DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gprk2 and rps6kal

DIOPT Version :9

Sequence 1:	NP_001263143.1	Gene:	Gprk2 / 49045	FlyBaseID:	FBgn0261988	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_956367.1	Gene:	rps6kal / 337670	ZFINID:	ZDB-GENE-030131-9616	Length:	740	Species:	Danio rerio

Alignment Length:	363	Identity:	125/363 - (34%)
Similarity:	187/363 - (51%)	Gaps:	60/363 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 PITY-----------KTFRMYRVLGKGGFGEVCACQVRA-----TGKMYACKKLEKKRIKKRKGE 351
            |||:           ..|.:.:|||:|.||:|..  ||.     .|::||.|.|:|..:|.| ..
Zfish    50 PITHHVKEGCEKADPSQFELLKVLGQGSFGKVFL--VRKLMGPDAGQLYAMKVLKKASLKVR-DR 111

  Fly   352 SMVLIEKQILQKINSPFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYA 416
            ....:|:.||.::|.||:|.|.||::|:..|.|:|..:.|||:   ...:..|..|..|..:||.
Zfish   112 VRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDV---FTRLSKEVMFTEEDVKFYL 173

  Fly   417 AEVACGLQHLHKQGIVYRDCKPENILLDDHGHVRISDLGLAVE-IPEGEMVRGRVGTVGYMAPEV 480
            ||:|..|.|||..||||||.||||||||:.||::::|.||:.| :.:.:......|||.||||||
Zfish   174 AELALALDHLHNLGIVYRDLKPENILLDEAGHIKLTDFGLSKESVDQDKKAYSFCGTVEYMAPEV 238

  Fly   481 IDNEKYAFSPDWFSFGCLLYEMIEGQAPFRMRKEKVKREEVDRRVKED---PEKYSSKFNDEAKS 542
            ::...:..|.||:|.|.|::||:.|..||   :.|.:.|.::..:|..   |:..|.    ||:.
Zfish   239 VNRRGHTQSADWWSLGVLMFEMLTGTLPF---QGKDRNETMNMILKAKLGMPQFLSL----EAQG 296

  Fly   543 MCQQLLAKSIKQRLGCRNGRMGGQDVMAHPFFHSTQLNWRRLEAGMLEPPFVP-----------D 596
            :.:.|..::...|||.  |..|.:::..|.||  :.::|.:|....|:|||.|           |
Zfish   297 LLRMLFKRNPSNRLGA--GPDGVEEIKRHTFF--STIDWNKLYRRELQPPFKPASGKPDDTFCFD 357

  Fly   597 PH--AVYAKDVLDI----------EQFSTVKGVNIDES 622
            |.  |...||...|          :.||.|..|:::||
Zfish   358 PEFTAKTPKDSPGIPPSANAHQLFKGFSFVAPVSLEES 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gprk2	NP_001263143.1	RGS	35..>111	CDD:295367
		RGS	<248..305	CDD:295367	1/1 (100%)
		STKc_GRK4_like	308..597	CDD:270756	110/308 (36%)
		S_TKc	309..574	CDD:214567	101/273 (37%)
rps6kal	NP_956367.1	S_TKc	67..326	CDD:214567	101/273 (37%)
		STKc_RSK_N	71..387	CDD:270734	117/332 (35%)
		STKc_RSK4_C	415..709	CDD:271079
		S_TKc	420..677	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910