Protein Alignment Gprk2 and grk7b

DIOPT Version :10

• Sequence 1: NP_476867.1
• Gene: Gprk2 / 49045
• FlyBaseID: FBgn0261988
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_001028262.1
• Gene: grk7b / 373871
• ZFINID: ZDB-GENE-030904-3
• Length: 548
• Species: Danio rerio
• Alignment Length: 652
• Identity: 248/652 - (38%)
• Similarity: 346/652 - (53%)
• Gaps: 136/652 - (20%)

  Fly     3 LENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCINLKDKLDISYGYVIDQQPIGRELF 67
            |:|:||||.||||:    ..::.:.||.|..|..||:..|.:::..:...:..:.:||||||..|
Zfish     7 LKNLVANTDYLKAQ----SLDEKEIKKRRCSLGLPHLGNCTDVRASVSKGFEDICEQQPIGRACF 67

  Fly    68 RLFCENKRPVYFRYITFLDEVVKYEIEYISNRIFIGHDIGRRFLDVEAQLELRNGSGGDALDAET 132
            |.|.....|.|......|||:..:.:                                  .:||.
Zfish    68 RQFLSVSSPEYLAAAELLDELNCWNL----------------------------------AEAEA 98

  Fly   133 QEELLLNSSNANPTETAETEHCNNTTANNCNNINNSNNSQHSSDINHKKLDTRNHNGDDATGNGS 197
            :||..||..|         :.|                          |.|::
Zfish    99 KEEARLNIIN---------KFC--------------------------KADSK------------ 116

  Fly   198 SHQDDGDESVKCQEGHDDAEKGGGGEGGGGGKCVPVGGYPDELVLDVLNDDLIAQVRNKLNSGGK 262
                    |.......|:||           ||..|.....|.|       ::.||:
Zfish   117 --------SFLAFLTEDEAE-----------KCKAVSEKDFEEV-------MMGQVK-------- 147

  Fly   263 DIFAQCVNAVKAFLAGEPFREFESSMYFHRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVCACQ 327
                   .|.:.||.|:||.|:::|::|.|::|||..|.||||.|.|..:|.||||||||||..|
Zfish   148 -------EATQKFLRGQPFEEYQTSLFFDRFVQWKKFEKQPITDKYFYEFRTLGKGGFGEVCGVQ 205

  Fly   328 VRATGKMYACKKLEKKRIKKRKGESMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNGG 392
            |:.||:|||||||:|||:||:.||.|.|:||:||:.:||.|:||||||::||..||||:|:|:||
Zfish   206 VKTTGQMYACKKLDKKRLKKKSGEKMALLEKKILEMVNSLFIVNLAYAFDTKTHLCLVMTLMSGG 270

  Fly   393 DLKFHIYNMGGEPGFELERARFYAAEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLA 457
            |||:||::: ||.|.|:||...|.|::..|:.|||...|||||.||||:|||..|..|:||||||
Zfish   271 DLKYHIFHV-GEVGIEMERIIHYTAQITSGILHLHSMDIVYRDMKPENVLLDCQGQCRLSDLGLA 334

  Fly   458 VEIPEGEMVRGRVGTVGYMAPEVIDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREEVD 522
            ||:|.|:....:.||.||||||::..|.|..|.||::.||.:|||:.|:.|||..||||.:||:.
Zfish   335 VELPNGKTTTQKAGTKGYMAPEILKQEPYRTSVDWWALGCSIYEMVAGRVPFRDHKEKVAKEELL 399

  Fly   523 RRVKEDPEKYSSK-FNDEAKSMCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRLEA 586
            ||..||..|:..: |:..:|.:....|.::|:.|||      ...|...|.||.|  :|:.||||
Zfish   400 RRTLEDEVKFEHRNFDAPSKDIISLFLKRNIEDRLG------SNDDPRKHEFFKS--INFPRLEA 456

  Fly   587 GMLEPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDTNFYTKFNTGSVSISWQNEMMETECFRE 651
            |::.||:.|..:.|||||..||.:||.||||..|.:|..|:.:|:||:|.|:||..|:::..|.|
Zfish   457 GLIPPPWEPKANVVYAKDTGDIREFSDVKGVKFDANDEKFFKEFSTGAVPIAWQQGMIDSGLFDE 521

  Fly   652 LN 653
            |:
Zfish   522 LS 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_476867.1	RGS	35..>111	CDD:470619	17/75 (23%)
		RGS	<248..305	CDD:470619	18/56 (32%)
		STKc_GRK4_like	308..597	CDD:270756	150/289 (52%)
		S_TK_X	578..642	CDD:214529	32/63 (51%)
grk7b	NP_001028262.1	RGS	37..177	CDD:470619	51/261 (20%)
		Protein Kinases, catalytic domain	184..466	CDD:473864	150/290 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	520..548		2/4 (50%)