DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and grk6

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_689783.2	Gene:	grk6 / 561288	ZFINID:	ZDB-GENE-101006-5	Length:	575	Species:	Danio rerio

Alignment Length:	674	Identity:	344/674 - (51%)
Similarity:	429/674 - (63%)	Gaps:	130/674 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            |||||||||||.|||||||..:.|||||||:::|||||||.|..|:..::..|..:.::|||||.
Zfish     1 MELENIVANTVLLKAREGGGGNRKGKSKKWKQMLQFPHISLCEELRQTIEKDYNSLCERQPIGRL 65

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            |||.||:. ||...|.:.|||.|.:||:                     ...|.|...|.:.||
Zfish    66 LFRQFCDT-RPELRRCVRFLDAVAEYEV---------------------TPDEKRKECGQELLD- 107

  Fly   131 ETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGN 195
                                                             |.|:|::.:
Zfish   108 -------------------------------------------------KYLNTKSED------- 116

  Fly   196 GSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSG 260
                                                    |..|     :.::::.:..::|...
Zfish   117 ----------------------------------------YIPE-----VTEEMVTKCADRLQQE 136

  Fly   261 G-KDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVC 324
            . |::|.:|...:..:|:..||.::..|||:.|:|||||||.||||..|||.|||||||||||||
Zfish   137 ACKELFMECTKLIHDYLSVAPFADYLDSMYYSRFLQWKWLERQPITKNTFRQYRVLGKGGFGEVC 201

  Fly   325 ACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIM 389
            |||||||||||||||||||||||||||||.|.|||||:|:||.|||:||||||||||||||||:|
Zfish   202 ACQVRATGKMYACKKLEKKRIKKRKGESMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLM 266

  Fly   390 NGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDL 454
            ||||||||||:| ||.||:.:||.|||||:.|||:.||::.|||||.||||||||||||:|||||
Zfish   267 NGGDLKFHIYHM-GEAGFDEKRAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDL 330

  Fly   455 GLAVEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKRE 519
            ||||.:|||:.::|||||||||||||:.||:|.|||||::.|||||||||||:||:.||:|:|||
Zfish   331 GLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIEGQSPFQQRKKKIKRE 395

  Fly   520 EVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRL 584
            ||:|.|||..|:|||||:::|||:|:.||||...:||||:.|  |..:|.||..|.|  :|::||
Zfish   396 EVERLVKEVEEEYSSKFSEDAKSLCKMLLAKDPSERLGCQGG--GASEVKAHLIFRS--INFKRL 456

  Fly   585 EAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECF 649
            .|||||.||:|||.|:|.|||||||||||||||.::..|.:||:|.:||||.|.|||||:|||||
Zfish   457 AAGMLEAPFIPDPQAIYCKDVLDIEQFSTVKGVELEPKDDSFYSKVSTGSVPIPWQNEMIETECF 521

  Fly   650 RELNVFGPEECPTPDLQINAAPEP 673
            :|||:...:....|||.....|.|
Zfish   522 KELNILNLDGTVPPDLDWRGQPSP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	28/75 (37%)
		RGS	<248..305	CDD:295367	20/57 (35%)
		STKc_GRK4_like	308..597	CDD:270756	212/288 (74%)
		S_TKc	309..574	CDD:214567	198/264 (75%)
grk6	XP_689783.2	RGS_GRK6	35..179	CDD:188705	56/267 (21%)
		STKc_GRK6	185..469	CDD:270779	212/288 (74%)
		S_TKc	186..445	CDD:214567	196/261 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590001
Domainoid	1	1.000	411	1.000	Domainoid score	I652
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	720	1.000	Inparanoid score	I617
OMA	1	1.010	-	-		QHG47927
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0001059
OrthoInspector	1	1.000	-	-		otm26301
orthoMCL	1	0.900	-	-		OOG6_102122
Panther	1	1.100	-	-	O	PTHR24355
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4592
SonicParanoid	1	1.000	-	-		X940
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800