DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and grk1a

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001029353.2	Gene:	grk1a / 564152	ZFINID:	ZDB-GENE-050823-1	Length:	563	Species:	Danio rerio

Alignment Length:	688	Identity:	266/688 - (38%)
Similarity:	379/688 - (55%)	Gaps:	145/688 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LENIVANTVYLKAR---EGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGR 64
            |..:|||:.|:.||   :|.::....:.||:...|:.|||:.|.:|::.||:.:..:..:||||:
Zfish     6 LTTVVANSAYISARGSFDGTANPASNRDKKYHSKLKLPHITVCEDLRETLDLQFRSICVEQPIGK 70

  Fly    65 ELFRLFCEN----KRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGG 125
            .||:.:.|.    |.|.                              |.:.|||..
Zfish    71 RLFQEYLETANEYKGPC------------------------------RLWRDVEEY--------- 96

  Fly   126 DALDAETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLD-TRNHNG 189
                                 :|||                :.:.:|.::.|..:.:: :..|..
Zfish    97 ---------------------DTAE----------------DKDRTQKAAKILQRYMEPSAKHFC 124

  Fly   190 DDATGNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVR 254
            .....||.:         |.:|.|.:|
Zfish   125 PFLPENGIT---------KVKERHQEA-------------------------------------- 142

  Fly   255 NKLNSGGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGG 319
                  ..|:|.:.:..|..||...||..:..:|||.|:|||||||.||:....|..:|||||||
Zfish   143 ------ADDLFVEILACVFDFLKEVPFTFYLETMYFKRFLQWKWLEMQPVAEDWFLDFRVLGKGG 201

  Fly   320 FGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCL 384
            ||||.|||:|||||:||||||.|||:|||||....::||:||.:::|.|:|:||||::||..|||
Zfish   202 FGEVSACQMRATGKLYACKKLNKKRLKKRKGYEGAMVEKRILARVHSRFIVSLAYAFQTKTELCL 266

  Fly   385 VLTIMNGGDLKFHIYNMG-GEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGH 448
            |:||||||||::||||:. ..|||...||.:|||::..||:|||::.|:|||.||||:|||:.|:
Zfish   267 VMTIMNGGDLRYHIYNVDENNPGFSEPRACYYAAQIIQGLEHLHQKKIIYRDLKPENVLLDNEGN 331

  Fly   449 VRISDLGLAVEIPEG-EMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMR 512
            |||||||||||:.:| |..:|..||.|:||||::..|:|.:|.|:|:.|..|||.|..:.|||.|
Zfish   332 VRISDLGLAVELADGQEKTKGYAGTPGFMAPELLKGEEYDYSVDYFTLGVTLYEFIAAKGPFRTR 396

  Fly   513 KEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHST 577
            .|||:.:||.:|:..||..||.||::.|||:|:.||||.:.:|||.:||..  .::..||||  :
Zfish   397 GEKVENKEVKKRILNDPVTYSEKFSENAKSICEGLLAKEVDKRLGFKNGTC--DEIRTHPFF--S 457

  Fly   578 QLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNE 642
            |||||:|:||:|.||||||...|||||:.|:..|||||||.:::.|..|:.:|.:|::||.||.|
Zfish   458 QLNWRKLDAGILPPPFVPDSKTVYAKDLDDVGAFSTVKGVCLEDDDKCFFDEFASGNISIPWQEE 522

  Fly   643 MMETECFRELNVFGPEECPTPDLQINAAPE--PDKAGC 678
            |:||..:.||||:||......||:..:..|  |..:.|
Zfish   523 MIETGIYGELNVWGPGGAVPNDLRRESILEQPPKSSTC 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	17/79 (22%)
		RGS	<248..305	CDD:295367	20/56 (36%)
		STKc_GRK4_like	308..597	CDD:270756	166/290 (57%)
		S_TKc	309..574	CDD:214567	150/266 (56%)
grk1a	NP_001029353.2	RGS	43..180	CDD:295367	46/265 (17%)
		STKc_GRK1	189..476	CDD:270759	165/290 (57%)
		S_TKc	195..456	CDD:214567	149/262 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590000
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24355
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850