DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and grk4

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001006112.1	Gene:	grk4 / 448587	XenbaseID:	XB-GENE-480159	Length:	575	Species:	Xenopus tropicalis

Alignment Length:	686	Identity:	360/686 - (52%)
Similarity:	433/686 - (63%)	Gaps:	132/686 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRE 65
            ||:||||||||.|||||||.....|:||||:::|:.||||||..|:..::..||.:.::|||||.
Frog     1 MEIENIVANTVLLKAREGGGGKRNGRSKKWKEMLRLPHISQCEELRHTIERDYGNLCEKQPIGRL 65

  Fly    66 LFRLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDA 130
            |||.||:. ||...|.|.|||.|.:||:.....|    .|.|.|.||.    ...|||
Frog    66 LFRQFCDT-RPELKRCIEFLDAVAEYELAPDEKR----KDHGLRILDT----YFNNGS------- 114

  Fly   131 ETQEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGN 195

Frog   115 ----------------------------------------------------------------- 114

  Fly   196 GSSHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKL-NS 259
             ::|                                          |..:..|.:.:.:.|| .|
Frog   115 -AAH------------------------------------------LPEIPQDTVHECKEKLEQS 136

  Fly   260 GGKDIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVC 324
            ..|::|..|...|..:|:|.||.:|:.||||.|:|||||||.||:|..|||.|||||||||||||
Frog   137 PCKELFKDCTRVVHDYLSGTPFGDFQDSMYFSRFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVC 201

  Fly   325 ACQVRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIM 389
            |||||||||||||||||||||||||||||.|.|||||:|:||.|||:|||.||||||||||||||
Frog   202 ACQVRATGKMYACKKLEKKRIKKRKGESMALNEKQILEKVNSRFVVSLAYTYETKDALCLVLTIM 266

  Fly   390 NGGDLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDL 454
            |||||||||||| |.|||:.:||.|||||:.|||:.|.::.|||||.|||||||||.||:|||||
Frog   267 NGGDLKFHIYNM-GNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDL 330

  Fly   455 GLAVEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKRE 519
            ||||:|||||.:|||||||||||||||:||.|.|||||:..|||:||||:||:|||.|||||||:
Frog   331 GLAVQIPEGESIRGRVGTVGYMAPEVINNESYTFSPDWWGLGCLVYEMIQGQSPFRKRKEKVKRD 395

  Fly   520 EVDRRVKEDPEKYSSKFNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRL 584
            ||||||:||.|:||.||:::|||:|:.||:|..||||||...  |...|..||.|.:  :|::||
Frog   396 EVDRRVREDEEEYSEKFSEDAKSICRMLLSKDPKQRLGCTGS--GASHVKQHPIFKN--INFKRL 456

  Fly   585 EAGMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECF 649
            ||.:|||||||||.|||.||||||||||||||||:|.:|.:||:||.||||||.||.||:|||||
Frog   457 EANILEPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDTTDDDFYSKFVTGSVSIPWQQEMIETECF 521

  Fly   650 RELNVFGPEECPTPDLQINAAPEPDKAGCFP--FRR 683
            :::||:..:.|.:|||.::......|...|.  |||
Frog   522 KDINVYETDGCLSPDLDVSKQNLKPKRSFFHRLFRR 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	33/75 (44%)
		RGS	<248..305	CDD:295367	27/57 (47%)
		STKc_GRK4_like	308..597	CDD:270756	216/288 (75%)
		S_TKc	309..574	CDD:214567	202/264 (77%)
grk4	NP_001006112.1	RGS_GRK4	52..183	CDD:188704	60/254 (24%)
grk4	NP_001006112.1	STKc_GRK4	185..469	CDD:173720	216/288 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	424	1.000	Domainoid score	I620
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	738	1.000	Inparanoid score	I598
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0001059
OrthoInspector	1	1.000	-	-		otm49533
Panther	1	1.100	-	-	LDO	PTHR24355
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4592
SonicParanoid	1	1.000	-	-		X940
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190