DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gprk2 and PRKCI

DIOPT Version :9

Sequence 1:NP_001263143.1 Gene:Gprk2 / 49045 FlyBaseID:FBgn0261988 Length:714 Species:Drosophila melanogaster
Sequence 2:NP_002731.4 Gene:PRKCI / 5584 HGNCID:9404 Length:596 Species:Homo sapiens


Alignment Length:361 Identity:113/361 - (31%)
Similarity:191/361 - (52%) Gaps:28/361 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   309 FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQIL-QKINSPFVVNL 372
            |.:.||:|:|.:.:|...:::.|.::||.|.::|:.:...:....|..||.:. |..|.||:|.|
Human   254 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGL 318

  Fly   373 AYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCK 437
            ...::|:..|..|:..:|||||.||:......|.   |.||||:||::..|.:||::||:|||.|
Human   319 HSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPE---EHARFYSAEISLALNYLHERGIIYRDLK 380

  Fly   438 PENILLDDHGHVRISDLGLAVE-IPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYE 501
            .:|:|||..||::::|.|:..| :..|:......||..|:|||::..|.|.||.||::.|.|::|
Human   381 LDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFE 445

  Fly   502 MIEGQAPFRM-----RKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNG 561
            |:.|::||.:     ..::...:.:.:.:.|...:.....:.:|.|:.:..|.|..|:|||| :.
Human   446 MMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGC-HP 509

  Fly   562 RMGGQDVMAHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNF 626
            :.|..|:..||||.:  ::|..:|...:.|||.|:....:..|..| .|| |.:.|.:...|.:.
Human   510 QTGFADIQGHPFFRN--VDWDMMEQKQVVPPFKPNISGEFGLDNFD-SQF-TNEPVQLTPDDDDI 570

  Fly   627 YTKFNTGSVSISWQNEMMETECFRELN--VFGPEEC 660
            ..|.           :..|.|.|..:|  :...|||
Human   571 VRKI-----------DQSEFEGFEYINPLLMSAEEC 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gprk2NP_001263143.1 RGS 35..>111 CDD:295367
RGS <248..305 CDD:295367
STKc_GRK4_like 308..597 CDD:270756 98/294 (33%)
S_TKc 309..574 CDD:214567 90/271 (33%)
PRKCINP_002731.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Regulatory domain 2..253
Required for interaction with RAB2 2..28
PB1_aPKC 26..108 CDD:99725
Interaction with PARD6A 72..91
Pseudosubstrate. /evidence=ECO:0000250 125..134
C1_1 141..191 CDD:365894
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 220..246
STKc_aPKC_iota 233..596 CDD:270769 113/361 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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