Protein Alignment Gprk2 and grk5l

DIOPT Version :9

• Sequence 1: NP_001263143.1
• Gene: Gprk2 / 49045
• FlyBaseID: FBgn0261988
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: XP_005167309.1
• Gene: grk5l / 567452
• ZFINID: ZDB-GENE-081105-95
• Length: 584
• Species: Danio rerio
• Alignment Length: 715
• Identity: 366/715 - (51%)
• Similarity: 454/715 - (63%)
• Gaps: 139/715 - (19%)

  Fly     1 MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            |||||||||||.|||||||....||:|||||:||:|||||||..|...::..|..:.::|||||.
Zfish     1 MELENIVANTVLLKAREGGGGKRKGRSKKWREILRFPHISQCTELNKAIERDYVCLCERQPIGRL 65

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            ||||:||. :|...|.|..||.:..||:.....|...|.:|.::||
Zfish    66 LFRLYCET-QPELQRCIQLLDAMDDYEVSPDEKRKSRGDEIIKKFL------------------- 110

  Fly   131 ETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGN 195
                                                   |.|.|
Zfish   111 ---------------------------------------NKQSS--------------------- 115

  Fly   196 GSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLN-S 259
                                             :||.|.            :.|..:.:..|. |
Zfish   116 ---------------------------------ECVDVA------------ESLAERCKENLELS 135

  Fly   260 GGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVC 324
            ..|:||:.|..|:..:|:|.||.::::||||.|:||||.||.||||..|||.|||||||||||||
Zfish   136 PCKEIFSDCRKALHDYLSGAPFTDYQNSMYFDRFLQWKMLERQPITKDTFRQYRVLGKGGFGEVC 200

  Fly   325 ACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIM 389
            |||||||||||||||||||||||||||:|.|.|||||:|:||.|||:||||||||||||||||||
Zfish   201 ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTIM 265

  Fly   390 NGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDL 454
            |||||||||||| |.||||.||.:.||||:.|||:.||::.|:|||.|||||||||:||:|||||
Zfish   266 NGGDLKFHIYNM-GTPGFEKERVQLYAAEICCGLEDLHRESIIYRDLKPENILLDDNGHIRISDL 329

  Fly   455 GLAVEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKRE 519
            |||:::|:||.:|||||||||||||||:||:|:.||||:..|||:|||..|::|||.|||:||||
Zfish   330 GLAIKVPDGEQIRGRVGTVGYMAPEVINNERYSMSPDWWGLGCLIYEMTAGRSPFRARKERVKRE 394

  Fly   520 EVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRL 584
            :|::||:|:.|:||.||:::.|::|:.||:|..||||||:..|..|  |.|||||.:  :|::||
Zfish   395 DVEKRVQEEEEEYSDKFSEDTKAICRMLLSKDPKQRLGCQTDRASG--VKAHPFFKN--INFKRL 455

  Fly   585 EAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECF 649
            |||:|||.|||||.|||.||||||||||||||||:|::|.:||:||.||||||.|||||:|||||
Zfish   456 EAGILEPSFVPDPRAVYCKDVLDIEQFSTVKGVNLDQTDNDFYSKFATGSVSIPWQNEMIETECF 520

  Fly   650 RELNVFGPEECPTPDLQINAAPEPDKAGCFP--FRRKKKQPARTQPIPIPEHLLTTS-HSVSSTT 711
            .:||||||:....|||..|..|||.:.....  |||.:.:...||     ..:|::| :||.|.|
Zfish   521 NDLNVFGPQGTRPPDLDWNQPPEPPRRSLLDRIFRRHRPEVTITQ-----SRVLSSSVNSVDSVT 580

  Fly   712  711
            Zfish   581  580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	30/75 (40%)
		RGS	<248..305	CDD:295367	25/57 (44%)
		STKc_GRK4_like	308..597	CDD:270756	207/288 (72%)
		S_TKc	309..574	CDD:214567	192/264 (73%)
grk5l	XP_005167309.1	RGS	35..178	CDD:295367	61/267 (23%)
		STKc_GRK4_like	184..468	CDD:270756	207/288 (72%)
		S_TKc	185..447	CDD:214567	192/264 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589997
Domainoid	1	1.000	411	1.000	Domainoid score	I652
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	720	1.000	Inparanoid score	I617
OMA	1	1.010	-	-		QHG47927
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0001059
OrthoInspector	1	1.000	-	-		otm26301
orthoMCL	1	0.900	-	-		OOG6_102122
Panther	1	1.100	-	-	O	PTHR24355
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4592
SonicParanoid	1	1.000	-	-		X940
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800