DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and grk5

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001166974.1	Gene:	grk5 / 560806	ZFINID:	ZDB-GENE-091204-274	Length:	588	Species:	Danio rerio

Alignment Length:	714	Identity:	297/714 - (41%)
Similarity:	410/714 - (57%)	Gaps:	157/714 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            ||:|.:.||...||||:.|:...||:|:||::||.||||:||..|::.::..|..:...||||::
Zfish     1 MEIETMAANCALLKARDAGNAYRKGRSRKWKEILHFPHINQCKELENSIERDYYSLCVNQPIGKQ 65

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            ||:|||..: |.....|..|:|:.|||:.                              .|.|..
Zfish    66 LFKLFCATE-PKLQHLIDLLEEMAKYEVT------------------------------TDDLKK 99

  Fly   131 ETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHS--SDINHKKLDTRNHNGDDAT 193
            .::::|                            ||....||.|  .::.||::...|.|
Zfish   100 TSRDKL----------------------------INKFKTSQSSMVREMVHKEMQNGNLN----- 131

  Fly   194 GNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLN 258
                                                                       :.|.::
Zfish   132 -----------------------------------------------------------MENFIS 137

  Fly   259 SGGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEV 323
            |        |.:|:..:|:|.||.|:::||||.|:||||.:|.:|:|...||.||:|||||||||
Zfish   138 S--------CHSALHEYLSGAPFSEYQNSMYFDRFLQWKMVERRPVTQDNFREYRILGKGGFGEV 194

  Fly   324 CACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTI 388
            ||||.||:|||||||||.|||:|::.||.|||.|||||:::||.|||:|||.|||||:||||||:
Zfish   195 CACQSRASGKMYACKKLVKKRVKRQGGEKMVLKEKQILERVNSRFVVSLAYTYETKDSLCLVLTV 259

  Fly   389 MNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISD 453
            |:||||.||||.||.:. .:..|.:||||||.|||.||||..:||||.||||||||..||:||||
Zfish   260 MDGGDLGFHIYKMGNQK-LDKNRVQFYAAEVLCGLDHLHKHNVVYRDLKPENILLDYEGHIRISD 323

  Fly   454 LGLAVEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKR 518
            ||||..:||.::|:|||||.|||||||:....|..|.||:..|||:|||...:.|||..||::.:
Zfish   324 LGLAEILPENKLVKGRVGTAGYMAPEVVAGTSYGVSVDWWGLGCLIYEMTAKKPPFRNHKEQISK 388

  Fly   519 EEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRR 583
            :::::|:.|..|.|...|::|.:::||:||||:.|:|||||:|: |.:.:.:|.||.:  :|:..
Zfish   389 KDLEQRILEKVELYDKMFDEETQNICQKLLAKNPKERLGCRSGQ-GAEVIKSHQFFKN--INFTL 450

  Fly   584 LEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETEC 648
            |||||::|||:|||.|:|..||.||:||:.||||.:||:|..||.:||||||::.||.||:||||
Zfish   451 LEAGMMQPPFIPDPRAIYCDDVSDIDQFAAVKGVTLDEADEAFYAEFNTGSVTVPWQTEMIETEC 515

  Fly   649 FRELNVFGPEECPTPDL----QINAAPEPDKAGCFP--------------FRRKKKQPARTQPI 694
            |::||||||....:.||    ||.:.....::....              |||.|.:||  :||
Zfish   516 FKDLNVFGPHGTRSQDLDRSEQIQSTVSEFQSSSLKIQSPLSRSRLLGKIFRRAKDEPA--EPI 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	24/75 (32%)
		RGS	<248..305	CDD:295367	20/56 (36%)
		STKc_GRK4_like	308..597	CDD:270756	171/288 (59%)
		S_TKc	309..574	CDD:214567	159/264 (60%)
grk5	NP_001166974.1	RGS	35..173	CDD:295367	55/268 (21%)
		PKc_like	180..464	CDD:304357	171/287 (60%)
		S_TKc	180..443	CDD:214567	159/264 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589998
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26301
orthoMCL	1	0.900	-	-		OOG6_102122
Panther	1	1.100	-	-	O	PTHR24355
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X940
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.710