DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and GRK1

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_002920.1	Gene:	GRK1 / 6011	HGNCID:	10013	Length:	563	Species:	Homo sapiens

Alignment Length:	659	Identity:	259/659 - (39%)
Similarity:	363/659 - (55%)	Gaps:	136/659 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LENIVANTVYLKAREG--GSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            ||.:|||:.::.||..  ||.|...:.||:...|:.|.:|:|.:|:|.|.:.:..|..:||||::
Human     6 LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQPIGKK 70

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            ||:.|.::..    :::..|:                      .:.|:|              |.
Human    71 LFQQFLQSAE----KHLPALE----------------------LWKDIE--------------DY 95

  Fly   131 ETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGN 195
            :|.:    |.......:|...::.:......|:.:
Human    96 DTAD----NDLQPQKAQTILAQYLDPQAKLFCSFL------------------------------ 126

  Fly   196 GSSHQDDGDESV--KCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLN 258
                    ||.:  |.:||..:.:.|
Human   127 --------DEGIVAKFKEGPVEIQDG--------------------------------------- 144

  Fly   259 SGGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEV 323
                 :|...:.|..|.|...||:|:..|:||.|:||||||||||:....|..:|||||||||||
Human   145 -----LFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGKGGFGEV 204

  Fly   324 CACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTI 388
            .|||::||||:||||||.|||:|||||....::||:||.|::|.|:|:||||:|||..||||:||
Human   205 SACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTI 269

  Fly   389 MNGGDLKFHIYNMGGE-PGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRIS 452
            |||||:::||||:..| |||...||.||.|::.|||:|||::.|||||.||||:|||:.|:||||
Human   270 MNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRIS 334

  Fly   453 DLGLAVEIPEGE-MVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKV 516
            |||||||:.:|: ..:|..||.|:||||::..|:|.||.|:|:.|..|||||..:.|||.|.|||
Human   335 DLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKV 399

  Fly   517 KREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNW 581
            :.:|:..|:..:|.||..||:..:|..|:.||.|..::|||.|:...  ..:.|||.|  ..|||
Human   400 ENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLGFRDETC--DKLRAHPLF--KDLNW 460

  Fly   582 RRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMET 646
            |:||||||.|||:||...|||||:.|:..|||||||..|::||.|:.:|.||:..|.||.||:||
Human   461 RQLEAGMLMPPFIPDSKTVYAKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIET 525

  Fly   647 ECFRELNVF 655
            ..|.||||:
Human   526 GIFGELNVW 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	15/75 (20%)
		RGS	<248..305	CDD:295367	21/56 (38%)
		STKc_GRK4_like	308..597	CDD:270756	164/290 (57%)
		S_TKc	309..574	CDD:214567	149/266 (56%)
GRK1	NP_002920.1	N-terminal	1..189		62/308 (20%)
		Interaction with RCVRN. /evidence=ECO:0000250\|UniProtKB:P28327	1..15		5/8 (63%)
		RGS	42..179	CDD:383028	42/262 (16%)
		STKc_GRK1	188..475	CDD:270759	163/290 (56%)
		C-terminal	456..563		47/79 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154962
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24355
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850