DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and grk7b

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001028262.1	Gene:	grk7b / 373871	ZFINID:	ZDB-GENE-030904-3	Length:	548	Species:	Danio rerio

Alignment Length:	652	Identity:	248/652 - (38%)
Similarity:	346/652 - (53%)	Gaps:	136/652 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRELF 67
            |:|:||||.||||:    ..::.:.||.|..|..||:..|.:::..:...:..:.:||||||..|
Zfish     7 LKNLVANTDYLKAQ----SLDEKEIKKRRCSLGLPHLGNCTDVRASVSKGFEDICEQQPIGRACF 67

  Fly    68 RLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDAET 132
            |.|.....|.|......|||:..:.:                                  .:||.
Zfish    68 RQFLSVSSPEYLAAAELLDELNCWNL----------------------------------AEAEA 98

  Fly   133 QEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGNGS 197
            :||..||..|         :.|                          |.|::
Zfish    99 KEEARLNIIN---------KFC--------------------------KADSK------------ 116

  Fly   198 SHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSGGK 262
                    |.......|:||           ||..|.....|.|       ::.||:
Zfish   117 --------SFLAFLTEDEAE-----------KCKAVSEKDFEEV-------MMGQVK-------- 147

  Fly   263 DIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVCACQ 327
                   .|.:.||.|:||.|:::|::|.|::|||..|.||||.|.|..:|.||||||||||..|
Zfish   148 -------EATQKFLRGQPFEEYQTSLFFDRFVQWKKFEKQPITDKYFYEFRTLGKGGFGEVCGVQ 205

  Fly   328 VRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNGG 392
            |:.||:|||||||:|||:||:.||.|.|:||:||:.:||.|:||||||::||..||||:|:|:||
Zfish   206 VKTTGQMYACKKLDKKRLKKKSGEKMALLEKKILEMVNSLFIVNLAYAFDTKTHLCLVMTLMSGG 270

  Fly   393 DLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLA 457
            |||:||::: ||.|.|:||...|.|::..|:.|||...|||||.||||:|||..|..|:||||||
Zfish   271 DLKYHIFHV-GEVGIEMERIIHYTAQITSGILHLHSMDIVYRDMKPENVLLDCQGQCRLSDLGLA 334

  Fly   458 VEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREEVD 522
            ||:|.|:....:.||.||||||::..|.|..|.||::.||.:|||:.|:.|||..||||.:||:.
Zfish   335 VELPNGKTTTQKAGTKGYMAPEILKQEPYRTSVDWWALGCSIYEMVAGRVPFRDHKEKVAKEELL 399

  Fly   523 RRVKEDPEKYSSK-FNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRLEA 586
            ||..||..|:..: |:..:|.:....|.::|:.|||      ...|...|.||.|  :|:.||||
Zfish   400 RRTLEDEVKFEHRNFDAPSKDIISLFLKRNIEDRLG------SNDDPRKHEFFKS--INFPRLEA 456

  Fly   587 GMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECFRE 651
            |::.||:.|..:.|||||..||.:||.||||..|.:|..|:.:|:||:|.|:||..|:::..|.|
Zfish   457 GLIPPPWEPKANVVYAKDTGDIREFSDVKGVKFDANDEKFFKEFSTGAVPIAWQQGMIDSGLFDE 521

  Fly   652 LN 653
            |:
Zfish   522 LS 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367	17/75 (23%)
		RGS	<248..305	CDD:295367	18/56 (32%)
		STKc_GRK4_like	308..597	CDD:270756	150/289 (52%)
		S_TKc	309..574	CDD:214567	138/265 (52%)
grk7b	NP_001028262.1	RGS	37..177	CDD:383028	51/261 (20%)
		PKc_like	184..466	CDD:389743	150/290 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..548		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0001059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24355
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920