DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and Rps6ka1

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_006239145.1	Gene:	Rps6ka1 / 81771	RGDID:	620675	Length:	741	Species:	Rattus norvegicus

Alignment Length:	311	Identity:	118/311 - (37%)
Similarity:	174/311 - (55%)	Gaps:	25/311 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 FRMYRVLGKGGFGEVCACQVRA-----TGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPF 368
            |.:.:|||:|.||:|..  ||.     .|.:||.|.|:|..:|.| ......:|:.||..:|.||
  Rat    68 FELLKVLGQGSFGKVFL--VRKVTRPDNGHLYAMKVLKKATLKVR-DRVRTKMERDILADVNHPF 129

  Fly   369 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVY 433
            ||.|.||::|:..|.|:|..:.||||   ...:..|..|..|..:||.||:|.||.|||..||:|
  Rat   130 VVKLHYAFQTEGKLYLILDFLRGGDL---FTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIY 191

  Fly   434 RDCKPENILLDDHGHVRISDLGLAVE-IPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGC 497
            ||.||||||||:.||::::|.||:.| |...:......|||.||||||::.:.:..|.||:|:|.
  Rat   192 RDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGV 256

  Fly   498 LLYEMIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGR 562
            |::||:.|..||:.:..|.....:.:.....|:..|:    ||:|:.:.|..::...|||  :|.
  Rat   257 LMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLST----EAQSLLRALFKRNPANRLG--SGP 315

  Fly   563 MGGQDVMAHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFST 613
            .|.:::..| .|:|| ::|.:|....::|||.|   ||...|  |...|.|
  Rat   316 DGAEEIKRH-IFYST-IDWNKLYRREIKPPFKP---AVAQPD--DTFYFDT 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367
		STKc_GRK4_like	308..597	CDD:270756	112/293 (38%)
		S_TKc	309..574	CDD:214567	103/270 (38%)
Rps6ka1	XP_006239145.1	S_TKc	68..326	CDD:214567	103/270 (38%)
		STKc_RSK_N	72..388	CDD:270734	117/307 (38%)
		STKc_RSK1_C	422..712	CDD:271077
		Pkinase	424..681	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910