DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and Grk1

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_112358.1	Gene:	Grk1 / 81760	RGDID:	619712	Length:	564	Species:	Rattus norvegicus

Alignment Length:	684	Identity:	260/684 - (38%)
Similarity:	372/684 - (54%)	Gaps:	136/684 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LENIVANTVYLKAREG--GSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            ||.:|||:.::.||..  ||.:...:.||:...|:.|.:|:|..|:|.:.:.:..:..:||||:.
  Rat     6 LETVVANSAFIAARGSFDGSSTPSSRDKKYLAKLRLPPLSKCEGLRDSISLEFDNLCSEQPIGKR 70

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            ||:.|.:...    |::..|:                      .:.|:|              |.
  Rat    71 LFQQFLKTDE----RHVPALE----------------------LWKDIE--------------DY 95

  Fly   131 ETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGN 195
            :|.::.|                                ..|.:..|..:.||
  Rat    96 DTADDDL--------------------------------RPQKAQAILAEYLD------------ 116

  Fly   196 GSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSG 260
                                                |.|    .|..:.|:..::|:|:......
  Rat   117 ------------------------------------PQG----TLFCNFLDQGMVARVKEGPTGS 141

  Fly   261 GKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVCA 325
            ...:|...:.|....|:..||:|:..|:||.|:|||||||||||....|..:|||||||||||.|
  Rat   142 QDGLFQPLLQATLEHLSQGPFQEYLGSLYFLRFLQWKWLEAQPIGEDWFLDFRVLGKGGFGEVSA 206

  Fly   326 CQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMN 390
            ||::|||||||||||.|||:|||||....::||:||.|::|.|:|:||||:|||..||||:||||
  Rat   207 CQMKATGKMYACKKLNKKRLKKRKGYQGAIVEKRILAKVHSRFIVSLAYAFETKTDLCLVMTIMN 271

  Fly   391 GGDLKFHIYNMGGE-PGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDL 454
            |||:::||||:..| |||...||.:|.|::..||:|||::.|||||.||||:|||:.|::|||||
  Rat   272 GGDVRYHIYNVDEENPGFPEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDL 336

  Fly   455 GLAVEIPEGE-MVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKR 518
            |||||:.||: ..:|..||.|:||||::..|:|.||.|:|:.|..|||||..:.|||.|.|||:.
  Rat   337 GLAVELKEGQNKTKGYAGTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVEN 401

  Fly   519 EEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRR 583
            :|:.:|:..:|.||..||:..:|..|:|||.|..::|||.|:|....  :.|:..|  ..::||:
  Rat   402 KELKQRIISEPVKYPEKFSQASKDFCEQLLEKDPEKRLGFRDGTCDA--LRANVLF--KDISWRQ 462

  Fly   584 LEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETEC 648
            ||||||.|||:||...||||::.|:..|||||||..|::||.|:.:|.:|:.||.||.||:||..
  Rat   463 LEAGMLIPPFIPDSRTVYAKNIQDVGAFSTVKGVVFDKADTEFFQEFASGNCSIPWQEEMIETGF 527

  Fly   649 FRELNVFGPEECPTPDLQ----INAAPEPDKAGC 678
            |.:|||:.|:.....|::    ..|||......|
  Rat   528 FGDLNVWRPDGQMPDDMKGITVEEAAPTAKSGMC 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	14/75 (19%)
		RGS	<248..305	CDD:295367	22/56 (39%)
		STKc_GRK4_like	308..597	CDD:270756	161/290 (56%)
		S_TKc	309..574	CDD:214567	148/266 (56%)
Grk1	NP_112358.1	N-terminal	1..189		62/306 (20%)
		Interaction with RCVRN. /evidence=ECO:0000250\|UniProtKB:P28327	1..15		5/8 (63%)
		RGS	42..179	CDD:383028	42/260 (16%)
		STKc_GRK1	188..475	CDD:270759	160/290 (55%)
		C-terminal	456..564		49/106 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348842
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24355
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850