DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and grk1b

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001017711.2	Gene:	grk1b / 550406	ZFINID:	ZDB-GENE-050417-211	Length:	559	Species:	Danio rerio

Alignment Length:	682	Identity:	262/682 - (38%)
Similarity:	360/682 - (52%)	Gaps:	137/682 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LENIVANTVYLKAREG--GSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            ||.:|||:.|:.||..  |:.:...:.||:|..|..|||.||..:|..:|.|:..:..:||||:.
Zfish     6 LETVVANSAYVSARGSIDGAAAATMRDKKYRSKLNLPHIRQCEQMKTIVDTSFDSMCVRQPIGKR 70

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            ||:.:.|:                  |.:| .|.:.:..||
Zfish    71 LFQQYLES------------------EADY-KNPVDLWKDI------------------------ 92

  Fly   131 ETQEELLLNSSN--ANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDAT 193
               |:.::...|  |...:....::..:::.|.|
Zfish    93 ---EDYIVAQENDRAKKAQKIVNKYYESSSKNFC------------------------------- 123

  Fly   194 GNGSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLN 258
                                                             |.|.|..:::|:....
Zfish   124 -------------------------------------------------DFLGDKAVSRVKEDFK 139

  Fly   259 SGGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEV 323
            :...|:|.:....:...|..:....|:.||||.||:|:||||:||:....|..:|||||||||||
Zfish   140 NIRGDLFKESEQQLLVHLEAKALTGFKDSMYFLRYVQFKWLESQPVAEDWFMDFRVLGKGGFGEV 204

  Fly   324 CACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTI 388
            .|||::|||||||.|||.|||:|||||....:|||:||.|::|.|:|.||||::||..||||:||
Zfish   205 HACQMKATGKMYANKKLNKKRLKKRKGYDGAIIEKRILAKVHSRFIVTLAYAFQTKTDLCLVMTI 269

  Fly   389 MNGGDLKFHIYNMGGE-PGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRIS 452
            ||||||:||:||:..: |||...||.:|.|::.|||:|||:..|||||.||||:||||.||||:|
Zfish   270 MNGGDLRFHMYNVDEKNPGFNETRACYYTAQIICGLEHLHQHRIVYRDLKPENVLLDDAGHVRLS 334

  Fly   453 DLGLAVEIPEG-EMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKV 516
            |||||||:|.| :..:|..||.|:||||::..::|.::.|:|:.|..||||:..:.|||.|.|:|
Zfish   335 DLGLAVELPPGKDKTQGYAGTPGFMAPELLQKKEYDYTVDYFTLGVTLYEMVAAKGPFRCRGEQV 399

  Fly   517 KREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNW 581
            ...||.||:..||..|...|:.|.|.:|:.|:.|..::|||.:|....  ::....||  .:|||
Zfish   400 DNNEVTRRILNDPVSYPPTFSQELKDLCEGLMEKDPEKRLGFKNNECA--ELKNQSFF--KELNW 460

  Fly   582 RRLEAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMET 646
            .|||||||.|||||||..|||||:.|:..|||||||.||..|..|||:|.||:|.|.||.||:||
Zfish   461 GRLEAGMLPPPFVPDPKMVYAKDIDDVGAFSTVKGVVIDNKDDEFYTEFATGNVPIPWQEEMIET 525

  Fly   647 ECFRELNVFGPEECPTPDLQINAAPEPDKAGC 678
            ..|.|||::|.......||..|.. |....||
Zfish   526 GVFGELNIWGQNGKLPNDLDPNFV-EAKGGGC 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	20/75 (27%)
		RGS	<248..305	CDD:295367	18/56 (32%)
		STKc_GRK4_like	308..597	CDD:270756	160/290 (55%)
		S_TKc	309..574	CDD:214567	143/266 (54%)
grk1b	NP_001017711.2	RGS_GRK1	42..179	CDD:188702	40/262 (15%)
		PKc_like	188..475	CDD:304357	159/290 (55%)
		S_TKc	194..455	CDD:214567	142/262 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589999
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24355
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950