Protein Alignment Gprk2 and Grk4

DIOPT Version :9

• Sequence 1: NP_001263143.1
• Gene: Gprk2 / 49045
• FlyBaseID: FBgn0261988
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: XP_017454835.1
• Gene: Grk4 / 59077
• RGDID: 61858
• Length: 589
• Species: Rattus norvegicus
• Alignment Length: 671
• Identity: 317/671 - (47%)
• Similarity: 401/671 - (59%)
• Gaps: 146/671 - (21%)

  Fly     1 MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            |||||.:|||:.||||:|.: ...|:|||||::|:.|.:|.|.:|:..::..:..:.|||||||.
  Rat     1 MELENFMANTLLLKARQGFT-KKTGRSKKWRELLKLPPVSMCSDLRHSIEKDFSSLCDQQPIGRL 64

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            |||.|| |.:|...|.|.|||...:||:.....:...|..|..||.
  Rat    65 LFRQFC-NTKPDLKRCIEFLDAAAEYEVTIEEEQREFGLSIYSRFF------------------- 109

  Fly   131 ETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGN 195
                                                 ..||
  Rat   110 -------------------------------------KENS------------------------ 113

  Fly   196 GSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKL--N 258
                                                       |:.|..:..||:.:.:..|  :
  Rat   114 -------------------------------------------EVSLPQIPPDLVKECKCNLKQS 135

  Fly   259 SGGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEV 323
            |..:::|..|...:..:|:.:||.|::.|.|::|:|||||||.:|:|..|||.||||||||||||
  Rat   136 SPSQNVFQDCAGVIYKYLSEKPFEEYQESTYYNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEV 200

  Fly   324 CACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTI 388
            ||||||||||||||||||||||||||||:|.|.||:||:|::|.|||:|||.|||||||||||||
  Rat   201 CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTI 265

  Fly   389 MNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISD 453
            |||||||:||||: |.||||.:||.|||||:.|||:.|.::.|||||.||||||||||||:||||
  Rat   266 MNGGDLKYHIYNL-GNPGFEEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDHGHIRISD 329

  Fly   454 LGLAVEIPEGEMVRGRVGTVGYM--------------APEVIDNEKYAFSPDWFSFGCLLYEMIE 504
            ||||:||||||||||||||||||              |||:|.:|||.|||||:..|||:||||.
  Rat   330 LGLALEIPEGEMVRGRVGTVGYMACVSGFFIKNRVSIAPEIISHEKYTFSPDWWGLGCLIYEMIA 394

  Fly   505 GQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVM 569
            |.:|||..||||.|||::||||.:.|:||.:|::.|||:|..||.|...:||||::.  |...|.
  Rat   395 GHSPFRKYKEKVNREEMERRVKTETEEYSERFSENAKSICSMLLTKDPSKRLGCQSD--GASAVK 457

  Fly   570 AHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGS 634
            .||.|  ..:|:.||||.||:|||.|||.|:|.||:|||.|||.|||||:|.:|..|||:|.||.
  Rat   458 QHPIF--KDINFSRLEANMLDPPFCPDPEAIYCKDILDIGQFSVVKGVNLDTNDEIFYTQFATGC 520

  Fly   635 VSISWQNEMMETECFRELNVF 655
            |:|.|||||:|:.||::||.:
  Rat   521 VTIPWQNEMIESGCFKDLNEY 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	28/75 (37%)
		RGS	<248..305	CDD:295367	21/58 (36%)
		STKc_GRK4_like	308..597	CDD:270756	205/302 (68%)
		S_TKc	309..574	CDD:214567	192/278 (69%)
Grk4	XP_017454835.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348845
Domainoid	1	1.000	416	1.000	Domainoid score	I638
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	690	1.000	Inparanoid score	I663
OMA	1	1.010	-	-		QHG47927
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0001059
OrthoInspector	1	1.000	-	-		otm46454
orthoMCL	1	0.900	-	-		OOG6_102122
Panther	1	1.100	-	-	LDO	PTHR24355
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X940
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770