DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and si:ch211-195b13.1

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001070770.2	Gene:	si:ch211-195b13.1 / 768159	ZFINID:	ZDB-GENE-030131-7626	Length:	423	Species:	Danio rerio

Alignment Length:	385	Identity:	125/385 - (32%)
Similarity:	184/385 - (47%)	Gaps:	59/385 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 EAQPITYKTFRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQK- 363
            |...|....|...:::|||.||:|...:.:.....||.|.|:||.|.|:|.:..::.|:.:|.|
Zfish    82 EETQIKPSDFDYLKIIGKGSFGKVLLARHKENELYYAVKVLQKKIIMKKKEQKHIMAERSVLMKN 146

  Fly   364 INSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHK 428
            |..||:|.|.|:::|.|.|..||..:|||:|.:|:..   |..|...||||||||:|..|.:||.
Zfish   147 IKHPFLVGLHYSFQTTDKLYFVLDYVNGGELFYHLQR---ERVFLEPRARFYAAEIASALGYLHS 208

  Fly   429 QGIVYRDCKPENILLDDHGHVRISDLGLAVE--IPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPD 491
            ..|||||.||||||||..||:.::|.||..|  .|.|.... ..||..|:||||:..:.|..:.|
Zfish   209 LHIVYRDLKPENILLDSQGHIVLTDFGLCKEGLDPNGTTTT-FCGTPEYLAPEVLQKQAYDRTVD 272

  Fly   492 WFSFGCLLYEMIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRL 556
            |:..|.:|:||:.|..||..|    ...|:...:...|.......::..:.:.:.||.|...:||
Zfish   273 WWCLGSVLFEMLYGLPPFYSR----NTAEMYNNILHKPLVLKPNVSNAGRDLLEGLLHKDRTKRL 333

  Fly   557 GCRNGRMGGQDVMAHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDE 621
            |.::..:   ::..|.||  :.:||..|.|..:.|||:|                 ||.|    .
Zfish   334 GSKDDFL---ELKFHSFF--SPINWDDLMAKRIVPPFIP-----------------TVTG----P 372

  Fly   622 SD-TNFYTKFNTGSVSISWQNEMMETECFRELNVFGPEECPTPDLQINAAPEPDKAGCFP 680
            :| .:|..:|....||.|.                    |.|.:|.:.::.. :.||.||
Zfish   373 TDLRHFDPEFTHLPVSTSL--------------------CNTDNLHVTSSVR-EAAGAFP 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367	1/4 (25%)
		STKc_GRK4_like	308..597	CDD:270756	107/291 (37%)
		S_TKc	309..574	CDD:214567	97/267 (36%)
si:ch211-195b13.1	NP_001070770.2	S_TKc	91..348	CDD:214567	97/267 (36%)
si:ch211-195b13.1	NP_001070770.2	STKc_SGK	95..415	CDD:270727	122/372 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910