DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and RPS6KA3

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_011543857.1	Gene:	RPS6KA3 / 6197	HGNCID:	10432	Length:	746	Species:	Homo sapiens

Alignment Length:	298	Identity:	108/298 - (36%)
Similarity:	165/298 - (55%)	Gaps:	24/298 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 FRMYRVLGKGGFGEVCACQVRATG----KMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFV 369
            |.:.:|||:|.||:|...: :.:|    ::||.|.|:|..:|.| ......:|:.||.::|.||:
Human    68 FELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVR-DRVRTKMERDILVEVNHPFI 130

  Fly   370 VNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYR 434
            |.|.||::|:..|.|:|..:.||||   ...:..|..|..|..:||.||:|..|.|||..||:||
Human   131 VKLHYAFQTEGKLYLILDFLRGGDL---FTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYR 192

  Fly   435 DCKPENILLDDHGHVRISDLGLAVE-IPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCL 498
            |.||||||||:.||::::|.||:.| |...:......|||.||||||::...:..|.||:|||.|
Human   193 DLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVL 257

  Fly   499 LYEMIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRL------G 557
            ::||:.|..||:.:..|.....:.:.....|:..|    .||:|:.:.|..::...||      |
Human   258 MFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLS----PEAQSLLRMLFKRNPANRLVNPFLIG 318

  Fly   558 CRNGRMGGQDVMAHPFFHSTQLNWRRLEAGMLEPPFVP 595
            .  |..|.:::..|.||  :.::|.:|....:.|||.|
Human   319 A--GPDGVEEIKRHSFF--STIDWNKLYRREIHPPFKP 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367
		STKc_GRK4_like	308..597	CDD:270756	108/298 (36%)
		S_TKc	309..574	CDD:214567	100/275 (36%)
RPS6KA3	XP_011543857.1	S_TKc	68..333	CDD:214567	100/275 (36%)
		STKc_RSK_N	72..394	CDD:270734	107/294 (36%)
		STKc_RSK2_C	408..737	CDD:271078
		Pkinase	428..685	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910