DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and grk3

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_009303964.1	Gene:	grk3 / 569403	ZFINID:	ZDB-GENE-030616-382	Length:	701	Species:	Danio rerio

Alignment Length:	654	Identity:	202/654 - (30%)
Similarity:	299/654 - (45%)	Gaps:	141/654 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCIN--LKDKLDISYGYVIDQQPIGR 64
            :||.::|:..||.|.|....:...::.| :.||..|.|...:.  |:::.::::..:.:|: ||.
Zfish     3 DLEAVLADVSYLMAMEKSKSTPAARASK-KIILPEPSIRSVMQKYLEERDELAFDKIFNQK-IGF 65

  Fly    65 ELFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALD 129
            .||:.||.|:.......:.|.:|:.:||                 .||.|   |.|........|
Zfish    66 LLFKDFCMNEIDEAVPQLKFYEEIKEYE-----------------KLDSE---EERLTRSRQIYD 110

  Fly   130 AETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATG 194
            ....:|||   |.::|......:|.....|.
Zfish   111 VYIMKELL---SCSHPFSKKAVDHVQTHLAK---------------------------------- 138

  Fly   195 NGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNS 259
                                              |.||
Zfish   139 ----------------------------------KQVP--------------------------- 142

  Fly   260 GGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQ-PITYKTFRMYRVLGKGGFGEV 323
              .::|...:..:...|.|..|::|..|..|.|:.|||.:|.. .:|...|.::|::|:||||||
Zfish   143 --PNLFQPYIVEICDSLRGNIFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEV 205

  Fly   324 CACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINS---PFVVNLAYAYETKDALCLV 385
            ..|:...||||||.|.|:|||||.::||::.|.|:.:|..:::   ||:|.:.||:.|.|.||.:
Zfish   206 YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFI 270

  Fly   386 LTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVR 450
            |.:||||||.:|:...|   .|..:..||||||:..||:|:|.:.:||||.||.|||||:|||||
Zfish   271 LDLMNGGDLHYHLSQHG---VFSEKDMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVR 332

  Fly   451 ISDLGLAVEIPEGEMVRGRVGTVGYMAPEVID-NEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKE 514
            |||||||.:..: :.....|||.|||||||:. ...|..|.||||.||:|::::.|.:|||..|.
Zfish   333 ISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKT 396

  Fly   515 KVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQL 579
            |.| .|:||.......:....|..|.||:.:.||.:.:.:||||. || |..:|..|.||..  :
Zfish   397 KDK-HEIDRMTLTMNVELPDSFTPELKSLLEGLLQRDVAKRLGCL-GR-GASEVKEHVFFKG--I 456

  Fly   580 NWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQF--STVKGVNIDESDTNFYTKFNTGSVSISWQNE 642
            :|:::......||.:|....|.|.|..||..|  ...||:.:.:||...|..|.. .:|..||.|
Zfish   457 DWQQVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYKNFPL-VISERWQQE 520

  Fly   643 MMET 646
            :.||
Zfish   521 VAET 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	15/77 (19%)
		RGS	<248..305	CDD:295367	12/57 (21%)
		STKc_GRK4_like	308..597	CDD:270756	130/292 (45%)
		S_TKc	309..574	CDD:214567	124/268 (46%)
grk3	XP_009303964.1	RGS_GRK2_GRK3	30..186	CDD:188701	46/277 (17%)
		PKc_like	185..530	CDD:304357	149/350 (43%)
		Pkinase	191..453	CDD:278497	124/268 (46%)
		PH_GRK2_subgroup	553..683	CDD:269946
		PH	560..663	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920