and nsf-1

DIOPT Version :10

• Sequence 1: NP_006169.2
• Gene: NSF / 4905
• HGNCID: 8016
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_001076603.1
• Gene: nsf-1 / 266842
• WormBaseID: WBGene00003818
• Length: 824
• Species: Caenorhabditis elegans
• Alignment Length: 757
• Identity: 409/757 - (54%)
• Similarity: 538/757 - (71%)
• Gaps: 28/757 - (3%)

Human     4 RSMQAARCPTDELSLTNCAVVNEKDFQSGQ--HVIVRTSPNHRYTFTLKTHPSVVPGSIAFSLPQ 66
            :..:..:.|::|.:|.|.|.||..||...|  ||.|...|.|.|.|:::...|:.||.|||.:|.
 Worm    66 KMFRVRKAPSEEHTLANYAYVNRSDFDDKQIKHVRVNPGPAHHYIFSIRNDGSIKPGEIAFGVPH 130

Human    67 RKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQAFS 131
            ||||.||:.||:.|:.:||.:: :.:|:|.:..||..||::.|.|.:.|.||.||..||..||||
 Worm   131 RKWAALSLDQEVRVTPFTFQQS-EYVGSMILTADFNAKKNVTSEPLNADLMAREFSIQFGGQAFS 194

Human   132 VGQQLVFSFNEK------LFGLLVKDIEAMDPSILKGEPATG----------KRQKIEVGLVVGN 180
            .|.|:.|.|.:|      ...|:||.||..|  |.|...|..          |.::||.|.::.|
 Worm   195 KGMQMAFRFEDKEKNKTHTLSLVVKSIEGFD--IGKAAAAASGASNTDSSATKPKQIEAGELLPN 257

Human   181 SQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIV 245
            |.:.|:|.|.|.||||||:|.|...:|||||||:|::|||||||.|||.||||||||||||||.:
 Worm   258 SVIVFDKEEGSMLNLIGKSKGKSAYRSIINPDWDFQQMGIGGLDTEFSHIFRRAFASRVFPPEFI 322

Human   246 EQMGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAE 310
            ||:|.|||:||||:||||.||||:||||||||||||||:||||:||:|||||||:|:||||||||
 Worm   323 EQLGMKHVRGILLFGPPGTGKTLMARQIGKMLNAREPKIVNGPQILDKYVGESESNVRKLFADAE 387

Human   311 EEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNR 375
            ||.||.|||||||||||||||||||||||||||:.||||||||||||:|||||||||||||||||
 Worm   388 EEWRRCGANSGLHIIIFDEIDAICKQRGSMAGSSSVHDTVVNQLLSKMDGVEQLNNILVIGMTNR 452

Human   376 PDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAE 440
            .|:|||||||||||||:||:.||||.||||||.|||||||.:..:..:||:::::..||||||||
 Worm   453 RDMIDEALLRPGRLEVQMEVSLPDETGRLQILKIHTARMREYNKMDPNVDLEDISKRTKNFSGAE 517

Human   441 LEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMN 505
            ||||||||||:||||.:||..|.:.|.:..|.|.:..|||..:||||||||||.:.|....::..
 Worm   518 LEGLVRAAQSSAMNRLVKAGGKAQADPDAIEKLAINSGDFDYALENDIKPAFGRSDESLNRFLSR 582

Human   506 GIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSP 570
            |:|.||..||::||:|.||....||.:.:...:|:|.|...:|||:|||::|:.|:|||:|:.||
 Worm   583 GMIVWGPEVTKILDEGSLLAATVKNPENSGFRTVVLAGAAKTGKTSLAAQMAKSSDFPFVKVISP 647

Human   571 DKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPP 635
            :..:||||:|||.|:||.|:||.:|:||.:::|::|||:||.|:|||:||||:|||||||...||
 Worm   648 EDTVGFSESAKCMALKKAFEDAKRSKLSVLLIDNLERLIDYHPVGPRYSNLVIQALLVLLNAPPP 712

Human   636 QGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQV-- 698
            .|.:|.:|.|:|.:..|::|.:::.|...|.:|.:.|..|::..::....:.|.:...|.|::
 Worm   713 AGHRLFVIATSSDRMFLRDMGLMDVFGDVIDIPKLTTAGQMMNVIQESNIYSDDQLPMIEQKLAS 777

Human   699 --KGKKV-WIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEG 737
              :|:.. .:|||.||.|||.:.|.:.:|||...|.::  ||
 Worm   778 ICRGEGFHGVGIKHLLELIESARQCEADYRVPTLLNMM--EG 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSF	NP_006169.2	CDC48_N	6..83	CDD:215012	33/78 (42%)
		CDC48_2	111..183	CDD:215011	32/87 (37%)
		CDC48	159..>606	CDD:273521	291/456 (64%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	152/175 (87%)
nsf-1	NP_001076603.1	CDC48_N	68..147	CDD:215012	33/78 (42%)
		CDC48_2	174..>222	CDD:215011	20/47 (43%)
		RecA-like_NSF-SEC18_r1-like	296..472	CDD:410912	152/175 (87%)
		CDC48	<297..>683	CDD:273521	260/385 (68%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<661..>730	CDD:476819	37/68 (54%)