DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gprk2 and PRKCH

DIOPT Version :9

Sequence 1:NP_001263143.1 Gene:Gprk2 / 49045 FlyBaseID:FBgn0261988 Length:714 Species:Drosophila melanogaster
Sequence 2:NP_006246.2 Gene:PRKCH / 5583 HGNCID:9403 Length:683 Species:Homo sapiens


Alignment Length:367 Identity:121/367 - (32%)
Similarity:178/367 - (48%) Gaps:52/367 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   309 FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKI-NSPFVVNL 372
            |...||||||.||:|...:|:.||.:||.|.|:|..|.:.......:.||:||... |.||:..|
Human   355 FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQL 419

  Fly   373 AYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCK 437
            ...::|.|.|..|:..:|||||.|||..   ...|:..||||||||:...|..||.:||:|||.|
Human   420 FCCFQTPDRLFFVMEFVNGGDLMFHIQK---SRRFDEARARFYAAEIISALMFLHDKGIIYRDLK 481

  Fly   438 PENILLDDHGHVRISDLGLAVE-IPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYE 501
            .:|:|||..||.:::|.|:..| |..|.......||..|:|||::....|..:.||::.|.||||
Human   482 LDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYE 546

  Fly   502 MIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQ 566
            |:.|.|||....|    :::...:..|...|.:..:::|..:.:..:.|:...|||...  .||:
Human   547 MLCGHAPFEAENE----DDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLT--QGGE 605

  Fly   567 D-VMAHPFFHSTQLNWRRLEAGMLEPPFVP-----------DPHAVYAKDVLDIEQFSTVKGVNI 619
            . ::.||||  .:::|.:|....:||||.|           ||..:..:.||             
Human   606 HAILRHPFF--KEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVL------------- 655

  Fly   620 DESDTNFYTKFNTGSVSISWQNEMMETECFRELNVFGPEECP 661
                    |..:.|.:.:..|:|      ||..:...||..|
Human   656 --------TPIDEGHLPMINQDE------FRNFSYVSPELQP 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gprk2NP_001263143.1 RGS 35..>111 CDD:295367
RGS <248..305 CDD:295367
STKc_GRK4_like 308..597 CDD:270756 108/301 (36%)
S_TKc 309..574 CDD:214567 99/267 (37%)
PRKCHNP_006246.2 C2_PKC_epsilon 8..140 CDD:175981
C1_1 172..225 CDD:278556
C1_1 246..298 CDD:278556
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 320..342
S_TKc 355..614 CDD:214567 99/267 (37%)
STKc_nPKC_eta 359..681 CDD:270742 118/359 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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