DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and prkacaa

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_021326630.1	Gene:	prkacaa / 564064	ZFINID:	ZDB-GENE-050114-6	Length:	389	Species:	Danio rerio

Alignment Length:	479	Identity:	125/479 - (26%)
Similarity:	216/479 - (45%)	Gaps:	103/479 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 TRNHNGD-DATGNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLND 247
            :|.|.|. ::..:|.|....|            :.:||||.|||.|.    ||       .|...
Zfish     7 SRRHGGKRESRSSGESRSSGG------------SAEGGGGGGGGSGS----GG-------GVEGP 48

  Fly   248 DLIAQVRNKLNSGGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMY 312
            .|:..|:..|....:|...:..|         |.:...|..:|.|                   .
Zfish    49 TLLVDVKEFLAKAKEDFLKKWEN---------PAQNTASLDHFER-------------------L 85

  Fly   313 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYE 377
            :.||.|.||.|...:.:.:|:.:|.|.|:|:::.|.|.....|.||:|||.::.||:|.|.::::
Zfish    86 KTLGTGSFGRVMLVKHKESGQHFAMKILDKQKVVKLKQIEHTLNEKRILQAVSFPFLVRLEHSFK 150

  Fly   378 TKDALCLVLTIMNGGDLKFHIYNMG--GEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPEN 440
            ....|.:|:..:.||::..|:..:|  .||     .||||||::....::||...::|||.||||
Zfish   151 DNTNLYMVMEYVPGGEMFSHLRRIGRFSEP-----HARFYAAQIVLTFEYLHSLDLIYRDLKPEN 210

  Fly   441 ILLDDHGHVRISDLGLAVEIPEGEMVRGRV----GTVGYMAPEVIDNEKYAFSPDWFSFGCLLYE 501
            :|:|..|:::::|.|.|      :.|:||.    ||..|:|||:|.::.|..:.||::.|.|:||
Zfish   211 LLIDQQGYIQVTDFGFA------KRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYE 269

  Fly   502 MIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQ 566
            |..|..|| ...:.:   ::..::.....::.|.|:.:.|.:.:.||...:.:|.|  |.:.|..
Zfish   270 MAAGYPPF-FADQPI---QIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFG--NLKNGVN 328

  Fly   567 DVMAHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFN 631
            |:..|.:|.:|  :|..:....:|.||:|                 ..||    ..||:.:..::
Zfish   329 DIKGHKWFATT--DWIAIYQKKVEAPFIP-----------------KCKG----PGDTSNFDDYD 370

  Fly   632 TGSVSISWQNEMMETECFRELNVF 655
            ...:.:|     :..:|.:|...|
Zfish   371 EEEIRVS-----ITEKCGKEFAEF 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367	9/56 (16%)
		STKc_GRK4_like	308..597	CDD:270756	91/294 (31%)
		S_TKc	309..574	CDD:214567	84/270 (31%)
prkacaa	XP_021326630.1	STKc_PKA	80..369	CDD:271111	97/347 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910