Protein Alignment Gprk2 and grk1b

DIOPT Version :10

• Sequence 1: NP_476867.1
• Gene: Gprk2 / 49045
• FlyBaseID: FBgn0261988
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_001017711.2
• Gene: grk1b / 550406
• ZFINID: ZDB-GENE-050417-211
• Length: 559
• Species: Danio rerio
• Alignment Length: 682
• Identity: 262/682 - (38%)
• Similarity: 360/682 - (52%)
• Gaps: 137/682 - (20%)

  Fly     3 LENIVANTVYLKAREG--GSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            ||.:|||:.|:.||..  |:.:...:.||:|..|..|||.||..:|..:|.|:..:..:||||:.
Zfish     6 LETVVANSAYVSARGSIDGAAAATMRDKKYRSKLNLPHIRQCEQMKTIVDTSFDSMCVRQPIGKR 70

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            ||:.:.|:                  |.:| .|.:.:..||
Zfish    71 LFQQYLES------------------EADY-KNPVDLWKDI------------------------ 92

  Fly   131 ETQEELLLNSSN--ANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDAT 193
               |:.::...|  |...:....::..:::.|.|
Zfish    93 ---EDYIVAQENDRAKKAQKIVNKYYESSSKNFC------------------------------- 123

  Fly   194 GNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLN 258
                                                             |.|.|..:::|:....
Zfish   124 -------------------------------------------------DFLGDKAVSRVKEDFK 139

  Fly   259 SGGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEV 323
            :...|:|.:....:...|..:....|:.||||.||:|:||||:||:....|..:|||||||||||
Zfish   140 NIRGDLFKESEQQLLVHLEAKALTGFKDSMYFLRYVQFKWLESQPVAEDWFMDFRVLGKGGFGEV 204

  Fly   324 CACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTI 388
            .|||::|||||||.|||.|||:|||||....:|||:||.|::|.|:|.||||::||..||||:||
Zfish   205 HACQMKATGKMYANKKLNKKRLKKRKGYDGAIIEKRILAKVHSRFIVTLAYAFQTKTDLCLVMTI 269

  Fly   389 MNGGDLKFHIYNMGGE-PGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRIS 452
            ||||||:||:||:..: |||...||.:|.|::.|||:|||:..|||||.||||:||||.||||:|
Zfish   270 MNGGDLRFHMYNVDEKNPGFNETRACYYTAQIICGLEHLHQHRIVYRDLKPENVLLDDAGHVRLS 334

  Fly   453 DLGLAVEIPEG-EMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKV 516
            |||||||:|.| :..:|..||.|:||||::..::|.::.|:|:.|..||||:..:.|||.|.|:|
Zfish   335 DLGLAVELPPGKDKTQGYAGTPGFMAPELLQKKEYDYTVDYFTLGVTLYEMVAAKGPFRCRGEQV 399

  Fly   517 KREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNW 581
            ...||.||:..||..|...|:.|.|.:|:.|:.|..::|||.:|....  ::....||  .:|||
Zfish   400 DNNEVTRRILNDPVSYPPTFSQELKDLCEGLMEKDPEKRLGFKNNECA--ELKNQSFF--KELNW 460

  Fly   582 RRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMET 646
            .|||||||.|||||||..|||||:.|:..|||||||.||..|..|||:|.||:|.|.||.||:||
Zfish   461 GRLEAGMLPPPFVPDPKMVYAKDIDDVGAFSTVKGVVIDNKDDEFYTEFATGNVPIPWQEEMIET 525

  Fly   647 ECFRELNVFGPEECPTPDLQINAAPEPDKAGC 678
            ..|.|||::|.......||..|.. |....||
Zfish   526 GVFGELNIWGQNGKLPNDLDPNFV-EAKGGGC 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_476867.1	RGS	35..>111	CDD:470619	20/75 (27%)
		RGS	<248..305	CDD:470619	18/56 (32%)
		STKc_GRK4_like	308..597	CDD:270756	160/290 (55%)
		S_TK_X	578..642	CDD:214529	43/63 (68%)
grk1b	NP_001017711.2	RGS_GRK1	42..179	CDD:188702	40/262 (15%)
		Protein Kinases, catalytic domain	188..475	CDD:473864	159/290 (55%)