DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and Grk6

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_113845.2	Gene:	Grk6 / 59076	RGDID:	61986	Length:	589	Species:	Rattus norvegicus

Alignment Length:	708	Identity:	355/708 - (50%)
Similarity:	431/708 - (60%)	Gaps:	144/708 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            |||||||||||.|||||||..:.||||||||::|||||||||..|:..|:..|..:.::|||||.
  Rat     1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRL 65

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            |||.||.. ||...|...|||.|.:||:.....|...|..:.:.||
  Rat    66 LFREFCAT-RPELTRCTAFLDGVAEYEVTPDEKRKACGRRLMQNFL------------------- 110

  Fly   131 ETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGN 195
                                                                   :|.|.|
  Rat   111 -------------------------------------------------------SHTGPD---- 116

  Fly   196 GSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSG 260
                                                        |:.:|.. .|::....:|..|
  Rat   117 --------------------------------------------LIPEVPR-QLVSNCAQRLEQG 136

  Fly   261 G-KDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVC 324
            . ||:|.:.......:|:..||.::..|:||:|:|||||||.||:|..|||.|||||||||||||
  Rat   137 PCKDLFQELTRLTHEYLSMAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVC 201

  Fly   325 ACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIM 389
            |||||||||||||||||||||||||||:|.|.|||||:|:||.|||:||||||||||||||||:|
  Rat   202 ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLM 266

  Fly   390 NGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDL 454
            ||||||||||:| |:.||...||.|||||:.|||:.||::.|||||.||||||||||||:|||||
  Rat   267 NGGDLKFHIYHM-GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDL 330

  Fly   455 GLAVEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKRE 519
            ||||.:|||:.::|||||||||||||:.||:|.|||||::.||||||||.||:||:.||:|:|||
  Rat   331 GLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE 395

  Fly   520 EVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRL 584
            ||:|.|||..|:|:.:|:.:|:|:|.|||.|...:|||||.|  |.::|..||.|  .:||::||
  Rat   396 EVERLVKEVAEEYTDRFSPQARSLCSQLLNKDPAERLGCRGG--GAREVKEHPLF--KKLNFKRL 456

  Fly   585 EAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECF 649
            .||||||||.|||.|:|.|||||||||||||||:::.:|.:||.||.||||||.|||||:|||||
  Rat   457 GAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVDLEPTDQDFYQKFATGSVSIPWQNEMVETECF 521

  Fly   650 RELNVFGPEECPTPDLQINAAP-EPDKAGCFP--FRR-----------KKKQPARTQP 693
            :||||||.:....|||.....| .|.|.|...  |.|           ||..|..:.|
  Rat   522 QELNVFGLDGSVPPDLDWKGQPTAPPKKGLLQRLFSRQRIAVGTAATVKKSSPPASSP 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	32/75 (43%)
		RGS	<248..305	CDD:295367	22/57 (39%)
		STKc_GRK4_like	308..597	CDD:270756	207/288 (72%)
		S_TKc	309..574	CDD:214567	192/264 (73%)
Grk6	NP_113845.2	N-terminal	1..185		89/307 (29%)
		RGS	35..179	CDD:295367	59/267 (22%)
		STKc_GRK6	185..469	CDD:270779	207/288 (72%)
		S_TKc	186..448	CDD:214567	192/264 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348844
Domainoid	1	1.000	416	1.000	Domainoid score	I638
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	690	1.000	Inparanoid score	I663
OMA	1	1.010	-	-		QHG47927
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0001059
OrthoInspector	1	1.000	-	-		otm46454
orthoMCL	1	0.900	-	-		OOG6_102122
Panther	1	1.100	-	-	O	PTHR24355
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X940
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810