DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gprk2 and prkcaa

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_021332537.1	Gene:	prkcaa / 497384	ZFINID:	ZDB-GENE-050208-100	Length:	679	Species:	Danio rerio

Alignment Length:	346	Identity:	126/346 - (36%)
Similarity:	194/346 - (56%)	Gaps:	27/346 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 FRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQIL-QKINSPFVVNL 372
            |....|||||.||:|...:::::.:::|.|.|:|..:.:.......::||::| |:...||:..|
Zfish   346 FNFLAVLGKGSFGKVMLAEMKSSDELFAIKILKKDVVIQDDDVECTMVEKRVLAQQDKPPFLTQL 410

  Fly   373 AYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCK 437
            ...::|.|.|..|:..:|||||.:||..:|   .|:..:|.|||||:|.||..|||:||:|||.|
Zfish   411 HSCFQTVDRLYFVMEYVNGGDLMYHIQQVG---KFKEPQAVFYAAEIAVGLFFLHKKGIIYRDLK 472

  Fly   438 PENILLDDHGHVRISDLGLAVE-IPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYE 501
            .:|::||..||::|:|.|:..| |.||...|...||..|:|||:|..:.|..|.||:::|.||||
Zfish   473 LDNVMLDAEGHIKIADFGMCKENIVEGVTTRTFCGTPDYIAPEIIAYQPYGRSVDWWAYGVLLYE 537

  Fly   502 MIEGQAPFRMRKEKVKREEVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQ 566
            |:.||.||....|    :|:.:.:.|....||...:.||.|:|:.|:.|...:||||  |:.|.:
Zfish   538 MLAGQPPFDGEDE----DELFQSIMEHNVSYSKTLSKEAVSICKGLMTKHPSKRLGC--GQEGER 596

  Fly   567 DVMAHPFFHSTQLNWRRLEAGMLEPPFVPDPHAVYAKDVLDIEQFST-----------VKGVNID 620
            |:..|.||.  :::|.||....::|||.|   .|..|...:.::|.|           :...|||
Zfish   597 DIREHAFFR--RIDWDRLANREVQPPFKP---KVCGKGAENFDKFFTRTQPQLTPPDELVIANID 656

  Fly   621 ESDTNFYTKFNTGSVSISWQN 641
            ::|.:.:|..|...|..|..|
Zfish   657 QADFDGFTFVNPQFVHPSLVN 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367
		STKc_GRK4_like	308..597	CDD:270756	113/289 (39%)
		S_TKc	309..574	CDD:214567	104/266 (39%)
prkcaa	XP_021332537.1	C1_1	35..87	CDD:278556
		C1_1	100..150	CDD:278556
		C2_PKC_alpha_gamma	157..287	CDD:175992
		STKc_cPKC_alpha	335..675	CDD:270766	124/342 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910